keyword
MENU ▼
Read by QxMD icon Read
search

hormonal and exercise

keyword
https://www.readbyqxmd.com/read/29778861/multicenter-randomized-controlled-crossover-trial-comparing-hemodynamic-optimization-against-echocardiographic-optimization-of-av-and-vv-delay-of-cardiac-resynchronization-therapy-the-bravo-trial
#1
Zachary I Whinnett, S M Afzal Sohaib, Mark Mason, Edward Duncan, Mark Tanner, David Lefroy, Mohamed Al-Obaidi, Sue Ellery, Francisco Leyva-Leon, Tim Betts, Mark Dayer, Paul Foley, Jon Swinburn, Martin Thomas, Raj Khiani, Tom Wong, Zaheer Yousef, Dominic Rogers, Paul R Kalra, Vignesh Dhileepan, Katherine March, James Howard, Andreas Kyriacou, Jamil Mayet, Prapa Kanagaratnam, Michael Frenneaux, Alun D Hughes, Darrel P Francis
OBJECTIVES: BRAVO (British Randomized Controlled Trial of AV and VV Optimization) is a multicenter, randomized, crossover, noninferiority trial comparing echocardiographic optimization of atrioventricular (AV) and interventricular delay with a noninvasive blood pressure method. BACKGROUND: Cardiac resynchronization therapy including AV delay optimization confers clinical benefit, but the optimization requires time and expertise to perform. METHODS: This study randomized patients to echocardiographic optimization or hemodynamic optimization using multiple-replicate beat-by-beat noninvasive blood pressure at baseline; after 6 months, participants were crossed over to the other optimization arm of the trial...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29775761/the-bone-anabolic-effects-of-irisin-are-through-preferential-stimulation-of-aerobic-glycolysis
#2
Dingdong Zhang, ChuHyun Bae, Junghak Lee, Jiho Lee, Zeyu Jin, Myeongmo Kang, Young Suk Cho, Jeong-Han Kim, Weontae Lee, Sung-Kil Lim
Irisin, a recently identified hormone secreted by skeletal muscle in response to exercise, exhibits anabolic effects on the skeleton primarily through the stimulation of bone formation. However, the mechanism underlying the irisin-stimulated anabolic response remains largely unknown. To uncover the underlying mechanism, we biosynthesized recombinant irisin (r-irisin) using an Escherichia coli expression system and used it to treat several osteoblast cell types. Our synthesized r-irisin could promote proliferation and differentiation of osteoblasts as evidenced by enhanced expression of osteoblast-specific transcriptional factors, including Runt-related transcription factor-2 (Runx2), Oster (Osx), as well as early osteoblastic differentiation markers such as alkaline phosphatase (Alp) and collagen type I alpha 1 (Col1a1)...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29774312/breast-cancer-prevention-current-approaches-and-future-directions
#3
REVIEW
Edward R Sauter
The topic of breast cancer prevention is very broad. All aspects of the topic, therefore, cannot be adequately covered in a single review. The objective of this review is to discuss strategies in current use to prevent breast cancer, as well as potential approaches that could be used in the future. This review does not discuss early detection strategies for breast cancer, including breast cancer screening. The breast is the most common site among women worldwide of noncutaneous cancer. Many clinical and genetic factors have been found to increase a woman's risk of developing the disease...
April 2018: European journal of breast health
https://www.readbyqxmd.com/read/29756416/testosterone-and-sarcopenia
#4
REVIEW
Myung Jun Shin, Yun Kyung Jeon, In Joo Kim
Aging affects metabolism, leading to physiological and functional impairments, and is also related to changes in body composition, including reduced skeletal muscle mass and increased body fat. These changes are correlated with the pathophysiology of sarcopenia, which is defined as age-related loss of skeletal muscle mass and strength. Low testosterone levels are associated with unfavorable body composition changes, and sex hormones decrease with aging. Androgen deficiency, along with lack of exercise and poor nutrition, may be among the modifiable contributors to sarcopenia...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29752954/regulation-of-the-activins-follistatins-inhibins-axis-by-energy-status-impact-on-reproductive-function
#5
Nikolaos Perakakis, Jagriti Upadhyay, Wael Ghaly, Joyce Chen, Pavlina Chrysafi, Athanasios D Anastasilakis, Christos S Mantzoros
BACKGROUND: We have previously demonstrated that the adipose tissue derived hormone leptin controls reproductive function by regulating the hypothalamic-pituitary-gonadal axis in response to energy deficiency. Here, we evaluate the activins-follistatins-inhibins (AFI) axis during acute (short-term fasting in healthy people) and chronic energy deficiency (women with hypothalamic amenorrhea due to strenuous exercise [HA]) and investigate their relation to leptin and reproductive function in healthy subjects and subjects with HA...
May 9, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29752345/randomized-outpatient-trial-of-single-and-dual-hormone-closed-loop-systems-that-adapt-to-exercise-using-wearable-sensors
#6
Jessica R Castle, Joseph El Youssef, Leah M Wilson, Ravi Reddy, Navid Resalat, Deborah Branigan, Katrina Ramsey, Joseph Leitschuh, Uma Rajhbeharrysingh, Brian Senf, Samuel M Sugerman, Virginia Gabo, Peter G Jacobs
OBJECTIVE: Automated insulin delivery is the new standard for type 1 diabetes, but exercise-related hypoglycemia remains a challenge. Our aim was to determine whether a dual-hormone closed-loop system using wearable sensors to detect exercise and adjust dosing to reduce exercise-related hypoglycemia would outperform other forms of closed-loop and open-loop therapy. RESEARCH DESIGN AND METHODS: Participants underwent four arms in randomized order: dual-hormone, single-hormone, predictive low glucose suspend, and continuation of current care over 4 outpatient days...
May 11, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29740398/neurosteroids-in-adult-hippocampus-of-male-and-female-rodents-biosynthesis-and-actions-of-sex-steroids
#7
REVIEW
Yasushi Hojo, Suguru Kawato
The brain is not only the target of steroid hormones but also is able to locally synthesize steroids de novo . Evidence of the local production of steroids in the brain has been accumulating in various vertebrates, including teleost fish, amphibia, birds, rodents, non-human primates, and humans. In this review, we mainly focus on the local production of sex steroids in the hippocampal neurons of adult rodents (rats and mice), a center for learning and memory. From the data of the hippocampus of adult male rats, hippocampal principal neurons [pyramidal cells in CA1-CA3 and granule cells in dentate gyrus (DG)] have a complete system for biosynthesis of sex steroids...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29738032/does-high-intensity-exercise-affects-irisin-plasma-levels-in-hemodialysis-patients-a-pilot-study
#8
Marta Gormicho Boavida Marques Esgalhado, Milena Barcza Stockler-Pinto, Ludmila Ferreira Medeiros de França Cardozo, Jorge Eduardo Barboza, Denise Mafra
BACKGROUND: Irisin is a recently identified exercise-induced hormone that stimulates the "browning" of the white adipose tissue, at least in mice. In chronic kidney disease (CKD) patients, irisin regulation is not fully understood, and little attention has been given to the effects of exercise on irisin levels in these patients. The purpose of this study was to assess the effects of high intensity exercise on irisin plasma levels in CKD patients under hemodialysis (HD). METHODS: Fifteen HD patients (5 men, 44...
April 23, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29728995/relationship-between-fatigue-symptoms-and-subjective-and-objective-indicators-in-hemodialysis-patients
#9
Manhua Zuo, Jun Tang, Miaomiao Xiang, Qing Long, Jianping Dai, Xiuying Hu
PURPOSE: The purpose of the study was to investigate the major factors affecting fatigue symptoms and to examine the relationships between fatigue symptoms and subjective and objective indicators in patients on hemodialysis (HD). METHODS: Patients on HD who met the inclusion criteria were chosen from two grade A tertiary general hospitals by convenience sampling and cross-sectional survey methods. RESULTS: A total of 511 patients were included in the study...
May 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29726656/-aerobic-exercise-improves-spermatogenesis-of-male-rats-results-of-itraq-based-proteomic-analysis-of-the-testis-tissue
#10
Yu-Ping Guo, En-Zhong Li, You-Jing Zhang, An-Li Wang
Objective: To investigate the effect of aerobic exercise on the spermatogenic function of male rats and screen out differentially expressed proteins related to spermatonesis-regulation by proteomic analysis. METHODS: We randomly divided 24 SD male rats into groups A (non-exercise control), B (exercise), and C (weight-bearing exercise), those in the latter two groups made to swim for 60 minutes a day and those in group C bearing a load 3% of the body weight, both 6 times a week for 9 weeks...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29725246/dehydroepiandrosterone-supplementation-combined-with-weight-loading-whole-body-vibration-training-wwbv-affects-exercise-performance-and-muscle-glycogen-storage-in-middle-aged-c57bl-6-mice
#11
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Background : Adequate nutritional intake and an optimal training program are important elements of any strategy to preserve or increase muscle mass and strength during aging. Purpose : In the current study, we investigate the effects of Dehydroepiandrosterone (DHEA), one of the most abundant circulating steroids in humans and a precursor hormone, supplementation combined with a weight-loading whole-body vibration (WWBV) on exercise performance, physical fatigue-related biochemical responses and testosterone content in middle-aged 9 months old C57BL/6 mice...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29719588/effects-of-repeated-sprints-training-on-fracture-risk-associated-mirna
#12
Veronica Sansoni, Silvia Perego, Gianluca Vernillo, Andrea Barbuti, Giampiero Merati, Antonio La Torre, Giuseppe Banfi, Giovanni Lombardi
Repeated-sprint training (RS, short-duration sprints at supramaximal intensities interspersed with brief recoveries) is a time-saving metabolically effective strategy whose effects on bone are unknown. Bone metabolism is a finely regulated process profoundly affected by exercise as assayable by studying specific systemic (e.g., hormones, cytokines) and bone-derived molecules (e.g., bone markers, miRNAs). Aim of this study was to determine the effect of a 8-week repeated-sprint on circulating levels of fracture risk-associated miRNA...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29716978/therapy-of-endocrine-disease-growth-hormone-replacement-therapy-in-adults-thirty-years-of-personal-clinical-experience
#13
Jens Otto L Jorgensen, Anders Juul
The acute metabolic actions of purified human GH was first documented in adult hypopituitary patients more than 50 years ago, and placebo controlled long term GH trials in GH-deficient adults (GHDA) surfaced in 1989 with the availability of biosynthetic human GH. Untreated GHDA is associated with excess morbidity and mortality from cardiovascular disease and the phenotype includes fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular biomarkers...
May 1, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29714992/issues-in-geriatric-care-maintaining-health-and-vigor
#14
Richard J Ackermann
Medicare covers annual wellness visits that are scheduled separately from regular medical appointments. These visits focus on prevention and health maintenance to help patients achieve successful aging, which is defined as living to old age without disability while also maintaining high physical and psychological levels of functioning and social engagement. To achieve these goals, most adults should perform at least 150 min/week of moderate-intensity exercise and maintain an optimal body mass index (ie, 23 to 32 kg/m2 )...
May 2018: FP Essentials
https://www.readbyqxmd.com/read/29708035/gender-differences-in-outcomes-after-aortic-aneurysm-surgery-should-foster-further-research-to-improve-screening-and-prevention-programmes
#15
Francesco Nicolini, Antonella Vezzani, Francesco Corradi, Riccardo Gherli, Filippo Benassi, Tullio Manca, Tiziano Gherli
Background Gender-related biases in outcomes after thoracic aortic surgery are an important factor to consider in the prevention of potential complications related to aortic diseases and in the analysis of surgical results. Methods The aim of this study is to provide an up-to-date review of gender-related differences in the epidemiology, specific risk factors, outcome, and screening and prevention programmes in aortic aneurysms. Results Female patients affected by aortic disease still have worse outcomes and higher early and late mortality than men...
June 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29706148/fluoxetine-treatment-of-prepubertal-male-rats-uniformly-diminishes-sex-hormone-levels-and-in-a-subpopulation-of-animals-negatively-affects-sperm-quality
#16
María E Ayala, Ayari Gonzáles, Rodrigo M Olivarez, Andrés Aragón-Martínez
Fluoxetine (Flx) is a selective serotonin reuptake inhibitor that alters the male reproductive system when administered at the adult stage or after maternal exposure. In the present study we evaluated the effects of Flx administration on reproductive parameters during juvenile-peripubertal development when treated male rats reached adulthood. Groups of rats were treated daily with Flx (5mgkg-1, i.p.) or saline (0.9% NaCl), or were left untreated. Rats were treated between 30 and 53 days of age and were killed at 65 days of age...
April 30, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29704911/vegans-report-less-bothersome-vasomotor-and-physical-menopausal-symptoms-than-omnivores
#17
Bonnie Beezhold, Cynthia Radnitz, Robert E McGrath, Arielle Feldman
OBJECTIVES: Lifestyle modifications that may reduce menopausal symptoms have generated much interest. The vegetarian diet has been associated with a lower risk of chronic disease as well as a more healthy hormonal milieu. Our objective in this cross-sectional study was to survey peri- and postmenopausal women to investigate menopausal symptoms and dietary pattern. STUDY DESIGN: Survey distribution in 2015-2016 was aimed at female vegans, vegetarians, and omnivores between the ages of 45 and 80 years, who were active on senior and vegetarian social networking websites and at vegan restaurants and events...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29698395/personalizing-physical-exercise-in-a-computational-model-of-fuel-homeostasis
#18
Maria Concetta Palumbo, Micaela Morettini, Paolo Tieri, Fasma Diele, Massimo Sacchetti, Filippo Castiglione
The beneficial effects of physical activity for the prevention and management of several chronic diseases are widely recognized. Mathematical modeling of the effects of physical exercise in body metabolism and in particular its influence on the control of glucose homeostasis is of primary importance in the development of eHealth monitoring devices for a personalized medicine. Nonetheless, to date only a few mathematical models have been aiming at this specific purpose. We have developed a whole-body computational model of the effects on metabolic homeostasis of a bout of physical exercise...
April 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29696212/feasibility-of-high-intensity-interval-training-with-hyperoxia-vs-intermittent-hyperoxia-and-hypoxia-in-cancer-patients-undergoing-chemotherapy-study-protocol-of-a-randomized-controlled-trial
#19
Moritz Schumann, Holger Schulz, Anthony C Hackney, Wilhelm Bloch
Exercise has been well demonstrated to potentially reduce chemotherapy-induced side effects and possibly aid slowing down tumor growth in cancer patients but exercise training adherence is typically low. Thus, training regimens which are perceived less strenuous but do not compromise the training-induced beneficial adaptations will help to increase adherence to exercise and reduce attrition. This 4-armed study aims to investigate the effects of high intensity interval training (HIIT) in hyperoxia versus intermittent hyperoxia and hypoxia in cancer patients undergoing chemotherapy...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695963/the-effects-of-ppar-stimulation-on-cardiac-metabolic-pathways-in-barth-syndrome-mice
#20
Caitlin Schafer, Vicky Moore, Nupur Dasgupta, Sabzali Javadov, Jeanne F James, Alexander I Glukhov, Arnold W Strauss, Zaza Khuchua
Aim: Tafazzin knockdown (TazKD) in mice is widely used to create an experimental model of Barth syndrome (BTHS) that exhibits dilated cardiomyopathy and impaired exercise capacity. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that play essential roles as transcription factors in the regulation of carbohydrate, lipid, and protein metabolism. We hypothesized that the activation of PPAR signaling with PPAR agonist bezafibrate (BF) may ameliorate impaired cardiac and skeletal muscle function in TazKD mice...
2018: Frontiers in Pharmacology
keyword
keyword
67842
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"