keyword
MENU ▼
Read by QxMD icon Read
search

hormone cardiovascular

keyword
https://www.readbyqxmd.com/read/29678491/polycystic-ovary-syndrome-pcos-an-inflammatory-systemic-lifestyle-endocrinopathy
#1
REVIEW
Seema Patel
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29677465/the-effect-of-sex-menstrual-cycle-phase-and-monophasic-oral-contraceptive-pill-use-on-local-and-central-arterial-stiffness-in-young-adults
#2
Stacey E Priest, Ninette Shenouda, Maureen J MacDonald
Arterial stiffness is associated with increased cardiovascular disease risk. Previous sex-based investigations of local and central stiffness report inconsistent findings and have not controlled for menstrual cycle phase in women. There is also evidence that sex hormones influence the vasculature, but their impact on arterial stiffness across a natural menstrual (NAT) or oral contraceptive pill (OCP) cycle has been understudied. This study sought to 1) examine potential sex differences in local and central stiffness, 2) compare stiffness profiles between NAT and OCP cycles, and 3) investigate the relationship between duration of OCP use and arterial stiffness...
April 20, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29677006/evidence-basis-for-integrated-management-of-mineral-metabolism-in-patients-with-end-stage-renal-disease
#3
Julia J Scialla
PURPOSE OF REVIEW: Treatment of mineral metabolism is a mainstay of dialysis care including some of its most widely used and costly pharmaceuticals. Although many mineral metabolites are associated with increased risk of mortality, cardiovascular disease, and other morbidities, few clinical trials are available to guide therapy and most focus on single drug approaches. In practice, providers manage many aspects of mineral metabolism simultaneously in integrated treatment approaches that incorporate multiple agents and changes in the dialysis prescription...
April 6, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29675134/leptin-and-leptin-resistance-in-the-pathogenesis-of-obstructive-sleep-apnea-a-possible-link-to-oxidative-stress-and-cardiovascular-complications
#4
REVIEW
Slava Berger, Vsevolod Y Polotsky
Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29674996/association-between-thyroid-hormones-thyroid-antibodies-and-cardiometabolic-factors-in-non-obese-individuals-with-normal-thyroid-function
#5
Jia Liu, Yan Duan, Jing Fu, Guang Wang
Background: Hypothyroidism is an important risk factor for cardiovascular diseases, and autoimmune thyroiditis (AIT) is the leading cause of hypothyroidism. Recent studies showed that even AIT patients with euthyroidism still had an increased number of early atherosclerotic lesions. However, the precise mechanism is not yet known. This study aimed to investigate the association of thyroid function, thyroid autoimmunity, and cardiometabolic risk factors in non-obese AIT patients with euthyroidism...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29673470/hypertension-across-a-woman-s-life-cycle
#6
REVIEW
Nanette K Wenger, Anita Arnold, C Noel Bairey Merz, Rhonda M Cooper-DeHoff, Keith C Ferdinand, Jerome L Fleg, Martha Gulati, Ijeoma Isiadinso, Dipti Itchhaporia, KellyAnn Light-McGroary, Kathryn J Lindley, Jennifer H Mieres, Mary L Rosser, George R Saade, Mary Norine Walsh, Carl J Pepine
Hypertension accounts for 1 in 5 deaths among American women, posing a greater burden for women than men, and is among their most important risk factors for death and development of cardiovascular and other diseases. Hypertension affects women in all phases of life, with specific characteristics relating to risk factors and management for primary prevention of hypertension in teenage and young adult women; hypertension in pregnancy; hypertension during use of oral contraceptives and assisted reproductive technologies, lactation, menopause, or hormone replacement; hypertension in elderly women; and issues of race and ethnicity...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673469/thyroid-hormones-and-cardiovascular-function-and-diseases
#7
REVIEW
Salman Razvi, Avais Jabbar, Alessandro Pingitore, Sara Danzi, Bernadette Biondi, Irwin Klein, Robin Peeters, Azfar Zaman, Giorgio Iervasi
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29671909/should-phosphate-management-be-limited-to-the-kdigo-kdoqi-guidelines
#8
Sangeet Dhillon-Jhattu, Stuart M Sprague
Hyperphosphatemia is a common complication of CKD. Prior to development of overt hyperphosphatemia, there are several adaptive mechanisms that occur to maintain normal phosphorus equilibrium in patients with CKD. These include an early and progressive rise in fibroblast growth factor 23 (FGF 23), followed by an increase in parathyroid hormone (PTH) with a decrease in 1,25-dihydroxyvitamin D (1,25 Vit D). Over the last 20 years, a large number of studies have shown that hyperphosphatemia is a strong predictor of adverse clinical outcomes including increased incidence of vascular calcification, cardiovascular disease, and all-cause mortality in both individuals with CKD as well as those with normal kidney function...
April 19, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29671893/gallstone-disease-and-increased-risk-of-mortality-two-large-prospective-studies-in-us-men-and-women
#9
Yan Zheng, Min Xu, Yoriko Heianza, Wenjie Ma, Tiange Wang, Dianjianyi Sun, Christine M Albert, Frank B Hu, Kathryn M Rexrode, Jo Ann E Manson, Lu Qi
BACKGROUND AND AIM: Gallstone disease has been related to a higher prevalence and incidence of chronic conditions, such as dyslipidemia, obesity, and cardiovascular disease (CVD). However, limited data are available regarding whether gallstone disease is related to mortality. METHODS: We examined the relationship of a history of gallstone disease and risk of death, using Cox proportional hazards regression analysis, among 86,030 women from the Nurses' Health Study and 43,949 men from the Health Professionals Follow-up Study...
April 19, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29671886/serum-androgens-and-risk-of-atrial-fibrillation-in-older-men-the-cardiovascular-health-study
#10
Michael A Rosenberg, Molly M Shores, Alvin M Matsumoto, Petra Bůžková, Leslie A Lange, Richard A Kronmal, Susan R Heckbert, Kenneth J Mukamal
BACKGROUND: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined. HYPOTHESIS: Low serum androgens are associated with an increased risk of AF. METHODS: We examined the prospective associations between testosterone, its more active metabolite dihydrotestosterone (DHT), and sex-hormone binding globulin (SHBG) with risk of AF among 1019 otherwise healthy men of average age 76...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29670001/epigenetic-programming-of-synthesis-release-and-or-receptor-expression-of-common-mediators-participating-in-the-risk-resilience-for-comorbid-stress-related-disorders-and-coronary-artery-disease
#11
REVIEW
Carlos Manuel Zapata-Martín Del Campo, Martín Martínez-Rosas, Verónica Guarner-Lans
Corticotrophin releasing factor, vasopressin, oxytocin, natriuretic hormones, angiotensin, neuregulins, some purinergic substances, and some cytokines contribute to the long-term modulation and restructuring of cardiovascular regulation networks and, at the same time, have relevance in situations of comorbid abnormal stress responses. The synthesis, release, and receptor expression of these mediators seem to be under epigenetic control since early stages of life, possibly underlying the comorbidity to coronary artery disease (CAD) and stress-related disorders (SRD)...
April 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29669938/canagliflozin-triggers-the-fgf23-1-25-dihydroxyvitamin-d-pth-axis-in-healthy-volunteers-in-a-randomized-crossover-study
#12
Jenny E Blau, Viviana Bauman, Ellen M Conway, Paolo Piaggi, Mary F Walter, Elizabeth C Wright, Shanna Bernstein, Amber B Courville, Michael T Collins, Kristina I Rother, Simeon I Taylor
BACKGROUND: Sodium glucose cotransporter-2 (SGLT2) inhibitors are the most recently approved class of drugs for type 2 diabetes and provide both glycemic efficacy and cardiovascular risk reduction. A number of safety issues have been identified, including treatment-emergent bone fractures. To understand the overall clinical profile, these safety issues must be balanced against an attractive efficacy profile. Our study was designed to investigate pathophysiological mechanisms mediating treatment-emergent adverse effects on bone health...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29667232/the-pleiotropic-cardiovascular-effects-of-dipeptidyl-peptidase-4-inhibitors
#13
REVIEW
Angelo Avogaro, Gian Paolo Fadini
Patients with Type 2 Diabetes have an excess risk for cardiovascular disease. One of the several approaches, included in the Guidelines for the management of Type 2 Diabetes, is based on dipeptidyl peptidase 4 (DPP-4; also termed CD26) inhibitors (DPP-4-I), also called gliptins. Gliptins inhibit the degradation of glucagon-like peptide-1 GLP-1RA: this effect is associated with increased circulating insulin-to-glucagon ratio, and a consequent reduction of HbA1c. Beside incretin hormones, there are several proteins that may be affected by DPP-4 and its inhibition: among these some are relevant for the cardiovascular system homeostasis such as SDF-1α and its receptor CXCR4, brain natriuretic peptides, neuropeptide Y, and peptide YY...
April 17, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29666146/identification-of-circadian-clock-modulators-from-existing-drugs
#14
T Katherine Tamai, Yusuke Nakane, Wataru Ota, Akane Kobayashi, Masateru Ishiguro, Naoya Kadofusa, Keisuke Ikegami, Kazuhiro Yagita, Yasufumi Shigeyoshi, Masaki Sudo, Taeko Nishiwaki-Ohkawa, Ayato Sato, Takashi Yoshimura
Chronic circadian disruption due to shift work or frequent travel across time zones leads to jet-lag and an increased risk of diabetes, cardiovascular disease, and cancer. The development of new pharmaceuticals to treat circadian disorders, however, is costly and hugely time-consuming. We therefore performed a high-throughput chemical screen of existing drugs for circadian clock modulators in human U2OS cells, with the aim of repurposing known bioactive compounds. Approximately 5% of the drugs screened altered circadian period, including the period-shortening compound dehydroepiandrosterone (DHEA; also known as prasterone)...
April 17, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29666136/systematic-review-and-meta-analysis-of-diabetes-mellitus-cardiovascular-and-respiratory-condition-epidemiology-in-sexual-minority-women
#15
Catherine Meads, Adam Martin, Jeffrey Grierson, Justin Varney
OBJECTIVE: Sexual minority women (SMW) experience higher chronic disease risk factors than heterosexual counterparts. However, it was unclear if these risks translate into higher physical condition rates. This systematic review evaluates cardiovascular disease (CVD), hypertension, respiratory disease and diabetes mellitus in SMW. METHODS: A protocol was registered with the Prospero database (CRD42016050299). Included were studies reporting mortality, incidence or prevalence of the above-listed conditions in SMW compared with heterosexual women...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#16
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29663637/reproductive-health-obesity-and-cardiometabolic-risk-factors-among-samoan-women
#17
H Maredia, N L Hawley, G Lambert-Messerlian, U Fidow, M S Reupena, T Naseri, S T McGarvey
OBJECTIVES: Obesity leads to deleterious effects on not only cardiovascular health but also on the reproductive health of women. We estimate the prevalence of menstrual irregularity and of polycystic ovarian syndrome (PCOS) in Samoan women, among whom obesity prevalence is extremely high. We explore the association of these reproductive health conditions with adiposity, cardiometabolic risk factors, and androgen levels. METHODS: A cross-sectional sample of Samoan women 25-39 years of age (n = 470) from a larger population-based genome-wide association study of adiposity and cardiometabolic disease was assessed for the prevalence of oligomenorrhea/amenorrhea (OM/AM) using a self-reported questionnaire...
April 16, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29663535/hypothyroidism-and-hyperthyroidism-change-ectoenzyme-activity-in-rat-platelets
#18
Jucimara Baldissarelli, Adriana Santi, Roberta Schmatz, Caroline C Martins, Daniela Zanini, Karine P Reichert, Gustavo R Thomé, Taís V Palma, Pauline da Costa, Vera M Morsch, Maria R C Schetinger
The purinergic system has an important role in the regulation of vascular functions. The interference of thyroid hormones in this system and in cardiovascular events has been studied in recent years. However, the mechanisms involved in vascular, purinergic, and oxidative changes in thyroid disorders are not completely understood. Therefore, the present study aimed to assess purinergic enzyme activity in platelets from rats with hypothyroidism and hyperthyroidism induced, respectively, by continuous exposure to methimazole (MMI) at 20 mg/100 mL or L-thyroxine at 1...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29663142/do-we-need-a-cool-down-after-exercise-a-narrative-review-of-the-psychophysiological-effects-and-the-effects-on-performance-injuries-and-the-long-term-adaptive-response
#19
REVIEW
Bas Van Hooren, Jonathan M Peake
It is widely believed that an active cool-down is more effective for promoting post-exercise recovery than a passive cool-down involving no activity. However, research on this topic has never been synthesized and it therefore remains largely unknown whether this belief is correct. This review compares the effects of various types of active cool-downs with passive cool-downs on sports performance, injuries, long-term adaptive responses, and psychophysiological markers of post-exercise recovery. An active cool-down is largely ineffective with respect to enhancing same-day and next-day(s) sports performance, but some beneficial effects on next-day(s) performance have been reported...
April 16, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29661902/brain-structure-and-cognition-3-years-after-the-end-of-an-early-menopausal-hormone-therapy-trial
#20
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Val J Lowe, Julie A Fields, Jeffrey L Gunter, Matthew L Senjem, Megan L Settell, Carey E Gleason, Lynne T Shuster, Kent R Bailey, N Maritza Dowling, Sanjay Asthana, Clifford R Jack, Walter A Rocca, Virginia M Miller
OBJECTIVE: The effects of 2 frequently used formulations of menopausal hormone therapy (mHT) on brain structure and cognition were investigated 3 years after the end of a randomized, placebo-controlled trial in recently menopausal women with good cardiovascular health. METHODS: Participants (aged 42-56 years; 5-36 months past menopause) were randomized to one of the following: 0.45 mg/d oral conjugated equine estrogen (oCEE); 50 μg/d transdermal 17β-estradiol (tE2); or placebo pills and patch for 4 years...
April 17, 2018: Neurology
keyword
keyword
67848
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"