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https://www.readbyqxmd.com/read/29474865/trajectories-of-plasma-igf-1-igfbp-3-and-their-ratio-in-the-mayo-clinic-study-of-aging
#1
Alexandra M V Wennberg, Clinton E Hagen, Ronald C Petersen, Michelle M Mielke
Insulin-like growth factor 1 (IGF-1) has been associated with osteoporosis, cardiovascular disease, cancer, neurodegenerative diseases, and mortality in middle and older aged adults. Cross-sectionally, IGF-1 decreases with age and levels of IGF-1 are markedly different between individuals. However, little is known about intra-individual trajectories of IGF-1. We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging...
February 20, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29473384/five-year-prospective-study-on-cardiovascular-events-in-patients-with-erectile-dysfunction-and-hypotestosterone
#2
Rosanna Iacona, Vito Bonomo, Mariaconcetta Di Piazza, Angela Sansone, Manuela Usala, Salvatore Novo, Carlo Pavone
OBJECTIVE: Testosterone levels play a role in cardiac and vascular pathology. In the present study we investigated the prognostic significance of this hormone for cardiovascular outcome, in a 5-year follow-up. MATERIALS AND METHODS: Our cohort included 802 adult subjects, from 40 to 80 years. Patients were excluded if they had a past history of peripheral or coronary artery disease, and revascularization. A blood sample was drawn to valuate testosterone level, and we considered normal testosterone levels 300 ng/dl...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29470149/chronic-complete-cervical-6-7-cord-transection-distinct-autonomic-and-cardiac-deficits
#3
Heidi L Lujan, Anne Tonson, Robert W Wiseman, Stephen E DiCarlo
Spinal cord injury (SCI) resulting in tetraplegia is a devastating, life-changing insult causing paralysis and sensory impairment as well as distinct autonomic dysfunction that triggers compromised cardiovascular, bowel, bladder and sexual activity. Life becomes a battle for independence as even routine bodily functions and the smallest activity of daily living become a major challenge. Accordingly, there is a critical need for a chronic pre-clinical model of tetraplegia. This report addresses this critical need by comparing, for the first time, resting, reflex and stress-induced cardiovascular, autonomic and hormonal responses each week for 4 weeks in 12 sham-operated intact rats and 12 rats with chronic, complete C6-7 spinal cord transection...
February 22, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29469738/dermatologic-manifestations-of-acromegaly-a-case-in-point-and-a-focused-review
#4
Ece Nur Degirmentepe, Sule Gungor, Emek Kocaturk, Utkan Kiziltac, Mine Adas, Selver Ozekinci, Amor Khachemoune
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469650/prenatal-androgen-exposure-causes-hypertension-and-gut-microbiota-dysbiosis
#5
Shermel Sherman, Nadeen Sarsour, Marziyeh Salehi, Allen Schroering, Blair Mell, Bina Joe, Jennifer W Hill
BACKGROUND: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant...
February 22, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29468912/hormone-treatments-in-congestive-heart-failure
#6
Lei Lei, Yuanjie Mao
The common ultimate pathological feature for all cardiovascular diseases, congestive heart failure (CHF), is now considered as one of the main public health burdens that is associated with grave implications. Neurohormonal systems play a critical role in cardiovascular homeostasis, pathophysiology, and cardiovascular diseases. Hormone treatments such as the newly invented dual-acting drug valsartan/sacubitril are promising candidates for CHF, in addition to the conventional medications encompassing beta receptor blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29463393/quel-pourrait-%C3%A3%C2%AAtre-le-futur-de-la-prise-en-charge-de-la-maladie-r%C3%A3-nale-chronique-en-nutrition
#7
D Fouque
The nutrition care of patients with chronic kidney disease (CKD) remains a central question which is permanently studied. The benefits of a dietary protein restriction are once again enlightened, either by reducing the urea found to be hyperglycemic, thus improving the peripheric insulin sensitivity, or by decreasing phosphorus and FGF23 hormone, whose reductions are respectively associated with nephroprotection and diminution of cardiovascular events. The numerous researches conducted on the gut microbiota also open promising avenues to better understand the role of this ecosystem in CKD...
June 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29462093/contraception-for-midlife-women-a-review
#8
Taniqua A Miller, Rebecca H Allen, Andrew M Kaunitz, Carrie A Cwiak
Family planning represents a key component of reproductive health care. Accordingly, the provision of contraception must span the reproductive age spectrum, including perimenopause. The risk of pregnancy is decreased, but not trivial, among women over 40 years of age. Evidence-based guidelines for contraceptive use can assist clinicians in counseling their patients in this population. Intrauterine contraception is one of the most effective methods and is safe to use in midlife women with few exceptions. Progestin-only contraception is another safe option for most midlife women because it is not associated with an increased risk of cardiovascular complications...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29460396/lower-sperm-quality-and-testicular-and-epididymal-structural-impairment-in-adult-rats-exposed-to-rosuvastatin-during-prepuberty
#9
Gabriel Adan Araújo Leite, Marciana Sanabria, Marilia Martins Cavariani, Janete Aparecida Anselmo-Franci, Patrícia Fernanda Felipe Pinheiro, Raquel Fantin Domeniconi, Wilma De Grava Kempinas
The increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid-lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0...
February 19, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29459266/risk-factors-for-progression-of-coronary-artery-calcification-in-patients-with-chronic-kidney-disease-the-cric-study
#10
Joshua D Bundy, Jing Chen, Wei Yang, Matthew Budoff, Alan S Go, Juan E Grunwald, Radhakrishna R Kallem, Wendy S Post, Muredach P Reilly, Ana C Ricardo, Sylvia E Rosas, Xiaoming Zhang, Jiang He
BACKGROUND AND AIMS: Coronary artery calcification (CAC) is common among patients with chronic kidney disease (CKD) and predicts the risk for cardiovascular disease (CVD). We examined the associations of novel risk factors with CAC progression among patients with CKD. METHODS: Among 1123 CKD patients in the Chronic Renal Insufficiency Cohort (CRIC) Study, CAC was measured in Agatston units at baseline and a follow-up visit using electron beam computed tomography or multidetector computed tomography...
February 10, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29457805/urinary-metabolomic-study-of-the-antagonistic-effect-of-p-ginseng-in-rats-with-estrogen-decline-using-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#11
He Lin, Zhongying Liu, Zifeng Pi, Lihui Men, Weijia Chen, Zhiqiang Liu
Estrogens are biologically active steroid hormones mainly released from the ovary by ovarian secretion of estrogen into the circulating blood to regulate or function at the distal target. Estrogens play an important role in the central nervous system, cardiovascular system and immune system, especially for post-menopausal women. Panax ginseng Mayer has been reported to relieve women's menopausal symptoms and affect estrogen activities. However, the mechanism of its estrogen regulation has not yet been clearly investigated...
February 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29455549/multiple-endocrine-neoplasia-2a-men-2a-syndrome
#12
J Breza, J Breza
INTRODUCTION: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism. MATERIAL AND METHODS: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification)...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455364/hyperirisinemia-is-independently-associated-with-subclinical-hypothyroidism-correlations-with-cardiometabolic-biomarkers-and-risk-factors
#13
Theodora Stratigou, Maria Dalamaga, Georgios Antonakos, Ioanna Marinou, Evaggelos Vogiatzakis, Gerasimos Socrates Christodoulatos, Irene Karampela, Athanasios G Papavassiliou
PURPOSE: Irisin, a newly discovered adipo-myokine, is implicated in the modulation of the adipose phenotype, increasing energy expenditure and ameliorating systemic metabolism. Our aim was to investigate circulating irisin in subclinical hypothyroidism (SH) and study its associations with cardiometabolic risk factors. METHODS: In a large case-control study, serum irisin, insulin resistance and lipid parameters, classic adipokines, inflammatory and hepatic biomarkers, and cardiovascular risk factors were determined in 120 consecutive patients with SH and 120 healthy controls matched on age, gender, and date of blood draw...
February 17, 2018: Endocrine
https://www.readbyqxmd.com/read/29452073/the-role-of-adiponectin-and-adipolin-as-anti-inflammatory-adipokines-in-the-formation-of-macrophage-foam-cells-and-their-association-with-cardiovascular-diseases
#14
REVIEW
Javad Sargolzaei, Elham Chamani, Tooba Kazemi, Soudabeh Fallah, Hosna Soori
Obesity is one of the major public health concerns that is closely associated with obesity-related disorders such as type 2 diabetes mellitus (T2DM), hypertension, and atherosclerosis. Atherosclerosis is a chronic disease characterized by excess cholesterol deposition in the arterial intima and the formation of foam cells. Adipocytokines or adipokines are secreted by the adipose tissue as endocrine glands; adiponectin and adipolin are among these adipokines that are associated with obese and insulin-resistant phenotypes...
February 13, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29451821/protection-from-vascular-dysfunction-in-female-rats-with-chronic-stress-and-depressive-symptoms
#15
Steven D Brooks, Stan Hileman, Paul D Chantler, Samantha Milde, Kent C Lemaster, Stephanie Frisbee, J Kevin Shoemaker, Dwayne N Jackson, Jefferson C Frisbee
The increasing prevalence and severity of clinical depression is strongly correlated with vascular disease risk, creating a comorbid condition with poor outcomes, although demonstrating a sexual disparity where females are at lower risk than males for subsequent cardiovascular events. To determine potential mechanisms responsible for this protection against stress/depression-induced vasculopathy in females, we exposed male and female ({plus minus}ovariectomy) rats to the unpredictable chronic mild stress (UCMS) model for 8 weeks and determined depressive symptom severity, vascular reactivity in aortic rings (AR) and ex vivo middle cerebral arteries (MCA), and determined the profile of major metabolites regulating vascular tone...
February 16, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#16
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29449807/atrial-natriuretic-peptide-acts-as-a-neuroprotective-agent-in-in-vitro-models-of-parkinson-s-disease-via-up-regulation-of-the-wnt-%C3%AE-catenin-pathway
#17
Arianna Colini Baldeschi, Eugenia Pittaluga, Federica Andreola, Simona Rossi, Mauro Cozzolino, Giuseppe Nicotera, Gianluca Sferrazza, Pasquale Pierimarchi, Annalucia Serafino
In the last decades increasing evidence indicated a crucial role of the Wnt/β-catenin signaling in development of midbrain dopaminergic (mDA) neurons. Recently dysregulation of this pathway has been proposed as a novel pathomechanism leading to Parkinson's disease (PD) and some of the molecules participating to the signaling have been evaluated as potential therapeutic targets for PD. Atrial natriuretic peptide (ANP) is a cardiac-derived hormone having a critical role in cardiovascular homeostasis. ANP and its receptors (NPRs) are widely expressed in mammalian central nervous system (CNS) where they could be implicated in the regulation of neural development, synaptic transmission and information processing, as well as in neuroprotection...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29445837/alkaline-phosphatases-in-the-complex-chronic-kidney-disease-mineral-and-bone-disorders
#18
Jordi Bover, Pablo Ureña, Armando Aguilar, Sandro Mazzaferro, Silvia Benito, Víctor López-Báez, Alejandra Ramos, Iara daSilva, Mario Cozzolino
Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they can also be deleterious for other processes, such as vascular calcification and the increasingly known cross-talk between bone and vessels. A proper balance between beneficial and harmful activities is further complicated in the context of chronic kidney disease (CKD)...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29441748/association-between-serum-parathyroid-hormone-levels-and-the-prevalence-of-atrial-fibrillation-the-dong-gu-study
#19
Ki Hong Lee, Min Ho Shin, Hyung Wook Park, Jeong Gwan Cho, Sun Seog Kweon, Young Hoon Lee
BACKGROUND AND OBJECTIVES: We aimed to investigate the association between serum parathyroid hormone (PTH) levels and the prevalence of atrial fibrillation (AF) in a population based study. METHODS: This study included a total of 9,007 community-dwelling Koreans aged 50 years and over who were enrolled in the Dong-gu study from 2007 to 2010. Electrocardiograms were recorded from the subjects using the HP-PageWriter 200 M1771A. All potential cases of AF were determined by 2 cardiologists...
February 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29439446/the-t2238c-human-atrial-natriuretic-peptide-molecular-variant-and-the-risk-of-cardiovascular-diseases
#20
REVIEW
Speranza Rubattu, Sebastiano Sciarretta, Simona Marchitti, Franca Bianchi, Maurizio Forte, Massimo Volpe
Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13-23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide...
February 11, 2018: International Journal of Molecular Sciences
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