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https://www.readbyqxmd.com/read/29899496/transcriptional-control-of-intestinal-cholesterol-absorption-adipose-energy-expenditure-and-lipid-handling-by-sortilin
#1
Sumihiko Hagita, Maximillian A Rogers, Tan Pham, Jennifer R Wen, Andrew K Mlynarchik, Masanori Aikawa, Elena Aikawa
The sorting receptor Sortilin functions in the regulation of glucose and lipid metabolism. Dysfunctional lipid uptake, storage, and metabolism contribute to several major human diseases including atherosclerosis and obesity. Sortilin associates with cardiovascular disease; however, the role of Sortilin in adipose tissue and lipid metabolism remains unclear. Here we show that in the low-density lipoprotein receptor-deficient (Ldlr-/- ) atherosclerosis model, Sortilin deficiency (Sort1-/- ) in female mice suppresses Niemann-Pick type C1-Like 1 (Npc1l1) mRNA levels, reduces body and white adipose tissue weight, and improves brown adipose tissue function partially via transcriptional downregulation of Krüppel-like factor 4 and Liver X receptor...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898623/depletion-of-sirt3-leads-to-the-impairment-of-adipogenic-differentiation-and-insulin-resistance-via-interfering-mitochondrial-function-of-adipose-derived-human-mesenchymal-stem-cells
#2
Yu-Ting Wu, Kun-Ting Chi, Yueh-Wen Lan, Jui-Chi Chan, Yi-Shing Ma, Yau-Huei Wei
Upregulation of mitochondrial function and oxidative metabolism is a hallmark in the differentiation of stem cells. However, the mechanism underlying the metabolic reprogramming and upregulation of mitochondrial function during the differentiation of human mesenchymal stem cells (hMSCs) is largely unclear. Sirt3 has emerged as a sensor in regulating mitochondrial function and antioxidant defense system in cellular response to energy demand or environmental stimuli, but its roles in stem cell differentiation has not been fully understood...
June 14, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29884358/hydrophilic-interaction-chromatography-coupled-to-tandem-mass-spectrometry-as-a-method-for-simultaneous-determination-of-guanidinoacetate-and-creatine
#3
Pavle Jovanov, Milan Vraneš, Marijana Sakač, Slobodan Gadžurić, Jovana Panić, Aleksandar Marić, Sergej Ostojić
The biosynthesis of creatine (Cr) is closely related to the bioavailability of guanidinoacetate (GAA). The lack of one or the other may compromise their role in the energy transport and cell signaling. A reliable estimate of their levels in biological samples is imperative since they are important markers of many metabolic disorders. Therefore, a new LC-MS/MS method for simultaneous determination and quantification of GAA and Cr by multiple reaction monitoring (MRM) mode was developed based on the hydrophilic interaction chromatography (HILIC) and response surface methodology (RSM) for the optimization of chromatographic parameters...
October 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29878108/impaired-melanocortin-pathway-function-in-prader-willi-syndrome-gene-magel2-deficient-mice
#4
Merve Oncul, Pelin Dilsiz, Edanur Ates Oz, Tayfun Ates, Iltan Aklan, Esref Celik, Nilufer Sayar Atasoy, Deniz Atasoy
Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder causing social and learning deficits, impaired satiety and severe childhood obesity. Genetic underpinning of PWS involves deletion of a chromosomal region with several genes, including MAGEL2, which is abundantly expressed in the hypothalamus. Of appetite regulating hypothalamic cell types, both AGRP and POMC-expressing neurons contain Magel2 transcripts but the functional impact of its deletion on these cells has not been fully characterized. Here, we investigated these key neurons in Magel2-null mice in terms of the activity levels at different energy states as well as their behavioral function...
June 5, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29860237/low-energy-availability-surrogates-correlate-with-health-and-performance-consequences-of-relative-energy-deficiency-in-sport
#5
Kathryn E Ackerman, Bryan Holtzman, Katherine M Cooper, Erin F Flynn, Georgie Bruinvels, Adam S Tenforde, Kristin L Popp, Andrew J Simpkin, Allyson L Parziale
Low energy availability (EA) is suspected to be the underlying cause of both the Female Athlete Triad and the more recently defined syndrome, Relative Energy Deficiency in Sport (RED-S). The International Olympic Committee (IOC) defined RED-S as a syndrome of health and performance impairments resulting from an energy deficit. While the importance of adequate EA is generally accepted, few studies have attempted to understand whether low EA is associated with the health and performance consequences posited by the IOC...
June 2, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29860127/ercc1-deficient-cells-and-mice-are-hypersensitive-to-lipid-peroxidation
#6
Jolanta Czerwińska, Małgorzata Nowak, Patrycja Wojtczak, Dorota Dziuban-Lech, Jarosław M Cieśla, Daria Kołata, Beata Gajewska, Anna Barańczyk-Kuźma, Andria R Robinson, Hillary L Shane, Siobhán Q Gregg, Lora H Rigatti, Matthew J Yousefzadeh, Aditi U Gurkar, Sara J McGowan, Konrad Kosicki, Małgorzata Bednarek, Ewelina Zarakowska, Daniel Gackowski, Ryszard Oliński, Elżbieta Speina, Laura J Niedernhofer, Barbara Tudek
Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks. Here, we used cells and mice deficient in the ERCC1-XPF endonuclease required for nucleotide excision repair and the repair of DNA interstrand crosslinks to ask if specifically LPO-induced DNA damage contributes to loss of cell and tissue homeostasis. Ercc1-/- mouse embryonic fibroblasts were more sensitive than wild-type (WT) cells to the LPO products: 4-hydroxy-2-nonenal (HNE), crotonaldehyde and malondialdehyde...
May 31, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29850651/phosphoinositide-3-kinase-is-integral-for-the-acute-activity-of-leptin-and-insulin-in-male-arcuate-npy-agrp-neurons
#7
Yiru Huang, Zhenyan He, Yong Gao, Linh Lieu, Ting Yao, Jia Sun, Tiemin Liu, Chris Javadi, Maria Box, Sadia Afrin, Hongbo Guo, Kevin W Williams
Neuropeptide Y (NPY)/Agouti-related protein (AgRP) neurons in the arcuate nucleus of the hypothalamus are part of a neuroendocrine feedback loop that regulates feeding behavior and glucose homeostasis. NPY/AgRP neurons sense peripheral signals (including the hormones leptin, insulin, and ghrelin) and integrate those signals with inputs from other brain regions. These inputs modify both long-term changes in gene transcription and acute changes in the electrical activity of these neurons, leading to a coordinated response to maintain energy and glucose homeostasis...
June 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29808042/comparison-of-vitamin-d-levels-with-bone-density-calcium-phosphate-and-alkaline-phosphatase-an-insight-from-major-cities-of-pakistan
#8
Muhammad Arif Nadeem Saqib, Ibrar Rafique, Ijaz Hayder, Rabia Irshad, Saira Bashir, Rizwan Ullah, Najma Javed Awan
OBJECTIVE: To compare vitamin D levels with bone mineral density, serum calcium, phosphorous and alkaline phosphatase. METHODS: The cross-sectional multicentre study was conducted at Pakistan Health Research Council centres in Islamabad, Lahore, and Karachi,and comprised subjects coming for either vitamin D testing or bone mineral density examination. Information related to demography, height/weight, skin colour, smoking, use of sun screen, daily milk intake, sun exposure and exercise was taken along with biochemical tests like serum calcium and phosphorous, alkaline phosphatase, and 25 hydroxy vitamin D...
April 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29803284/red-blood-cell-enzyme-disorders
#9
REVIEW
Rachael F Grace, Bertil Glader
Mature red blood cells are reliant on the glycolytic pathway for energy production and the hexose monophosphate shunt for cell protection from oxidative insults. The most common red blood cell enzyme disorders are characterized by hemolysis but with wide clinical variability. Glucose-6-phosphate dehydrogenase deficiency is the most common red cell enzyme disorder worldwide. Frequent clinical presentations include neonatal jaundice and episodic hemolysis after exposure to oxidative stress. Symptoms of pyruvate kinase deficiency and other glycolytic enzyme disorders include neonatal jaundice, chronic hemolytic anemia, gallstones, and transfusion-related and transfusion-independent iron overload...
June 2018: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29795232/dlx1-2-and-otp-coordinate-the-production-of-hypothalamic-ghrh-and-agrp-neurons
#10
Bora Lee, Janghyun Kim, Taekyeong An, Sangsoo Kim, Esha M Patel, Jacob Raber, Soo-Kyung Lee, Seunghee Lee, Jae W Lee
Despite critical roles of the hypothalamic arcuate neurons in controlling the growth and energy homeostasis, the gene regulatory network directing their development remains unclear. Here we report that the transcription factors Dlx1/2 and Otp coordinate the balanced generation of the two functionally related neurons in the hypothalamic arcuate nucleus, GHRH-neurons promoting the growth and AgRP-neurons controlling the feeding and energy expenditure. Dlx1/2-deficient mice show a loss-of-GHRH-neurons and an increase of AgRP-neurons, and consistently develop dwarfism and consume less energy...
May 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29786968/p62-mediated-autophagy-affects-nutrition-dependent-insulin-receptor-substrate-1-dynamics-in-3t3-l1-preadipocytes
#11
Hirobumi Igawa, Akihiro Kikuchi, Hirofumi Misu, Kiyo-Aki Ishii, Shuichi Kaneko, Toshinari Takamura
AIMS/INTRODUCTION: Previous studies have shown that the organism's nutritional status changes the protein levels of insulin receptor substrate 1 (IRS-1) in a tissue-specific manner. Although the mechanisms underlying the regulation of IRS-1 in the nutrient-rich conditions associated with diabetes and insulin resistance have been well studied, those under nutrient-poor conditions remain unknown. The aim of this study was to investigate how IRS-1 protein levels change depending on the nutritional status of 3T3-L1 preadipocytes...
May 22, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29782205/nad-repletion-produces-no-therapeutic-effect-in-mice-with-respiratory-chain-complex-iii-deficiency-and-chronic-energy-deprivation
#12
Janne Purhonen, Jayasimman Rajendran, Saara Tegelberg, Olli-Pekka Smolander, Eija Pirinen, Jukka Kallijärvi, Vineta Fellman
Biosynthetic precursors of NAD+ can replenish a decreased cellular NAD+ pool and, supposedly via sirtuin (SIRT) deacetylases, improve mitochondrial function. We found decreased hepatic NAD+ concentration and downregulated biosynthesis in Bcs1lp.S78G knock-in mice with respiratory chain complex III deficiency and mitochondrial hepatopathy. Aiming at ameliorating disease progression via NAD+ repletion and improved mitochondrial function, we fed these mice nicotinamide riboside (NR), a NAD+ precursor. A targeted metabolomics verified successful administration and suggested enhanced NAD+ biosynthesis in the treated mice, although hepatic NAD+ concentration was unchanged at the end point...
May 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29777486/physiological-and-quantitative-proteomic-analyses-unraveling-potassium-deficiency-stress-response-in-alligator-weed-alternanthera-philoxeroides-l-root
#13
Li-Qin Li, Lun Liu, Wei Zhuo, Qian Chen, Sheng Hu, Shuang Peng, Xi-Yao Wang, Yi-Fei Lu, Li-Ming Lu
Physiological and iTRAQ based proteomic analysis provided new insights into potassium deficiency stress response in alligator weed root. Alligator weed (Alternanthera philoxeroides) has a strong ability to adapt to potassium deficiency (LK) stress. Proteomic changes in response to this stress are largely unknown in alligator weed. In this study, we investigated physiological and molecular mechanisms under LK using isobaric tags for relative and absolute quantitation to characterize proteome-level changes in this plant...
May 18, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29773865/perlecan-a-heparan-sulfate-proteoglycan-regulates-systemic-metabolism-with-dynamic-changes-in-adipose-tissue-and-skeletal-muscle
#14
Yuri Yamashita, Satoshi Nakada, Toshinori Yoshihara, Takeshi Nara, Norihiko Furuya, Takashi Miida, Nobutaka Hattori, Eri Arikawa-Hirasawa
Perlecan (HSPG2), a heparan sulfate proteoglycan, is a component of basement membranes and participates in a variety of biological activities. Here, we show physiological roles of perlecan in both obesity and the onset of metabolic syndrome. The perinatal lethality-rescued perlecan knockout (Hspg2-/- -Tg) mice showed a smaller mass and cell size of white adipose tissues than control (WT-Tg) mice. Abnormal lipid deposition, such as fatty liver, was not detected in the Hspg2-/- -Tg mice, and those mice also consumed more fat as an energy source, likely due to their activated fatty acid oxidation...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773536/ioc-consensus-statement-on-relative-energy-deficiency-in-sport-red-s-2018-update
#15
Margo Mountjoy, Jorunn Kaiander Sundgot-Borgen, Louise M Burke, Kathryn E Ackerman, Cheri Blauwet, Naama Constantini, Constance Lebrun, Bronwen Lundy, Anna Katarina Melin, Nanna L Meyer, Roberta T Sherman, Adam S Tenforde, Monica Klungland Torstveit, Richard Budgett
No abstract text is available yet for this article.
June 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29771953/mitochondrial-disease-patient-motivations-and-barriers-to-participate-in-clinical-trials
#16
Zarazuela Zolkipli-Cunningham, Rui Xiao, Amy Stoddart, Elizabeth M McCormick, Amy Holberts, Natalie Burrill, Shana McCormack, Lauren Williams, Xiaoyan Wang, John L P Thompson, Marni J Falk
BACKGROUND: Clinical treatment trials are increasingly being designed in primary mitochondrial disease (PMD), a phenotypically and genetically heterogeneous collection of inherited multi- system energy deficiency disorders that lack effective therapy. We sought to identify motivating factors and barriers to clinical trial participation in PMD. METHODS: A survey study was conducted in two independent mitochondrial disease subject cohorts. A discovery cohort invited subjects with well-defined biochemical or molecularly- confirmed PMD followed at a single medical center (CHOP, n = 30/67 (45%) respondents)...
2018: PloS One
https://www.readbyqxmd.com/read/29771168/international-olympic-committee-ioc-consensus-statement-on-relative-energy-deficiency-in-sport-red-s-2018-update
#17
Margo Mountjoy
No abstract text is available yet for this article.
May 17, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29768198/myocardin-related-transcription-factor-a-promotes-recruitment-of-itga5-profibrotic-progenitors-during-obesity-induced-adipose-tissue-fibrosis
#18
Jean Z Lin, Nabil Rabhi, Stephen R Farmer
Adipose tissue fibrosis is associated with inflammation and insulin resistance in human obesity. In particular, visceral fat fibrosis is correlated with hyperlipidemia and ectopic fat accumulation. Myocardin-related transcription factor A (MRTFA) is an important coactivator that mediates the transcription of extracellular matrix and other fibrogenic genes. Here, we examine the role of MRTFA in the development of adipose tissue fibrosis and identify a signaling pathway that regulates the fate of vascular progenitors...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29767755/protein-phosphatase-2c-ap2c1-interacts-with-and-negatively-regulates-the-function-of-cipk9-under-potassium-deficient-conditions-in-arabidopsis
#19
Amarjeet Singh, Akhilesh K Yadav, Kanwaljeet Kaur, Sibaji K Sanyal, Saroj K Jha, Joel L Fernandes, Pankhuri Sharma, Indu Tokas, Amita Pandey, Sheng Luan, Girdhar K Pandey
Potassium (K+) is a major macronutrient required for plant growth. In response to low- K+ condition, an adaptive mechanism entails activation of the Ca2+ signaling network consisting of calcineurin B-like proteins (CBLs) and their interacting kinases (CIPKs) in plants. The CBL-interacting protein kinase 9 (CIPK9) is previously implicated in low-K+ responses in Arabidopsis thaliana. Here, we report a protein phosphatase 2C (PP2C), AP2C1, as an interactor of CIPK9. Fluorescence resonance energy transfer (FRET), bimolecular fluorescence complementation (BiFC) and co-localization analyses revealed that CIPK9 and AP2C1 interact in the cytoplasm...
May 15, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29766801/naringenin-and-its-nano-formulations-for-fatty-liver-cellular-modes-of-action-and-clinical-perspective
#20
Mahdi Zobeiri, Tarun Belwal, Fatemeh Parvizi, Rozita Naseri, Mohammad Hosein Farzaei, Seyed Fazel Nabavi, Antoni Sureda, Seyed Mohammad Nabavi
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease mainly caused by high fat diets and sudden feed changes, vitamin and energy deficiency, and inflammatory processes. Fatty liver leads to cirrhosis, hepatocellular carcinoma as well as liver failure. Lifestyle-modifying such as weight loss and healthy diet have an inverse correlation with the risk of fatty liver. The promising effect of a diet rich in vegetables and fruits against fatty liver has been evidenced by several empirical studies focused on flavonoids...
May 14, 2018: Current Pharmaceutical Biotechnology
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