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https://www.readbyqxmd.com/read/29143667/validation-of-whole-blood-transcriptome-signature-during-microdose-recombinant-human-erythropoietin-rhuepo-administration
#1
Guan Wang, Jérôme Durussel, Jonathan Shurlock, Martin Mooses, Noriyuki Fuku, Georgie Bruinvels, Charles Pedlar, Richard Burden, Andrew Murray, Brendan Yee, Anne Keenan, John D McClure, Pierre-Edouard Sottas, Yannis P Pitsiladis
BACKGROUND: Recombinant human erythropoietin (rHuEpo) can improve human performance and is therefore frequently abused by athletes. As a result, the World Anti-Doping Agency (WADA) introduced the Athlete Biological Passport (ABP) as an indirect method to detect blood doping. Despite this progress, challenges remain to detect blood manipulations such as the use of microdoses of rHuEpo. METHODS: Forty-five whole-blood transcriptional markers of rHuEpo previously derived from a high-dose rHuEpo administration trial were used to assess whether microdoses of rHuEpo could be detected in 14 trained subjects and whether these markers may be confounded by exercise (n = 14 trained subjects) and altitude training (n = 21 elite runners and n = 4 elite rowers, respectively)...
November 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29129021/the-effect-of-natural-or-simulated-altitude-training-on-high-intensity-intermittent-running-performance-in-team-sport-athletes-a-meta-analysis
#2
REVIEW
Michael J Hamlin, Catherine A Lizamore, Will G Hopkins
BACKGROUND: While adaptation to hypoxia at natural or simulated altitude has long been used with endurance athletes, it has only recently gained popularity for team-sport athletes. OBJECTIVE: To analyse the effect of hypoxic interventions on high-intensity intermittent running performance in team-sport athletes. METHODS: A systematic literature search of five journal databases was performed. Percent change in performance (distance covered) in the Yo-Yo intermittent recovery test (level 1 and level 2 were used without differentiation) in hypoxic (natural or simulated altitude) and control (sea level or normoxic placebo) groups was meta-analyzed with a mixed model...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29112625/ischemic-preconditioning-improves-time-trial-performance-at-moderate-altitude
#3
Pénélope Paradis-Deschênes, Denis R Joanisse, François Billaut
PURPOSE: Endurance athletes often compete and train at altitude where exercise capacity is reduced. Investigating acclimation strategies is therefore critical. Ischemic preconditioning (IPC) can improve endurance performance at sea level through improved O2 delivery and utilization, which could also prove beneficial at altitude. However, data are scarce and there is no study at altitudes commonly visited by endurance athletes. METHODS: In a randomized, crossover study, we investigated performance and physiological responses in thirteen male endurance cyclists during four 5-km cycling time trials (TT), preceded by either IPC (3x5-minutes ischemia/5-minutes reperfusion cycles at 220 mmHg) or SHAM (20 mmHg) administered to both thighs, at simulated low (FIO2 0...
November 6, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29111287/transcatheter-closure-of-a-small-atrial-septal-defect-with-an-amplatzer%C3%A2-patent-foramen-ovale-occluder-in-a-working-dog-with-cyanosis-and-exercise-intolerance-at-high-altitude
#4
A Shelden, S Wesselowski, S G Gordon, A B Saunders
A 6.5-year-old male Border Collie presented for transcatheter closure of an atrial septal defect due to exercise intolerance and cyanosis while working and training at altitude. A small, left-to-right shunting secundum atrial septal defect was confirmed with no evidence of significant right-sided volume overload. Pulmonary hypertension with subsequent right-to-left interatrial shunting occurring during exercise at high altitude was suspected and prompted the closure of the defect due to the dog's continued athletic requirements...
October 27, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29098323/three-question-set-from-michigan-neuropathy-screening-instrument-adds-independent-prognostic-information-on-cardiovascular-outcomes-analysis-of-altitude-trial
#5
Jelena P Seferovic, Marc A Pfeffer, Brian Claggett, Akshay S Desai, Dick de Zeeuw, Steven M Haffner, John J V McMurray, Hans-Henrik Parving, Scott D Solomon, Nish Chaturvedi
AIMS/HYPOTHESIS: The self-administered Michigan Neuropathy Screening Instrument (MNSI) is used to diagnose diabetic peripheral neuropathy. We examined whether the MNSI might also provide information on risk of death and cardiovascular outcomes. METHODS: In this post hoc analysis of the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) trial, we divided 8463 participants with type 2 diabetes and chronic kidney disease (CKD) and/or cardiovascular disease (CVD) into independent training (n = 3252) and validation (n = 5211) sets...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29064292/psychophysiological-response-and-fine-motor-skills-in-high-altitude-parachute-jumps
#6
Vicente Javier Clemente-Suárez, José Juan Robles-Pérez, Ketty Herrera-Mendoza, Beliña Herrera-Tapias, Jesús Fernández-Lucas
Clemente-Suárez, Vicente Javier, José Juan Robles-Pérez, Ketty Herrera-Mendoza, Beliña Herrera-Tapias, and Jesús Fernández-Lucas. Psychophysiological response and fine motor skills in high-altitude parachute jumps. High Alt Med Biol 00:000-000, 2017.-We analyzed the psychophysiological response and specific fine motor skill of an experienced jumper in HALO (high altitude low opening) and HAHO (high altitude high opening) parachute jumps. Eight HALO and eight HAHO jumpers were analyzed. They jumped at 5500 m, HALO jumpers opened the parachute at 500 m and HAHO jumpers at 4300 m of altitude...
October 24, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29029300/flight-activity-and-field-infestation-relationships-for-coffee-berry-borer-in-commercial-coffee-plantations-in-kona-and-kau-districts-hawaii
#7
Luis F Aristizábal, Suzanne Shriner, Robert Hollingsworth, Steven Arthurs
The coffee berry borer (CBB), Hypothenemus hampei Ferrari (Coleoptera: Curculionidae: Scolytinae) is a recent invader to Hawaii. To date, limited information regarding the seasonal phenology of this pest on the islands limits the implementation of integrated control strategies. As part of a coffee farmer training program, we monitored CBB flight activity in 15 coffee plantations (Kona and Kau Districts) over 10 mo with methanol-ethanol (3:1 ratio) baited traps. Concurrently, we quantified CBB infestation and penetration rates inside developing coffee berries through the end of harvest...
September 27, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29024137/do-male-athletes-with-already-high-initial-hemoglobin-mass-benefit-from-live-high-train-low-altitude-training
#8
Anna Hauser, Severin Troesch, Thomas Steiner, Franck Brocherie, Olivier Girard, Jonas J Saugy, Laurent Schmitt, Grégoire P Millet, Jon P Wehrlin
It has been proposed that athletes with high initial values of hemoglobin mass (Hbmass ) will have a lower Hbmass increase in response to 'live high-train low' (LHTL) altitude training. To verify this assumption, the relationship between initial absolute and relative Hbmass values and their respective Hbmass increase following LHTL in male endurance and team-sport athletes was investigated. Overall, 58 male athletes (35 well-trained endurance athletes and 23 elite male field hockey players) undertook an LHTL training camp with similar hypoxic doses (200-230 h)...
October 11, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29023329/living-and-training-at-825m-for-8-weeks-supplemented-with-intermittent-hypoxic-training-at-3000m-improves-blood-parameters-and-running-performance
#9
Preetiwat Wonnabussapawich, Michael J Hamlin, Catherine A Lizamore, Nuttaset Manimmanakorn, Naruemon Leelayuwat, Orathai Tunkamnerdthai, Worrawut Thuwakum, Apiwan Manimmanakorn
We aimed to investigate the effect of an 8-week low-altitude training block supplemented with intermittent hypoxic training, on blood and performance parameters in soccer players. Forty university-level male soccer players were separated into altitude (n = 20, 825m) or sea level (n = 20, 125m) groups. Before (1-2 days prior) and after (1 and 14 days post) training, players were asked to give a resting venous blood sample and complete a series of performance tests. Compared to sea level, the altitude group increased erythropoietin, red cell count and hematocrit 1 day post training (42...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28956166/acute-and-chronic-changes-in-baroreflex-sensitivity-in-hypobaric-vs-normobaric-hypoxia
#10
Nicolas Bourdillon, Jonas Saugy, Laurent Schmitt, Thomas Rupp, Sasan Yazdani, Jean-Marc Vesin, Grégoire P Millet
Normobaric hypoxia (NH) is used as a surrogate for hypobaric hypoxia (HH). Recent studies reported physiological differences between NH and HH. Baroreflex sensitivity (BRS) decreases at altitude or following intense training. However, until now no study compared the acute and chronic changes of BRS in NH vs. HH. First, BRS was assessed in 13 healthy male subjects prior and after 20 h of exposure at 3450 m (study 1), and second in 15 well-trained athletes prior and after 18 days of "live-high train-low" (LHTL) at 2250 m (study 2) in NH vs...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28949829/performance-mood-and-anxiety-during-a-climb-of-mount-everest
#11
Heikki M Karinen, Martti T Tuomisto
Karinen, Heikki M., and Martti T. Tuomisto. Performance, mood, and anxiety during a climb of Mount Everest. High Alt Med Biol. 16:000-000, 2017. BACKGROUND: Various studies have shown the deleterious effects of high-altitude hypoxia on visual, motor, somatosensory, cognitive, and emotional function and also in intelligence tests, reaction time, speech comprehension, hand steadiness, visual contrast discrimination, and word association tests. Because optimal cognitive abilities may be crucial for mountain climbers' safety, this study was intended to evaluate the changes in cognitive performance, mood, and anxiety during an Everest expedition lasting almost 3 months...
September 26, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28929623/influence-of-combined-iron-supplementation-and-simulated-hypoxia-on-the-haematological-module-of-the-athlete-biological-passport
#12
Laura A Garvican-Lewis, Victor L Vuong, Andrew D Govus, Yorck Olaf Schumacher, David Hughes, Greg Lovell, Daniel Eichner, Christopher J Gore
The integrity of Athlete Biological Passport (ABP) is underpinned by understanding normal fluctuations of its biomarkers to environmental or medical conditions, e.g. altitude training or iron deficiency. The combined impact of altitude and iron supplementation on the ABP was evaluated in endurance-trained athletes (n=34) undertaking 3-weeks of simulated live-high: train-low (14 h.d(-1) , 3000m). Athletes received either oral, intravenous (IV) or placebo iron supplementation, commencing two weeks prior and continuing throughout hypoxic exposure...
September 19, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28859408/fuel-use-in-mammals-conserved-patterns-and-evolved-strategies-for-aerobic-locomotion-and-thermogenesis
#13
Grant B McClelland, Sulayman A Lyons, Cayleih E Robertson
Effective aerobic locomotion depends on adequate delivery of oxygen and an appropriate allocation of metabolic substrates. The use of metabolic substrates during exercise follows a predictive pattern of lipid and carbohydrate oxidation that is similar in lowland native cursorial mammals. We have found that in two highland lineages of mice (Phyllotis and Peromyscus) the fuel use pattern is shifted to a greater reliance on carbohydrates compared to their lowland conspecifics and congenerics. However, there is variation between lineages in the importance of phenotypic plasticity in the expression of this metabolic phenotype...
August 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28859401/do-bar-headed-geese-train-for-high-altitude-flights
#14
Lucy A Hawkes, Nyambayar Batbayar, Patrick J Butler, Beverley Chua, Peter B Frappell, Jessica U Meir, William K Milsom, Tseveenmyadag Natsagdorj, Nicole Parr, Graham R Scott, John Y Takekawa, Martin WikeIski, Matthew J Witt, Charles M Bishop
Exercise at high altitude is extremely challenging, largely due to hypobaric hypoxia (low oxygen levels brought about by low air pressure). In humans, the maximal rate of oxygen consumption decreases with increasing altitude, supporting progressively poorer performance. Bar-headed geese (Anser indicus) are renowned high altitude migrants and, although they appear to minimize altitude during migration where possible, they must fly over the Tibetan Plateau (mean altitude 4800 m) for much of their annual migration...
August 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#15
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28828048/initial-evaluation-and-key-principles-of-critically-ill-pediatric-patient-aerial-transport
#16
Constanta Pick
Recent advances in more efficient communications, modern telemedicine systems, medical progress, better training of the medical professionals with the possibility of sub-specialisation has led to shorter transfer times in safer conditions of this and overall affording a better chance of survival. High altitude air transport has considerable implications on the respiratory system's efficiency. Caregiver selection is key in avoiding the dangers of debilitating altitude sickness on the medical team. Minimizing physiological or anatomical derangements and minimizing potential complications in the very small critically ill patients while achieving short transfer times are major objectives...
December 2016: Mædica
https://www.readbyqxmd.com/read/28810963/treating-decompression-sickness-military-flight-simulation-site-community-hospital-partnership
#17
Whitney C Rhodes, George Hertner, Robert Price, Lani Finck, Claudia Temmer, Tracy Cushing, Kathleen Flarity
BACKGROUND: High-altitude flight simulation familiarizes military trainees with the symptoms of hypoxia to prepare them for emergency situations. Decompression sickness (DCS) can occur as a result of these simulations. In cases when ground-level supplemental oxygen does not resolve symptoms, hyperbaric oxygen (HBO) therapy is indicated. Many military hyperbaric chambers have been closed because of cost reductions, necessitating partnerships with community hospitals to ensure access to treatment...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28798201/remote-ischemic-preconditioning-does-not-prevent-acute-mountain-sickness-after-rapid-ascent-to-3450-m
#18
Marc M Berger, Franziska Macholz, Lukas Lehmann, Daniel Dankl, Marcel Hochreiter, Bernhard Bacher, Peter Bärtsch, Heimo Mairbäurl
Remote ischemic preconditioning (RIPC) has been shown to protect remote organs, such as the brain and the lung, from damage induced by subsequent hypoxia or ischemia. Acute mountain sickness (AMS) is a syndrome of non-specific neurologic symptoms and in high altitude pulmonary edema excessive hypoxic pulmonary vasoconstriction (HPV) plays a pivotal role. We hypothesized that RIPC protects the brain from AMS and attenuates the magnitude of HPV after rapid ascent to 3450 m. Forty non-acclimatized volunteers were randomized into 2 groups...
August 10, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28772091/riding-high-into-the-danger-zone-a-review-of-potential-differences-in-chemical-exposures-in-fighter-pilots-resulting-from-high-altitude-and-g-forces
#19
REVIEW
Matthew W Linakis, Kathleen M Job, Xiaoxi Liu, Scott C Collingwood, Heather A Pangburn, Darrin K Ott, Catherine M T Sherwin
When in flight, pilots of high performance aircraft experience conditions unique to their profession. Training flights, performed as often as several times a week, can expose these pilots to altitudes in excess of 15 km (~50,000 ft, with a cabin pressurized to an altitude of ~20,000 ft), and the maneuvers performed in flight can exacerbate the G-forces felt by the pilot. While the pilots specifically train to withstand these extreme conditions, the physiologic stress could very likely lead to differences in the disposition of chemicals in the body, and consequently, dangerously high exposures...
September 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28712261/application-of-living-high-training-low-enhances-cardiac-function-and-skeletal-muscle-oxygenation-during-submaximal-exercises-in-athletes
#20
Hun-Young Park, Sang-Seok Nam
PURPOSE: The aim of this study was to determine the efficiency of the application of living high-training low (LHTL) on cardiac function and skeletal muscle oxygenation during submaximal exercises compared with that of living low-training low (LLTL) in athletes. METHODS: Male middle- and long-distance runners (n = 20) were randomly assigned into the LLTL group (n = 10, living at 1000-m altitude and training at 700-1330-m altitude) and the LHTL group (n = 10, living at simulated 3000-m altitude and training at 700-1330-m altitude)...
March 31, 2017: Journal of Exercise Nutrition & Biochemistry
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