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Adhd tdcs

Lirong Tan, Xinyu Guo, Sheng Ren, Jeff N Epstein, Long J Lu
In this paper, we investigated the problem of computer-aided diagnosis of Attention Deficit Hyperactivity Disorder (ADHD) using machine learning techniques. With the ADHD-200 dataset, we developed a Support Vector Machine (SVM) model to classify ADHD patients from typically developing controls (TDCs), using the regional brain volumes as predictors. Conventionally, the volume of a brain region was considered to be an anatomical feature and quantified using structural magnetic resonance images. One major contribution of the present study was that we had initially proposed to measure the regional brain volumes using fMRI images...
2017: Frontiers in Computational Neuroscience
Vahid Nejati, Mohammad Ali Salehinejad, Michael A Nitsche, Asal Najian, Amir-Homayoun Javadi
OBJECTIVE: This study examined effects of transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) and orbitofrontal cortex (OFC) on major executive functions (EFs), including response inhibition, executive control, working memory (WM), and cognitive flexibility/task switching in ADHD. METHOD: ADHD children received (a) left anodal/right cathodal DLPFC tDCS and (b) sham stimulation in Experiment 1 and (a) left anodal DLPFC/right cathodal OFC tDCS, (b) left cathodal DLPFC/right anodal OFC tDCS, and (c) sham stimulation in Experiment 2...
September 1, 2017: Journal of Attention Disorders
Sunghyon Kyeong, Jae-Jin Kim, Eunjoo Kim
Attention-deficit/hyperactivity disorder (ADHD) is a clinically heterogeneous condition and identification of clinically meaningful subgroups would open up a new window for personalized medicine. Thus, we aimed to identify new clinical phenotypes in children and adolescents with ADHD and to investigate whether neuroimaging findings validate the identified phenotypes. Neuroimaging and clinical data from 67 children with ADHD and 62 typically developing controls (TDCs) from the ADHD-200 database were selected...
2017: PloS One
Anna Sotnikova, Cornelia Soff, Enzo Tagliazucchi, Katja Becker, Michael Siniatchkin
Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has been repeatedly shown to improve working memory (WM). Since patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in WM, the modulation of prefrontal activity with tDCS in ADHD patients may increase their WM performance as well as improve the activation and connectivity of the WM network. In the present study, this hypothesis was tested using a double-blind sham-controlled experimental design...
February 17, 2017: Brain Topography
Carolina Tosetto Cachoeira, Douglas Teixeira Leffa, Suzana Doneda Mittelstadt, Lorenna Sena Teixeira Mendes, Andre R Brunoni, Jairo Vinicius Pinto, Vítor Blazius, Vitoria Machado, Claiton Henrique Dotto Bau, Luis Augusto Rohde, Eugenio Horacio Grevet, Pedro Schestatsky
Almost 30% of adult patients with attention-deficit/hyperactivity disorder (ADHD) do not respond or tolerate standard pharmacological interventions. Few clinical investigations addressed the efficacy and tolerability of transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, in the disorder. We performed a double-blind, sham-controlled randomized clinical trial in 17 patients with ADHD. The set up for tDCS was the following: 2mA/20min/day for 5 days with the anode over the right dorsolateral prefrontal cortex and cathode over the left dorsolateral prefrontal cortex...
January 2017: Psychiatry Research
Cornelia Soff, Anna Sotnikova, Hanna Christiansen, Katja Becker, Michael Siniatchkin
Anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex has repeatedly been shown to improve working memory. As patients with attention deficit hyperactivity disorder (ADHD) are characterized by both underactivation of the prefrontal cortex and deficits in working memory that correlate with clinical symptoms, it is hypothesized that the modulation of prefrontal activity with tDCS in patients with ADHD increases performance in working memory and reduces symptoms of ADHD. To test this hypothesis, fifteen adolescents with ADHD (12-16 years old, three girls and 12 boys) were treated according to the randomized, double-blinded, sham-controlled, crossover design with either 1 mA anodal tDCS over the left dorsolateral prefrontal cortex or with the sham protocol 5 days each with a 2 weeks pause between these conditions...
January 2017: Journal of Neural Transmission
L Brandejsky, J-A Micoulaud Franchi, R Lopez, S Bioulac, D Da Fonseca, C Daudet, L Boyer, R Richieri, C Lançon
OBJECTIVES: The aim of this review is to summarize the available data in the literature about the therapeutic applications of transcranial magnetic stimulation and transcranial direct current stimulation in attention-deficit hyperactivity disorder (ADHD). METHOD: The scientific literature search of international articles was performed in February 2016 using the PubMed electronic database. The following MeSH terms were employed: "attention-deficit disorder with hyperactivity" AND "transcranial magnetic stimulation", "attention-deficit disorder with hyperactivity" AND "transcranial direct current stimulation"...
October 2017: L'Encéphale
Carolin Breitling, Tino Zaehle, Moritz Dannhauer, Björn Bonath, Jana Tegelbeckers, Hans-Henning Flechtner, Kerstin Krauel
The use of transcranial direct current stimulation (tDCS) in patients with attention deficit hyperactivity disorder (ADHD) has been suggested as a promising alternative to psychopharmacological treatment approaches due to its local and network effects on brain activation. In the current study, we investigated the impact of tDCS over the right inferior frontal gyrus (rIFG) on interference control in 21 male adolescents with ADHD and 21 age matched healthy controls aged 13-17 years, who underwent three separate sessions of tDCS (anodal, cathodal, and sham) while completing a Flanker task...
2016: Frontiers in Cellular Neuroscience
Débora Muszkat, Guilherme Vanoni Polanczyk, Taciana G Costa Dias, André Russowsky Brunoni
OBJECTIVES: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that consists of applying a weak electric current over the scalp to modulate cortical excitability. tDCS has been extensively investigated in adults with psychiatric disorders. The aim of this study was to review the current literature regarding the use of tDCS in children and adolescents with psychiatric disorders. METHODS: We searched MEDLINE and EMBASE databases for studies evaluating the safety and efficacy of tDCS in children and adolescents from age 0 to 18 years with psychiatric disorders...
September 2016: Journal of Child and Adolescent Psychopharmacology
Douglas Teixeira Leffa, Andressa de Souza, Vanessa Leal Scarabelot, Liciane Fernandes Medeiros, Carla de Oliveira, Eugenio Horacio Grevet, Wolnei Caumo, Diogo Onofre de Souza, Luis Augusto Paim Rohde, Iraci L S Torres
Attention deficit hyperactivity disorder (ADHD) is characterized by impairing levels of hyperactivity, impulsivity and inattention. However, different meta-analyses have reported disruptions in short and long-term memory in ADHD patients. Previous studies indicate that mnemonic dysfunctions might be the result of deficits in attentional circuits, probably due to ineffective dopaminergic modulation of hippocampal synaptic plasticity. In this study we aimed to evaluate the potential therapeutic effects of a neuromodulatory technique, transcranial direct current stimulation (tDCS), in short-term memory (STM) deficits presented by the spontaneous hypertensive rats (SHR), the most widely used animal model of ADHD...
February 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Zahra Soltaninejad, Vahid Nejati, Hamed Ekhtiari
OBJECTIVE: The purpose of this study was to improve the inhibitory control functions through transcranial direct current stimulation (tDCS) in adolescents with ADHD symptoms. METHOD: Twenty high school students with ADHD symptoms participated in this single-blinded, crossover, sham-controlled study. All the participants were tested during the application of Stroop and Go/No-Go tasks that is used to measure inhibitory control, using 1.5 mA of tDCS for 15 min over the left dorsolateral prefrontal cortex (DLPFC)...
December 20, 2015: Journal of Attention Disorders
Camila Cosmo, Cândida Ferreira, José Garcia Vivas Miranda, Raphael Silva do Rosário, Abrahão Fontes Baptista, Pedro Montoya, Eduardo Pondé de Sena
BACKGROUND: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attention-deficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated...
2015: Frontiers in Psychiatry
Camila Cosmo, Abrahão Fontes Baptista, Arão Nogueira de Araújo, Raphael Silva do Rosário, José Garcia Vivas Miranda, Pedro Montoya, Eduardo Pondé de Sena
BACKGROUND: Current standardized treatments for cognitive impairment in attention-deficit/hyperactivity disorder remain limited and their efficacy restricted. Transcranial direct current stimulation (tDCS) is a promising tool for enhancing cognitive performance in several neuropsychiatric disorders. Nevertheless, the effects of tDCS in reducing cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD) have not yet been investigated. METHODS: A parallel, randomized, double-blind, sham-controlled trial was conducted to examine the efficacy of tDCS on the modulation of inhibitory control in adults with ADHD...
2015: PloS One
Camila Cosmo, Abrahão Fontes Baptista, Eduardo Pondé de Sena
BACKGROUND: The applicability of transcranial direct current stimulation (tDCS) in individuals with attention deficit hyperactivity disorder (ADHD) has not yet been investigated. This low-cost, non-invasive, and safe technique optimized to modulate the inhibitory response might be a useful treatment option for those affected by this condition. OBJECTIVE: The aim of this single center, parallel, randomized, double-blinded, sham-controlled trial is to investigate the efficacy of transcranial direct current stimulation over the prefrontal cortex on the modulation of inhibitory control in adults with attention deficit hyperactivity disorder...
May 18, 2015: JMIR Research Protocols
Leigh E Charvet, Margaret Kasschau, Abhishek Datta, Helena Knotkova, Michael C Stevens, Angelo Alonzo, Colleen Loo, Kevin R Krull, Marom Bikson
The effect of transcranial direct current stimulation (tDCS) is cumulative. Treatment protocols typically require multiple consecutive sessions spanning weeks or months. However, traveling to clinic for a tDCS session can present an obstacle to subjects and their caregivers. With modified devices and headgear, tDCS treatment can be administered remotely under clinical supervision, potentially enhancing recruitment, throughput, and convenience. Here we propose standards and protocols for clinical trials utilizing remotely-supervised tDCS with the goal of providing safe, reproducible and well-tolerated stimulation therapy outside of the clinic...
2015: Frontiers in Systems Neuroscience
Benjamin E Yerys, Lauren Kenworthy, Kathryn F Jankowski, John Strang, Gregory L Wallace
OBJECTIVE: The present investigation examined whether higher functioning children with autism would demonstrate impaired response inhibition performance in an emotional go/no-go task, and whether severity of attention-deficit/hyperactivity disorder (ADHD) or autism symptoms correlated with performance. METHOD: Forty-four children (21 meeting criteria for autism; 23 typically developing controls [TDCs]) completed an emotional go/no-go task in which an emotional facial expression (angry, fearful, happy, or sad) was the go stimulus and a neutral facial expression was the no-go stimulus, and vice versa...
September 2013: Neuropsychology
Karen E Seymour, Matthew F Pescosolido, Brooke L Reidy, Thania Galvan, Kerri L Kim, Matthew Young, Daniel P Dickstein
OBJECTIVE: Bipolar disorder (BD) and attention-deficit/hyperactivity disorder (ADHD) are often comorbid or confounded; therefore, we evaluated emotional face identification to better understand brain/behavior interactions in children and adolescents with either primary BD, primary ADHD, or typically developing controls (TDC). METHOD: Participants included individuals 7 to 17 years of age (overall sample mean age 12.40 ± 3.01 years), with "narrow-phenotype" pediatric BD (n = 30) or ADHD (n = 38), or typically developing controls (TDC) with no psychiatric disorders themselves or in their first-degree relatives (n = 41)...
May 2013: Journal of the American Academy of Child and Adolescent Psychiatry
Asli Demirtas-Tatlidede, Andrew M Vahabzadeh-Hagh, Alvaro Pascual-Leone
Cognitive impairment is a core symptom of many neuropsychiatric diseases and a key contributor to the patient's quality of life. However, an effective therapeutic strategy has yet to be developed. Noninvasive brain stimulation techniques, namely transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), are promising techniques that are under investigation for a variety of otherwise treatment-resistant neuropsychiatric diseases. Notably, these tools can induce alterations in neural networks subserving cognitive operations and thus may provide a means for cognitive restoration...
January 2013: Neuropharmacology
Thomas Ditye, Liron Jacobson, Vincent Walsh, Michal Lavidor
Cognitive training is an effective tool to improve a variety of cognitive functions, and a small number of studies have now shown that brain stimulation accompanying these training protocols can enhance their effects. In the domain of behavioral inhibition, little is known about how training can affect this skill. As for transcranial direct current stimulation (tDCS), it was previously found that stimulation over the right inferior frontal gyrus (rIFG) facilitates behavioral inhibition performance and modulates its electrophysiological correlates...
June 2012: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Liron Jacobson, Adi Ezra, Uri Berger, Michal Lavidor
OBJECTIVE: Studies have mainly documented behavioral changes induced by transcranial direct current stimulation (tDCS), but recently cortical modulations of tDCS have also been investigated. Our previous work revealed behavioral inhibition modulation by anodal tDCS over the right inferior frontal gyrus (rIFG); however, the electrophysiological correlates underlying this stimulation montage have yet to be established. The current work aimed to evaluate the distribution of neuronal oscillations changes following anodal tDCS over rIFG coupled with cathodal tDCS over left orbitofrontal cortex (lOFC) using spectral power analysis...
May 2012: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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