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Sessile serrated adenoma

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https://www.readbyqxmd.com/read/29445907/management-of-serrated-polyps-of-the-colon
#1
REVIEW
Claire Fan, Adam Younis, Christine E Bookhout, Seth D Crockett
PURPOSE OF REVIEW: The purpose of this review is to summarize the management of serrated colorectal polyps (SPs), with a particular focus on the most common premalignant SP, sessile serrated adenoma or polyp (SSA/P). These lesions present a challenge for endoscopists with respect to detection and resection, and are also susceptible to pathologic misdiagnosis. RECENT FINDINGS: Patients with SSA/Ps are at an increased risk of future colorectal neoplasia, including advanced polyps and cancer...
February 14, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29435136/epigenetic-silencing-of-smoc1-in-traditional-serrated-adenoma-and-colorectal-cancer
#2
Hironori Aoki, Eiichiro Yamamoto, Akira Takasawa, Takeshi Niinuma, Hiro-O Yamano, Taku Harada, Hiro-O Matsushita, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Yoshihito Tanaka, Yuko Yoshida, Tomoyuki Aoyama, Makoto Eizuka, Akira Yorozu, Hiroshi Kitajima, Masahiro Kai, Norimasa Sawada, Tamotsu Sugai, Hiroshi Nakase, Hiromu Suzuki
Colorectal sessile serrated adenoma/polyps (SSA/Ps) are well-known precursors of colorectal cancer (CRC) characterized by BRAF mutation and microsatellite instability. By contrast, the molecular characteristics of traditional serrated adenoma (TSAs) are not fully understood. We analyzed genome-wide DNA methylation in TSAs having both protruding and flat components. We identified 11 genes, including SMOC1, methylation of which progressively increased during the development of TSAs. SMOC1 was prevalently methylated in TSAs, but was rarely methylated in SSA/Ps (p < 0...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422808/clinical-outcomes-of-surveillance-colonoscopy-for-patients-with-sessile-serrated-adenoma
#3
Sung Jae Park, Hyuk Yoon, In Sub Jung, Cheol Min Shin, Young Soo Park, Na Young Kim, Dong Ho Lee
Background/Aims: Sessile serrated adenomas (SSAs) are known to be precursors of colorectal cancer (CRC). The proper interval of follow-up colonoscopy for SSAs is still being debated. We sought to determine the proper interval of colonoscopy surveillance in patients diagnosed with SSAs in South Korea. Methods: We retrospectively reviewed the medical records of patients diagnosed with SSAs who received 1 or more follow-up colonoscopies. The information reviewed included patient baseline characteristics, SSA characteristics, and colonoscopy information...
January 2018: Intestinal Research
https://www.readbyqxmd.com/read/29416927/herniation-of-crypts-in-hyperplastic-polyp-and-sessile-serrated-adenoma-a-prospective-study
#4
Kun Hu, Shiqian Shen, Lanjing Zhang
Presence of colonic crypts in submucosa was previously termed as herniation of crypts, pseudoinvasion, epithelial-misplacement, or inverted hyperplastic-polyp. It is considered as an important criterion for diagnosing sessile serrated adenoma (SSA), which links to a higher risk of synchronous and future colorectal cancers compared with hyperplastic polyp (HP). Here, we aimed to study the frequencies, diagnostic specificity and synchronous neoplasms of herniation of crypts in HP and SSA. We prospectively included all HP and SSA cases and 514 randomly-selected colorectal polyps of normal histology diagnosed from 2013 to 2015 at our institution...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29409923/hot-snare-polypectomy-with-or-without-saline-solution-epinephrine-lift-for-the-complete-resection-of-small-colorectal-polyps
#5
Hyun-Soo Kim, Ho Yeon Jung, Hong Jun Park, Hee Man Kim, Jae Ho Seong, Yong Seok Kang, Mee Yon Cho, Min Heui Yu, Dae Ryong Kang
BACKGROUND: /Aim: The criterion standard polypectomy technique for the complete removal of small colorectal polyps has not yet been established. This study aimed to compare the complete resection rate of hot snare polypectomy (HSP) with that of endoscopic mucosal resection (EMR) for small, sessile, or flat polyps. METHODS: Patients with 5-9-mm non-pedunculated colorectal polyps were prospectively randomized to the HSP or EMR group. The presence of residual polyps was assessed by performing histological assessment of 4-quadrant forceps biopsies taken from the edges of the polypectomy site...
February 1, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29399338/expression-of-doublecortin-and-cam-kinase-like-1-protein-in-serrated-neoplasia-of-the-colorectum
#6
Keiko Morio, Kazuo Yashima, Akihiro Tamoto, Kohei Hosoda, Sohei Yamamoto, Taku Iwamoto, Naoki Ueda, Yuichiro Ikebuchi, Koichiro Kawaguchi, Kenichi Harada, Yoshikazu Murawaki, Hajime Isomoto
The adenoma-carcinoma sequence (ACS) and the serrated pathway are two distinct developmental routes leading to the formation of colorectal carcinoma. Recently, the doublecortin and CaM kinase-like-1 protein (DCLK1) has been reported to serve as an intestinal cancer stem cell marker and has been demonstrated to be overexpressed through the ACS; however, there is a lack of reports on the role of DCLK1 in the serrated pathway. To clarify the correlation between DCLK1 protein expression and clinicopathological characteristics of the serrated tumorigenic pathway, the present study used immunohistochemistry to examine the expression of DCLK1 in endoscopically resected samples of 62 serrated polyps [20 hyperplastic polyps (HPs), 16 traditional serrated adenomas (TSAs) and 26 sessile serrated adenoma-polyps (SSA/Ps)], as well as 20 non-serrated adenomas, 20 carcinoma in adenomas (CIAs) and 18 early pure colorectal carcinomas without any adenoma component (EPCs)...
January 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29385427/diagnostic-yield-of-dysplasia-in-polyp-adjacent-biopsies-for-patients-with-inflammatory-bowel-disease-a-cross-sectional-study
#7
Conor Lahiff, Lai Mun Wang, Simon P L Travis, James E East
Introduction: Patients with inflammatory bowel disease (IBD) undergoing polypectomy are recommended by current guidelines to have biopsies taken from adjacent mucosa to determine whether there is dysplasia present. With improvements in endoscopic imaging it is now possible to characterise colonic lesions with higher levels of confidence than previously. We reviewed the diagnostic yield of polyp-adjacent biopsies in IBD. Materials and Methods: A systematic search of our histopathology database revealed cases where polyps had been endoscopically resected or biopsied in patients with IBD...
January 27, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29383606/clinical-effectiveness-of-submucosal-injection-with-indigo-carmine-mixed-solution-for-colon-endoscopic-mucosal-resection
#8
Su Jung Han, Yunho Jung, Young Sin Cho, Il-Kwun Chung, Jae Yun Kim, Jun Young Eun, Seoung Ho Lee, Gyu Bong Ko, Tae Hoon Lee, Sang Hum Park, Hyun Deuk Cho, Sun-Joo Kim
BACKGROUND/AIMS: Submucosal injection with indigo carmine mixed solution can improve the delineation of colorectal neoplasia during endoscopic mucosal resection (EMR). Thus, the aim of this study was to evaluate the efficacy of submucosal injection with indigo carmine mixed solution during EMR of colorectal neoplasia. METHODS: This was a prospective, randomized, controlled study of a total of 212 neoplastic colon polyps (5-20 mm) subjected to EMR in a single tertiary university hospital...
January 30, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29377243/clinical-and-endoscopic-evaluations-of-sessile-serrated-adenoma-polyps-with-cytological-dysplasia
#9
Wataru Sano, Takahiro Fujimori, Kazuhito Ichikawa, Hironori Sunakawa, Takahiro Utsumi, Mineo Iwatate, Noriaki Hasuike, Santa Hattori, Hidekazu Kosaka, Yasushi Sano
BACKGROUND AND AIM: Although sessile serrated adenoma/polyps (SSA/Ps) are considered to be premalignant lesions and rapidly progress to carcinomas after they develop cytological dysplasia (CD), a treatment strategy for SSA/Ps in Asian countries is still being debated and has not yet been established. The present study aimed to propose a treatment strategy for SSA/Ps. METHODS: Histopathological data of patients, who underwent colonoscopy at our center between January 2011 and December 2016, were reviewed...
January 29, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29365221/colorectal-cancer-screening-and-surveillance-in-individuals-at-increased-risk
#10
Thad Wilkins, Danielle McMechan, Asif Talukder, Alan Herline
Individuals at increased risk of developing colorectal cancer include those with a personal or family history of advanced adenomas or colorectal cancer, a personal history of inflammatory bowel disease, or genetic polyposis syndromes. In general, these persons should undergo more frequent or earlier testing than individuals at average risk. Individuals who have a first-degree relative with colorectal cancer or advanced adenoma diagnosed before 60 years of age or two first-degree relatives diagnosed at any age should be advised to start screening colonoscopy at 40 years of age or 10 years younger than the earliest diagnosis in their family, whichever comes first...
January 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29363535/improved-adenoma-detection-with-endocuff-vision-the-adenoma-randomised-controlled-trial
#11
Wee Sing Ngu, Roisin Bevan, Zacharias P Tsiamoulos, Paul Bassett, Zoë Hoare, Matthew D Rutter, Gayle Clifford, Nicola Totton, Thomas J Lee, Arvind Ramadas, John G Silcock, John Painter, Laura J Neilson, Brian P Saunders, Colin J Rees
OBJECTIVE: Low adenoma detection rates (ADR) are linked to increased postcolonoscopy colorectal cancer rates and reduced cancer survival. Devices to enhance mucosal visualisation such as Endocuff Vision (EV) may improve ADR. This multicentre randomised controlled trial compared ADR between EV-assisted colonoscopy (EAC) and standard colonoscopy (SC). DESIGN: Patients referred because of symptoms, surveillance or following a positive faecal occult blood test (FOBt) as part of the Bowel Cancer Screening Programme were recruited from seven hospitals...
January 23, 2018: Gut
https://www.readbyqxmd.com/read/29304767/mlh1-93%C3%A2-g-a-polymorphism-is-associated-with-mlh1-promoter-methylation-and-protein-loss-in-dysplastic-sessile-serrated-adenomas-with-brafv600e-mutation
#12
Lochlan J Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett, Vicki Whitehall
BACKGROUND: Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSADs and BRAF mutant traditional serrated adenomas (TSA) develop into microsatellite stable cancers with a poor prognosis. The reason for this dichotomy is unknown. In this study, we assessed the genotypic frequency of the MLH1-93 polymorphism rs1800734 in SSADs and TSAs to determine if the uncommon variant A allele predisposes to MLH1 promoter hypermethylation...
January 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29284484/platform-independent-gene-expression-signature-differentiates-sessile-serrated-adenomas-polyps-and-hyperplastic-polyps-of-the-colon
#13
Yasir Rahmatallah, Magomed Khaidakov, Keith K Lai, Hannah E Goyne, Laura W Lamps, Curt H Hagedorn, Galina Glazko
BACKGROUND: Sessile serrated adenomas/polyps are distinguished from hyperplastic colonic polyps subjectively by their endoscopic appearance and histological morphology. However, hyperplastic and sessile serrated polyps can have overlapping morphological features resulting in sessile serrated polyps diagnosed as hyperplastic. While sessile serrated polyps can progress into colon cancer, hyperplastic polyps have virtually no risk for colon cancer. Objective measures, differentiating these types of polyps would improve cancer prevention and treatment outcome...
December 28, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/29233671/endoscopic-detection-rate-of-sessile-serrated-lesions-in-lynch-syndrome-patients-is-comparable-to-an-age-and-gender-matched-control-population-case-control-study-with-expert-pathology-review
#14
Jasper L A Vleugels, Husna Sahin, Yark Hazewinkel, Lianne Koens, Jose G van den Berg, Monique E van Leerdam, Evelien Dekker
BACKGROUND: Carcinogenesis in Lynch syndrome involves fast progression of adenomas to colorectal cancer (CRC) due to microsatellite instability. The role of sessile serrated lesions (SSLs) and the serrated neoplasia pathway in these patients is unknown. The aim of this matched case-control study was to compare endoscopic detection rates and distribution of SSLs in Lynch syndrome patients to a matched control population. METHODS: We collected data of Lynch syndrome patients with a proven germline mutation who underwent colonoscopy between January 2011 and April 2016 in 2 tertiary referral hospitals...
December 9, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29233113/clinicopathologic-and-endoscopic-features-of-early-stage-colorectal-serrated-adenocarcinoma
#15
Daiki Hirano, Shiro Oka, Shinji Tanaka, Kyoku Sumimoto, Yuki Ninomiya, Yuzuru Tamaru, Kenjiro Shigita, Nana Hayashi, Yuji Urabe, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
BACKGROUND: Serrated adenocarcinoma (SAC) is a distinct colorectal carcinoma variant that accounts for approximately 7.5% of all advanced colorectal carcinomas. While its prognosis is worse than conventional carcinoma, its early-stage clinicopathologic features are unclear. We therefore aimed to clarify the clinicopathologic and endoscopic characteristics of early-stage SACs. METHODS: Forty consecutive early-stage SAC patients at Hiroshima University Hospital were enrolled; SACs were classified into epithelial serration (Group A, n = 17) and non-epithelial serration (Group B, n = 23) groups...
December 12, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29231190/lesions-of-all-types-exist-in-colon-polyps-of-all-sizes
#16
Kevin O Turner, Robert M Genta, Amnon Sonnenberg
OBJECTIVES: Although large polyps are known to harbor more advanced neoplasia than small polyps, the extent of the relationship between size and type is not fully known. The study aim was to establish benchmarks for the prevalence of different histologic polyp types among varying size categories. METHODS: The Miraca Life Sciences Database is an electronic repository of histopathologic patient records from private practices throughout the United States. We extracted the records of 483,998 unique patients who underwent colonoscopy with polypectomy between January 2008 and December 2014...
December 12, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29216529/sessile-serrated-adenoma-polyp-leading-to-acute-appendicitis-with-multiple-pyogenic-liver-abscesses-a-case-report
#17
Koki Sato, Masataka Banshodani, Masahiro Nishihara, Junko Nambu, Yasuo Kawaguchi, Fumio Shimamoto, Kiyohiko Dohi, Keizo Sugino, Hideki Ohdan
INTRODUCTION: Although appendicitis is a common disease, appendicitis concurrent with liver abscesses and sessile serrated adenoma/polyp (SSA/P) is rare. PRESENTATION OF CASE: A 69-year-old man presented with symptoms of abdominal pain and fever. Computed tomography (CT) revealed multiple liver abscesses and an enlarged appendix with a pseudotumoral appearance, which suggested acute appendicitis. In the emergency operation, ileocecal resection was performed for the perforated appendicitis with an inflammatory mass in the ileocecum...
December 2, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29202003/implementation-of-an-optical-diagnosis-strategy-saves-costs-and-does-not-impair-clinical-outcomes-of-a-fecal-immunochemical-test-based-colorectal-cancer-screening-program
#18
Jasper L A Vleugels, Marjolein J E Greuter, Yark Hazewinkel, Veerle M H Coupé, Evelien Dekker
Background and study aims:  In an optical diagnosis strategy, diminutive polyps that are endoscopically characterized with high confidence are removed without histopathological analysis and distal hyperplastic polyps are left in situ. We evaluated the effectiveness and costs of optical diagnosis. Methods:  Using the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model, we simulated biennial fecal immunochemical test (FIT) screening in individuals aged 55 - 75 years...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29195676/alcohol-smoking-and-the-risk-of-premalignant-and-malignant-colorectal-neoplasms
#19
REVIEW
Ifewumi O Fagunwa, Maurice B Loughrey, Helen G Coleman
Colorectal cancer (CRC) is the third most common cancer worldwide and has a complex aetiology consisting of environmental and genetic factors. In this review, we evaluate the roles of alcohol and tobacco smoking in colorectal neoplasia. Alcohol intake and tobacco smoking are associated with modest, but significantly, increased risks of CRC, adenomatous and serrated polyps. There is consistent evidence of dose-response relationships for both alcohol and smoking, and risk of these neoplasms. Alcohol and smoking appear to be more strongly associated with colorectal polyp than CRC development, suggesting roles in the initiation of neoplastic growths...
October 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/29168233/progression-to-invasive-cancer-from-sessile-serrated-adenoma-polyp
#20
Satoshi Kinoshita, Toshihiro Nishizawa, Toshio Uraoka
A 86-year-old female had a positive fecal immunochemical test, and a subsequent colonoscopy revealed a whitish, flat elevated lesion (Paris class IIa) 10 mm in diameter in the ascending colon (Figure 1, A). Biopsy was performed and histology confirmed sessile serrated adenoma/polyp (SSA/P). At 2 years, the lesion changed into a flat elevated lesion with depression (Paris class IIa+IIc) 12 mm in diameter (Figure 1, B). However, she refused endoscopic resection because of older age. At 4 years, the lesion increased to 15 mm in diameter, and the right side of the lesion was reddish (Figure 1, C)...
November 23, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
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