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https://www.readbyqxmd.com/read/28945015/membrane-fusion-mediated-intracellular-delivery-of-lipid-bilayer-coated-mesoporous-silica-nanoparticles
#1
Jian Yang, Jing Tu, Gerda E M Lamers, René C L Olsthoorn, Alexander Kros
Protein delivery into the cytosol of cells is a challenging topic in the field of nanomedicine, because cellular uptake and endosomal escape are typically inefficient, hampering clinical applications. In this contribution cuboidal mesoporous silica nanoparticles (MSNs) containing disk-shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome-c (cytC) as a model membrane-impermeable protein. To ensure colloidal stability, the MSNs are coated with a fusogenic lipid bilayer (LB) and cellular uptake is induced by a complementary pair of coiled-coil (CC) lipopeptides...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944945/safety-and-efficacy-of-ventriculostomy-procedures-under-dual-antiplatelet-therapy-in-patients-treated-with-stent-assisted-coiling-in-subarachnoid-hemorrhage
#2
Soner Civi, Cagatay Andic, Ozgur Kardes, Halil İbrahim Suner, Emre Durdag, Ozlem Ozmete, Kadir Tufan
AIM: Stent assisted coilling (SAC) is an alternative in the treatment of ruptured aneurysms. Stenting requires the use of dual antiplatelet agents. Hydrocephaly is a complication of subarachnoid hemorrhage (SAH) requiring ventriculostomy. Antiplatelet treatment reveal a risk of hemorrhage in ventriculostomy. Anti-aggregant effect starts at least four hours after the initial doses of treatment. However, in many studies, ventriculostomy was performed before antiplatelet treatment and the hemorrhagic complications were related to the procedure...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944708/partial-thrombosis-of-an-anterior-communicating-artery-aneurysm-prior-to-endovascular-coiling-with-intra-procedural-distal-thrombus-embolization
#3
Will Guest, Dipanka Sarma, Thomas Marotta
Thromboembolic stroke from migration of thrombus formed in non-giant intracranial aneurysms is a recognized but rare event. We describe a case of partial thrombosis of a 7 mm anterior communicating artery aneurysm, which embolized to the right callosomarginal artery in the brief time interval between two sequential diagnostic angiograms performed as part of elective endovascular coiling, and before any instrumentation had been advanced into the intracranial circulation. To our knowledge, this is the first reported case of aneurysmal thrombus embolization observed angiographically in near real time...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28944531/short-term-respiratory-effects-of-e-cigarettes-in-healthy-individuals-and-smokers-with-asthma
#4
Andreas S Lappas, Anna S Tzortzi, Efstathia M Konstantinidi, Stephanie I Teloniatis, Chara K Tzavara, Sofia A Gennimata, Nikolaos G Koulouris, Panagiotis K Behrakis
BACKGROUND AND OBJECTIVE: This study investigated the duration of immediate respiratory effects of e-cigarette smoking (ECS) and tested the hypothesis that ECS has more prominent effects in asthmatics compared with healthy smokers (HS). METHODS: Fifty-four smokers, 27 healthy (HS group) and 27 with intermittent asthma (mild asthma (MA) group) underwent a control session (no liquid, no resistor coil inside e-cigarette cartridge) and an experimental session of ECS using standardized puffing settings...
September 24, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28944082/ultra-short-echo-time-magnetic-resonance-imaging-for-detection-of-pulmonary-arteriovenous-malformation-recanalization-after-coil-embolization-a-case-report-and-a-phantom-study
#5
Kohei Hamamoto, Emiko Chiba, Katsuhiko Matsuura, Tomohisa Okochi, Keisuke Tanno, Osamu Tanaka
A pulmonary arteriovenous malformation (PAVM) is a direct connection between the pulmonary arteries and veins for which metallic coil transcatheter embolization is the standard of care. Detecting recanalization after PAVM treatment is crucial, but direct visualization with computed tomography or magnetic resonance imaging (MRI) is generally difficult. Here, we report a case of a recanalized PAVM that was directly detected with ultra-short echo time MRI. The detection of these signals in the coils was confirmed in a phantom study...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28943156/a-continuum-theoretical-model-and-finite-elements-simulation-of-bacterial-flagellar-filament-phase-transition
#6
REVIEW
Xiaoling Wang, Shuo Meng, Jingshi Han
The Bacterial flagellar filament can undergo a polymorphic phase transition in response to both mechanical and chemical variations in vitro and in vivo environments. Under mechanical stimuli, such as viscous flow or forces induced by motor rotation, the filament changes its phase from left-handed normal (N) to right-handed semi-coiled (SC) via phase nucleation and growth. Our detailed mechanical analysis of existing experiments shows that both torque and bending moment contribute to the filament phase transition...
September 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28942645/aggregation-induced-chirality-twist-and-stacking-handedness-of-the-biphenylene-groups-of-n-c12h25o-bp-co-ala-ala-dipeptides
#7
Lianglin Zhang, Jiaming Qin, Shuwei Lin, Yi Li, Baozong Li, Yonggang Yang
In mixtures of water and dimethyl sulfoxide, 4'-(n-dodecyloxy)-1,1'-biphenyl-4-carbonyl Ala-Ala dipeptides can self-assemble into tubular structures that are formed by coiled nanoribbons. The twist and stacking handedness of biphenylene groups were studied using circular dichroism and confirmed by theoretical chemical calculations. The handedness of the coiled nanoribbons and the stacking handedness of the biphenylene groups are controlled by the chirality of the alanine at the C-terminus, while the twist handedness of the biphenylene is determined by the chirality of the alanine at the N-terminus...
September 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28941729/3d-modelling-of-the-pathogenic-leptospira-protein-lipl32-a-bioinformatics-approach
#8
Sharmilah Kumari Kumaran, Mohd Faizal Abu Bakar, Hirzahida Mohd-Padil, Shuhaila Mat-Sharani, S Sakinah, Poorani K, Hiba Alsaeedy, Amira Peli, Teh Seoh Wei, Mok Pooi Ling, Rukman Awang Hamat, Vasantha Kumari Neela, Akon Higuchi, Abdullah A Alarfaj, Mariappan Rajan, Giovanni Benelli, Palanisamy Arulselvan, S Suresh Kumar
Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species (Leptospiraceae). LipL32 is a highly abundant lipoprotein from the outer membrane proteins (OMPs) group, which highly conserved among pathogenic and intermediate Leptospira species. Several studies used LipL32 as a specific gene to identify the presence of leptospires. This research was aimed to study on the characteristics of LipL32 protein gene code, to fill the knowledge gap concerning the most appropriate gene that can be used as antigen to detect the Leptospira...
September 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28941519/iatrogenic-pulmonary-pseudoaneurysm-treated-with-percutaneous-coil-and-glue%C3%A2-embolization
#9
Vittorio Pedicini, Orazio Giuseppe Santonocito, Dario Poretti, Marco Tramarin, Ezio Lanza
No abstract text is available yet for this article.
October 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28941038/switchable-hydrolase-based-on-reversible-formation-of-supramolecular-catalytic-site-using-a-self-assembling-peptide
#10
Rein V Ulijn, Chunqiu Zhang, Ramim Shafi, Ayala Lampel, Douglas MacPherson, Charalampas Pappas, Vishal Narang, Tong Wang, Charles Madarelli
The reversible regulation of catalytic activity is a feature found in natural enzymes which is not commonly observed in artificial catalytic systems. Here, we fabricate an artificial hydrolase with pH-switchable activity, achieved by introducing a catalytic histidine residue at the terminus of a pH-responsive peptide. The peptide exhibits a conformational transition from random coil to β-sheet by changing the pH from acidic to alkaline. The β-sheet self-assembles to form long fibrils with the hydrophobic edge and histidine residues extending in an ordered array as the catalytic microenvironment, which shows significant esterase activity...
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28939769/human-rab-small-gtpase-and-class-v-myosin-mediated-membrane-tethering-in-a-chemically-defined-reconstitution-system
#11
Motoki Inoshita, Joji Mima
Membrane tethering is a fundamental process essential for compartmental specificity of intracellular membrane trafficking in eukaryotic cells. Rab-family small GTPases and specific sets of Rab-interacting effector proteins, including coiled-coil tethering proteins and multisubunit tethering complexes, have been reported to be responsible for membrane tethering. However, whether and how these key components directly and specifically tether subcellular membranes still remains enigmatic. Using chemically defined proteoliposomal systems reconstituted with purified human Rab proteins and synthetic liposomal membranes to study the molecular basis of membrane tethering, we established here that Rab-family GTPases have a highly conserved function to directly mediate membrane tethering, even in the absence of any types of Rab effectors such as the so-called tethering proteins...
September 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28939719/clinical-characteristics-and-management-of-coronary-artery-perforations-a-single-center-11-year-experience-and-practical-overview
#12
Miguel E Lemmert, Rutger J van Bommel, Roberto Diletti, Jeroen M Wilschut, Peter P de Jaegere, F Zijlstra, Joost Daemen, Nicolas M Van Mieghem
BACKGROUND: Coronary artery perforation (CAP) is a potentially lethal complication of percutaneous coronary intervention. We report on the incidence, clinical characteristics, and management of iatrogenic coronary perforations based on an 11-year single-center experience. METHODS AND RESULTS: From February 9, 2005, through November 20, 2016, 150 CAP cases were identified from our percutaneous coronary intervention database of 21 212 procedures (0.71%). Mean age of CAP patients was 66±11 years, and 62...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28938647/long-non-coding-rna-malat1-for-promoting-metastasis-and-proliferation-by-acting-as-a-cerna-of-mir-144-3p-in-osteosarcoma-cells
#13
Yong Wang, Yueyang Zhang, Tao Yang, Wei Zhao, Ningning Wang, Pengcheng Li, Xiandong Zeng, Weiguo Zhang
Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases including osteosarcoma. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overly expressed in osteosarcoma. But the function and mechanism it works on in osteosarcoma proliferation and metastasis mediated by Rho associated coiled-coil containing protein kinase 1 (ROCK1) and Rho associated coiled-coil containing protein kinase 2 (ROCK2) remain unclear. In the present study, an elevated MALAT1 was found in osteosarcoma tissues and cell lines, and the elevated MALAT1 was correlated with a poor prognosis in osteosarcoma patients...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938330/temporal-scalp-thickness-body-mass-index-and-suprafascial-placement-of-receiver-coil-of-the-cochlear-implant
#14
Orhan Ozturan, Alper Yenigun, Erol Senturk, Omer Faruk Calim, Fadlullah Aksoy, Sabri Baki Eren
OBJECTIVE: The objectives of this study are to demonstrate the relationship between the thickness of the temporal scalp and body mass index (BMI), age, and sex, and to present the surgical technique which we perform in patients with a thick scalp. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. This study was performed in a tertiary referral center. Cranial computed tomography images of 469 subjects were included in the study. These subjects were evaluated according to BMI, age, and sex...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28937746/-juice-monsters-sub-ohm-vaping-and-toxic-volatile-aldehyde-emissions
#15
Soha Talih, Rola Salman, Nareg Karaoghlanian, Ahmad El-Hellani, Najat Aoun Saliba, Thomas Eissenberg, Alan Shihadeh
An emerging category of electronic cigarettes (ECIGs) are sub-Ohm devices (SODs) that operate at ten or more times the power of conventional ECIGs. Because carcinogenic volatile aldehyde (VAs) emissions increase sharply with power, SODs may expose users to greater VAs. In this study, we compared VA emissions from several SODs and found that across device, VAs and power were un-correlated unless power was normalized by coil surface area. VA emissions and liquid consumed were correlated highly. Analyzed in light of EU regulations limiting ECIG liquid nicotine concentration, these findings suggest potential regulatory levers and pitfalls for protecting public health...
September 22, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28937698/evolution-of-mechanics-in-%C3%AE-helical-peptide-conjugated-linear-and-star-block-peg
#16
S C O'Neill, Z H Bhuiyan, R S Tu
We have designed a peptide conjugated poly-ethylene glycol (PEG) bioconjugate system that allows us to examine the intra- and inter-molecular dynamics of gelation. We measure the kinetics of gelation for end-functionalized linear- and star-architectures, and we correlate the gelation behavior with the molecular structure and self-association. The 23-amino acid peptide sequence is known to form a coiled-coil structure as a function of the solution's electrolyte concentration, and the two topologies of the PEG are peptide end-functionalized to examine formation of supramolecular assemblies...
September 22, 2017: Soft Matter
https://www.readbyqxmd.com/read/28937325/revascularization-of-the-upper-posterior-circulation-with-the-anterior-temporal-artery-an-anatomical-feasibility-study
#17
Ali Tayebi Meybodi, Michael T Lawton, Dylan Griswold, Pooneh Mokhtari, Andre Payman, Halima Tabani, Sonia Yousef, Arnau Benet
OBJECTIVE In various disease processes, including unclippable aneurysms, a bypass to the upper posterior circulation (UPC) including the superior cerebellar artery (SCA) and posterior cerebral artery (PCA) may be needed. Various revascularization options exist, but the role of intracranial (IC) donors has not been scrutinized. The objective of this study was to evaluate the anatomical feasibility of utilizing the anterior temporal artery (ATA) for revascularization of the UPC. METHODS ATA-SCA and ATA-PCA bypasses were performed on 14 cadaver specimens...
September 22, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28936502/effects-of-stereo-regularity-on-the-single-chain-mechanics-of-polylactic-acid-and-its-implications-on-the-physical-properties-of-bulk-materials
#18
Bo Cheng, Lu Qian, Hu-Jun Qian, Zhong-Yuan Lu, Shuxun Cui
The material properties of polylactic acid (PLA) are largely determined by its stereo-regularity (tacticity). To find out the origin at the molecular level, the single-chain mechanics of poly-l-lactic acid (PLLA) and poly-d,l-lactide (PDLLA) were comparatively investigated by single-molecule atomic force microscopy (AFM). At a low concentration, PLLA adopted a random-coil conformation in a good solvent. At a high concentration, however, the PLLA chain can be induced into a helix, which consumed additional energy during unfolding by further stretching...
September 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28936276/microscopic-origin-of-wall-slip-during-flow-of-an-entangled-dna-solution-in-microfluidics-flow-induced-chain-stretching-versus-chain-desorption
#19
Orin Hemminger, Pouyan E Boukany
Despite the relevance and importance of slip, a fundamental understanding of the underlying molecular mechanisms of wall slip in polymer flow is still missing. In this work, we investigate the slip behavior of an entangled DNA solution at a molecular scale using a confocal microscope coupled to a microfluidic device. From microscopic measurement, we obtain both the velocity profile and conformation of polymeric chains by visualizing DNA molecules during flow on various surfaces (ranging from weak to strong interactions with DNA molecules)...
July 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28935998/theory-of-amyloid-fibril-nucleation-from-folded-proteins
#20
Lingyun Zhang, Jeremy D Schmit
We present a theoretical model for the nucleation of amyloid fibrils. In our model we use helix-coil theory to describe the equilibrium between a soluble native state and an aggregation-prone unfolded state. We then extend the theory to include oligomers with β-sheet cores and calculate the free energy of these states using estimates for the energies of H-bonds, steric zipper interactions, and the conformational entropy cost of forming secondary structure. We find that states with fewer than ~10 β-strands are unstable relative to the dissociated state and three β-strands is the highest free energy state...
July 2017: Israel Journal of Chemistry
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