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https://www.readbyqxmd.com/read/28222046/evaluation-method-for-in-situ-electric-field-in-standardized-human-brain-for-different-transcranial-magnetic-stimulation-coils
#1
Masahiro Iwahashi, Jose Gomez-Tames, Ilkka Laakso, Akimasa Hirata
This study proposes a method to evaluate the electric field induced in the brain by transcranial magnetic stimulation (TMS) to realize focal stimulation in the target area considering the inter-subject difference of the brain anatomy. The TMS is a non-invasive technique used for treatment/diagnosis, and it works by inducing an electric field in a specific area of the brain via a coil-induced magnetic field. Recent studies that report on the electric field distribution in the brain induced by TMS coils have been limited to simplified human brain models or a small number of detailed human brain models...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28221767/construction-of-a-chassis-for-a-tripartite-protein-based-molecular-motor
#2
Lara Sioban Small, Marc Bruning, Andrew Thomson, Aimee L Boyle, Roberta Davies, Paul M G Curmi, Nancy R Forde, Heiner Linke, Derek N Woolfson, Elizabeth Bromley
Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors. We demonstrate the use of orthogonal coiled-coil dimers (including both parallel and anti-parallel coiled-coils) as a hub for linking other components of a previously described synthetic molecular motor, the Tumbleweed...
February 21, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28221748/fe3-ph-thermo-responsive-supramolecular-hydrogel-with-multi-shape-memory-effect
#3
Xiaoxia Le, Wei Lu, He Xiao, Li Wang, Chunxin Ma, Jiawei Zhang, Youju Huang, Tao Chen
Poor, non-tunable mechanical properties as well as finite shape memory performance pose a barrier to shape memory hydrogels to realize practical applications. Here, a new shape memory hydrogel with tunable mechanical properties and multi-shape memory effect was presented. Three programmable reversible systems including PBA-diol ester bonds, AAc-Fe3+ and coil-helix transition of agar were applied to memorize temporary shapes and endow the hydrogel with outstanding multi-shape memory functionalities. Moreover, through changing the crosslinking densities, the mechanical properties of the as-prepared hydrogel can be adjusted...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28221172/interventional-pulmonology-in-chronic-obstructive-pulmonary-disease
#4
Daniela Gompelmann, Nilab Sarmand, Felix J F Herth
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) and emphysema are widespread diseases associated with progressive dyspnea because of airflow limitation and hyperinflation. Fundamental therapeutic strategies consist of pulmonary rehabilitation, pharmacotherapy, long-term oxygen therapy, noninvasive ventilation, and surgical therapeutic approaches. RECENT FINDINGS: In the last 14 years, endoscopic therapeutic modalities emerged as a substantial part of severe COPD and emphysema treatment...
February 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28220617/wave-caipi-for-highly-accelerated-mp-rage-imaging
#5
Daniel Polak, Kawin Setsompop, Stephen F Cauley, Borjan A Gagoski, Himanshu Bhat, Florian Maier, Peter Bachert, Lawrence L Wald, Berkin Bilgic
PURPOSE: To introduce a highly accelerated T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) acquisition that uses wave-controlled aliasing in parallel imaging (wave-CAIPI) encoding to retain high image quality. METHODS: Significant acceleration of the MP-RAGE sequence is demonstrated using the wave-CAIPI technique. Here, sinusoidal waveforms are used to spread aliasing in all three directions to improve the g-factor. Combined with a rapid (2 s) coil sensitivity acquisition and data-driven trajectory calibration, we propose an online integrated acquisition-reconstruction pipeline for highly efficient MP-RAGE imaging...
February 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28219914/nickel-associated-delayed-multiple-white-matter-lesions-after-stent-assisted-coil-embolization-of-intracranial-unruptured-aneurysm
#6
Hun Soo Park, Ichiro Nakagawa, Shohei Yokoyama, Daisuke Wajima, Takeshi Wada, Yasushi Motoyama, Kimihiko Kichikawa, Hiroyuki Nakase
Metal-induced encephalopathy after stent-assisted coil embolization is extremely rare. The present report describes two patients who presented with symptomatic intracranial parenchymal edematous lesions after stent-assisted coil embolization. A 64-year-old woman underwent stent-assisted coil embolization for a left internal carotid artery aneurysm; 21 days after the procedure she presented with right hand weakness and MRI revealed multifocal white matter lesions. Another woman aged 52 years underwent stent-assisted coil embolization for right vertebral artery aneurysm; 18 days after the procedure she presented with left-sided sensory disturbance and MRI demonstrated multiple white matter lesions...
February 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28219797/spectroscopy-analysis-and-molecular-dynamics-studies-on-the-binding-of-penicillin-v-and-sulbactam-to-beta-lactamase-ii-from-bacillus-cereus
#7
Penghui Shi, Pan Qiao, Yeli Zhang, Shuaihua Li, Xuan Feng, Liujiao Bian
The molecular recognition and interaction of beta-lactamase II from Bacillus cereus (Bc II) with penicillin V (PV) and sulbactam (Sul) especially conformational changes of Bc II in the binding process were studied through spectroscopy analysis in combination with molecular dynamics (MD) simulation. The results show that in the binding process, a new coordination bond is observed between the Zn2 of Bc II and the carboxyl-O of PV or Sul by replacing His204. Electrostatic interaction between Zn2 and the ligand provide main driving force for the binding affinity...
February 11, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28219565/epicardial-implantable-cardioverter-defibrillator-in-a-2-month-old-infant
#8
Koichi Sughimoto, Yuta Tsuchida, Hidenori Hayashi, Shinzo Torii, Tadashi Kitamura, Tetsuya Horai, Kagami Miyaji
We describe the implantation of an implantable cardioverter defibrillator (ICD) in a 2-month-old infant with frequent sustained ventricular tachycardia (VT) refractory to antiarrhythmic agents. An epicardial ICD shock coil lead and pacing leads were placed, as was a cumbersome device console that was stored in a pocket between the left external and internal oblique muscles. These methods were safe and feasible even for such a small infant, and possible adverse events were avoided.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219360/interobserver-and-intraobserver-agreement-of-ligamentous-injuries-on-conventional-mri-after-simple-elbow-dislocation
#9
Marc Schnetzke, Svenja Schüler, Johannes Hoffend, Rainer Simon, Holger Keil, Felix Porschke, Stefan Studier-Fischer, Paul-Alfred Grützner, Thorsten Guehring
BACKGROUND: The primary objective of this study was to assess the interobserver and intraobserver agreement on ligamentous injuries on conventional magnetic resonance imaging (MRI) in acute simple elbow dislocation. The secondary objectives were to determine the interobserver agreement on the assessment of joint congruity, joint effusion, loose bodies and chondral lesions on conventional MRI. METHODS: Conventional MRIs (1.5 Tesla, elbow specific surface coil) of 30 patients (40...
February 20, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28218823/review-of-the-development-of-methods-for-characterization-of-microspheres-for-use-in-embolotherapy-translating-bench-to-cathlab
#10
REVIEW
Marcus Caine, Dario Carugo, Xunli Zhang, Martyn Hill, Matthew R Dreher, Andrew L Lewis
Therapeutic embolotherapy is the deliberate occlusion of a blood vessel within the body, which can be for the prevention of internal bleeding, stemming of flow through an arteriovenous malformation, or occlusion of blood vessels feeding a tumor. This is achieved using a wide selection of embolic devices such as balloons, coils, gels, glues, and particles. Particulate embolization is often favored for blocking smaller vessels, particularly within hypervascularized tumors, as they are available in calibrated sizes and can be delivered distally via microcatheters for precise occlusion with associated locoregional drug delivery...
February 20, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28218613/first-experimental-comparison-between-the-cartesian-and-the-lissajous-trajectory-for-magnetic-particle-imaging
#11
Franziska Werner, Nadine Gdaniec, Tobias Knopp
Magnetic Particle Imaging (MPI) is a quantitative imaging modality that allows to determine the distribution of superparamagnetic nanoparticles. Sampling is achieved by moving a field-free point (FFP) along a specific trajectory through the volume of interest. The magnetic material that lies along the path or in the close vicinity of the FFP changes its magnetization and induces a voltage in surrounding receive coils. Various trajectories for the FFP are conceivable, but most experimental MPI scanners either use a Cartesian or a Lissajous sampling trajectory...
February 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28218432/becn2-interacts-with-atg14-through-a-metastable-coiled-coil-to-mediate-autophagy
#12
Minfei Su, Yue Li, Shane Wyborny, David Neau, Srinivas Chakravarthy, Beth Levine, Christopher L Colbert, Sangita C Sinha
ATG14 binding to BECN/Beclin homologs is essential for autophagy, a critical catabolic homeostasis pathway. Here we show that the α-helical, coiled-coil domain (CCD) of BECN2, a recently identified mammalian BECN1 paralog, forms an anti-parallel, curved homodimer with seven pairs of non-ideal packing interactions, while the BECN2 CCD and ATG14 CCD form a parallel, curved heterodimer stabilized by multiple, conserved polar interactions. Compared to BECN1, the BECN2 CCD forms a weaker homodimer, but binds more tightly to the ATG14 CCD...
February 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28216791/molecular-processes-leading-to-necking-in-extensional-flow-of-polymer-solutions-using-microfluidics-and-single-dna-imaging
#13
Shaurya Sachdev, Aswin Muralidharan, Pouyan E Boukany
We study the necking and pinch-off dynamics of liquid droplets that contain a semidilute polymer solution of polyacrylamide close to overlap concentration by combining microfluidics and single DNA observation. Polymeric droplets are stretched by passing them through the stagnation point of a T-shaped microfluidic junction. In contrast with the sudden breakup of Newtonian droplets, a stable neck is formed between the separating ends of the droplet which delays the breakup process. Initially, polymeric filaments experience exponential thinning by forming a stable neck with extensional flow within the filament...
December 27, 2016: Macromolecules
https://www.readbyqxmd.com/read/28216398/engaging-in-a-keyhole-concept-for-the-management-of-ruptured-and-unruptured-aneurysms
#14
Daniel D Cavalcanti, Roberto C de Paula, Paula L Alvarenga, Paulo José P da Mata, Paulo Niemeyer Filho
OBJECTIVE: Many new endovascular devices have been used under the guidance of the International Subarachnoid Aneurysm Trial (ISAT). Clipping still offers higher occlusion rates, and its technique continues to evolve, resulting in smaller exposures and reduced manipulation to brain tissue. We sought to evaluate the routine use of the minisphenoidal approach to manage intracranial aneurysms in a high-volume institution. METHODS: We retrospectively reviewed our database of aneurysm patients from October 2013 to May 2016...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28216394/the-pconus-device-for-treatment-of-complex-wide-neck-anterior-communicating-artery-aneurysms
#15
Paul Emile Labeyrie, Benjamin Gory, Marta Aguilar-Perez, Elisa Pomero, Alessandra Biondi, Roberto Riva, Francis Turjman, Hans Henkes
BACKGROUND: and Purpose: Anterior communicating artery (AcomA) aneurysms with a wide neck are often not feasible for endovascular coiling. Emerging devices for neck protection, as the pCONus stent, are promising for endovascular treatment of challenging intracranial aneurysms. We report the preliminary results with pCONus in the treatment of wide-neck AcomA aneurysms. MATERIALS AND METHODS: All consecutive patients harboring AcomA aneurysms treated with pCONus in 3 European centers were retrospectively reviewed...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28216317/tropomyosin-isoforms-specify-functionally-distinct-actin-filament-populations-in%C3%A2-vitro
#16
Gergana Gateva, Elena Kremneva, Theresia Reindl, Tommi Kotila, Konstantin Kogan, Laurène Gressin, Peter W Gunning, Dietmar J Manstein, Alphée Michelot, Pekka Lappalainen
Actin filaments assemble into a variety of networks to provide force for diverse cellular processes [1]. Tropomyosins are coiled-coil dimers that form head-to-tail polymers along actin filaments and regulate interactions of other proteins, including actin-depolymerizing factor (ADF)/cofilins and myosins, with actin [2-5]. In mammals, >40 tropomyosin isoforms can be generated through alternative splicing from four tropomyosin genes. Different isoforms display non-redundant functions and partially non-overlapping localization patterns, for example within the stress fiber network [6, 7]...
February 14, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28216297/high-water-content-and-resilient-peg-containing-hydrogels-with-low-fibrotic-response
#17
Yu Zhang, Duo An, Yehudah Pardo, Alan Chiu, Wei Song, Qingsheng Liu, Fang Zhou, Sean P McDonough, Minglin Ma
: Hydrogels such as those based on polyethylene glycol (PEG) are broadly used in biomedicine where high water contents, robust mechanical properties such as resilience and favorable interactions with the body are often simultaneously desirable. However, the mechanical properties of conventional hydrogels often degrade rapidly after swelling or with increasing water content, limiting their potential in many applications. Here we describe a new class of PEG-containing hydrogels that remain highly resilient after maximum swelling...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28214495/internal-iliac-venous-aneurysm-associated-with-pelvic-venous-insufficiency
#18
Christopher O Audu, Anna E Boniakowski, Scott Robinson, Narasimham L Dasika, Thomas Wakefield, Dawn M Coleman
Aneurysmal disease of the internal iliac vein is rare, with no standard indication for or accepted modality of treatment. Here we report an instance of unilateral, primary left internal iliac venous aneurysm and associated pelvic venous insufficiency. Following extensive workup for alternative causes, the aneurysm and left gonadal vein were coil embolized with good effect.
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28213604/efficacy-and-safety-of-super-selective-bronchial-artery-coil-embolisation-for-haemoptysis-a-single-centre-retrospective-observational-study
#19
Hideo Ishikawa, Masahiko Hara, Misaki Ryuge, Jun Takafuji, Mihoko Youmoto, Masanori Akira, Yukio Nagasaka, Daijiro Kabata, Kouji Yamamoto, Ayumi Shintani
OBJECTIVES: Evidence on the safety and long-term efficacy of super selective bronchial artery embolisation (ssBAE) using platinum coils in patients with haemoptysis is insufficient. The objective of the present study was to evaluate the safety and the 3-year postprocedure haemoptysis-free survival rate of de novo elective ssBAE using platinum coils rather than particles for the treatment of haemoptysis. DESIGN: A single-centre retrospective observational study. SETTING: Hemoptysis and Pulmonary Circulation Center in Japan...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28213248/multi-reverse-flow-injection-analysis-integrated-with-multi-optical-sensor-for-simultaneous-determination-of-mn-ii-fe-ii-cu-ii-and-fe-iii-in-natural-waters
#20
Napaporn Youngvises, Kittigan Suwannasaroj, Jaroon Jakmunee, Awadh AlSuhaimi
Multi-reverse flow injection analysis (Mr-FIA) integrated with multi-optical sensor was developed and optimized for the simultaneous determination of multi ions; Mn(II), Fe(II), Cu(II) and Fe(III) in water samples. The sample/standard solutions were propelled making use of a four channels peristaltic pump whereas 4 colorimetric reagents specific for the metal ions were separately injected in sample streams using multi-syringe pump. The color zones that formed in the individual mixing coils were then streamed into multi-channels spectrometer, which comprised of four flows through cell and four pairs of light emitting diode and photodiode, whereby signals were measured concurrently...
May 1, 2017: Talanta
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