keyword
MENU ▼
Read by QxMD icon Read
search

Guanidinoacetic

keyword
https://www.readbyqxmd.com/read/29756995/guanidinoacetic-acid-supplementation-in-broiler-chickens-fed-corn-soybean-diets-affects-performance-in-the-finisher-period-and-energy-metabolites-in-breast-muscle-independent-of-diet-nutrient-density
#1
Maryam Majdeddin, Abolghasem Golian, Hassan Kermanshahi, Stefaan De Smet, Joris Michiels
Guanidinoacetic acid (GAA) is the single immediate endogenous precursor of creatine. It was hypothesised that dietary GAA would have different effects on performance and energy metabolites in breast muscle depending on the nutrient density (ND) of corn-soybean based diets. A total of 540 one-day-old male Ross 308 broilers were allocated to nine dietary treatments with six replicates (10 birds each) in a 3 × 3 factorial arrangement with three levels of ND (low, 2800; medium, 2950 and high, 3100 kcal ME/kg; and with the other nutrients being constant relative to ME) and supplemented with three levels of GAA (0, 0...
May 14, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29741632/effects-of-guanidinoacetic-acid-on-growth-performance-creatine-and-energy-metabolism-and-carcass-characteristics-in-growing-finishing-pigs
#2
D T He, X R Gai, L B Yang, J T Li, W Q Lai, X L Sun, L Y Zhang
The aim of this study was to investigate the effects of dietary supplementation with guanidinoacetic acid (GAA) on the growth performance, creatine and energy metabolism, and carcass characteristics in growing-finishing pigs. In Exp. 1, Duroc × Landrace × Yorkshire pigs (n = 180, 33.61 ± 3.91 kg average BW) were blocked by weight and sex, and allotted to five treatments with six replicates (3 gilts and 3 barrows per replicate pen). Diets were corn-soybean meal basal diets supplemented with 0, 300, 600, 900, and 1,200 mg/kg of GAA and fed to the pigs for 98 d...
May 7, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29690949/energy-utilisation-of-broiler-chickens-in-response-to-guanidinoacetic-acid-supplementation-in-diets-with-various-energy-contents
#3
Sayed Sadra Ale Saheb Fosoul, Arash Azarfar, Abbasali Gheisari, Heshmatollah Khosravinia
This experiment was conducted to investigate the effects of guanidinoacetic acid (GAA) on productive performance, intestinal morphometric features, blood parameters and energy utilisation in broiler chickens. A total of 390 male broiler chicks (Ross 308) were assigned to six dietary treatments based on a factorial arrangement (2×3) across 1-15 and 15-35-d periods. Experimental treatments consisted of two basal diets with standard (STD; starter: 12·56 MJ/kg and grower: 12·97 MJ/kg) and reduction (LME; starter: 11·93 MJ/kg and grower: 12·33 MJ/kg) of apparent metabolisable energy (AME) requirement of broiler chickens each supplemented with 0, 0·6 and 1·2 g/kg GAA...
April 25, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29669056/performance-meat-quality-and-pectoral-myopathies-of-broilers-fed-either-corn-or-sorghum-based-diets-supplemented-with-guanidinoacetic-acid
#4
H A Córdova-Noboa, E O Oviedo-Rondón, A H Sarsour, J Barnes, P Ferzola, M Rademacher-Heilshorn, U Braun
One experiment was conducted to evaluate the effects of guanidinoacetic acid (GAA) supplementation in broilers fed corn or sorghum-based diets on live performance, carcass and cut up yields, meat quality, and pectoral myopathies. The treatments consisted of corn or sorghum-based diets with or without the addition of GAA (600 g/ton). A total of 800 one-d-old male Ross 708 broiler chicks were randomly placed in 40 floor pens with 10 replicates (20 birds per pen) per each of the four treatments. At hatch, 14, 35, and 50 d, BW and feed intake were recorded...
April 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/29669035/effect-of-guanidinoacetic-acid-supplementation-on-live-performance-meat-quality-pectoral-myopathies-and-blood-parameters-of-male-broilers-fed-corn-based-diets-with-or-without-poultry-by-products
#5
H A Córdova-Noboa, E O Oviedo-Rondón, A H Sarsour, J Barnes, D Sapcota, D López, L Gross, M Rademacher-Heilshorn, U Braun
Creatine is a nitrogenous compound naturally occurring in animal tissues and is obtained from dietary animal protein or de novo synthesis from guanidinoacetic acid (GAA). The dietary supply of this semi-essential nutrient could be adversely compromised when feeding purely vegetable-based diets. The objective of this experiment was to evaluate the effects of GAA supplementation in broilers fed corn-based diets with or without the inclusion of poultry by-products (PBP) on live performance, carcass and cut up yields, meat quality, pectoral muscle myopathies, differential blood count, blood clinical chemistry, serum GAA and its metabolites...
April 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/29580081/pulmonary-hypertensive-response-of-broiler-chickens-to-arginine-and-guanidinoacetic-acid-under-high-altitude-hypoxia
#6
Behnam Ahmadipour, Mohammadreza Sharifi, Fariborz Khajali
This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens. Four isoenergetic and isonitrogenous diets were prepared, including: (i) the control, (ii) the control supplemented with 1 g/kg ARG, (iii) the control supplemented with 1 g/kg GAA, and (iv) the control supplemented with 1.5 g/kg GAA. These diets were fed to broilers (Ross 308) from day 1 to 42 post-hatch. Criteria evaluated in the experiment were growth performance, carcass characteristics, serum and blood variables, lead-II electrocardiogram, and ET-1 and iNOS gene expression in heart and lungs...
March 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29506905/treatment-outcome-of-twenty-two-patients-with-guanidinoacetate-methyltransferase-deficiency-an-international-retrospective-cohort-study
#7
Yannay Khaikin, Sarah Sidky, Jose Abdenur, Arnaud Anastasi, Diana Ballhausen, Sabrina Buoni, Alicia Chan, David Cheillan, Nathalie Dorison, Alice Goldenberg, Jennifer Goldstein, Floris C Hofstede, Marie-Line Jacquemont, Dwight D Koeberl, Laurence Lion-Francois, Allan Meldgaard Lund, Karine Mention, Helen Mundy, Declan O'Rourke, Gaele Pitelet, Miquel Raspall-Chaure, Maria Tassini, Thierry Billette de Villemeur, Monique Williams, Gajja S Salomons, Saadet Mercimek-Andrews
PURPOSE: Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessive disorder caused by pathogenic variants in GAMT. Brain creatine depletion and guanidinoacetate accumulation cause developmental delay, seizures and movement disorder. Treatment consists of creatine, ornithine and arginine-restricted diet. We initiated an international treatment registry using Research Electronic Data Capture (REDCap) software to evaluate treatment outcome. METHODS: Physicians completed an online REDCap questionnaire...
May 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29449460/pfn2-and-gamt-as-common-molecular-determinants-of-axonal-charcot-marie-tooth-disease
#8
Manisha Juneja, Abdelkrim Azmi, Jonathan Baets, Andreas Roos, Matthew J Jennings, Paola Saveri, Chiara Pisciotta, Nathalie Bernard-Marissal, Bernard L Schneider, Catherine Verfaillie, Roman Chrast, Pavel Seeman, Angelika F Hahn, Peter de Jonghe, Stuart Maudsley, Rita Horvath, Davide Pareyson, Vincent Timmerman
BACKGROUND: Charcot-Marie-Tooth type 2 (CMT2) neuropathy is characterised by a vast clinical and genetic heterogeneity complicating its diagnosis and therapeutic intervention. Identification of molecular signatures that are common to multiple CMT2 subtypes can aid in developing therapeutic strategies and measuring disease outcomes. METHODS: A proteomics-based approach was performed on lymphoblasts from CMT2 patients genetically diagnosed with different gene mutations to identify differentially regulated proteins...
February 15, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29409353/serum-creatine-is-not-a-reliable-marker-of-muscular-fitness-in-young-adults
#9
Valdemar Stajer, Milan Vranes, Vladan Kocic, Sergej M Ostojic
PURPOSE: Elevated serum creatine and higher handgrip strength are individually associated with better health profiles yet the link between two variables remains unknown. In this cross-sectional study, we evaluated serum creatine levels in relation to handgrip strength in a cohort of 130 young healthy adults (61 women and 69 men; age 23.3 ± 2.6 years), while controlling for age, gender, fat-free mass and biomarkers of creatine metabolism as effect modifiers. MATERIALS AND METHODS: Serum creatine, creatinine and guanidinoacetic acid (GAA) levels were measured with liquid chromatography-tandem mass spectroscopy, while handgrip strength was assessed with a hydraulic hand dynamometer...
February 19, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29406829/human-skeletal-muscle-contains-no-detectable-guanidinoacetic-acid
#10
Sergej M Ostojic, Jelena Ostojic
We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.
February 6, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29384270/cognitive-deficits-and-increases-in-creatine-precursors-in-a-brain-specific-knockout-of-the-creatine-transporter-gene-slc6a8
#11
K C Udobi, A N Kokenge, E R Hautman, G Ullio, J Coene, M T Williams, C V Vorhees, A Mabondzo, M R Skelton
Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X-linked disorder characterized by severe cognitive deficits, impairments in language and an absence of brain creatine (Cr). In a previous study, we generated floxed Slc6a8 (Slc6a8 flox ) mice to create ubiquitous Slc6a8 knockout (Slc6a8-/y ) mice. Slc6a8-/y mice lacked whole body Cr and exhibited cognitive deficits. While Slc6a8-/y mice have a similar biochemical phenotype to CTD patients, they also showed a reduction in size and reductions in swim speed that may have contributed to the observed deficits...
January 31, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29342866/guanidinoacetic-acid-and-creatine-are-associated-with-cardiometabolic-risk-factors-in-healthy-men-and-women-a-cross-sectional-study
#12
Sergej M Ostojic, Milan Vranes, Davor Loncar, Natasa Zenic, Damir Sekulic
Guanidinoacetic acid (GAA) conversion to creatine is thought to be involved in cardiometabolic disturbances through its role in biological methylation and insulin secretion. We evaluated the association of serum GAA and creatine with cardiometabolic risk factors in a cohort of 151 apparently healthy adults (82 women and 69 men) aged 18-63 years. Serum levels of GAA and creatine were measured with liquid chromatography-tandem mass spectrometry. A multiple linear regression model adjusted for age and sex was employed to examine the relationship of serum GAA and creatine with cardiometabolic risk factors...
January 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29232678/effects-of-guanidinoacetic-acid-loading-on-biomarkers-of-cardiometabolic-risk-and-inflammation
#13
Sergej M Ostojic, Tatjana Trivic, Patrik Drid, Valdemar Stajer, Milan Vranes
No abstract text is available yet for this article.
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29226642/homoarginine-associates-with-zonulin-and-tryptophan-findings-in-a-high-risk-cohort-of-patients-carrying-an-aicd
#14
Elli Mann, Robert Kluesener, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Christoph Melzer, Thomas B Dschietzig
BACKGROUND: Homoarginine (hArg) is known to have an impact on nitric oxide (NO) metabolism. It seems to increase NO generation and/or availability, thereby enhancing endothelial function. In addition, hArg is connected to energy metabolism since the key enzyme, L-arginine-glycine amidinotransferase (AGAT) for hArg synthesis in the kidneys, is also involved in the synthesis of energy metabolites like guanidinoacetate. Former studies indicate that low levels of hArg are linked to cardiovascular disease and increased all-cause mortality...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29209878/cell-type-specific-spatiotemporal-expression-of-creatine-biosynthetic-enzyme-s-adenosylmethionine-guanidinoacetate-n-methyltransferase-in-developing-mouse-brain
#15
Masanori Tachikawa, Masahiko Watanabe, Masahiro Fukaya, Kazuhisa Sakai, Tetsuya Terasaki, Ken-Ichi Hosoya
Creatine is synthesized by S-adenosylmethionine:guanidinoacetate N-methyltransferase (GAMT), and the creatine/phosphocreatine shuttle system mediated by creatine kinase (CK) is essential for storage and regeneration of high-energy phosphates in cells. Although the importance of this system in brain development is evidenced by the hereditary nature of creatine deficiency syndrome, the spatiotemporal cellular expression patterns of GAMT in developing brain remain unknown. Here we show that two waves of high GAMT expression occur in developing mouse brain...
February 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29175673/astrocytic-%C3%AE-aminobutyric-acid-gaba-transporters-mediate-guanidinoacetate-transport-in-rat-brain
#16
Masanori Tachikawa, Ayane Yashiki, Shin-Ichi Akanuma, Haruka Matsukawa, Soichiro Ide, Masabumi Minami, Ken-Ichi Hosoya
Guanidinoacetate (GAA) is a biosynthetic precursor of creatine, which plays a critical role in homeostasis of high-energy phosphates in the brain, but cerebral accumulation of GAA leads to neurological complications, such as epilepsy and seizures. The purpose of the present study was to clarify the contribution of the γ-aminobutyric acid (GABA) transport systems to GAA transport in astrocytes by means of uptake studies in rat brain slices, primary astrocyte cultures and Chinese hamster ovary (CHO) cells expressing human GABA transporters (GATs)...
February 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29104251/influence-of-glycine-and-arginine-on-cylindrospermopsin-production-and-aoa-gene-expression-in-aphanizomenon-ovalisporum
#17
Ángel Barón-Sola, Francisca Fernández Del Campo, Soledad Sanz-Alférez
Arginine (Arg) and glycine (Gly) seem to be the only substrates accepted by the amidinotransferase that catalyze the first step of the synthesis pathway of the cyanotoxin cylindrospermopsin (CYN), leading to guanidinoacetate (GAA). Here, the effect of these amino acids on the production of CYN in cultures of the cylindrospermopsin-producing strain, Aphanizomenon ovalisporum UAM-MAO, has been studied. Arg clearly increased CYN content, the increment appearing triphasic along the culture. On the contrary, Gly caused a decrease of CYN, observable from the first day on...
November 1, 2017: Toxins
https://www.readbyqxmd.com/read/29048809/-determination-of-guanidinoacetic-acid-in-feed-by-ion-chromatography-coupled-with-ultraviolet-detection
#18
Xiangli Sun, Yanyan Wei, Weiguo Liu, Liying Zhang
A novel ion chromatography method for the determination of guanidinoacetic acid (GAA) in animal feed samples was developed. The optimal detection mode, chromatography column, gradient condition of mobile phases and sample pretreatment conditions were investigated. Using a linear gradient of methane sulfonic acid and ultraviolet detector at 200 nm, the interfering substances in feed samples and GAA could be separated successfully on a Dionex IonPac(TM) CS16 cation exchange analysis column. The calibration curves showed a range of linearity between 0...
October 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/28971744/benefits-and-drawbacks-of-guanidinoacetic-acid-as-a-possible-treatment-to-replenish-cerebral-creatine-in-agat-deficiency
#19
Sergej M Ostojic
Arginine-glycine amidinotransferase (AGAT) deficiency is a rare inherited metabolic disorder that severely affects brain bioenergetics. Characterized by mental retardation, language impairment, and behavioral disorders, AGAT deficiency is a treatable condition, where long-term creatine supplementation usually restores brain creatine levels and improves its clinical features. In some cases of AGAT deficiency, creatine treatment might be somewhat limited due to possible shortcomings in performance and transport of creatine to the brain...
October 3, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28961344/investigation-of-the-contribution-of-total-creatine-to-the-cest-z-spectrum-of-brain-using-a-knockout-mouse-model
#20
Lin Chen, Haifeng Zeng, Xiang Xu, Nirbhay N Yadav, Shuhui Cai, Nicolaas A Puts, Peter B Barker, Tong Li, Robert G Weiss, Peter C M van Zijl, Jiadi Xu
The current study aims to assign and estimate the total creatine (tCr) signal contribution to the Z-spectrum in mouse brain at 11.7 T. Creatine (Cr), phosphocreatine (PCr) and protein phantoms were used to confirm the presence of a guanidinium resonance at this field strength. Wild-type (WT) and knockout mice with guanidinoacetate N-methyltransferase deficiency (GAMT-/-), which have low Cr and PCr concentrations in the brain, were used to assign the tCr contribution to the Z-spectrum. To estimate the total guanidinium concentrations, two pools for the Z-spectrum around 2 ppm were assumed: (i) a Lorentzian function representing the guanidinium chemical exchange saturation transfer (CEST) at 1...
December 2017: NMR in Biomedicine
keyword
keyword
67853
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"