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Chloroprocaine

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https://www.readbyqxmd.com/read/29914426/effects-of-local-anesthetics-on-breast-cancer-cell-viability-and-migration
#1
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P Dilger, Jun Lin
BACKGROUND: Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical studies have suggested that use of regional anesthesia leads to improved patient outcomes. Laboratory studies have reported that breast cancer cells are inhibited by some local anesthetics at millimolar concentration. Here, we present a comprehensive analysis of the effects of six common local anesthetics on two human breast cancer cell lines...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29756162/retrospective-analysis-of-mepivacaine-prilocaine-and-chloroprocaine-for-low-dose-spinal-anaesthesia-in-outpatient-perianal-procedures
#2
Volker Gebhardt, Kevin Kiefer, Dieter Bussen, Christel Weiss, Marc D Schmittner
PURPOSE: Perianal procedures are carried out in an outpatient setting regularly. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics (LA) for spinal anaesthesia (SPA) on operating room (OR) efficiency (perioperative process times, turnaround times) and postoperative recovery. This study aims on the determination of the optimal LA for low-dose SPA in the specific setting of a high-volume day-surgery centre. METHODS: Anaesthesia records of all patients undergoing perianal outpatient surgery under saddle-block SPA at the Mannheim University Medical Centre from 2008 until 2017 were analysed...
May 13, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29521661/spinal-anaesthesia-with-chloroprocaine-1-versus-total-intravenous-anaesthesia-for-outpatient-knee-arthroscopy-a-randomised-controlled-trial
#3
Volker Gebhardt, Vera Zawierucha, Oliver Schöffski, Anke Schwarz, Christel Weiss, Marc D Schmittner
BACKGROUND: Both general and spinal anaesthesia with short-acting local anaesthetics are suitable and reliable for knee arthroscopy as an ambulatory procedure. Chloroprocaine (CP) 1% seems to be the ideal spinal local anaesthetic for this indication. OBJECTIVE: The aim of this study was to compare spinal anaesthesia using CP 1% with general for outpatient knee arthroscopy with regard to procedure times, occurrence of pain, patient satisfaction and recovery, and also costs...
March 7, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29503214/nurse-practitioner-administered-chloroprocaine-in-children-with-postoperative-pain
#4
REVIEW
Erin Sweet, Christine S Shusterman, Marina S Nedeljkovic, Jean C Solodiuk
Pain is a complex physical and emotional experience. Therefore, assessment of acute pain requires self-report when possible, observations of emotional and behavioral responses and changes in vital signs. Peripheral nerve and epidural catheters often provide postoperative analgesia in children. Administration of chloroprocaine (a short acting local anesthetic) via a peripheral nerve or epidural catheter allows for a comparison of pain scores, observations of emotional and behavioral responses and changes in vital signs to determine catheter function...
March 1, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29502993/intraperitoneal-chloroprocaine-is-a-useful-adjunct-to-neuraxial-block-during-cesarean-delivery-a-case-series
#5
M Werntz, R Burwick, B Togioka
BACKGROUND: Use of intraperitoneal local anesthetic to treat intraoperative pain during cesarean delivery has not been described previously. The aim of this study was to determine if intraperitoneal chloroprocaine may be useful as an adjunct to neuraxial block in reducing the proportion of patients with severe intraoperative pain that requires conversion to general anesthesia. Intraperitoneal chloroprocaine was administered during cesarean delivery as a potential alternative, when the anesthesiologist considered performing a general anesthetic due to severe intraoperative pain...
March 1, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29349036/alternative-topical-anesthesia-for-bronchoscopy-in-a-case-of-severe-lidocaine-allergy
#6
Matthew Hensley, Benjamin H Singer
Lidocaine allergy presents a unique difficulty for both patients and providers who undergo/perform bronchoscopy. We present a case of a 73 yo male with severe lidocaine allergy who successfully underwent bronchoscopy with chloroprocaine topical anesthesia and discuss alternative topical anesthetic agents that may be used in this special situation.
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29184436/continuous-wound-infusion-with-chloroprocaine-in-a-pig-model-of-surgical-lesion-drug-absorption-and-effects-on-inflammatory-response
#7
Massimo Allegri, Dario Bugada, Manuela De Gregori, Maria A Avanzini, Annalisa De Silvestri, Anna Petroni, Angelo Sala, Claudia Filisetti, Antonia Icaro Cornaglia, Lorenzo Cobianchi
Continuous wound infusion (CWI) may protect from inflammation, hyperalgesia and persistent pain. Current local anesthetics display suboptimal pharmacokinetic profile during CWI; chloroprocaine (CP) has ideal characteristics, but has never been tested for CWI. We performed an animal study to investigate the pharmacokinetic profile and anti-inflammatory effect of CP during CWI. A total of 14 piglets received an infusion catheter after pararectal laparotomy and were randomly allocated to one of three groups: 5 mL/h infusion of saline (group A), CP 1...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29077661/is-low-concentration-2-chloroprocaine-for-epidural-labor-analgesia-a-better-option
#8
John C Coffman, Kristin I Brower, Robert H Small
No abstract text is available yet for this article.
February 15, 2018: A&A practice
https://www.readbyqxmd.com/read/28321983/chloroprocaine-for-epidural-anesthesia-in-infants-and-children
#9
REVIEW
Giorgio Veneziano, Joseph D Tobias
Continuous epidural infusions are an effective and safe method of providing anesthesia and postoperative analgesia in infants and children with multiple advantages over systemic medications, including earlier tracheal extubation, decreased perioperative stress response, earlier return of bowel function, and decreased exposure to volatile anesthetic agents with uncertain long-term neurocognitive effects. Despite these benefits, local anesthetic toxicity remains a concern in neonates and infants because of their decreased metabolic capacity for amide local anesthetics...
June 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28306579/continuous-epidural-analgesia-using-an-ester-linked-local-anesthetic-agent-2-chloroprocaine-during-labor-a-case-report
#10
Simon C Lee, Vanessa Moll
We report the use of the ester-linked local anesthetic, 2-chloroprocaine, for continuous epidural analgesia in a patient in labor with a history of allergic reaction to amide local anesthetics. The patient gave a reliable history of pruritus, hives, erythema, and swelling on her lower extremity after having received a preservative-free amide local anesthetic. This allergy had been confirmed by a dermatologist by her reports. The patient requested an epidural for labor analgesia that was placed successfully...
June 1, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28102539/determination-of-the-median-effective-dose-ed50-of-spinal-chloroprocaine-in-labour-analgesia
#11
M Coppens, S Anssens, A Parashchanka, K Roelens, E Deschepper, S De Hert, P F Wouters
The primary goal of this study was to determine the median effective dose (ED50 ) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 μg sufentanil in 7 ml saline...
May 2017: Anaesthesia
https://www.readbyqxmd.com/read/27892594/chloroprocaine-10-mg-ml-for-low-dose-spinal-anaesthesia-in-perianal-surgery-a-randomised-dose-finding-study
#12
RANDOMIZED CONTROLLED TRIAL
V Gebhardt, L Mueller-Hansen, A Schwarz, D Bussen, C Weiss, M D Schmittner
BACKGROUND: Low-dose spinal anaesthesia is a safe and reliable anaesthesia technique in outpatient perianal surgery. Regarding its short duration of action and its trend to hyperbaric characteristics, plain chloroprocaine 10 mg/ml seems to be ideal to perform low-dose spinal anaesthesia. The aim of this trial was to determine the optimal dosage of chloroprocaine for this indication. METHODS: Hundred and twenty patients undergoing perianal surgery were enrolled and randomly allocated to receive 10, 20 or 30 mg of chloroprocaine 10 mg/ml intrathecally...
February 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27873010/regional-block-via-continuous-caudal-infusion-as-sole-anesthetic-for-inguinal-hernia-repair-in-conscious-neonates
#13
Claudia M Mueller, Tiffany J Sinclair, Megan Stevens, Micaela Esquivel, Noah Gordon
PURPOSE: The use of general anesthesia in young children has come under increasing scrutiny due to its potential long-term neurotoxic effects. Meanwhile, regional anesthesia for surgical procedures in neonates has many advantages, including preservation of respiratory status and faster return to feeding. We describe the successful use of 3% 2-chloroprocaine administered via continuous caudal infusion as the sole anesthetic agent during elective surgical procedures in infants. METHODS: A retrospective chart review of all patients who underwent elective surgical procedures under continuous caudal regional anesthetic at a single institution was performed...
March 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/27871549/a-multicenter-study-of-the-analgesic-effects-of-epidural-chloroprocaine-after-lower-limb-orthopedic-surgery
#14
RANDOMIZED CONTROLLED TRIAL
Hongwei Xu, Huiping Li, Yunxia Zuo, Baxian Yang, Yuke Tian, Qulian Guo, Jianguo Xu, Chaoran Wu
STUDY OBJECTIVE: To investigate the effects and optimal concentration of chloroprocaine for epidural analgesia after lower limb orthopedic surgery. DESIGN: Prospective, randomized, observational, multicenter clinical study. SETTING: Operating room, postoperative recovery area, university hospital. PATIENTS: One hundred and twenty patients from 4 hospitals were enrolled and randomized into 5 groups after lower limb orthopedic surgery under epidural anesthesia with lidocaine...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27464944/a-novel-approach-to-brachial-plexus-catheter-management-a-brachial-plexus-test-dose-for-phrenic-nerve-paralysis-and-patient-controlled-demand-only-dosing-for-a-patient-with-extreme-obesity
#15
Adam W Meier, Shin-E Lin, Neil A Hanson, David B Auyong
A 53-year-old woman with extreme obesity (body mass index = 82 kg/m) presented for an open reduction and internal fixation of the proximal humerus. This report describes the novel management of her continuous brachial plexus catheter in the setting of her comorbidities. Phrenic nerve paralysis from brachial plexus blocks can cause clinically significant dyspnea in obese patients. Brachial plexus catheters can be used effectively for these patients with some modification to routine management. We detail our use of a short-acting chloroprocaine test dose for phrenic paralysis and demand-only dosing to provide effective analgesia while avoiding respiratory complications associated with these blocks...
September 15, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27352633/prilocaine-spinal-anesthesia-for-ambulatory-surgery-a-review-of-the-available-studies
#16
REVIEW
Jan Boublik, Ruchir Gupta, Supurna Bhar, Arthur Atchabahian
Transient neurologic symptoms (TNS) led to the abandonment of intrathecal lidocaine. We reviewed the published literature for information about the duration of action and side effects of intrathecal prilocaine, which has been recently reintroduced in Europe. Medline and EMBASE databases were searched for the time period from 1966 to 2015. Fourteen prospective and one retrospective study were retrieved. The duration of the surgical block can be adjusted using doses between 40 and 80mg. Hyperbaric prilocaine in doses as low as 10mg can be used for perianal procedures...
December 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27290959/can-the-choice-of-the-local-anesthetic-have-an-impact-on-ambulatory-surgery-perioperative-costs-chloroprocaine-for-popliteal-block-in-outpatient-foot-surgery
#17
Andrea Saporito, Luciano Anselmi, Alain Borgeat, José A Aguirre
STUDY OBJECTIVE: Short-acting regional anesthetics have already been successfully used for peripheral nerve blocks in an ambulatory surgery setting. However, the impact on direct and indirect perioperative costs comparing 2 different short-acting local anesthetics has not been performed yet. DESIGN: Observational, prospective, case-control, cost-minimization study. SETTING: Operating room, regional hospital PATIENTS: One hundred adult American Society of Anesthesiologists status I-III patients scheduled for popliteal block after minor ambulatory foot surgery...
August 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27281722/comparison-of-2-chloroprocaine-bupivacaine-and-lidocaine-for-spinal-anesthesia-in-patients-undergoing-knee-arthroscopy-in-an-outpatient-setting-a-double-blind-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
An Teunkens, Kristien Vermeulen, Elke Van Gerven, Steffen Fieuws, Marc Van de Velde, Steffen Rex
BACKGROUND AND OBJECTIVES: Knee arthroscopy is a well-established procedure in day-case surgery, which is frequently performed under spinal anesthesia. It is, however, controversial whether the choice for a specific local anesthetic translates into relevant outcomes. We hypothesized that the use of 2-chloroprocaine would be associated with a faster recovery from sensorimotor block. METHODS: Ninety-nine patients were included in this prospective, double-blind, randomized controlled trial and randomly allocated to receive either 40 mg 2-chloroprocaine, 40 mg lidocaine, or 7...
September 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27275062/epidural-chloroprocaine-bolus-in-emergency-cesarean-section-lessons-learned-from-a-near-mishap
#19
Basavana G Goudra, Preet Mohinder Singh, Maisie Jackson, Ashish C Sinha
Administration of a large bolus of epidural chloroprocaine to hasten the spread of anesthesia is an accepted practice during emergency cesarean section. Occasionally, this practice can result in a very high block that can compromise patient's safety. We describe a case of epidural chloroprocaine administration in a 4 point position resulting in a high dermatomal block requiring respiratory assistance. Events surrounding the case are discussed, with a view to warn the reader about the pitfalls of such a practice...
April 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27089835/chloroprocaine-local-anesthetic-systemic-toxicity-in-a-9-month-infant-with-paravertebral-catheter
#20
Maria A Hernandez, Karen Boretsky
Regional anesthesia use in pediatric patients has a good safety profile. 2-Chloroprocaine is used frequently in infants due to rapid onset, lack of accumulation, and rapid plasma degradation. We present a case of local anesthetic systemic toxicity following the administration of 3% 2-chloroprocaine through a paravertebral catheter in an infant. The episode lasted 40 s followed by complete recovery. The infrequent reporting of local anesthetic systemic toxicity and limited duration of symptoms supports the continued use of 2-chloroprocaine in infants...
June 2016: Paediatric Anaesthesia
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