Fabio Busonero, Stefania Lenarduzzi, Francesca Crobu, Roberta Marie Gentile, Andrea Carta, Francesco Cracco, Andrea Maschio, Silvia Camarda, Michele Marongiu, Daniela Zanetti, Claudio Conversano, Giovanni Di Lorenzo, Daniela Mazzà, Francesco De Seta, Giorgia Girotto, Serena Sanna
AIMS: Epidemiological research has shown relevant differences between sexes in clinical manifestations, severity, and progression of cardiovascular and metabolic disorders. To date, the mechanisms underlying these differences remain unknown. Given the rising incidence of such diseases, gender-specific research on established and emerging risk factors, such as dysfunction of glycaemic and/or lipid metabolism, of sex hormones and of gut microbiome, is of paramount importance. The relationships between sex hormones, gut microbiome, and host glycaemic and/or lipid metabolism are largely unknown even in the homoeostasis status...
March 2024: Eur Heart J Open