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https://www.readbyqxmd.com/read/29453206/elevation-of-hippocampal-neurogenesis-induces-a-temporally-graded-pattern-of-forgetting-of-contextual-fear-memories
#1
Aijing Gao, Frances Xia, Axel Guskjolen, Adam I Ramsaran, Adam Santoro, Sheena A Josselyn, Paul W Frankland
Throughout life neurons are continuously generated in the subgranular zone of the hippocampus. The subsequent integration of newly-generated neurons alters patterns of dentate gyrus input and output connectivity, potentially rendering memories already stored in those circuits harder to access. Consistent with this prediction, we previously showed that increasing hippocampal neurogenesis after training induces forgetting of hippocampus-dependent memories, including contextual fear memory. However, the brain regions supporting contextual fear memories change with time, and this time-dependent memory reorganization might regulate the sensitivity of contextual fear memories to fluctuations in hippocampal neurogenesis...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29451881/population-based-coverage-survey-results-following-the-mass-drug-administration-of-azithromycin-for-the-treatment-of-trachoma-in-amhara-ethiopia
#2
Tigist Astale, Eshetu Sata, Mulat Zerihun, Andrew W Nute, Aisha E P Stewart, Demelash Gessesse, Gedefaw Ayenew, Berhanu Melak, Melsew Chanyalew, Zerihun Tadesse, E Kelly Callahan, Scott D Nash
BACKGROUND: Trachoma is the leading infectious cause of blindness worldwide. In communities where the district level prevalence of trachomatous inflammation-follicular among children ages 1-9 years is ≥5%, WHO recommends annual mass drug administration (MDA) of antibiotics with the aim of at least 80% coverage. Population-based post-MDA coverage surveys are essential to understand the effectiveness of MDA programs, yet published reports from trachoma programs are rare. METHODS: In the Amhara region of Ethiopia, a population-based MDA coverage survey was conducted 3 weeks following the 2016 MDA to estimate the zonal prevalence of self-reported drug coverage in all 10 administrative zones...
February 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29446212/free-dialysis-in-nepal-logistical-challenges-explored
#3
John Mcgee, Bimal Pandey, Abhishek Maskey, Tifany Frazer, Theodore Mackinney
Nepal's Ministry of Health began offering free lifetime hemodialysis (HD) in 2016. There has been a large growth in renal replacement therapy (RRT) services offered in Nepal since 2010, when the last known data on the subject was published. In 2016, 42 HD centers existed (223% increase since 2010) serving 1975 end stage renal disease patients (303% increase since 2010); 36 nephrologists were registered (200% increase since 2010), 12 were trained in transplantation, and 790 transplants had been performed to date...
February 15, 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29443325/a-survey-on-integrated-management-of-neonatal-and-childhood-illness-implementation-by-nurses-in-four-districts-of-west-arsi-zone-of-ethiopia
#4
Sheka Shemsi Seid, Endalew Gemechu Sendo
Background: In Ethiopia, one in 17 children dies before 1 year of age and one in 11 children dies before 5 years. Research that examines the factors influencing the implementation of the Integrated Management of Neonatal and Childhood Illnesses (IMNCI) strategy in Ethiopia is limited. This study aimed to identify the factors compelling the execution of IMNCI by nurses in four districts of West Arsi zone of Ethiopia. Methods: A mixed-method cross-sectional study was conducted from February to March 2016 in West Arsi zone of Oromia regional state, Ethiopia...
2018: Pediatric Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/29433003/mixing-of-ultrasonic-lamb-waves-in-thin-plates-with-quadratic-nonlinearity
#5
Feilong Li, Youxuan Zhao, Peng Cao, Ning Hu
This paper investigates the propagation of Lamb waves in thin plates with quadratic nonlinearity by one-way mixing method using numerical simulations. It is shown that an A0-mode wave can be generated by a pair of S0 and A0 mode waves only when mixing condition is satisfied, and mixing wave signals are capable of locating the damage zone. Additionally, it is manifested that the acoustic nonlinear parameter increases linearly with quadratic nonlinearity but monotonously with the size of mixing zone. Furthermore, because of frequency deviation, the waveform of the mixing wave changes significantly from a regular diamond shape to toneburst trains...
February 6, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29411074/bridging-the-divide-challenges-and-opportunities-for-public-sector-agricultural-professionals-working-with-amish-and-mennonite-producers-on-conservation
#6
Caroline Brock, Jessica D Ulrich-Schad, Linda Prokopy
As Amish and Old Order and Conservative Mennonite (i.e., Plain) farmers increase their presence in the agricultural sector, it is crucial for public sector agricultural professionals to effectively work with them to mediate nonpoint source pollution and address issues like the hypoxic zone in the Gulf of Mexico. However, there is a dearth of research on how public sector agricultural professionals can better work with Plain producers on environmental management. There are also few training resources for those working with this key, yet hard to reach, population...
February 6, 2018: Environmental Management
https://www.readbyqxmd.com/read/29409595/the-pediatric-resuscitative-thoracotomy-during-combat-operations-in-iraq-and-afghanistan-a-retrospective-cohort-study
#7
Steven G Schauer, Guyon J Hill, Richard E Connor, John S Oh, Michael D April
BACKGROUND: Combat zone trauma poses a unique set of challenges and injury patterns not seen in the civilian setting. The role of the pediatric resuscitative thoracotomy in combat zones remains unclear given a paucity of data regarding procedure outcomes in this setting. We compare outcomes among children in traumatic arrest undergoing resuscitative thoracotomy versus cardiopulmonary (CPR) resuscitation only. METHODS: We queried the Department of Defense Trauma Registry (DODTR) from 2007 to 2016 for all pediatric subjects that underwent a resuscitative thoracotomy or CPR in the prehospital or emergency department setting during operations in Iraq or Afghanistan...
January 31, 2018: Injury
https://www.readbyqxmd.com/read/29391079/update-on-minimal-standards-for-electroencephalography-in-canada-a-review-by-the-canadian-society-of-clinical-neurophysiologists
#8
Dianne Dash, Chelsea Dash, Sara Primrose, Lizbeth Hernandez-Ronquillo, Farzad Moien-Afshari, Lady D Ladino, Juan Pablo Appendino, Lindsay Mazepa, Christine Elliott, Seyed M Mirsattari, Paolo Federico, Esther Bui, Gary Hunter, Rajesh RamachandranNair, Rohit Sharma, Paula Melendres, Joanne Nikkel, Dang Khoa Nguyen, Salah Almubarak, Mike Rigby, Jose F Téllez-Zenteno
Surface electroencephalogram (EEG) recording remains the gold standard for noninvasive assessment of electrical brain activity. It is the most efficient way to diagnose and classify epilepsy syndromes as well as define the localization of the epileptogenic zone. The EEG is useful for management decisions and for establishing prognosis in some types of epilepsy. Electroencephalography is an evolving field in which new methods are being introduced. The Canadian Society of Clinical Neurophysiologists convened an expert panel to develop new national minimal guidelines...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29384413/having-the-headspace-for-compassion-toward-self-and-others-a-qualitative-study-of-medical-students-views-and-experiences
#9
Stephanie Tierney, Cameron-Tosh Ozer, Sophie Perry
Phenomenon: Debate about compassion exhibited by healthcare professionals has escalated, following a perceived decline over recent years. At the same time, a growing interest in self-compassion has emerged, which is seen as facilitating compassion toward others. Little research has explored, in depth, what compassion to self and others means to medical students. Therefore, a study was designed to address this gap in knowledge. APPROACH: A qualitative study was conducted, involving students from all 4 years of a graduate-entry medical school in the United Kingdom...
January 31, 2018: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/29384303/-overlapping-interdependence-or-complementarity-interprofessional-collaboration-between-nurse-practitioners-and-other-health-professionals-in-ontario
#10
Monique Benoit, Roger Pilon, Anne-Marise Lavoie, Pierre Pariseau-Legault
OBJECTIVE: The Naylor Report (2015) states that nurse practitioners (NP) are still underutilized in Canada despite positive evidence of their work and the benefits they provide to health systems and, more generally, the health of the population. METHODS: Why are nurse practitioners not more actively involved in the Canadian health care system? A socio-historical literature review showed that there is overlap, interdependence or complementarity between the role of NPs and that of other health professionals and that this concerns their status, training as well as the scope of their practice...
December 5, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29369076/analysis-of-pediatric-trauma-in-combat-zone-to-inform-high-fidelity-simulation-predeployment-training
#11
Patrick T Reeves, Marc M Auerbach, Tuan D Le, Nicole W Caldwell, Mary J Edwards, Elizabeth A Mann-Salinas, Jennifer M Gurney, Zsolt T Stockinger, Matthew A Borgman
OBJECTIVES: The military uses "just-in-time" training to refresh deploying medical personnel on skills necessary for medical and surgical care in the theater of operations. The burden of pediatric care at Role 2 facilities has yet to be characterized; pediatric predeployment training has been extremely limited and primarily informed by anecdotal experience. The goal of this analysis was to describe pediatric care at Role 2 facilities to enable data-driven development of high-fidelity simulation training and core knowledge concepts specific to the combat zone...
January 23, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29363532/automated-diabetic-retinopathy-detection-using-optical-coherence-tomography-angiography-a-pilot-study
#12
Harpal Singh Sandhu, Nabila Eladawi, Mohammed Elmogy, Robert Keynton, Omar Helmy, Shlomit Schaal, Ayman El-Baz
BACKGROUND: Optical coherence tomography angiography (OCTA) is increasingly being used to evaluate diabetic retinopathy, but the interpretation of OCTA remains largely subjective. The purpose of this study was to design a computer-aided diagnostic (CAD) system to diagnose non-proliferative diabetic retinopathy (NPDR) in an automated fashion using OCTA images. METHODS: This was a two-centre, cross-sectional study. Adults with type II diabetes mellitus (DMII) were eligible for inclusion...
January 23, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29361244/characterization-of-prostate-cancer-with-gleason-score-of-at-least-7-by-using-quantitative-multiparametric-mr-imaging-validation-of-a-computer-aided-diagnosis-system-in-patients-referred-for-prostate-biopsy
#13
Au Hoang Dinh, Christelle Melodelima, Rémi Souchon, Paul C Moldovan, Flavie Bratan, Gaële Pagnoux, Florence Mège-Lechevallier, Alain Ruffion, Sébastien Crouzet, Marc Colombel, Olivier Rouvière
Purpose To determine the performance of a computer-aided diagnosis (CAD) system trained at characterizing cancers in the peripheral zone (PZ) with a Gleason score of at least 7 in patients referred for multiparametric magnetic resonance (MR) imaging before prostate biopsy. Materials and Methods Two institutional review board-approved prospective databases of patients who underwent multiparametric MR imaging before prostatectomy (database 1) or systematic and targeted biopsy (database 2) were retrospectively used...
January 22, 2018: Radiology
https://www.readbyqxmd.com/read/29357458/transmitter-release-site-organization-can-predict-synaptic-function-at-the-neuromuscular-junction
#14
Rozita Laghaei, Jun Ma, Tyler Tarr, Anne E Homan, Lauren Kelly, Megha Tilvawala, Blake Vuocolo, Harini Rajasekaran, Stephen D Meriney, Markus Dittrich
We have investigated the impact of transmitter release site (active zone; AZ) structure on synaptic function by physically rearranging the individual AZ elements in a previously published frog neuromuscular junction (NMJ) AZ model into the organization observed in a mouse NMJ AZ. We have used this strategy, purposefully without changing the properties of AZ elements between frog and mouse models (even though there are undoubtedly differences between frog and mouse AZ elements in vivo), to directly test how structure influences function at the level of an AZ...
December 27, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29353529/ultrasound-shear-wave-elastography-of-the-normal-prostate-interobserver-reproducibility-and-comparison-with-functional-magnetic-resonance-tissue-characteristics
#15
Hugh Harvey, Veronica Morgan, Jeremie Fromageau, Tuathan O'Shea, Jeffrey Bamber, Nandita M deSouza
The purpose of this study was to establish interobserver reproducibility of Young's modulus (YM) derived from ultrasound shear wave elastography (US-SWE) in the normal prostate and correlate it with multiparametric magnetic resonance imaging (mpMRI) tissue characteristics. Twenty men being screened for prostate cancer underwent same-day US-SWE (10 done by two blinded, newly-trained observers) and mpMRI followed by 12-core biopsy. Bland-Altman plots established limits of agreement for YM. Quantitative data from the peripheral zone (PZ) and the transitional zone (TZ) for YM, apparent diffusion coefficient (ADC, mm2/s from diffusion-weighted MRI), and Ktrans (volume transfer coefficient, min-1), Ve (extravascular-extracellular space, %), Kep (rate constant, /min), and initial area under the gadolinium concentration curve (IAUGC60, mmol/L/s) from dynamic contrast-enhanced MRI were obtained for slice-matched prostate sextants...
January 1, 2018: Ultrasonic Imaging
https://www.readbyqxmd.com/read/29351677/use-of-risk-model-for-assessment-of-residents-perception-of-complexity-of-surgical-steps-example-of-modular-component-steps-of-lumbar-spinal-fusion-surgery
#16
Jeffrey S Raskin, Jesse J Liu, Katherine Holste, Sarah Brown, Fran Hardaway, Priscilla Pang, Ahmed M Raslan
BACKGROUND: Quality improvement projects increasingly emphasize standardization of surgical work flow to optimize operative room efficiency. Removing special cause variability resulting from nonsurgical waste is an obvious target; however, resident surgical education must be maintained, even in the setting of process improvement. OBJECTIVE: To describe the impact of resident-identified "risky" or "uncomfortable" procedural steps on operative time during transforaminal lumbar interbody fusion (TLIF)...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29344083/psychosocial-problems-in-traumatized-refugee-families-overview-of-risks-and-some-recommendations-for-support-services
#17
EDITORIAL
J M Fegert, C Diehl, B Leyendecker, K Hahlweg, V Prayon-Blum
This article is an abridged version of a report by an advisory council to the German government on the psychosocial problems facing refugee families from war zones who have settled in Germany. It omits the detailed information contained in the report about matters that are specific to the German health system and asylum laws, and includes just those insights and strategies that may be applicable to assisting refugees in other host countries as well. The focus is on understanding the developmental risks faced by refugee children when they or family members are suffering from trauma-related psychological disorders, and on identifying measures that can be taken to address these risks...
2018: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29340940/characterizing-potentially-preventable-admissions-a-mixed-methods-study-of-rates-associated-factors-outcomes-and-physician-decision-making
#18
Lisa M Daniels, Atsushi Sorita, Deanne T Kashiwagi, Masashi Okubo, Evan Small, Eric C Polley, Adam P Sawatsky
BACKGROUND: Potentially preventable admissions are a target for healthcare cost containment. OBJECTIVE: To identify rates of, characterize associations with, and explore physician decision-making around potentially preventable admissions. DESIGN: A comparative cohort study was used to determine rates of potentially preventable admissions and to identify associated factors and patient outcomes. A qualitative case study was used to explore physicians' clinical decision-making...
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29340002/performance-changes-of-elite-paralympic-judo-athletes-during-a-paralympic-games-cycle-a-case-study-with-the-brazilian-national-team
#19
Irineu Loturco, Lucas A Pereira, Ciro Winckler, Jaime R Bragança, Roger A da Fonseca, Ronaldo Kobal, Cesar C Cal Abad, Katia Kitamura, Fabio Y Nakamura, Emerson Franchini
The aim of this study was to describe the variations in power performance of elite Paralympic judo athletes across three consecutive training cycles of preparation for the ParaPan American Games, the World Championship and the Paralympic Games. Eleven Paralympic judokas from the Brazilian National team participated in this study. They were repeatedly assessed using squat and countermovement jumps, mean propulsive power (MPP) in the jump-squat (JS), the bench press and prone bench pull at several moments of the preparation...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339992/effects-of-passive-and-active-rest-on-physiological-responses-and-time-motion-characteristics-in-different-small-sided-soccer-games
#20
Ersan Arslan, Utku Alemdaroglu, Yusuf Koklu, Tahir Hazir, Surhat Muniroglu, Baris Karakoc
The purpose of this study was to investigate the effects of resting regimes on physiological responses and time motion characteristics between bouts during small sided games (SSGs) in young soccer players. Sixteen players (average age 16.87 ± 0.34 years; body height 176.69 ± 3.21 cm; body mass 62.40 ± 2.59 kg; training experience 3.75 ± 0.44 years) performed four bouts 2-a-side, 3-a-side and 4-a-side games with three minutes active (SSGar: Running at 70% of HRmax) and passive (SSGpr) rest between bouts at two-day intervals...
December 2017: Journal of Human Kinetics
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