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Chloroprocaine

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https://www.readbyqxmd.com/read/28321983/chloroprocaine-for-epidural-anesthesia-in-infants-and-children
#1
REVIEW
Giorgio Veneziano, Joseph D Tobias
Continuous epidural infusions are an effective and safe method of providing anesthesia and postoperative analgesia in infants and children with multiple advantages over systemic medications, including earlier tracheal extubation, decreased perioperative stress response, earlier return of bowel function, and decreased exposure to volatile anesthetic agents with uncertain long-term neurocognitive effects. Despite these benefits, local anesthetic toxicity remains a concern in neonates and infants because of their decreased metabolic capacity for amide local anesthetics...
June 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28306579/continuous-epidural-analgesia-using-an-ester-linked-local-anesthetic-agent-2-chloroprocaine-during-labor-a-case-report
#2
Simon C Lee, Vanessa Moll
We report the use of the ester-linked local anesthetic, 2-chloroprocaine, for continuous epidural analgesia in a patient in labor with a history of allergic reaction to amide local anesthetics. The patient gave a reliable history of pruritus, hives, erythema, and swelling on her lower extremity after having received a preservative-free amide local anesthetic. This allergy had been confirmed by a dermatologist by her reports. The patient requested an epidural for labor analgesia that was placed successfully...
June 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28102539/determination-of-the-median-effective-dose-ed50-of-spinal-chloroprocaine-in-labour-analgesia
#3
M Coppens, S Anssens, A Parashchanka, K Roelens, E Deschepper, S De Hert, P F Wouters
The primary goal of this study was to determine the median effective dose (ED50 ) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 μg sufentanil in 7 ml saline...
January 19, 2017: Anaesthesia
https://www.readbyqxmd.com/read/27892594/chloroprocaine-10-mg-ml-for-low-dose-spinal-anaesthesia-in-perianal-surgery-a-randomised-dose-finding-study
#4
RANDOMIZED CONTROLLED TRIAL
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
February 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27873010/regional-block-via-continuous-caudal-infusion-as-sole-anesthetic-for-inguinal-hernia-repair-in-conscious-neonates
#5
Claudia M Mueller, Tiffany J Sinclair, Megan Stevens, Micaela Esquivel, Noah Gordon
PURPOSE: The use of general anesthesia in young children has come under increasing scrutiny due to its potential long-term neurotoxic effects. Meanwhile, regional anesthesia for surgical procedures in neonates has many advantages, including preservation of respiratory status and faster return to feeding. We describe the successful use of 3% 2-chloroprocaine administered via continuous caudal infusion as the sole anesthetic agent during elective surgical procedures in infants. METHODS: A retrospective chart review of all patients who underwent elective surgical procedures under continuous caudal regional anesthetic at a single institution was performed...
March 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/27871549/a-multicenter-study-of-the-analgesic-effects-of-epidural-chloroprocaine-after-lower-limb-orthopedic-surgery
#6
Hongwei Xu, Huiping Li, Yunxia Zuo, Baxian Yang, Yuke Tian, Qulian Guo, Jianguo Xu, Chaoran Wu
STUDY OBJECTIVE: To investigate the effects and optimal concentration of chloroprocaine for epidural analgesia after lower limb orthopedic surgery. DESIGN: Prospective, randomized, observational, multicenter clinical study. SETTING: Operating room, postoperative recovery area, university hospital. PATIENTS: One hundred and twenty patients from 4 hospitals were enrolled and randomized into 5 groups after lower limb orthopedic surgery under epidural anesthesia with lidocaine...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27464944/a-novel-approach-to-brachial-plexus-catheter-management-a-brachial-plexus-test-dose-for-phrenic-nerve-paralysis-and-patient-controlled-demand-only-dosing-for-a-patient-with-extreme-obesity
#7
Adam W Meier, Shin-E Lin, Neil A Hanson, David B Auyong
A 53-year-old woman with extreme obesity (body mass index = 82 kg/m) presented for an open reduction and internal fixation of the proximal humerus. This report describes the novel management of her continuous brachial plexus catheter in the setting of her comorbidities. Phrenic nerve paralysis from brachial plexus blocks can cause clinically significant dyspnea in obese patients. Brachial plexus catheters can be used effectively for these patients with some modification to routine management. We detail our use of a short-acting chloroprocaine test dose for phrenic paralysis and demand-only dosing to provide effective analgesia while avoiding respiratory complications associated with these blocks...
September 15, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27352633/prilocaine-spinal-anesthesia-for-ambulatory-surgery-a-review-of-the-available-studies
#8
REVIEW
Jan Boublik, Ruchir Gupta, Supurna Bhar, Arthur Atchabahian
Transient neurologic symptoms (TNS) led to the abandonment of intrathecal lidocaine. We reviewed the published literature for information about the duration of action and side effects of intrathecal prilocaine, which has been recently reintroduced in Europe. Medline and EMBASE databases were searched for the time period from 1966 to 2015. Fourteen prospective and one retrospective study were retrieved. The duration of the surgical block can be adjusted using doses between 40 and 80mg. Hyperbaric prilocaine in doses as low as 10mg can be used for perianal procedures...
December 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27290959/can-the-choice-of-the-local-anesthetic-have-an-impact-on-ambulatory-surgery-perioperative-costs-chloroprocaine-for-popliteal-block-in-outpatient-foot-surgery
#9
Andrea Saporito, Luciano Anselmi, Alain Borgeat, José A Aguirre
STUDY OBJECTIVE: Short-acting regional anesthetics have already been successfully used for peripheral nerve blocks in an ambulatory surgery setting. However, the impact on direct and indirect perioperative costs comparing 2 different short-acting local anesthetics has not been performed yet. DESIGN: Observational, prospective, case-control, cost-minimization study. SETTING: Operating room, regional hospital PATIENTS: One hundred adult American Society of Anesthesiologists status I-III patients scheduled for popliteal block after minor ambulatory foot surgery...
August 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27281722/comparison-of-2-chloroprocaine-bupivacaine-and-lidocaine-for-spinal-anesthesia-in-patients-undergoing-knee-arthroscopy-in-an-outpatient-setting-a-double-blind-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
An Teunkens, Kristien Vermeulen, Elke Van Gerven, Steffen Fieuws, Marc Van de Velde, Steffen Rex
BACKGROUND AND OBJECTIVES: Knee arthroscopy is a well-established procedure in day-case surgery, which is frequently performed under spinal anesthesia. It is, however, controversial whether the choice for a specific local anesthetic translates into relevant outcomes. We hypothesized that the use of 2-chloroprocaine would be associated with a faster recovery from sensorimotor block. METHODS: Ninety-nine patients were included in this prospective, double-blind, randomized controlled trial and randomly allocated to receive either 40 mg 2-chloroprocaine, 40 mg lidocaine, or 7...
September 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27275062/epidural-chloroprocaine-bolus-in-emergency-cesarean-section-lessons-learned-from-a-near-mishap
#11
Basavana G Goudra, Preet Mohinder Singh, Maisie Jackson, Ashish C Sinha
Administration of a large bolus of epidural chloroprocaine to hasten the spread of anesthesia is an accepted practice during emergency cesarean section. Occasionally, this practice can result in a very high block that can compromise patient's safety. We describe a case of epidural chloroprocaine administration in a 4 point position resulting in a high dermatomal block requiring respiratory assistance. Events surrounding the case are discussed, with a view to warn the reader about the pitfalls of such a practice...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27089835/chloroprocaine-local-anesthetic-systemic-toxicity-in-a-9-month-infant-with-paravertebral-catheter
#12
Maria A Hernandez, Karen Boretsky
Regional anesthesia use in pediatric patients has a good safety profile. 2-Chloroprocaine is used frequently in infants due to rapid onset, lack of accumulation, and rapid plasma degradation. We present a case of local anesthetic systemic toxicity following the administration of 3% 2-chloroprocaine through a paravertebral catheter in an infant. The episode lasted 40 s followed by complete recovery. The infrequent reporting of local anesthetic systemic toxicity and limited duration of symptoms supports the continued use of 2-chloroprocaine in infants...
June 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26608876/randomised-controlled-trial-of-spinal-anaesthesia-with-bupivacaine-or-2-chloroprocaine-during-caesarean-section
#13
RANDOMIZED CONTROLLED TRIAL
S Maes, M Laubach, J Poelaert
BACKGROUND: Neuraxial anaesthesia is the desired method for Caesarean section. Bupivacaine is a well-known local anaesthetic. It has a long duration of action and can cause unpredictable levels of anaesthesia with subsequent prolonged discharge time. 2-Chloroprocaine has a rapid onset of action, producing an excellent sensory and motor block and has a rapid hydrolysis in the bloodstream by pseudocholinesterase. We compared bupivacaine and 2-chloroprocaine for spinal anaesthesia during Caesarean section...
May 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/26530835/continuous-chloroprocaine-infusion-for-thoracic-and-caudal-epidurals-as-a-postoperative-analgesia-modality-in-neonates-infants-and-children
#14
Giorgio Veneziano, Peter Iliev, Jennifer Tripi, David Martin, Jennifer Aldrink, Tarun Bhalla, Joseph Tobias
BACKGROUND: Neonates and infants have decreased metabolic capacity for amide local anesthetics and increased risk of local anesthetic toxicity compared to the general population. Chloroprocaine is an ester local anesthetic that has an extremely short plasma half-life in infants as well as adults. Existing reports support the safety and efficacy of continuous chloroprocaine epidural infusions in neonates and young infants during the intraoperative period. Despite this, continuous chloroprocaine epidural infusion may be an under-utilized method of postoperative analgesia for this patient population...
January 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26372882/determination-of-the-90-effective-dose-ed90-of-phenylephrine-for-hypotension-during-elective-cesarean-delivery-using-a-continual-reassessment-method
#15
Hui Liu, Yan Huang, Min Diao, Hao Li, Yushan Ma, Xuemei Lin, Jie Zhou
OBJECTIVE: The purpose of this study was to determine, by continual reassessment, the 90% effective dose (ED90) of phenylephrine for hypotension after combined spinal-epidural anesthesia. STUDY DESIGN: Term pregnant women scheduled for elective cesarean delivery received combined spinal epidural anesthesia. Subjects received phenylephrine at one of 6 incremental doses ranging from 60 to 160μg (n=3 for each dose). While the first cohort received a conservative, predetermined dose of 60μg, subsequent cohorts received phenylephrine doses determined using Bayesian-based software...
November 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26306545/a-retrospective-comparison-of-ropivacaine-and-2-chloroprocaine-continuous-thoracic-epidural-analgesia-for-management-of-postthoracotomy-pain-in-infants
#16
COMPARATIVE STUDY
Wallis T Muhly, Harshad G Gurnaney, Francis W Kraemer, Arjunan Ganesh, Lynne G Maxwell
INTRODUCTION: Continuous thoracic epidural analgesia is useful in the management of infants following thoracotomy. Concerns about drug accumulation and toxicity limit the amount of amide local anesthetics that can be delivered. Continuous epidural infusions of the ester local anesthetic chloroprocaine result in little drug accumulation allowing for higher infusion rates. We retrospectively compared patients managed with 1.5% 2- chloroprocaine or 0.1% ropivacaine epidural infusions to determine if the increased infusion rate resulted in similar or improved analgesia...
November 2015: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26302690/history-of-t-cain-a-local-anesthetic-developed-and-manufactured-in-japan
#17
REVIEW
Masaru Tobe, Shigeru Saito
In many anesthesia textbooks written in English, lidocaine, tetracaine, bupivacaine, ropivacaine, and chloroprocaine are listed as useful local anesthetics for spinal anesthesia. In contrast, T-cain is not included in these lists, even though it has been reported to be suitable for spinal anesthesia in Japan. T-cain was developed as a local anesthetic in the early 1940s by Teikoku Kagaku Sangyo Inc. in Itami, Japan, by replacing a methyl group on tetracaine (Pantocaine(®)) with an ethyl group. T-cain was clinically approved for topical use in Japan in November 1949, and a mixture of dibucaine and T-cain (Neo-Percamin S(®)) was approved for spinal use in May 1950...
October 2015: Journal of Anesthesia
https://www.readbyqxmd.com/read/26272104/paravertebral-nerve-block-catheters-using-chloroprocaine-in-infants-with-prolonged-mechanical-ventilation-for-treatment-of-long-gap-esophageal-atresia
#18
Sigrid Bairdain, Brenda Dodson, David Zurakowski, David B Waisel, Russell W Jennings, Karen R Boretsky
BACKGROUND: Infants with long-gap esophageal atresia (LGEA) undergo repeated thoracotomies for staged surgical repair known as the Foker process (FP). Associated prolonged mechanical ventilation results in exposure to high doses of opioids and benzodiazepines, and prolonged weaning times and ICU stays. AIM: The aim of this study was to determine the effectiveness of short-term paravertebral nerve block (PVNB) catheters in reducing opioid/benzodiazepine exposure and effects on clinical variables...
November 2015: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/26219196/evaluation-of-prolonged-epidural-chloroprocaine-for-postoperative-analgesia-in-infants
#19
Emma L Ross, Pamela D Reiter, Michael E Murphy, Alan R Bielsky
STUDY OBJECTIVE: To describe the use and adverse effects of chloroprocaine for epidural analgesia in young infants for infusion durations greater than 3.5 hours. DESIGN: A retrospective cohort review of the electronic medical record over a 14-month period. SETTING: The level IV neonatal intensive care unit of a 414-bed free-standing children's hospital. PATIENTS: Eighteen infants (mean age, 1.7 ± 1.8 months [0.03-6...
September 2015: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/26202459/inhibition-of-kv7-m-channel-currents-by-the-local-anesthetic-chloroprocaine
#20
Fan Zhang, Yanxin Cheng, Hong Li, Qingzhong Jia, Hailin Zhang, Senming Zhao
BACKGROUND: Chloroprocaine is a local ester anesthetic, producing excellent sensory block in clinical use. The Kv7/M potassium channel plays an important role in the control of neuronal excitability. In this study, we investigated the effects of the local anesthetic chloroprocaine on Kv7/M channels as well as the effect of retigabine on chloroprocaine-induced seizures. METHODS: A perforated whole-cell patch technique was used to record Kv7 currents from HEK293 cells and M-type currents from rat dorsal root ganglion (DRG) neurons...
2015: Pharmacology
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