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https://www.readbyqxmd.com/read/29424201/hereditary-hyperhomocysteinemia-associated-with-nephrotic-syndrome-complicated-by-artery-thrombosis-and-chronic-thromboembolic-pulmonary-hypertension-a-case-report
#1
Paolo Ruggeri, Federica Lo Bello, Francesco Nucera, Michele Gaeta, Francesco Monaco, Gaetano Caramori, Giuseppe Girbino
We present here the case of a 30-year-old man with a long term history of nephrotic syndrome (NS) who developed an episode of acute left main pulmonary artery thrombosis complicated by a lung abscess. During the hospital admission was also identified a concomitant hyperhomocysteinemia. After an atypical resection of the left upper pulmonary lobe and the starting of long term anticoagulation the patient was discharged but did not attend the planned follow up visits until one year later when he was seen again for severe dyspnea and exercise intolerance...
December 19, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29416329/sex-specific-cardiopulmonary-exercise-testing-indices-to-estimate-the-severity-of-inoperable-chronic-thromboembolic-pulmonary-hypertension
#2
Tian-Xiang Chen, Bigyan Pudasaini, Jian Guo, Su-Gang Gong, Rong Jiang, Lan Wang, Qin-Hua Zhao, Wen-Hui Wu, Ping Yuan, Jin-Ming Liu
Background: Sex differences in chronic thromboembolic pulmonary hypertension (CTEPH) have been revealed in few studies. Although right heart catheterization (RHC) is the gold standard for clinical diagnosis and assessment of prognosis in pulmonary hypertension (PH), cardiopulmonary exercise testing (CPET) has been a more widely used assessment of functional capacity, disease severity, prognosis, and treatment response in PH. We hypothesized that the "sex-specific" CPET indices could estimate the severity of inoperable CTEPH...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29406784/resistance-training-recovers-attenuated-appl1-expression-and-improves-insulin-induced-akt-signal-activation-in-skeletal-muscle-of-type-2-diabetic-rats
#3
Kohei Kido, Satoru Ato, Takumi Yokokawa, Koji Sato, Satoshi Fujita
Adapter protein containing PH domain, PTB domain, and leucine zipper motif 1 (APPL1) has been reported as a positive regulator of insulin-stimulated Akt activation. The expression of APPL1 is reduced in skeletal muscles of type 2 diabetic (T2D) animals, implying that APPL1 may be an important factor affecting insulin sensitivity. However, the regulation of APPL1 expression and the physiological interventions modulating these effects are unclear. Accordingly, we first confirmed that APPL1 expression and Akt phosphorylation were significantly attenuated in skeletal muscles of T2D rats...
February 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29405511/a-flattening-oxygen-consumption-trajectory-phenotypes-disease-severity-and-poor-prognosis-in-patients-with-heart-failure-with-reduced-mid-range-and-preserved-ejection-fraction
#4
Dejana Popovic, Ross Arena, Marco Guazzi
BACKGROUND: In heart failure (HF), a flattening oxygen consumption (VO2 ) trajectory during cardiopulmonary exercise test (CPET) reflects an acutely compromised cardiac output. We hypothesized that a flattening VO2 trajectory is helpful in phenotyping disease severity and prognosis in HF with either reduced (HFrEF), mid-range (HFmrEF), or preserved (HFpEF) ejection fraction. METHODS AND RESULTS: Overall, 319 HF patients (198 HFrEF, 80 HFmrEF, and 41 HFpEF) underwent CPET...
February 6, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29393628/acid-base-control-of-valency-within-carboranedithiol-self-assembled-monolayers-molecules-do-the-can-can
#5
John C Thomas, Dominic P Goronzy, Andrew C Serino, Harsharn S Auluck, Olivia R Irving, Elisa Jimenez-Izal, Jacqueline Deirmenjian, Jan Machacek, Philippe Sautet, Anastassia N Alexandrova, Tomas Base, Paul S Weiss
We use simple acid-base chemistry to control the valency in self-assembled monolayers of two different carboranedithiol isomers on Au{111}. Monolayer formation proceeds via Au-S bonding, where manipulation of pH prior to or during deposition enables the assembly of dithiolate species, monothiol/monothiolate species, or combination. Scanning tunneling microscopy (STM) images identify two distinct binding modes in each unmodified monolayer, where simultaneous spectroscopic imaging confirms different dipole offsets for each binding mode...
February 2, 2018: ACS Nano
https://www.readbyqxmd.com/read/29393546/comparison-of-metabolic-adaptations-between-endurance-and-sprint-trained-athletes-after-an-exhaustive-exercise-in-two-different-calf-muscles-using-a-multi-slice-31-p-mr-spectroscopic-sequence
#6
Kevin Moll, Alexander Gussew, Maria Nisser, Steffen Derlien, Martin Krämer, Jürgen R Reichenbach
Measurements of exercise-induced metabolic changes, such as oxygen consumption, carbon dioxide exhalation or lactate concentration, are important indicators for assessing the current performance level of athletes in training science. With exercise-limiting metabolic processes occurring in loaded muscles, 31 P-MRS represents a particularly powerful modality to identify and analyze corresponding training-induced alterations. Against this background, the current study aimed to analyze metabolic adaptations after an exhaustive exercise in two calf muscles (m...
February 2, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29389691/the-effect-of-ischemic-preconditioning-on-maximal-swimming-performance
#7
N Williams, M Russell, C J Cook, L P Kilduff
The effect of ischemic preconditioning (IPC) on swimming performance was examined. Using a randomized, crossover design, National-and International-level swimmers (n=20; 14 males, 6 females) participated in three trials (Con, IPC-2h, IPC-24h). Lower-body IPC (4 x 5 min bi-lateral blood-flow restriction at 160-228 mmHg, and 5 min reperfusion) was used 2- (IPC-2h) or 24-h (IPC-24h) before a self-selected (100 m, n=15; 200 m, n=5) swimming time-trial (TT). The Con trial used a sham intervention (15 mmHg) 2h prior to exercise...
January 30, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29388467/emerging-therapeutics-in-pulmonary-hypertension
#8
Matthew K Hensley, Andrea Levine, Mark T Gladwin, Yen-Chun Lai
Pulmonary hypertension (PH) is a progressive and often fatal illness presenting with nonspecific symptoms of dyspnea, lower extremity edema, and exercise intolerance. Pathologically, endothelial dysfunction leads to abnormal intimal and smooth muscle proliferation along with reduced apoptosis, resulting in increased pulmonary vascular resistance (PVR) and elevated pulmonary pressures. PH is subdivided into five WHO groups based on the disease pathology and specific cause. While there are FDA-approved medications for the treatment of pulmonary arterial hypertension (PAH, Group 1 PH), as well as for chronic thromboembolic pulmonary hypertension (CTEPH, Group 4 PH), the morbidity and mortality remain high...
February 1, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29382472/exercise-induced-pulmonary-hypertension-translating-pathophysiological-concepts-into-clinical-practice
#9
Robert Naeije, Rajeev Saggar, David Badesch, Sanjay Rajagopalan, Luna Gargani, Franz Rischard, Francesco Ferrara, Alberto M Marra, Michele D'Alto, Todd M Bull, Rajan Saggar, Ekkehard Grünig, Eduardo Bossone
Exercise stress testing of the pulmonary circulation for the diagnosis of latent or early stage pulmonary hypertension is gaining acceptance. There is emerging consensus to define exercise-induced pulmonary hypertension by a mean pulmonary artery pressure higher than 30 mmHg at a cardiac output of less than 10 L/min and a total pulmonary vascular resistance higher than 3 Wood units at maximum exercise, in the absence of pulmonary hypertension at rest. Exercise-induced pulmonary hypertension has been reported in association with a bone morphogenetic receptor-2 gene mutation, in systemic sclerosis, in left heart conditions, in chronic lung diseases and in chronic pulmonary thrombo-embolism...
January 27, 2018: Chest
https://www.readbyqxmd.com/read/29363985/pulmonary-hypertension-and-exercise-training-a-synopsis-on-the-more-recent-evidences
#10
Massimo Leggio, Augusto Fusco, Massimo Armeni, Stefania D'Emidio, Paolo Severi, Salvatore Calvaruso, Giorgio Limongelli, Luca Sgorbini, Maria Grazia Bendini, Andrea Mazza
The benefits of exercise training in virtually all humans, including those with a clinically stable chronic disease are numerous. The potential value lies in the fact that functional capacity is oftentimes significantly compromised. Exercise training not only play a role in reversing some of the pathophysiologic processes associated with chronic diseases but also improves clinical trajectory. Given the significant pathologic consequences associated with pulmonary hypertension and its implications for deteriorating right ventricular function as well as the perceived potential for a precipitous and possibly critical drop in cardiac output during periods of physical exertion, exercise training was historically not recommended for these patients...
January 30, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29361351/power-of-resting-echocardiographic-measurements-to-classify-pulmonary-hypertension-patients-according-to-european-society-of-cardiology-exercise-testing-risk-stratification-cut-offs
#11
Michaela B Rehman, Rodrigue Garcia, Luc Christiaens, Elisa Larrieu-Ardilouze, Luke S Howard, Petros Nihoyannopoulos
BACKGROUND: Right ventricular function is the major determinant of morbidity and mortality in pulmonary arterial hypertension (PAH). The ESC risk assessment strategy for PAH is based on clinical status, exercise testing, NTproBNP, imaging and haemodynamics but does not include right ventricular function. Our aims were to test the power of resting echocardiographic measurements to classify PAH patients according to ESC exercise testing risk stratification cut-offs and to determine if the classification power of echocardiographic parameters varied in chronic thrombo-embolic pulmonary hypertension (CTEPH)...
January 17, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29349700/adrenergic-and-metabolic-effects-of-electrical-weapons-review-and-meta-analysis-of-human-data
#12
REVIEW
S N Kunz, H G Calkins, J Adamec, M W Kroll
INTRODUCTION: Electronic control with the CEW (conducted electrical weapon) has gained widespread acceptance as the preferred force option due to its significant injury reduction. However, a CEW application does stress the human body. In the case of the CEW, the human body response is similar to the challenge of physical exercise combined with emotional stress over a very short time interval. There has been concern whether the tension of the skeletal-muscle system together with the emotional stress of being exposed to the effects of a CEW, can lead to severe metabolic dysfunction...
January 19, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29344729/sodium-bicarbonate-supplementation-improves-severe-intensity-intermittent-exercise-under-moderate-acute-hypoxic-conditions
#13
Sanjoy K Deb, Lewis A Gough, S Andy Sparks, Lars R McNaughton
Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H+) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO3) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. Eleven recreationally active individuals participated in this randomised, double-blind, crossover study performed under acute normobaric hypoxic conditions (FiO2% = 14...
January 17, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29342993/-analysis-of-prognosis-and-associated-risk-factors-in-pediatric-idiopathic-pulmonary-arterial-hypertension
#14
Q Liu, C Zhang, Q Q Li, Y Zhu, D Zhang, W G Zhao, H Gu
Objective: To analyze the prognosis and associated risk factors of pediatric idiopathic pulmonary arterial hypertension. Methods: A total of 119 patients under 18 years of age diagnosed as idiopathic pulmonary arterial hypertension in the Pulmonary Arterial Hypertension Center in Beijing Anzhen Hospital between June 2007 and May 2017 were enrolled in this retrospective study. The clinical informations and follow-up data were collected. The endpoints of follow-up were defined as death or undergoing lung transplantation...
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29341364/food-dependent-exercise-induced-anaphylaxis-in-japanese-elementary-school-children
#15
Tetsuharu Manabe, Norihiro Oku, Yukoh Aihara
BACKGROUND: In 2012, we clarified that the prevalence of food-dependent exercise-induced anaphylaxis (FDEIA) was 0.018% among junior-high students in Yokohama, Japan. Furthermore, although different from FDEIA, one student who had completed oral immunotherapy developed anaphylaxis during exercise after eating causative food. However, there have been few large-scale epidemiological studies of FDEIA in elementary school children, so we conducted the epidemiological study among elementary school children in Yokohama to clarify the frequency and characteristic of FDEIA...
January 17, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29339921/cardiopulmonary-exercise-test-and-pao2-in-evaluation-of-pulmonary-hypertension-in-copd
#16
Ingunn Skjørten, Janne Mykland Hilde, Morten Nissen Melsom, Jonny Hisdal, Viggo Hansteen, Kjetil Steine, Sjur Humerfelt
Background: Exercise tolerance decreases as COPD progresses. Pulmonary hypertension (PH) is common in COPD and may reduce performance further. COPD patients with and without PH could potentially be identified by cardiopulmonary exercise test (CPET). However, results from previous studies are diverging, and a unified conclusion is missing. We hypothesized that CPET combined with arterial blood gases is useful to discriminate between COPD outpatients with and without PH. Methods: In total, 93 COPD patients were prospectively included...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29326818/coping-social-support-and-information-in-patients-with-pulmonary-arterial-hypertension-or-chronic-thromboembolic-pulmonary-hypertension-a-2-year-retrospective-cohort-study
#17
Bodil Ivarsson, Göran Rådegran, Roger Hesselstrand, Barbro Kjellström
Objectives: Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension are severe diseases with complicated treatment that need care at specialist clinics. The aim was to investigate changes in the patients' perceptions on coping, social support and received information when attending a newly started nurse-coordinated pulmonary arterial hypertension-outpatient clinic. Methods: The present study was a descriptive, questionnaire-based cohort study including 42 adult patients...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29290029/the-clinical-value-of-assessing-right-ventricular-diastolic-function-after-balloon-pulmonary-angioplasty-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#18
Hidenori Moriyama, Mitsushige Murata, Toshimitsu Tsugu, Takashi Kawakami, Masaharu Kataoka, Takahiro Hiraide, Mai Kimura, Sarasa Isobe, Jin Endo, Takashi Kohno, Yuji Itabashi, Keiichi Fukuda
Chronic thromboembolic pulmonary hypertension (CTEPH) has a poor prognosis because of the associated progressive right heart failure. Accurate evaluation of right ventricular (RV) function would thus be useful to predict prognosis. However, the significance of RV diastolic function remains unclear. We aimed to identify which echocardiographic measures are most accurate, and potentially useful, in assessing RV diastolic function in patients with CTEPH, and to study the effects of balloon pulmonary angioplasty (BPA) on them...
December 30, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29277444/entrainment-of-the-mouse-circadian-clock-effects-of-stress-exercise-and-nutrition
#19
REVIEW
Yu Tahara, Shigenobu Shibata
The circadian clock system in mammals plays a fundamental role in maintaining homeostasis. Entrainment is an important characteristic of the internal clock, by which appropriate timing is maintained according to external daily stimuli, such as light, stress, exercise, and/or food. Disorganized entrainment or a misaligned clock time, such as jet lag, increases health disturbances. The central clock in the suprachiasmatic nuclei, located in the hypothalamus, receives information about arousal stimuli, such as physical stress or exercise, and changes the clock time by modifying neural activity or the expression of circadian clock genes...
December 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29275453/inhaled-treprostinil-in-pulmonary-hypertension-associated-with-lung-disease
#20
Mariana Faria-Urbina, Rudolf K F Oliveira, Manyoo Agarwal, Aaron B Waxman
PURPOSE: Pulmonary hypertension (PH) in the setting of parenchymal lung disease adversely affects quality of life and survival. However, PH-specific drugs may result in ventilation/perfusion imbalance and currently, there are no approved PH treatments for this patient population. In the present retrospective study, data from 22 patients with PH associated with lung disease treated with inhaled treprostinil (iTre) and followed up clinically for at least 3 months are presented. METHODS: PH was defined by resting right heart catheterization as a mean pulmonary artery pressure (mPAP) ≥ 35 mmHg, or mPAP ≥ 25 mmHg associated with pulmonary vascular resistance ≥ 4 Woods Units...
December 23, 2017: Lung
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