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https://www.readbyqxmd.com/read/29781319/assessing-the-role-of-ranibizumab-in-improving-the-outcome-of-glaucoma-filtering-surgery-and-neovascular-glaucoma
#1
Andreas Katsanos, Kostantina Gorgoli, Dimitrios G Mikropoulos, Esther Arranz-Marquez, Georgios P Athanasopoulos, Miguel A Teus, Anastasios G P Konstas
Ranibizumab was the first anti-vascular endothelial growth factor (VEGF) agent approved for the treatment of neovascular age-related macular degeneration. The use of ranibizumab and other anti-VEGF medications in recent years has revolutionized the treatment of several sight-threatening retinal disorders. Emerging evidence has demonstrated that anti-VEGF treatment can offer advantages in the management of other ocular conditions where VEGFs play a key role: ocular scarring following glaucoma filtering surgery and neovascular glaucoma (NVG)...
May 19, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29769433/medical-imaging-dose-optimization-from-ground-up-expert-opinion-of-an-international-summit
#2
Ehsan Samei, Hannu Jarvinen, Mika Kortesniemi, Georgios Simantirakis, Charles Goh, Anthony Wallace, Eliseo Vano, Adrian Bejan, M M Rehani, J Vassileva
As in any medical intervention, there is either a known or an anticipated benefit to the patient from undergoing a medical imaging procedure. This benefit is generally significant as demonstrated by the manner in which medical imaging has transformed clinical medicine. At the same time, when it comes to imaging that deploys ionizing radiation, there is a potential associated risk from radiation. Radiation risk has been recognized as a key liability in the practice of medical imaging, creating a motivation for radiation dose optimization...
May 17, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29768934/a-safety-profile-of-medications-used-to-treat-waldenstr%C3%A3-m-s-macroglobulinemia
#3
Ramón García-Sanz, Cristina Jiménez, Verónica González de la Calle, María Eugenia Sarasquete
Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disease with serum IgM monoclonal component and bone marrow infiltration by lymphoplasmacytic lymphoma. Traditional therapy was based on that regimens used for closely related entities, such as chronic lymphocytic leukemia or multiple myeloma. This resulted in a lack of drugs specifically approved for WM, until the discovery of the BTK inhibitors. Areas covered. Two main therapeutic attitudes are possible: 1) conventional therapies based on combinations with alkylating agents or proteasome inhibitors with steroids and anti-CD20 monoclonal antibodies, or; 2) new approaches with BTK inhibitors, usually alone...
May 17, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29767543/efficacy-of-single-tablet-darunavir-cobicistat-emtricitabine-and-tenofovir-alafenamide-in-the-treatment-of-hiv-1
#4
Eugènia Negredo, Bonaventura Clotet
HIV eradication is not feasible and lifelong treatment is warranted to manage HIV infection. In this scenario, the advent of single-tablet, once-daily, fixed-dose co-formulations is important for reducing pill burden and maximize long-term drug adherence. Cobicistat-boosted darunavir along with emtricitabine and tenofovir alafenamide co-formulation (DRV/c/FTC/TAF or the trade name Symtuza®) is the first marketed protease inhibitor-based fixed-dose combination regimen for the treatment of HIV infection. It was approved in late 2017 by the European Medical Agency both for naïve patients and treatment-experienced patients with viral suppression...
May 16, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29750166/statistical-validation-for-clinical-measures-repeatability-and-agreement-of-kinect%C3%A2-based-software
#5
Natalia Lopez, Elisa Perez, Emanuel Tello, Alejandro Rodrigo, Max E Valentinuzzi
Background: The rehabilitation process is a fundamental stage for recovery of people's capabilities. However, the evaluation of the process is performed by physiatrists and medical doctors, mostly based on their observations, that is, a subjective appreciation of the patient's evolution. This paper proposes a tracking platform of the movement made by an individual's upper limb using Kinect sensor(s) to be applied for the patient during the rehabilitation process. The main contribution is the development of quantifying software and the statistical validation of its performance, repeatability, and clinical use in the rehabilitation process...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29743842/a-simple-phenotypic-classification-for-celiac-disease
#6
Ajit Sood, Vandana Midha, Govind Makharia, B K Thelma, Shivalingappa S Halli, Varun Mehta, Ramit Mahajan, Vikram Narang, Kriti Sood, Kirandeep Kaur
Background/Aims: Celiac disease is a global health problem. The presentation of celiac disease has unfolded over years and it is now known that it can manifest at different ages, has varied presentations, and is prone to develop complications, if not managed properly. Although the Oslo definitions provide consensus on the various terminologies used in literature, there is no phenotypic classification providing a composite diagnosis for the disease. Methods: Various variables identified for phenotypic classification included age at diagnosis, age at onset of symptoms, clinical presentation, family history and complications...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29743831/evidence-based-consensus-on-opportunistic-infections-in-inflammatory-bowel-disease-republication
#7
REVIEW
(no author information available yet)
Inflammatory bowel disease (IBD) patients are a high-risk population for opportunistic infections. The IBD group of the Chinese Society of Gastroenterology of the Chinese Medical Association organized an expert group to discuss and develop this consensus opinion. This consensus opinion referenced clinical study results from China and other countries to provide guidance for clinical practices. Eight major topics, including cytomegalovirus infection, Epstein-Barr virus infection, viral hepatitis, bacterial infection, Mycobacterium tuberculosis infection, fungal infection, parasitic infection, and vaccines were introduced in this article...
April 2018: Intestinal Research
https://www.readbyqxmd.com/read/29741108/the-safety-of-indacaterol-for-the-treatment-of-copd
#8
Evgenios I Metaxas, Evangelos Balis
Bronchodilators, namely long-acting inhaled β2-agonists and long-acting muscarinic antagonists, are the first-line medications for chronic obstructive pulmonary disease (COPD). The safety of these medicines is of great concern since COPD patients usually have other co-morbidities such as cardio- and cerebrovascular diseases. Areas covered: In this review we present information about the safety and the use of indacaterol in COPD. Indacaterol is the first once-daily, long-acting inhaled β2-agonist approved for COPD...
May 9, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29740754/a-practical-guide-on-how-to-handle-patients-with-bleeding-events-while-on-oral-antithrombotic-treatment
#9
REVIEW
M E Gimbel, S C S Minderhoud, J M Ten Berg
Bleeding is a feared complication in patients who are treated with antithrombotic therapy (oral anticoagulation or antiplatelet therapy). Management of antithrombotic therapy after bleeding poses a dilemma where restarting the crucial medication could lead to recurrent bleeding, while interrupting or even discontinuing treatment could increase the thrombotic risk. In this review, we provide recommendations regarding the treatment of patients with a bleeding event while on oral antithrombotic therapy, based on the literature and expert opinion...
May 8, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29732946/prehospital-trauma-care-among-68-european-neurotrauma-centers-results-of-the-center-tbi-provider-profiling-questionnaires
#10
Maryse C Cnossen, Ruben van den Brande, Hester Lingsma, Suzanne Polinder, Fiona Lecky, Andrew Maas
The first hour following traumatic brain injury (TBI) is considered crucial to prevent death and disability. It is however not established yet how the prehospital care should be organized to optimize recovery during the first hour. The objective of the current study was to examine variation in prehospital trauma care across Europe aiming to inform comparative effectiveness analyses on care for neurotrauma patients. A survey on prehospital trauma care was sent to 68 neurotrauma centers from 20 European countries participating in the CENTER-TBI study...
May 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29726758/pharmacotherapy-for-the-treatment-of-depression-in-patients-with-alzheimer-s-disease-a-treatment-resistant-depressive-disorder
#11
Madia Lozupone, Maddalena La Montagna, Francesca D'Urso, Carla Piccininni, Rodolfo Sardone, Vittorio Dibello, Gianluigi Giannelli, Vincenzo Solfrizzi, Antonio Greco, Antonio Daniele, Nicola Quaranta, Davide Seripa, Antonello Bellomo, Giancarlo Logroscino, Francesco Panza
Pharmacotherapy for the treatment of depressive disorders in Alzheimer's Disease (AD) represents a clinical challenge. pharmacological options are often attempted after a period of watchful waiting (8-12 weeks). monoaminergic antidepressant drugs have shown only modest or null clinical benefits, maybe because the etiology of depressive symptoms in ad patients is fundamentally different from that of nondemented subjects. Areas covered: The following article looks at the selective serotonin reuptake inhibitor sertraline, which is one of the most frequently studied antidepressant medications in randomized controlled trials (RCTs)...
May 4, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29724430/acr-appropriateness-criteria-%C3%A2-hematuria-child
#12
Jonathan R Dillman, Cynthia K Rigsby, Ramesh S Iyer, Adina L Alazraki, Sudha A Anupindi, Brandon P Brown, Sherwin S Chan, Scott R Dorfman, Richard A Falcone, Matthew D Garber, Jie C Nguyen, Craig A Peters, Nabile M Safdar, Andrew T Trout, Boaz K Karmazyn
Hematuria is the presence of red blood cells in the urine, either visible to the eye (macroscopic hematuria) or as viewed under the microscope (microscopic hematuria). The clinical evaluation of children and adolescents with any form of hematuria begins with a meticulous history and thorough evaluation of the urine. The need for imaging evaluation depends on the clinical scenario in which hematuria presents, including the suspected etiology. Ultrasound and CT are the most common imaging methods used to assess hematuria in children, although other imaging modalities may be appropriate in certain instances...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724429/acr-appropriateness-criteria-%C3%A2-headache-child
#13
Laura L Hayes, Susan Palasis, Twyla B Bartel, Timothy N Booth, Ramesh S Iyer, Jeremy Y Jones, Nadja Kadom, Sarah S Milla, John S Myseros, Ann Pakalnis, Sonia Partap, Richard L Robertson, Maura E Ryan, Gaurav Saigal, Bruno P Soares, Aylin Tekes, Boaz K Karmazyn
Headaches in children are not uncommon and have various causes. Proper neuroimaging of these children is very specific to the headache type. Care must be taken to choose and perform the most appropriate initial imaging examination in order to maximize the ability to properly determine the cause with minimum risk to the child. This evidence-based report discusses the different headache types in children and provides appropriate guidelines for imaging these children. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724428/acr-appropriateness-criteria-%C3%A2-first-trimester-vaginal-bleeding
#14
Douglas L Brown, Ann Packard, Katherine E Maturen, Sandeep Prakash Deshmukh, Kika M Dudiak, Tara L Henrichsen, Benjamin J Meyer, Liina Poder, Elizabeth A Sadowski, Thomas D Shipp, Lynn Simpson, Therese M Weber, Carolyn M Zelop, Phyllis Glanc
Vaginal bleeding is not uncommon in the first trimester of pregnancy. The majority of such patients will have a normal intrauterine pregnancy (IUP), a nonviable IUP, or an ectopic pregnancy. Ultrasound (US) is the primary imaging modality in evaluation of these patients. US, along with clinical observations and serum human chorionic gonadotropin levels, can usually distinguish these causes. Although it is important to diagnose ectopic pregnancies and nonviable IUPs, one should also guard against injury to normal pregnancies due to inappropriate treatment with methotrexate or surgical intervention...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724427/acr-appropriateness-criteria-%C3%A2-colorectal-cancer-screening
#15
Courtney Moreno, David H Kim, Twyla B Bartel, Brooks D Cash, Kevin J Chang, Barry W Feig, Kathryn J Fowler, Evelyn M Garcia, Avinash R Kambadakone, Drew L Lambert, Angela D Levy, Daniele Marin, Christine M Peterson, Christopher D Scheirey, Martin P Smith, Stefanie Weinstein, Laura R Carucci
This review summarizes the relevant literature regarding colorectal screening with imaging. For individuals at average or moderate risk for colorectal cancer, CT colonography is usually appropriate for colorectal cancer screening. After positive results on a fecal occult blood test or immunohistochemical test, CT colonography is usually appropriate for colorectal cancer detection. For individuals at high risk for colorectal cancer (eg, hereditary nonpolyposis colorectal cancer, ulcerative colitis, or Crohn colitis), optical colonoscopy is preferred because of its ability to obtain biopsies to detect dysplasia...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724426/acr-appropriateness-criteria-%C3%A2-chronic-wrist-pain
#16
David A Rubin, Catherine C Roberts, Jenny T Bencardino, Angela M Bell, R Carter Cassidy, Eric Y Chang, Soterios Gyftopoulos, Darlene F Metter, William B Morrison, Naveen Subhas, Siddharth Tambar, Jeffrey D Towers, Joseph S Yu, Mark J Kransdorf
Radiographs are indicated as the first imaging test in all patients with chronic wrist pain, regardless of the suspected diagnosis. When radiographs are normal or equivocal, advanced imaging with MRI (without or without intravenous contrast or following arthrography), CT (usually without contrast), and ultrasound each has a role in establishing a diagnosis. Furthermore, these examinations may contribute to staging disease, treatment planning, and prognostication, even when radiographs are diagnostic of a specific condition...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724425/acr-appropriateness-criteria-%C3%A2-chronic-ankle-pain
#17
Eric Y Chang, Anthony S Tadros, Behrang Amini, Angela M Bell, Stephanie A Bernard, Michael G Fox, Tetyana Gorbachova, Alice S Ha, Kenneth S Lee, Darlene F Metter, Pekka A Mooar, Nehal A Shah, Adam D Singer, Stacy E Smith, Mihra S Taljanovic, Ralf Thiele, Mark J Kransdorf
Chronic ankle pain is a common clinical problem whose cause is often elucidated by imaging. The ACR Appropriateness Criteria for chronic ankle pain define best practices of image ordering. Clinical scenarios are followed by the imaging choices and their appropriateness. The information is in ordered tables with an accompanying narrative explanation to guide physicians to order the right test. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724424/acr-appropriateness-criteria-%C3%A2-suspected-thoracic-aortic-aneurysm
#18
Shelby J Bennett, Karin E Dill, Michael Hanley, Osmanuddin Ahmed, Benoit Desjardins, Kenneth L Gage, Michael Ginsburg, Ali Khoynezhad, Isabel B Oliva, Michael L Steigner, Richard Strax, Nupur Verma, Frank J Rybicki
Although the incidence of thoracic aortic aneurysm is on the rise, initial imaging diagnosis can present a challenge for many clinicians. Providers are faced with many imaging choices as part of the initial workup. Considering level of invasiveness, relative radiation level, and quality of associated diagnostic data, CT angiography and MR angiography are believed to be the most appropriate options for radiological diagnosis of suspected thoracic aortic aneurysm. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724423/acr-appropriateness-criteria-%C3%A2-abdominal-aortic-aneurysm-interventional-planning-and-follow-up
#19
Christopher J Francois, Erik P Skulborstad, Bill S Majdalany, Ankur Chandra, Jeremy D Collins, Khashayar Farsad, Marie D Gerhard-Herman, Heather L Gornik, A Tuba Kendi, Minhajuddin S Khaja, Margaret H Lee, Patrick D Sutphin, Baljendra S Kapoor, Sanjeeva P Kalva
Abdominal aortic aneurysms (AAAs) are a relatively common vascular problem that can be treated with either open, surgical repair or endovascular aortic aneurysm repair (EVAR). Both approaches to AAA repair require dedicated preoperative imaging to minimize adverse outcomes. After EVAR, cross-sectional imaging has an integral role in confirming the successful treatment of the AAA and early detection of complications related to EVAR. CT angiography is the primary imaging modality for both preoperative planning and follow-up after repair...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724422/acr-appropriateness-criteria-%C3%A2-staging-and-follow-up-of-ovarian-cancer
#20
Stella K Kang, Caroline Reinhold, Mostafa Atri, Carol B Benson, Priyadarshani R Bhosale, Anuja Jhingran, Yulia Lakhman, Katherine E Maturen, Refky Nicola, Pari V Pandharipande, Gloria M Salazar, Thomas D Shipp, Lynn Simpson, William Small, Betsy L Sussman, Jennifer W Uyeda, Darci J Wall, Bradford P Whitcomb, Carolyn M Zelop, Phyllis Glanc
In the management of epithelial ovarian cancers, imaging is used for cancer detection and staging, both before and after initial treatment. The decision of whether to pursue initial cytoreductive surgery for ovarian cancer depends in part on accurate staging. Contrast-enhanced CT of the abdomen and pelvis (and chest where indicated) is the current imaging modality of choice for the initial staging evaluation of ovarian cancer. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT and MRI may be appropriate for problem-solving purposes, particularly when lesions are present on CT but considered indeterminate...
May 2018: Journal of the American College of Radiology: JACR
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