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https://www.readbyqxmd.com/read/27896942/mid-childhood-outcomes-of-infant-siblings-at-familial-high-risk-of-autism-spectrum-disorder
#1
Elizabeth Shephard, Bosiljka Milosavljevic, Greg Pasco, Emily J H Jones, Teodora Gliga, Francesca Happé, Mark H Johnson, Tony Charman
Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling with an ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-risk infants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age 7, high-risk children without ASD, and low-risk control children...
November 29, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27893232/narrative-production-in-children-with-autism-spectrum-disorder-asd-and-children-with-attention-deficit-hyperactivity-disorder-adhd-similarities-and-differences
#2
Sanne J M Kuijper, Catharina A Hartman, Suzanne T M Bogaerds-Hazenberg, Petra Hendriks
The present study focuses on the similarities and differences in language production between children with autism spectrum disorder (ASD) and children with attention-deficit/hyperactivity disorder (ADHD). In addition, we investigated whether Theory of Mind (ToM), working memory, and response inhibition are associated with language production. Narratives, produced by 106 Dutch-speaking children (36 with ASD, 34 with ADHD, and 36 typically developing) aged 6 to 12 during ADOS assessment, were examined on several linguistic measures: verbal productivity, speech fluency, syntactic complexity, lexical semantics, and discourse pragmatics...
November 28, 2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/27828696/current-and-investigational-medication-delivery-systems-for-treating-attention-deficit-hyperactivity-disorder
#3
Rakesh Jain, Alain Katic
OBJECTIVE: To review currently available formulations and emphasize unmet needs in the pharmacologic management of attention-deficit/hyperactivity disorder (ADHD). DATA SOURCES: Publications and clinical trials were identified through PubMed and ClinicalTrials.gov, respectively. A Web-based search identified prescribing information for approved agents for treating ADHD, along with relevant guidelines and diagnostic criteria. STUDY SELECTION: The following search terms were used: (1) ADHD or attention-deficit/hyperactivity disorder or ADD or attention deficit hyperactivity disorder and/or (2) amphetamine or methylphenidate or atomoxetine or guanfacine or clonidine...
August 18, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27821161/relationship-between-early-language-skills-and-the-development-of-inattention-hyperactivity-symptoms-during-the-preschool-period-results-of-the-eden-mother-child-cohort
#4
Hugo Peyre, Cedric Galera, Judith van der Waerden, Nicolas Hoertel, Jonathan Y Bernard, Maria Melchior, Franck Ramus
BACKGROUND: This study aims to examine bidirectional relationships between children's language skills and Inattention/Hyperactivity (IH) symptoms during preschool. METHOD: Children (N = 1459) from the EDEN mother-child cohort were assessed at ages 3 and 5.5 years. Language skills were evaluated using the WPPSI-III, NEPSY and ELOLA batteries. Children's behavior, including IH symptoms, was assessed using the parent-rated Strengths & Difficulties Questionnaire (SDQ)...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27818011/human-grin2b-variants-in-neurodevelopmental-disorders
#5
REVIEW
Chun Hu, Wenjuan Chen, Scott J Myers, Hongjie Yuan, Stephen F Traynelis
The development of whole exome/genome sequencing technologies has given rise to an unprecedented volume of data linking patient genomic variability to brain disorder phenotypes. A surprising number of variants have been found in the N-methyl-d-aspartate receptor (NMDAR) gene family, with the GRIN2B gene encoding the GluN2B subunit being implicated in many cases of neurodevelopmental disorders, which are psychiatric conditions originating in childhood and include language, motor, and learning disorders, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), developmental delay, epilepsy, and schizophrenia...
October 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27806167/association-of-genetic-risk-variants-with-attention-deficit-hyperactivity-disorder-trajectories-in-the-general-population
#6
Lucy Riglin, Stephan Collishaw, Ajay K Thapar, Søren Dalsgaard, Kate Langley, George Davey Smith, Evie Stergiakouli, Barbara Maughan, Michael C O'Donovan, Anita Thapar
Importance: Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder that shows clinical and genetic overlap with other childhood neurodevelopmental disorders. Levels of ADHD symptoms typically decline across childhood and adolescence, although they remain elevated for some individuals. The determinants of symptom persistence and decline are not yet fully understood. Objectives: To test the hypothesis that genetic risk variant load for ADHD (indexed by polygenic risk scores [PRS]), but not for other psychiatric disorders, is associated with population-based ADHD symptom trajectories across childhood and adolescence, and to examine whether higher genetic liability for ADHD is correlated with total number of additional neurodevelopmental disorders (multimorbidity) in childhood...
December 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27801620/preschool-self-regulation-predicts-later-mental-health-and-educational-achievement-in-very-preterm-and-typically-developing-children
#7
Lianne J Woodward, Zhigang Lu, Alyssa R Morris, Dione M Healey
OBJECTIVE: To examine the extent to which preschool emotional and behavioral regulatory difficulties were associated with an increased risk of later mental health and educational problems. Of particular interest was whether early regulatory abilities contributed to later risk once baseline child behavioral adjustment and cognitive function were taken into account. METHOD: Data were drawn from a prospective longitudinal study of 223 children born very preterm (VPT; <32 weeks gestation, n = 110) and full term (37-40 weeks gestation)...
November 1, 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27797585/beneficial-effects-of-everolimus-on-autism-and-attention-deficit-hyperactivity-disorder-symptoms-in-a-group-of-patients-with-tuberous-sclerosis-complex
#8
Ayse Kilincaslan, Burcu Ece Kok, Pinar Tekturk, Cengiz Yalcinkaya, Cigdem Ozkara, Zuhal Yapici
OBJECTIVES: Such neuropsychiatric symptoms as autism spectrum disorders, attention-deficit/hyperactivity disorder (ADHD), intellectual disability, aggression, and epilepsy are very common in patients with tuberous sclerosis complex (TSC). Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, is a recent and effective treatment for TSC patients with giant cell astrocytomas and renal angiomyolipoma, and it has been shown to have a potential to reduce tumor volume. However, there is a paucity of studies on the effects of everolimus on neuropsychiatric symptoms...
October 31, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27785593/communication-deficits-and-the-motor-system-exploring-patterns-of-associations-in-autism-spectrum-disorder-asd
#9
M Mody, A M Shui, L A Nowinski, S B Golas, C Ferrone, J A O'Rourke, C J McDougle
Many children with autism spectrum disorder (ASD) have notable difficulties in motor, speech and language domains. The connection between motor skills (oral-motor, manual-motor) and speech and language deficits reported in other developmental disorders raises important questions about a potential relationship between motor skills and speech-language deficits in ASD. To this end, we examined data from children with ASD (n = 1781), 2-17 years of age, enrolled in the Autism Speaks-Autism Treatment Network (AS-ATN) registry who completed a multidisciplinary evaluation that included diagnostic, physical, cognitive and behavioral assessments as part of a routine standard of care protocol...
October 26, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27775648/language-problems-and-adhd-symptoms-how-specific-are-the-links
#10
Erin Hawkins, Susan Gathercole, Duncan Astle, The Calm Team, Joni Holmes
Symptoms of inattention and hyperactivity frequently co-occur with language difficulties in both clinical and community samples. We explore the specificity and strength of these associations in a heterogeneous sample of 254 children aged 5 to 15 years identified by education and health professionals as having problems with attention, learning and/or memory. Parents/carers rated pragmatic and structural communication skills and behaviour, and children completed standardised assessments of reading, spelling, vocabulary, and phonological awareness...
October 21, 2016: Brain Sciences
https://www.readbyqxmd.com/read/27677260/gnb5-mutation-causes-a-novel-neuropsychiatric-disorder-featuring-attention-deficit-hyperactivity-disorder-severely-impaired-language-development-and-normal-cognition
#11
Hanan E Shamseldin, Ikuo Masuho, Ahmed Alenizi, Suad Alyamani, Dipak N Patil, Niema Ibrahim, Kirill A Martemyanov, Fowzan S Alkuraya
BACKGROUND: Neuropsychiatric disorders are common forms of disability in humans. Despite recent progress in deciphering the genetics of these disorders, their phenotypic complexity continues to be a major challenge. Mendelian neuropsychiatric disorders are rare but their study has the potential to unravel novel mechanisms that are relevant to their complex counterparts. RESULTS: In an extended consanguineous family, we identified a novel neuropsychiatric phenotype characterized by severe speech impairment, variable expressivity of attention deficit hyperactivity disorder (ADHD), and motor delay...
September 27, 2016: Genome Biology
https://www.readbyqxmd.com/read/27651829/a-boy-with-conduct-disorder-cd-attention-deficit-hyperactivity-disorder-adhd-borderline-intellectual-disability-and-47-xxy-syndrome-in-combination-with-a-7q11-23-duplication-11p15-5-deletion-and-20q13-33-deletion
#12
Gerasimos Kolaitis, Christian G Bouwkamp, Alexia Papakonstantinou, Ioanna Otheiti, Maria Belivanaki, Styliani Haritaki, Terpsihori Korpa, Zinovia Albani, Elena Terzioglou, Polyxeni Apostola, Aggeliki Skamnaki, Athena Xaidara, Konstantina Kosma, Sophia Kitsiou-Tzeli, Maria Tzetis
BACKGROUND: This is a case with multiple chromosomal aberrations which are likely etiological for the observed psychiatric phenotype consisting of attention deficit hyperactivity and conduct disorders. CASE PRESENTATION: We report on an 11 year-old boy, admitted to the pediatric hospital for behavioral difficulties and a delayed neurodevelopmental trajectory. A cytogenetic analysis and high-resolution microarray comparative genomic hybridization (CGH) analysis was performed...
2016: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/27617154/the-7q11-23-microduplication-syndrome-a-clinical-report-with-review-of-literature
#13
REVIEW
Elham Abbas, Devin M Cox, Teri Smith, Merlin G Butler
We report a 14-year-old adolescent girl with selective mutism (SM) and a 7q11.23 microduplication detected by chromosomal microarray (CMA) analysis and reviewed the literature from 18 published clinical reports. Our patient had specific phobias, SM, extreme anxiety, obesity, cutis marmorata, and a round appearing face with a short neck and over folded ears. We reviewed the published clinical, cognitive, behavioral, and cytogenetic findings grouped by speech and language delay, growth and development, craniofacial, clinical, and behavior and cognitive features due to the 7q11...
September 2016: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/27599397/attention-and-executive-functioning-profiles-in-children-following-perinatal-arterial-ischemic-stroke
#14
Danielle D Bosenbark, Lauren Krivitzky, Rebecca Ichord, Laura Jastrzab, Lori Billinghurst
Perinatal arterial ischemic stroke (PAIS) is a form of childhood stroke; the majority of those affected experience neurologic sequelae, including motor, language and neurocognitive impairments. This study examines the attention and executive functioning (EF) profiles of children following PAIS, as well as the impact of age and sex. In this single-center cross-sectional study, 40 children aged 3 to 16 years (median age 7.2 years; 58% male) who have suffered a PAIS underwent a comprehensive neuropsychological battery to assess attention and EF...
September 7, 2016: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/27569542/functional-decoding-and-meta-analytic-connectivity-modeling-in-adult-attention-deficit-hyperactivity-disorder
#15
Samuele Cortese, F Xavier Castellanos, Claudia R Eickhoff, Giulia D'Acunto, Gabriele Masi, Peter T Fox, Angela R Laird, Simon B Eickhoff
BACKGROUND: Task-based functional magnetic resonance imaging (fMRI) studies of adult attention-deficit/hyperactivity disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. METHODS: We first conducted an activation likelihood estimation meta-analysis of 24 task-based fMRI studies in adults with ADHD...
December 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27538964/ratings-of-broader-autism-phenotype-and-personality-traits-in-optimal-outcomes-from-autism-spectrum-disorder
#16
Joyce Suh, Alyssa Orinstein, Marianne Barton, Chi-Ming Chen, Inge-Marie Eigsti, Nairan Ramirez-Esparza, Deborah Fein
The study examines whether "optimal outcome" (OO) children, despite no longer meeting diagnostic criteria for Autism Spectrum Disorder (ASD), exhibit personality traits often found in those with ASD. Nine zero acquaintance raters evaluated Broader Autism Phenotype (BAP) and Big Five personality traits of 22 OO individuals, 27 high functioning individuals with ASD (HFA), and 23 typically developing (TD) peers. HFA children displayed higher ratings than their peers on all BAP traits. OO were indistinguishable from TD, with the exception of greater extraversion (e...
November 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27519964/somatic-and-neuropsychiatric-comorbidities-in-pediatric-restless-legs-syndrome-a-systematic-review-of-the-literature
#17
Marco Angriman, Samuele Cortese, Oliviero Bruni
Restless legs syndrome (RLS) is a relatively common neurological disorder in childhood, although it is usually overlooked due to the atypical presentation in children and associated comorbid conditions that may affect its clinical presentation. Here, we aimed to perform, for the first time, a systematic review of studies reporting the association between RLS in children and adolescents (<18 y) and somatic or neuropsychiatric conditions. We searched for peer-reviewed studies in PubMed, Ovid (including PsycINFO, Ovid MEDLINE(®), and Embase), Web of Knowledge (Web of Science, Biological abstracts, BIOSIS, FSTA) through November 2015, with no language restrictions...
July 1, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27471442/neural-biomarkers-for-dyslexia-adhd-and-add-in-the-auditory-cortex-of-children
#18
Bettina Serrallach, Christine Groß, Valdis Bernhofs, Dorte Engelmann, Jan Benner, Nadine Gündert, Maria Blatow, Martina Wengenroth, Angelika Seitz, Monika Brunner, Stefan Seither, Richard Parncutt, Peter Schneider, Annemarie Seither-Preisler
Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N = 147) using neuroimaging, magnetencephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10-40 ms) of the primary auditory evoked P1-response...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27424260/the-influence-of-maternal-dietary-exposure-to-dioxins-and-pcbs-during-pregnancy-on-adhd-symptoms-and-cognitive-functions-in-norwegian-preschool-children
#19
Ida Henriette Caspersen, Heidi Aase, Guido Biele, Anne Lise Brantsæter, Margaretha Haugen, Helen Engelstad Kvalem, Annette Holth Skogan, Pål Zeiner, Jan Alexander, Helle Margrete Meltzer, Helle K Knutsen
BACKGROUND: Polychlorinated dibenzo-p-dioxins/dibenzofurans (dioxins) and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) with potentially adverse impact on child neurodevelopment. Whether the potential detrimental effects of dioxins and PCBs on neurodevelopment are of specific or unspecific character is not clear. OBJECTIVES: The purpose of the current study was to examine the influence of maternal dietary exposure to dioxins and PCBs on ADHD symptoms and cognitive functioning in preschoolers...
September 2016: Environment International
https://www.readbyqxmd.com/read/27416629/-potential-effects-of-screen-media-on-cognitive-development-among-children-under-3-years-old-review-of-literature
#20
REVIEW
Inga Brzozowska, Iwona Sikorska
The literature review regarding potential effects of screen media on cognitive development among children under 3 years old, is presented. In this article, cognitive aspects of development include acquisition of language, attention, learning and later school performance. The constant increase of children's access to television is noted, indicating that 60% of infants and toddlers watch TV regularly for 1-2 hours per day. The review included 40 articles and book chapters of significant such as Anderson, Barr, Christakis, Zimmerman, Meltzoff, Courage, Setliff, Troseth...
January 2016: Developmental Period Medicine
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