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Sessile serrated adenoma

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https://www.readbyqxmd.com/read/27906163/expression-of-annexin-a10-in-serrated-polyps-predicts-the-development-of-metachronous-serrated-polyps
#1
Carole Macaron, Rocio Lopez, Rish K Pai, Carol A Burke
OBJECTIVES: The ability to differentiate histological characteristics between serrated polyps (SPs) and make a pathological diagnosis of a sessile serrated polyp (SSP) is highly variable. Recent studies have shown that immunohistochemical (IHC) expression of Annexin A10 (ANXA10) is a marker of a SSP. However, the clinical utility of ANXA10 expression in patients with SPs is unknown. The objective of this study was to evaluate the utility of ANXA10 expression in SPs in predicting the development of subsequent polyps at follow-up colonoscopy...
December 1, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27896617/comprehensive-dna-methylation-and-mutation-analyses-reveal-a-methylation-signature-in-colorectal-sessile-serrated-adenomas
#2
Árpád V Patai, Barbara Kinga Barták, Bálint Péterfia, Tamás Micsik, Réka Horváth, Csaba Sumánszki, Zoltán Péter, Árpád Patai, Gábor Valcz, Alexandra Kalmár, Kinga Tóth, Tibor Krenács, Zsolt Tulassay, Béla Molnár
Colorectal sessile serrated adenomas (SSA) are hypothesized to be precursor lesions of an alternative, serrated pathway of colorectal cancer, abundant in genes with aberrant promoter DNA hypermethylation. In our present pilot study, we explored DNA methylation profiles and examined selected gene mutations in SSA. Biopsy samples from patients undergoing screening colonoscopy were obtained during endoscopic examination. After DNA isolation and quality analysis, SSAs (n = 4) and healthy controls (n = 5) were chosen for further analysis...
November 29, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27885175/cpg-island-methylator-phenotype-high-colorectal-cancers-and-their-prognostic-implications-and-relationships-with-the-serrated-neoplasia-pathway
#3
REVIEW
Ye-Young Rhee, Kyung-Ju Kim, Gyeong Hoon Kang
The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation of multiple CpG island loci. The concept of CIMP as a molecular carcinogenesis mechanism was consolidated by the identification of the serrated neoplasia pathway, in which CIMP participates in the initiation and progression of serrated adenomas. Distinct clinicopathological and molecular features of CIMP-high (CIMP-H) CRCs have been characterized, including proximal colon location, older age of onset, female preponderance, and frequent associations of high-level microsatellite instability and BRAF mutations...
November 28, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27860102/high-prevalence-of-sessile-serrated-adenomas-in-contemporary-outpatient-colonoscopy-practice
#4
Mark Bettington, Neal Walker, Tony Rahman, Ann Vandeleur, Vicki Whitehall, Barbara Leggett, John Croese
BACKGROUND: Sessile serrated adenomas are the polyp precursor of 15-20% of colorectal carcinomas. There is debate about their prevalence and increasing discussion about the need for a serrated polyp detection rate as a quality indicator for colonoscopy. AIMS: We aimed to assess the prevalence of sessile serrated adenomas at an outpatient gastroenterology service. METHODS: This is a retrospective study of an unselected consecutive series of patients who had an outpatient colonoscopy between April 2013 and May 2014...
November 16, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27852795/modifiable-lifestyle-factors-associated-with-risk-of-sessile-serrated-polyps-conventional-adenomas-and-hyperplastic-polyps
#5
James R Davenport, Timothy Su, Zhiguo Zhao, Helen G Coleman, Walter E Smalley, Reid M Ness, Wei Zheng, Martha J Shrubsole
OBJECTIVE: To identify modifiable factors associated with sessile serrated polyps (SSPs) and compare the association of these factors with conventional adenomas (ADs) and hyperplastic polyps (HPs). DESIGN: We used data from the Tennessee Colorectal Polyp Study, a colonoscopy-based case-control study. Included were 214 SSP cases, 1779 AD cases, 560 HP cases and 3851 polyp-free controls. RESULTS: Cigarette smoking was associated with increased risk for all polyps and was stronger for SSPs than for ADs (OR 1...
November 15, 2016: Gut
https://www.readbyqxmd.com/read/27798903/gut-associated-lymphoid-tissue-galt-carcinoma-or-dome-carcinoma
#6
Carlos A Rubio, Peter T Schmidt
BACKGROUND/AIM: The vast majority of colorectal carcinomas (CRCs) evolve from mucosa not associated to lymphoid tissues aggregates via the adenoma-carcinoma sequence or via the serrated pathway. Rarely CRCs evolve from gut mucosa associated to lymphoid tissue (GALT). MATERIALS AND METHODS: Based on the presence of a circumscribed elevation in the colorectal mucosa, GALT carcinomas are also referred to as dome carcinomas (DC). Descriptions of the surface mucosa covering 21 GALT-CRCs appearing in pathological reports were reviewed...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27775962/optical-diagnosis-of-sessile-serrated-polyps-bottleneck-for-the-optical-diagnosis-paradigm
#7
Jasper L A Vleugels, Joep E G IJspeert, Yark Hazewinkel, Manon van der Vlugt, Paul Fockens, Lianne Koens, Evelien Dekker
BACKGROUND: Optical diagnosis of diminutive (1 to 5 mm) polyps could result in a more cost-effective colonoscopy practice. Previous optical diagnosis studies did not incorporate the differentiation of sessile serrated polyps (SSPs). This study aimed to evaluate the impact of optical diagnosis of diminutive SSPs on the overall performance of endoscopic polyp differentiation in daily colonoscopy practice. METHODS: Endoscopy data were prospectively collected between 2011 and 2014 in a colonoscopy center...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27773125/synchronous-sessile-serrated-adenoma-and-goblet-cell-carcinoid-in-the-appendix-a-case-report-and-literature-review
#8
Zheqin R Lu, Phillip Jayasurya
No abstract text is available yet for this article.
February 2016: Pathology
https://www.readbyqxmd.com/read/27771216/prevalence-of-sessile-serrated-adenoma-polyp-in-hyperplastic-appearing-diminutive-rectosigmoid-polyps
#9
Prasanna Ponugoti, Jingmei Lin, Robert Odze, Dale Snover, Charles Kahi, Douglas K Rex
BACKGROUND: The American Society for Gastrointestinal Endoscopy recommends that distal colon hyperplastic lesions can be left in place without resection if adenomatous histology can be excluded with > 90% negative predictive value. However, some of the lesions could be sessile serrated adenoma/polyp (SSA/P), which is also precancerous. AIM: Describe the prevalence of SSA/P in hyperplastic appearing diminutive rectosigmoid polyps. METHODS: We prospectively placed 513 consecutive diminutive rectosigmoid polyps that appeared hyperplastic to an expert endoscopist in individual bottles for pathologic examination...
October 19, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27749532/giant-tubular-adenoma-with-malignancy-clinical-characteristics-in-a-female-teenager-case-report-and-a-review-of-the-literature
#10
Cristina Oana Mărginean, Maria Oana Mărginean, Iunius Simu, Adrienne Horvath, Lorena Elena Meliţ
BACKGROUND: Adenomas of the colon are usually benign tumors which carry a tendency for malignancy. These tumors can be villous, tubular, tubulovillous, or sessile serrated. Those with adenomatous structure can develop malignant characteristics in 1.5% to 9.4% of cases. METHODS: We present a case report of a 16-year-old female adolescent with an adenoma of the descending colon. History revealed prolonged diarrheic syndrome for the past 6 months, repeated headache, and a weight loss of ∼5 kg in the past month...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27748334/detection-rate-distribution-clinical-and-pathological-features-of-colorectal-serrated-polyps
#11
Hai-Long Cao, Xue Chen, Shao-Chun Du, Wen-Jing Song, Wei-Qiang Wang, Meng-Que Xu, Si-Nan Wang, Mei-Yu Piao, Xiao-Cang Cao, Bang-Mao Wang
BACKGROUND: Colorectal serrated polyp is considered as histologically heterogeneous lesions with malignant potential in western countries. However, few Asian studies have investigated the comprehensive clinical features of serrated polyps in symptomatic populations. The aim of the study was to evaluate the features of colorectal serrated polyps in a Chinese symptomatic population. METHODS: Data from all consecutive symptomatic patients were documented from a large colonoscopy database and were analyzed...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27716085/clinical-significance-of-incidental-18%C3%A2-f-fdg-uptake-in-the-gastrointestinal-tract-on-pet-ct-imaging-a-retrospective-cohort-study
#12
Eugenia Shmidt, Vandana Nehra, Val Lowe, Amy S Oxentenko
BACKGROUND: The frequency and clinically important characteristics of incidental (18)F-fluorodeoxyglucose ([18 F]FDG) positron emission tomography (PET) uptake in the gastrointestinal tract (GIT) on PET/CT imaging in adults remain elusive. METHODS: All PET/CT reports from 1/1/2000 to 12/31/2009 at a single tertiary referral center were reviewed; clinical information was obtained from cases with incidental (18)F-FDG uptake in the GIT, with follow-up through October, 2012...
October 6, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27705923/mucins-and-associated-o-glycans-based-immunoprofile-for-stratification-of-colorectal-polyps-clinical-implication-for-improved-colon-surveillance
#13
Shiv Ram Krishn, Sukhwinder Kaur, Yuri M Sheinin, Lynette M Smith, Shailendra K Gautam, Asish Patel, Maneesh Jain, Vasthala Juvvigunta, Priya Pai, Audrey J Lazenby, Hemant K Roy, Surinder K Batra
Sessile serrated adenoma/polyps (SSA/P) are premalignant lesions of colorectal cancer that are difficult to distinguish histologically from hyperplastic polyps (HP) of minimal to no malignant potential. Specific markers for differentiating SSA/P from HP can aid clinicians for optimizing colon surveillance intervals. The present study investigates the potential of mucins and associated O-glycans to distinguish SSA/P from HP. Expression of colonic mucins (MUC1, MUC4, MUC17, MUC2, and MUC5AC) and O-glycans [Sialyl LewisA (CA19-9) and Tn/Sialyl-Tn on MUC1] were analyzed in HP (n=33), SSA/P (n=39), and tubular adenoma (TA) (n=36) samples by immunohistochemistry...
September 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27684980/a-historical-perspective-and-expos%C3%A3-on-serrated-polyps-of-the-colorectum
#14
Eun-Young Karen Choi, Henry D Appelman
This article offers a historical perspective on the discovery of 3 types of serrated colorectal polyps recognized in the past 60 years. The first to be discovered was the hyperplastic polyp, which is still the most commonly encountered serrated polyp. In the past 20 years, the carcinoma-associated sessile serrated adenoma/polyp has been recognized, but its diagnosis can be difficult owing to overlapping histologic features with hyperplastic polyps. Less is known about the third type, the traditional serrated adenoma, because it is far less common than the other 2 types, and its association with cancer is currently under investigation...
October 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27678358/sessile-serrated-adenoma-polyps-where-are-we-at-in-2016
#15
REVIEW
Rajvinder Singh, Leonardo Zorrón Cheng Tao Pu, Doreen Koay, Alastair Burt
It is currently known that colorectal cancers (CRC) arise from 3 different pathways: the adenoma to carcinoma chromosomal instability pathway (50%-70%); the mutator "Lynch syndrome" route (3%-5%); and the serrated pathway (30%-35%). The World Health Organization has classified serrated polyps into three types of lesions: hyperplastic polyps (HP), sessile serrated adenomas/polyps (SSA/P) and traditional serrated adenomas (TSA), the latter two strongly associated with development of CRCs. HPs do not cause cancer and TSAs are rare...
September 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27663716/distinct-endoscopic-characteristics-of-sessile-serrated-adenoma-polyp-with-and-without-dysplasia-carcinoma
#16
Takashi Murakami, Naoto Sakamoto, Hideaki Ritsuno, Tomoyoshi Shibuya, Taro Osada, Hiroyuki Mitomi, Takashi Yao, Sumio Watanabe
BACKGROUND AND AIMS: Sessile serrated adenoma/polyp (SSA/P) is a colorectal polyp that possesses malignant potential. However, the dysplastic components within a SSA/P can be difficult to detect. This study aimed to clarify the endoscopic characteristics of SSA/P with advanced histology. METHODS: We examined 462 endoscopically or surgically resected lesions that were pathologically diagnosed as SSA/P, including 414 without and 41 with cytological dysplasia, and 7 with invasive carcinoma...
September 20, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27658891/microrna-signatures-of-colonic-polyps-on-screening-and-histology
#17
Vassiliki L Tsikitis, Amiee Potter, Motomi Mori, Julie A Buckmeier, Christina R Preece, Christina A Harrington, Angela N Bartley, Achyut K Bhattacharyya, Stanley R Hamilton, M Peter Lance, Patricia A Thompson
Colorectal cancer and adenoma adjacent to cancer exhibit distinct microRNA (miRNA) alterations in an apparent mucosa-to-adenocarcinoma sequence. The pattern of microRNAs in screen-detected polyps in relation to histologic features and cancer risk has not been investigated. miRNA expression analysis was performed on normal mucosa (NM), hyperplastic polyps (HP), tubular adenomas (TA), tubulovillous adenomas or high-grade dysplasia (TVHG), and serrated polyps [sessile serrated adenoma/polyps (SSA/P) and traditional serrated adenomas (TSA)] in biopsy specimens from 109 patients undergoing screening/surveillance colonoscopy...
December 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27641149/external-validation-of-the-endoscopic-features-of-sessile-serrated-adenomas-in-expert-and-trainee-colonoscopists
#18
Hyo-Joon Yang, Jeong In Lee, Soo-Kyung Park, Yoon Suk Jung, Jin Hee Sohn, Kyu Yong Choi, Dong Il Park
Background/Aims: It is unclear whether the endoscopic features of sessile serrated adenomas (SSAs) would be useful to trainee colonoscopists to predict SSA. Therefore, the present study aimed to identify features that expert and trainee colonoscopists can use to independently and reliably predict SSA by using high-resolution white-light endoscopy. Methods: Endoscopic images of 81 polyps (39 SSAs, 22 hyperplastic polyps, and 20 tubular adenomas) from 43 patients were retrospectively evaluated by 10 colonoscopists (four experts and six trainees)...
September 13, 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27639804/lifestyle-risk-factors-for-serrated-colorectal-polyps-a%C3%A2-systematic-review-and-meta-analysis
#19
Lesley Bailie, Maurice B Loughrey, Helen G Coleman
BACKGROUND & AIMS: Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs. METHODS: We conducted a systematic search of Medline, Embase, and Web of Science for observational or interventional studies that contained the terms risk or risk factor, and serrated or hyperplastic, and polyps or adenomas, and colorectal (or synonymous terms), published by March 2016...
September 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27639802/fucosylation-deficiency-in-mice-leads-to-colitis-and%C3%A2-adenocarcinoma
#20
Yiwei Wang, Dan Huang, Kai-Yuan Chen, Min Cui, Weihuan Wang, Xiaoran Huang, Amad Awadellah, Qing Li, Ann Friedman, William W Xin, Luca Di Martino, Fabio Cominelli, Alex Miron, Ricky Chan, James Fox, Yan Xu, Xiling Shen, Mathew F Kalady, Sanford Markowitz, Ivan Maillard, John B Lowe, Wei Xin, Lan Zhou
BACKGROUND & AIMS: De novo synthesis of guanosine diphosphate (GDP)-fucose, a substrate for fucosylglycans, requires sequential reactions mediated by GDP-mannose 4,6-dehydratase (GMDS) and GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase (FX or TSTA3). GMDS deletions and mutations are found in 6%-13% of colorectal cancers; these mostly affect the ascending and transverse colon. We investigated whether a lack of fucosylation consequent to loss of GDP-fucose synthesis contributes to colon carcinogenesis...
September 14, 2016: Gastroenterology
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