Coco Newton, Marianna Pope, Catarina Rua, Richard Henson, Zilong Ji, Neil Burgess, Christopher T Rodgers, Matthias Stangl, Maria-Eleni Dounavi, Andrea Castegnaro, Ivan Koychev, Paresh Malhotra, Thomas Wolbers, Karen Ritchie, Craig W Ritchie, John O'Brien, Li Su, Dennis Chan
INTRODUCTION: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)-based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD. METHODS: We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors...
February 29, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association