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Bupivacaine

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https://www.readbyqxmd.com/read/29219935/intrathecal-morphine-for-laparoscopic-segmental-colonic-resection-as-part-of-an-enhanced-recovery-protocol-a-randomized-controlled-trial
#1
Mark V Koning, Aart Jan W Teunissen, Erwin van der Harst, Elisabeth J Ruijgrok, Robert Jan Stolker
BACKGROUND AND OBJECTIVES: Management of postoperative pain after laparoscopic segmental colonic resections remains controversial. We compared 2 methods of analgesia within an Enhanced Recovery After Surgery (ERAS) program. The goal of the study was to investigate whether administration of intrathecal bupivacaine/morphine would lead to an enhanced recovery. METHODS: A single-center, randomized, double-blind controlled trial was performed (NL43488.101.13). Patients scheduled for laparoscopic segmental intestinal resections were considered...
December 6, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29215511/liposomal-bupivacaine-during-robotic-colpopexy-and-posterior-repair-a-randomized-controlled-trial
#2
Jennifer Yeung, Catrina C Crisp, Donna Mazloomdoost, Steven D Kleeman, Rachel N Pauls
OBJECTIVE: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair. METHODS: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Perioperative care was standardized. Visual analog scales were collected at 4, 18, and 24 hours postoperatively in hospital...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29208329/the-effects-of-body-mass-index-on-pain-control-with-liposomal-bupivacaine-in-hip-and-knee-arthroplasty
#3
Abigail L Campbell, Stephen Yu, Raj Karia, Richard Iorio, Steven A Stuchin
BACKGROUND: There is evidence to suggest that liposomal bupivacaine (LB) is an effective component of a multimodal pain regimen for total joint arthroplasty (TJA). Obesity has been associated with chronic pain following TJA. This study assessed whether early postoperative pain is affected by body mass index (BMI), and whether the standard LB dose has similar effects on obese vs nonobese patients. METHODS: A retrospective analysis of 2629 primary TJA over a 12-month period was conducted, with LB used in half of this group...
November 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29206315/intrathecal-trialing-of-continuous-infusion-combination-therapy-with-hydromorphone-and-bupivacaine-in-failed-back-surgery-patients
#4
Ryan J Galica, Salim M Hayek, Elias Veizi, Matthew T McEwan, Sivakanth Katta, Omar Ali, Nida Aziz, Nidhi Sondhi
OBJECTIVES: Intrathecal (IT) trial is a prognostic interventional pain management procedure employed to determine the potential success of treating intractable pain with an implantable infusion device system. There is a dearth of data regarding trials with continuous infusion of combination therapy (e.g. opioid combined with local anesthetic). The objective of the this study was to determine the overall outcomes of continuous infusion IT trials and factors influencing long-term success of IT therapy in patients with chronic intractable pain post-laminectomy...
December 5, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29204926/alginate-liposomal-construct-for-bupivacaine-delivery-and-msc-function-regulation
#5
Mollie S Davis, Ileana Marrero-Berrios, Xiomara I Perez, Timothy Maguire, Palangat Radhakrishnan, Devasena Manchikalapati, Joseph SchianodiCola, Hattiyangangadi Kamath, Rene S Schloss, Joel Yarmush
Mesenchymal stromal cell (MSC) therapies have become potential treatment options for multiple ailments and traumatic injuries. In the clinical setting, MSC are likely to be co-administered with local anesthetics (LA) which have been shown to have dose- and potency-dependent detrimental effects on the viability and function of cells. We previously developed and characterized a sustained-release LA delivery formulation comprised of alginate-encapsulated liposomal bupivacaine. The current studies were designed to evaluate the effect of this formulation on the secretion of three key MSC regulatory molecules, interleukin 6 (IL-6), prostaglandin E2 (PGE2), and transforming growth factor-beta 1 (TGF-β1)...
December 4, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29201516/effectiveness-of-spinal-anesthesia-combined-with-obturator-nerve-blockade-in-preventing-adductor-muscle-contraction-during-transurethral-resection-of-bladder-tumor
#6
Cyrus Emir Alavi, Seyed Alaeddin Asgari, Siavash Falahatkar, Siamak Rimaz, Mohammadreza Naghipour, Hossein Khoshrang, Mehdi Jafari, Nadia Herfeh
Objective: To determine whether spinal anesthesia combined with obturator nerve blockade (SOB) is effective in preventing obturator nerve stimulation, jerking and bladder perforation during transurethral resection of bladder tumor (TURBT). Material and methods: In this clinical trial, 30 patients were randomly divided into two groups: spinal anesthesia (SA) and SOB. In SA group, 2.5 cc of 0.5% bupivacaine was injected intrathecally using a 25-gauge spinal needle and in SOB after spinal anesthesia, a classic obturator nerve blockade was performed by using nerve stimulation technique...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29197080/determination-of-the-optimal-programmed-intermittent-epidural-bolus-volume-of-bupivacaine-0-0625-with-fentanyl-2-%C3%AE-g-ml-1-at-a-fixed-interval-of-forty-minutes-a-biased-coin-up-and-down-sequential-allocation-trial
#7
P Zakus, C Arzola, R Bittencourt, K Downey, X Y Ye, J C Carvalho
The optimum time interval for 10 ml boluses of bupivacaine 0.0625% + fentanyl 2 μg.ml-1 as part of a programmed intermittent epidural bolus regimen has been found to be 40 min. This regimen was shown to be effective without the use of supplementary patient-controlled epidural analgesia boluses in 90% of women during the first stage of labour, although with a rate of sensory block to ice above T6 in 34% of women. We aimed to determine the optimum programmed intermittent epidural bolus volume at a 40 min interval to provide effective analgesia in 90% of women (EV90 ) during the first stage of labour, without the use of patient-controlled epidural analgesia...
December 2, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29194065/delayed-respiratory-depression-secondary-to-opioid-overdose-after-multimodal-analgesia-with-transversus-abdominis-plane-blocks-in-postanesthesia-care-unit-a-case-report
#8
Michael O'Rourke, Emily S Schmidt, Jonathan E Metry, Michael B Majewski
Pain control after open abdominal surgery often includes multimodal analgesia with thoracic epidural or transversus abdominis plane (TAP) block. After liposomal bupivacaine was approved for TAP blocks in 2015, it became an alternative to indwelling catheters. However, the pharmacokinetics and safety of its use during the perioperative period have not been thoroughly investigated, especially in conjunction with parenteral opioids. We present a case report of an elderly patient having urgent laparoscopic converted to open abdominal surgery, who experienced postoperative respiratory depression in the recovery room after multimodal therapy with liposomal bupivacaine TAP blocks, intravenous (IV) opioids, and ketorolac...
November 30, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29189291/effect-of-thoracic-epidural-ropivacaine-versus-bupivacaine-on-lower-urinary-tract-function-a-randomized-clinical-trial
#9
Stefan A Girsberger, Marc P Schneider, Lukas M Löffel, Fiona C Burkhard, Patrick Y Wuethrich
BACKGROUND: Thoracic epidural analgesia with bupivacaine resulted in clinically relevant postvoid residuals due to detrusor underactivity. This study aimed to compare the risk of bladder dysfunction with ropivacaine versus bupivacaine using postvoid residuals and maximum flow rates. Our hypothesis was that ropivacaine would result in lower postvoid residuals, because ropivacaine has been shown to have less effect on motor blockade. METHODS: In this single-center, parallel-group, randomized, double-blind superiority trial, 42 patients undergoing open renal surgery were equally allocated to receive epidural bupivacaine 0...
November 21, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29189284/the-use-of-liposomal-bupivacaine-in-erector-spinae-plane-block-to-minimize-opioid-consumption-for-breast-surgery-a-case-report
#10
Amanda Kumar, Alina Hulsey, Hector Martinez-Wilson, James Kim, Jeff Gadsden
The erector spinae plane block is a novel interfascial plane block that can provide thoracic and abdominal analgesia. We describe a patient with opioid intolerance scheduled for breast surgery who received an erector spinae plane block with liposomal bupivacaine as well as a supplemental T1 paravertebral block resulting in profound analgesia throughout her postoperative course. This case report demonstrates that use of liposomal bupivacaine in the erector spinae plane block can be successful in providing extended duration postoperative analgesia and minimizing systemic opioid requirements...
November 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29184438/efficacy-of-local-dexmedetomidine-add-on-for-spermatic-cord-block-anesthesia-in-patients-undergoing-intrascrotal-surgeries-randomized-controlled-multicenter-clinical-trial
#11
Diab Fuad Hetta, Emad E Kamal, Ali M Mahran, Doaa G Ahmed, Abdelraheem Elawamy, Abdelraouf Ms Abdelraouf
Study objective: The objective of this study was to evaluate the effect of adding dexmedetomidine (DEX) to bupivacaine on the quality of spermatic cord block anesthesia and postoperative analgesia. Design: This is a randomized, double-blind study. Setting: This study was performed in an educational and research hospital. Patients: One hundred twenty adult males were scheduled for intrascrotal surgeries. Interventions: Patients were divided into two groups: group B received 10 mL of bupivacaine 0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29181841/epidural-therapy-for-the-treatment-of-severe-pre-eclampsia-in-non-labouring-women
#12
REVIEW
Amita Ray, Sujoy Ray
BACKGROUND: Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and reduced uteroplacental flow form the etiopathological basis of pre-eclampsia. There are several established therapies for pre-eclampsia including antihypertensives and anticonvulsants. Most of these therapies aim at controlling the blood pressure or preventing complications of elevated blood pressure, or both...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29181332/intravenous-midazolam-as-more-effective-than-propofol-for-preventing-pruritus-after-intrathecal-sufentanil-in-surgical-patients-a-randomized-blinded-trial
#13
Jalil Makarem, Seyed Mohammad Mireskandari, Afshin Jafarzadeh, Laya Rahbar Nikoukar, Sara Aghaii
Background: Pruritus is a troublesome side effect of intrathecal opioids. Midazolam can reinforce GABA-mediated inhibition of the medullary dorsal horn neurons, and thus theoretically has potential to suppress opioid-induced pruritus. Objectives: This prospective double-blinded randomized trial aimed at comparing the effects of propofol, midazolam, and a combination of the two on the prevention of pruritus induced by intrathecal sufentanil. Methods: Eighty-four patients undergoing spinal anesthesia with 3 mL hyperbaric bupivacaine 0...
June 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29177501/a-comparison-of-prilocaine-vs-prilocaine%C3%A2-%C3%A2-bupivacaine-in-periprostatic-block-in-ambulatory-prostate-biopsies-a-single-blind-randomized-controlled-study
#14
Ekrem Akdeniz, Mustafa Suat Bolat, Sevda Akdeniz
Objective: The purpose of this study was to evaluate the analgesic effect of a prilocaine + bupivacaine combination in patients undergoing periprostatic nerve block (PNB) by comparing its effects with those of prilocaine alone. Design: Single center, single-blind, prospective descriptive study. Subjects: Four hundred patients with transrectal prostate biopsy pain. Methods: The patients in this prospective, randomized controlled study were divided into two groups...
November 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29170009/factors-associated-with-inadequate-pain-control-among-postoperative-patients-with-cancer
#15
Aqel El-Aqoul, Abdullah Obaid, Eman Yacoub, Malek Al-Najar, Mahmoud Ramadan, Muhammad Darawad
Postoperative pain is considered a major, complex and multidimensional problem that affects the clinical and functional outcomes of patients and may contribute to increased postoperative complications. The goal of this study was to determine the prevalence of inadequate pain control and to investigate the factors associated with inadequate pain control among postoperative cancer patients. A descriptive correlational, cross-sectional design was used. The study was conducted at four adult inpatient oncology departments at King Hussein Cancer Center, a nongovernmental, nonprofit, comprehensive hospital for treating cancer patients in Amman, Jordan...
November 20, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29169790/control-of-postoperative-pain-following-implantable-cardioverter-defibrillator-placement-a-randomized-study
#16
M Luque Oliveros
OBJECTIVE: To evaluate local anesthetic infiltration with 0.5% bupivacaine in the management of surgical wound pain during the postoperative period. DESIGN: A randomized controlled trial was carried out from 1 January to 1 June 2017 SCOPE: Cardiovascular Surgery Department and Heart Area. PATIENTS: Patients scheduled for implantable cardioverter defibrillator (ICD) placement, aged ≥ 18 years and who following verbal and written explanation of the purpose of the study, accepted and signed the informed consent document...
November 20, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29166664/is-there-a-reasonable-excuse-for-not-providing-post-operative-analgesia-when-using-animal-models-of-peripheral-neuropathic-pain-for-research-purposes
#17
Sara Hestehave, Gordon Munro, Rie Christensen, Tina Brønnum Pedersen, Lars Arvastson, Philip Hougaard, Klas S P Abelson
INTRODUCTION: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of researchers avoid providing such care based largely on anecdotal opinions that it might interfere with model pathophysiology in the longer term. OBJECTIVES: To investigate effects of various peri-operative analgesic regimens encapsulating different mechanisms and duration of action, on the development of post-operative stress/welfare and pain-like behaviors in the Spared Nerve Injury (SNI)-model of neuropathic pain...
2017: PloS One
https://www.readbyqxmd.com/read/29163750/long-acting-liposomal-bupivacaine-for-percutaneous-sympathetic-stellate-ganglion-blockade-a-technical-note
#18
Adnan I Qureshi, Muhammad A Waqas, Vikram Jadhav, Muhammad A Saleem, Jeff Campbell, Shawn S Wallery
Introduction: We describe the use of long acting liposomal bupivacaine for percutaneous stellate ganglion blockade to treat severe headaches following internal carotid artery dissection. Methods: A 43-year old woman developed right-sided refractory headache after right internal carotid artery dissection. Patient underwent percutaneous stellate ganglion block using bupivacaine hydrochloride (0.25%-20 ml) in the past with short acting relief. Liposomal bupivacaine (EXPAREL) 13...
October 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29155035/utility-of-anesthetic-block-for-endometrial-ablation-pain-a-randomized-controlled-trial
#19
Jordan S Klebanoff, Nima R Patel, Nancy L Sloan
BACKGROUND: Second-generation endometrial ablation has been demonstrated safe for abnormal uterine bleeding treatment in premenopausal women, who have completed childbearing, in short-stay surgical centers and in physicians' offices. However, no standard regarding anesthesia exists and practice varies depending on physician or patient preference and hospital policy and setting. OBJECTIVE: To evaluate whether local anesthetic, in combination with general anesthesia, affects postoperative pain and associated narcotic use following endometrial ablation...
November 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29149146/dexamethasone-and-dexmedetomidine-as-an-adjuvant-to-intraarticular-bupivacaine-for-postoperative-pain-relief-in-knee-arthroscopic-surgery-a-randomized-trial
#20
Seham M Moeen, Islam K Ramadan, Hesham A Elkady
BACKGROUND: Knee arthroscopy causes minimal trauma, however, good analgesia is required for early rehabilitation and return to normal life in the patients. OBJECTIVE: We aimed to compare the analgesic effects of intraarticular dexamethasone and dexmedetomidine added to bupivacaine with those of bupivacaine alone. STUDY DESIGN: This study uses a double-blind, randomized, controlled design with allocation concealment in a 3-armed parallel group format among patients undergoing arthroscopic meniscal surgery...
November 2017: Pain Physician
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