keyword
https://read.qxmd.com/read/38536878/increased-risk-of-diabetes-mellitus-and-hyperlipidemia-in-patients-with-differentiated-thyroid-cancer
#1
JOURNAL ARTICLE
Hwa Young Ahn, Jooyoung Lee, Jinmo Kang, Eun Kyung Lee
OBJECTIVE: This study aimed to assess the risk of cardiometabolic disease (CMD) in patients with differentiated thyroid cancer (DTC) using a population-based nationwide cohort in Korea. DESIGN: This was a population-based cohort study. METHODS: We selected 2649 patients with DTC and 7947 matched controls. The primary outcome was the composite of CMD including diabetes mellitus (DM), hypertension, hyperlipidemia, cerebrovascular disease, and ischemic heart disease...
March 2, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#2
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532851/the-women4health-cohort-a-unique-cohort-to-study-women-specific-mechanisms-of-cardio-metabolic-regulation
#3
JOURNAL ARTICLE
Fabio Busonero, Stefania Lenarduzzi, Francesca Crobu, Roberta Marie Gentile, Andrea Carta, Francesco Cracco, Andrea Maschio, Silvia Camarda, Michele Marongiu, Daniela Zanetti, Claudio Conversano, Giovanni Di Lorenzo, Daniela Mazzà, Francesco De Seta, Giorgia Girotto, Serena Sanna
AIMS: Epidemiological research has shown relevant differences between sexes in clinical manifestations, severity, and progression of cardiovascular and metabolic disorders. To date, the mechanisms underlying these differences remain unknown. Given the rising incidence of such diseases, gender-specific research on established and emerging risk factors, such as dysfunction of glycaemic and/or lipid metabolism, of sex hormones and of gut microbiome, is of paramount importance. The relationships between sex hormones, gut microbiome, and host glycaemic and/or lipid metabolism are largely unknown even in the homoeostasis status...
March 2024: Eur Heart J Open
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#4
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38531396/practices-in-the-prescription-of-antiseizure-medications-is-it-time-to-change
#5
JOURNAL ARTICLE
Lécio Figueira Pinto, Lucas Scárdua Silva, Rafael Batista João, Vinícius Boldrini, Fernando Cendes, Clarissa Lin Yasuda
The treatment of epilepsy has advanced over the past 30 years through the development of new antiseizure medications (ASMs). Unfortunately, not all of them have been approved yet in Brazil, and many are still underused. When comparing new ASMs to older ones, they are generally not more effective in treating epilepsy. However, they offer better tolerability, with fewer interactions and long-term side effects, especially for patients with comorbidities or those requiring polytherapy. Enzyme induction caused by older ASMs is associated with increased cholesterol levels, drug interactions with decreased effects of statins and other cardiovascular medications, anticoagulants, chemotherapy, immunosuppressors, anti-infective agents (including HIV treatment), antidepressants, and contraceptives...
June 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38529566/a-practical-guide-for-assessing-and-managing-cardiovascular-risk-during-androgen-deprivation-therapy-in-patients-with-prostate-cancer
#6
REVIEW
Aum J Solanki, Mitchell Kamrava, Edwin M Posadas, Stephen J Freedland, Leslie Ballas, Howard M Sandler, C Noel Bairey Merz, Katelyn M Atkins, Andriana P Nikolova
Prostate cancer is the most common malignancy among men worldwide, and androgen-deprivation therapy (ADT) is a mainstay of treatment. There are observational data demonstrating an increased risk of cardiovascular events in patients who receive ADT, particularly those who have an elevated baseline cardiovascular risk. Because, for most patients with prostate cancer, death is predominantly from noncancer-related causes, cardiovascular disease and its risk factors should be optimized during cancer treatment. This review provides an overview of the landscape of ADT treatment and serves as a guide for appropriate cardiovascular screening and risk-mitigation strategies...
March 26, 2024: Cancer
https://read.qxmd.com/read/38529333/gender-specific-genetic-and-epigenetic-signatures-in-cardiovascular-disease
#7
REVIEW
Justin Bridges, Jose A Ramirez-Guerrero, Manuel Rosa-Garrido
Cardiac sex differences represent a pertinent focus in pursuit of the long-awaited goal of personalized medicine. Despite evident disparities in the onset and progression of cardiac pathology between sexes, historical oversight has led to the neglect of gender-specific considerations in the treatment of patients. This oversight is attributed to a predominant focus on male samples and a lack of sex-based segregation in patient studies. Recognizing these sex differences is not only relevant to the treatment of cisgender individuals; it also holds paramount importance in addressing the healthcare needs of transgender patients, a demographic that is increasingly prominent in contemporary society...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38529169/effect-of-ketogenic-diet-on-obesity-and-other-metabolic-disorders-narrative-review
#8
REVIEW
Temesgen Baylie, Tiget Ayelgn, Markeshaw Tiruneh, Kibur Hunie Tesfa
Obesity is defined as an abnormal or excessive accumulation of fat that increases the burden of different chronic diseases in the population. It has reached epidemic proportions and is a major risk factor for a variety of diseases, including hypertension, cardiovascular disease, type 2 diabetes, dyslipidaemia, atherosclerosis, and some malignancies. Weight gain is a result of excessive energy intake compared to energy expenditure (energy loss from metabolism and physical exercise). A ketogenic diet has a more useful effect on obesity than other diets...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38528787/pre-diagnostic-free-androgen-and-estradiol-levels-influence-heart-failure-risk-in-both-women-and-men-a-prospective-cohort-study-in-the-uk-biobank
#9
JOURNAL ARTICLE
Jungeun Lim, Maryam Hashemian, Batel Blechter, Véronique L Roger, Jason Y Y Wong
AIMS: Serum sex hormones have been linked to cardiovascular disease risk. However, their roles in the pathogenesis of heart failure (HF) in both men and women are unclear. We investigated the associations between free androgen, testosterone, and estradiol, and future risk of HF. METHODS AND RESULTS: This prospective cohort study evaluated UK Biobank participants free of prevalent cardiovascular disease and HF at baseline. Unitless free androgen, testosterone, and estradiol indices were generated using serum concentrations of total testosterone (nmol/L), estradiol (pmol/L), sex hormone binding globulin (SHBG, nmol/L), and albumin (g/L) in blood collected at enrolment...
March 25, 2024: European Journal of Heart Failure
https://read.qxmd.com/read/38528174/safety-and-clinical-outcomes-of-two-session-catheter-directed-sclerotherapy-using-ethanol-for-endometrioma
#10
JOURNAL ARTICLE
Chu Hui Zeng, Chuan Wu Cao, Ji Hoon Shin, Gun Ha Kim, Sung Hoon Kim, Sa Ra Lee, Shin Wha Lee
PURPOSE: To evaluate the safety and clinical outcome of two-session catheter-directed sclerotherapy (CDS) with 99% ethanol in patients with endometrioma. MATERIALS AND METHODS: This prospective study was approved by the institutional review board with written informed consent obtained from all participants and was registered on clinicaltrial.gov. Consecutive patients with ovarian endometrioma between June 2020 and March 2023 were prospectively evaluated for two sessions of CDS...
March 25, 2024: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/38526391/potential-risks-and-benefits-of-desiccated-thyroid-extract-for-the-treatment-of-hypothyroidism-a-systematic-review
#11
JOURNAL ARTICLE
Kamilla Ryom Riis, Camilla Bøgelund Larsen, Steen Joop Bonnema
BACKGROUND: Desiccated thyroid extract (DTE) is no longer recommended for treatment of hypothyroidism but is still in use. This review aimed to summarize the available literature on treatment with DTE in adult hypothyroid patients. METHODS: The search was conducted up until the 6th of January 2024 in six electronic databases. Two reviewers independently screened all search results. The retrieved studies compared DTE treatment with levothyroxine or combination therapy with liothyronine and levothyroxine...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38525540/the-role-of-nano-systems-in-the-delivery-of-glucose-lowering-drugs-for-the-pre-emption-and-treatment-of-diabetes-associated-atherosclerosis
#12
REVIEW
Luke James Conroy, Alyssa McCann, Nan Zhang, Monica de Gaetano
Diabetes is one of the most prevalent diseases worldwide. In recent decades, type-2 diabetes has become increasingly common, particularly in younger individuals. Diabetes leads to many vascular complications, including atherosclerosis. Atherosclerosis is a cardiovascular disease characterized by lipid-rich plaques within the vasculature. Plaques develop over time, restricting blood flow; and can therefore be the underlying cause of major adverse cardiovascular events, including myocardial infarction and stroke...
March 25, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38522953/recent-advances-in-the-application-of-mendelian-randomization-to-chronic-kidney-disease
#13
REVIEW
Chaofan Wen, Lanlan Chen, Dan Jia, Ziqi Liu, Yidan Lin, Guan Liu, Shuo Zhang, Baoshan Gao
OBJECTIVE: Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves into the advances and challenges in the application of MR in the field of nephrology, shifting from a mere summary of its principles and limitations to a more nuanced exploration of its contributions to our understanding of CKD...
December 2024: Renal Failure
https://read.qxmd.com/read/38521431/qixian-granule-inhibits-ferroptosis-in-vascular-endothelial-cells-by-modulating-trpml1-in-the-lysosome-to-prevent-postmenopausal-atherosclerosis
#14
JOURNAL ARTICLE
Meng Zhang, Chenhan Mao, Yang Dai, Xiaojin Xu, Xindong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: QiXian Granule (QXG) is an integrated traditional Chinese medicine formula used to treat postmenopausal atherosclerotic (AS) cardiovascular diseases. The previous studies have found that QXG inhibited isoproterenol (ISO)-induced myocardial remodeling. And its active ingredient, Icraiin, can inhibit ferroptosis by promoting oxidized low-density lipoprotein (xo-LDL)-induced vascular endothelial cell injury and autophagy in atherosclerotic mice. Another active ingredient, Salvianolic Acid B, can suppress ferroptosis and apoptosis during myocardial ischemia/reperfusion injury by reducing ubiquitin-proteasome degradation of Glutathione Peroxidase 4 (GPX4) and down-regulating the reactive oxygen species (ROS)- c-Jun N-terminal kinases (JNK)/mitogen-activated protein kinase (MAPK) pathway...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38520613/validity-of-galactin-3-in-acromegaly-comparison-with-traditional-markers
#15
JOURNAL ARTICLE
Maryam Thaer Saadi, Noor Ulhuda G Mohammed, Baydaa Ahmed Abed, Layla Othman Farhan, Isam Noori Salman
BACKGROUND: Acromegaly occurs due to overproduction of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Galectin-3 (Gal-3) has recently emerged as a novel biomarker, related to IGF-1. This study aimed to assess Gal-3 in patients with acromegaly and compare its effectiveness with traditional biomarker tests. MATERIALS AND METHODS: A randomized case control study conducted in a single center included 50 acromegaly patients and 40 apparently healthy subjects (HS) serve as control group matched both age and BMI...
March 23, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38518995/human-recombinant-relaxin-2-serelaxin-regulates-the-proteome-lipidome-lipid-metabolism-and-inflammatory-profile-of-rat-visceral-adipose-tissue
#16
JOURNAL ARTICLE
Alana Aragón-Herrera, Sandra Feijóo-Bandín, Xocas Vázquez-Abuín, Laura Anido-Varela, Sandra Moraña-Fernández, Susana B Bravo, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Javier García-Seara, José Seijas, Diego Rodríguez-Penas, Daniele Bani, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several cardiovascular diseases (CVD). Considering these effects, together with the influence of relaxin-2 on adipocyte physiology and adipokine secretion, and the connection between visceral adipose tissue (VAT) dysfunction and the development of CVD, we could hypothesize that relaxin-2 may regulate VAT metabolism. Our objective was to evaluate the impact of a 2-week serelaxin treatment on the proteome and lipidome of VAT from Sprague-Dawley rats...
March 20, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38518006/causal-association-of-tsh-with-ischemic-heart-diseases-and-heart-failure-a-2-sample-mendelian-randomization-study
#17
JOURNAL ARTICLE
Yuan Gao, Tianwei Zhan, Yingchun Xu, Kaijun Zhu, Yifei Shi, Langping Jin, Liwei Meng
Thyroid dysfunction is associated with the risk of cardiovascular disease; however, whether plasma thyroid-stimulating hormone (TSH) levels in subjects with euthyroidism affect the risk of cardiovascular disease remains unclear. This study aimed to investigate the causal association between plasma TSH levels and cardiovascular diseases, particularly ischemic heart disease and heart failure (HF). Summary statistics from the Integrative Epidemiology Unit Open genome-wide association studies Project and FinnGen consortium were used to investigate the causal relationship between plasma TSH levels and the risk of cardiovascular diseases...
March 22, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38517399/surgical-treatment-of-secondary-hyperparathyroidism-in-children-with-chronic-kidney-disease-experience-in-19-patients
#18
JOURNAL ARTICLE
Silvia Mercedes Gil, Mariana Aziz, Valeria De Dona, Laura Lopez, Maria Florencia Soto, Victor Ayarzabal, Marta Adragna, Alicia Belgorosky, Marta Ciaccio, Gisela Viterbo
OBJECTIVES: Secondary hyperparathyroidism (sHPT) is an important contributor to bone disease and cardiovascular calcifications in children with chronic kidney disease (CKD). When conservative measures are ineffective, parathyroidectomy is indicated. The aim of our study was to evaluate the efficacy and safety of subtotal parathyroidectomy (sPTX) in pediatric and adolescent patients, and to provide a rationale for considering this aggressive treatment in CKD patients with uncontrolled sHPT...
March 25, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38514591/association-between-triglyceride-glucose-index-and-endothelial-dysfunction
#19
JOURNAL ARTICLE
Yan Li, Ming Yi, Xinyi Wang, Yinghua Zhang, Keling Xiao, Jin Si, Lijie Sun, Haoyu Zhang, Jinghao Sun, Zhaoli Liu, Jing Zhao, Xi Chu, Jing Li
BACKGROUND: Triglyceride-glucose (TyG) index, a simple surrogate marker for insulin resistance (IR), has been reported as an independent predictor of arterial structural damage and future cardiovascular events. The association between TyG index and endothelial dysfunction remains uncertain. OBJECTIVE: The purpose of this study was to investigate the association between TyG index and endothelial dysfunction. METHODS: Endothelial dysfunction was measured using flow-mediated dilation (FMD)...
March 21, 2024: Endocrine
https://read.qxmd.com/read/38512441/patient-preference-on-once-daily-oral-versus-injectable-androgen-deprivation-therapy-for-asian-patients-with-advanced-prostate-cancer
#20
JOURNAL ARTICLE
Ho-Ming Chris Wong, Bernice Cheuk-Sin Cheung, Violet Wai-Fan Yuen, Jeremy Yuen-Chun Teoh, Peter Ka-Fung Chiu, Chi-Fai Ng
PURPOSE: The study aimed at investigating prostate cancer patients' choice of androgen deprivation treatment (ADT) and possible factors that would affect their preferences of ADT. METHODS: This was a single-centre cross-sectional study investigating the usage and preferences of ADT. Consecutives prostate cancer patients who were receiving injectable luteinizing hormone-releasing hormone (LHRH) agonist or antagonist were recruited from the prostate cancer clinic in a tertiary academic hospital...
March 21, 2024: International Urology and Nephrology
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