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Twin pregnancy and molar pregnancy

Antonio Braga, Bruna Obeica, Heron Werner, Sue Yazaki Sun, Joffre Amim Júnior, Jorge Rezende Filho, Edward Araujo Júnior
Twin molar pregnancy with a hydatidiform mole and a coexisting live fetus is a rare form of gestational trophoblastic disease associated with an increased risk of obstetric complications and poor perinatal outcome. Prenatal diagnosis is essential for couple counseling and follow-up in Tertiary Reference Centers. Magnetic resonance imaging is important for the diagnostic differentiation of placental mesenchymal dysplasia and exclusion of myometrial invasion. Here we present a case of twin molar pregnancy with a hydatidiform mole and a coexisting live fetus diagnosed at gestational week 14 using two-dimensional (2D) and three-dimensional (3D) ultrasound and magnetic resonance imaging...
December 2017: Journal of Ultrasonography
Johanna Savage, Emily Adams, Emanuela Veras, Kathleen M Murphy, Brigitte M Ronnett
Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. Distinction of these subtypes has prognostic and therapeutic implications. Twenty-two tumors were genotyped using polymerase chain reaction amplification of 15 short tandem repeat loci and the amelogenin locus (XY determination). DNA patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature (containing vs...
December 2017: American Journal of Surgical Pathology
Rafael José Pio Barbosa Teixeira, Natália Silva Andrade, Lisanca Carvalho Cavalcante Queiroz, Fausto Medeiros Mendes, Marcoeli Silva Moura, Lúcia de Fátima Almeida de Deus Moura, Marina Deus Moura Lima
BACKGROUND: The etiology of molar-incisor hypomineralization (MIH) remains unknown. Studies indicate that it is multifactorial, and that genetic and environmental factors are involved. Research with twins provides important subsidy to investigate the Influence of genetics and environmental factors that act during pregnancy on the etiology of alterations. AIM: This cross-sectional study evaluated the agreement of molar incisor hypomineralization (MIH) between monozygotic and dizygotic twin pairs and the association with environmental factors...
March 2018: International Journal of Paediatric Dentistry
Sarah Gillett, Kam Singh, Jane Ireson, Annie Hills, Matthew Winter, John Tidy, Ruth Logan, Barry Hancock
OBJECTIVE: To describe the evolution of a teenage and young adult (TYA) service for patients with gestational trophoblastic neoplasia (GTN). BACKGROUND: Since its opening in 2002 the TYA unit has demonstrated its effectiveness and ability to care for GTN patients, offering additional emotional assessment and meeting the specific needs that many young GTN patients have. Patients using the TYA unit were identified from the Centre's databases, and individual records were scrutinized for demographics, clinical presentation, barriers to care, compliance, and specific needs...
May 2016: Journal of Reproductive Medicine
Kaoru Kawasaki, Eiji Kondoh, Sachiko Minamiguchi, Fumihiko Matsuda, Koichiro Higasa, Kohei Fujita, Haruta Mogami, Yoshitsugu Chigusa, Ikuo Konishi
A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. We describe a rare case of a singleton, partial molar pregnancy with a seemingly huge placenta, which continued to delivery of a live-born diploid baby. A 27-year-old primigravida suffered from severe pre-eclampsia and progressive anemia. The uterus was enormously enlarged for the gestational age. A cesarean section was performed because of deterioration of maternal status at 25 weeks' gestation, when more than 3000 mL blood spouted concurrently with the delivery of the placenta...
August 2016: Journal of Obstetrics and Gynaecology Research
Ikram Boubess, Adib Filali, Fayssal Benbrahim, Salma Ouassour, Mokha Tazi, Mohammad Hassan Alami
No abstract text is available yet for this article.
2015: Pan African Medical Journal
Antonio Braga, Izildinha Maestá, Michelle Matos, Kevin M Elias, Julianna Rizzo, Maurício Guilherme Campos Viggiano
OBJECTIVE: To evaluate the risk of gestational trophoblastic neoplasia (GTN) after spontaneous human chorionic gonadotropin normalization in postmolar follow-up. METHODS: Retrospective chart review of 2284 consecutive cases of hydatidiform mole with spontaneous normalization of hCG following uterine evacuation treated at one of five Brazilian reference centers from January 2002 to June 2013. RESULTS: After hCG normalization, GTN occurred in 10/2284 patients (0...
November 2015: Gynecologic Oncology
Lavanya Rai, Hebbar Shripad, Shyamala Guruvare, Adiga Prashanth, Anjali Mundkur
This is a case report of a twin pregnancy with one fetus and a coexistent mole diagnosed at 13 weeks. After thorough counseling, the pregnancy was continued as per the patient's desire. The pregnancy was closely monitored with serial S β hCG, ultrasound for fetal growth, size of molar sac, and theca lutein cysts, which gradually decreased in size during the second trimester of pregnancy. An emergency caesarean delivery was done at 36 weeks due to breech in early labour. A live baby weighing 1.8 kg was delivered in good condition...
November 2014: Malaysian Journal of Medical Sciences: MJMS
Barış Büke, Hasan Onur Topçu, Ece Bulgu, Elmin Eminov, Mert Kazandı
We present a case of a patient with a complete hydatidiform mole co-existing with a normal foetus (CMCF) who had a caesarean section in week 32 of gestation, resulting in a live female infant weighing 1590 grams. The mother, with a normal bleeding pattern, did not require any surgical intervention. She was discharged from hospital on the third post-operative day. Premature termination is recommended in this type of pregnancy because of the risks associated with molar pregnancies. However, with the close follow-up of these pregnancies, good maternal and perinatal results may be obtained...
2014: Journal of the Turkish German Gynecological Association
Chih-Ping Chen, Tsang-Ming Ko, Chen-Yu Chen, Tao-Yeuan Wang, Schu-Rern Chern, Yu-Ling Kuo, Wayseen Wang
OBJECTIVE: To present first-trimester molecular diagnosis of complete hydatidiform mole (CHM) associated with dizygotic twin pregnancy conceived by intrauterine insemination. MATERIALS AND METHODS: A 32-year-old woman presented to the hospital with a huge complex cystic mass measuring about 8.5 cm × 4.1 cm in the uterine cavity and a living co-existing fetus with fetal biometry equivalent to 9 weeks. She underwent chorionic villus sampling at 13 weeks of gestation, and microsatellite genotyping for molar pregnancy test was applied...
December 2014: Taiwanese Journal of Obstetrics & Gynecology
Kirsten J Curnow, Louise Wilkins-Haug, Allison Ryan, Eser Kırkızlar, Melissa Stosic, Megan P Hall, Styrmir Sigurjonsson, Zachary Demko, Matthew Rabinowitz, Susan J Gross
OBJECTIVE: We sought to determine the ability of single-nucleotide polymorphism-based noninvasive prenatal testing (NIPT) to identify triploid, unrecognized twin, and vanishing twin pregnancies. STUDY DESIGN: The study included 30,795 consecutive reported clinical cases received for NIPT for fetal whole-chromosome aneuploidies; known multiple gestations were excluded. Cell-free DNA was isolated from maternal blood samples, amplified via 19,488-plex polymerase chain reaction, and sequenced...
January 2015: American Journal of Obstetrics and Gynecology
Hsiu-Huei Peng, Kuan-Gen Huang, Ho-Yen Chueh, Aizura-Syafinaz Adlan, Shuenn-Dyn Chang, Chyi-Long Lee
OBJECTIVE: A twin pregnancy consisting of a complete hydatidiform mole with a coexisting normal fetus is extremely rare with an incidence of 1/22,000 to 1/100,000. The incidence of preterm delivery is high and few pregnancies reach near term with a viable fetus. CASE REPORT: A 34-year-old woman presented at 20 weeks of gestation with increased levels of serum beta human chorionic gonadotropin (beta-HCG) at 4.74 multiples of the median (310277.7 mIU/mL). Ultrasonography showed a hydatidiform mole together with a normal fetus...
September 2014: Taiwanese Journal of Obstetrics & Gynecology
Annie N Y Cheung
Extensive use of ultrasound in early pregnancy has given rise to increased diagnostic dilemma, particularly the differential diagnosis of early complete mole, partial mole and abnormal nonmolar villous lesions. The rare entities of placental mesenchymal dysplasia, twin pregnancy with one complete mole further pose problems. Overdiagnosis of hydatidiform mole in ectopic pregnancy should also be avoided.Molecular cytogenetic studies, besides enhancing our understanding of pathogenesis, also facilitate diagnosis and management...
October 2014: Pathology
Mark K Santillan, Donna A Santillan, Sabrina M Scroggins, James Y Min, Jeremy A Sandgren, Nicole A Pearson, Kimberly K Leslie, Stephen K Hunter, Gideon K D Zamba, Katherine N Gibson-Corley, Justin L Grobe
Preeclampsia, a cardiovascular disorder of late pregnancy, is characterized as a low-renin hypertensive state relative to normotensive pregnancy. Because other nonpregnant low-renin hypertensive disorders often exhibit and are occasionally dependent on elevated arginine vasopressin (AVP) secretion, we hypothesized a possible use for plasma AVP measurements in the prediction of preeclampsia. Copeptin is an inert prosegment of AVP that is secreted in a 1:1 molar ratio and exhibits a substantially longer biological half-life compared with AVP, rendering it a clinically useful biomarker of AVP secretion...
October 2014: Hypertension
Ee Tein Tay
Twin partial hydatidiform molar pregnancy with a viable fetus is an uncommon occurrence. Presentations of molar pregnancies include vaginal bleeding, unusually elevated β-human chorionic gonadotropin level, and preeclampsia. Previous descriptions of twin molar and fetus pregnancies in the literature have been described in the outpatient obstetric setting. We present a case of partial molar pregnancy with a viable fetus detected with emergency ultrasound in a pediatric emergency department.
December 2013: Pediatric Emergency Care
Tuomo Heikkinen, Virpi Harila, Juha S Tapanainen, Lassi Alvesalo
The aim of this study is to explore the effect of prenatal androgenization on the clinical eruption of permanent teeth expressing dimorphism and bimaturism. The eruption curves of permanent teeth (except third molars), including those that make up the canine complex (permanent canines, lower first premolars), are compared among opposite sex twins (OS twins) relative to single-born boys and girls. The comparisons are made with regard to three phases of eruption (pierced mucosa, half- erupted, and completely erupted) from a cross-sectional sample of dental casts, using Kaplan-Meier survival and Cox regression analyzes...
August 2013: American Journal of Physical Anthropology
S Dalmia, K Sivakumar, R Kathirvel, K Phillips, A M Coady
No abstract text is available yet for this article.
April 2013: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Jerome Rebollos Barrera, Mark Anthony Santiago Sandoval, Leslie Quizon Quiwa, Elizabeth Paz-Pacheco
Twin molar pregnancy with coexistent viable fetus in a patient with Graves' disease is a rare entity. The patient is a 37-year-old woman who was hospitalised owing to persistent vomiting and vaginal bleeding. The pregnancy test was positive and the pelvic ultrasound disclosed twin gestation of complete mole and a coexistent viable 12-week fetus. β-Human chorionic gonadotropin (β-HCG) and free thyroid hormones were both elevated. The patient was also a diagnosed case of Graves' disease prior to this pregnancy...
February 21, 2013: BMJ Case Reports
Tiago José Santos de Matos Ferraz, Carla Maria Magno Bartosch, Carla Maria Almeida Ramalho, Filipa Abreu Gomes de Carvalho, Berta Cecília Campos Lima de Carvalho, Otília Gonçalves Bento Cavaleiro Brandão, Nuno Aires Mota Mendonça Montenegro
A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform mole, leading to pregnancy termination. Autopsy and histological examinations diagnosed a complete mole coexisting with a normal fetus, and the genetic analysis showed a diploid fetus with biparental genome and molar tissue with paternal diploidy...
January 2013: Revista Brasileira de Ginecologia e Obstetrícia
Cheng-juan Sun, You-ping Zhao, Song Yu, Ling Fan, Qing-qing Wu, Guang-hui Li, Wei-yuan Zhang
Twin pregnancy with mosaic partial hydatidiform mole (PHM) and survival of two healthy fetuses following in vitro fertilization and embryos transfer (IVF-ET) is a rare situation and is considered a challenge for management. A 32-year-old Chinese woman conceived twin pregnancy following IVF-ET. At 22 weeks' gestation, an additional intrauterine echogenic mass with features of PHM were shown by successive ultrasound examinations. At 35 weeks' gestation, two live male infants and two placentas were delivered by caesarean section (CS)...
December 2012: Chinese Medical Journal
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