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https://www.readbyqxmd.com/read/29455181/a-child-with-tubulointerstitial-nephritis-and-uveitis-tinu-syndrome
#1
Cátia Pereira, Patrícia Costa-Reis, José Esteves da Silva, Rosário Stone
Tubulointerstitial nephritis and uveitis syndrome is an uncommon disease, probably underdiagnosed in clinical practice. Its aetiology and pathogenesis remain unknown. This syndrome is defined by an association of uveitis and tubulointerstitial nephritis, with no evidence of systemic disease or infection that might cause both ocular and renal inflammation. Renal and ocular manifestations may not occur simultaneously, making the diagnosis even more challenging. Treatment includes topical and oral corticosteroids...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29454539/quantification-of-the-risk-of-urinary-calcium-stone-formation-in-the-urine-collected-at-2-times-of-the-day-in-a-group-of-children-studied-to-rule-out-prelithiasis
#2
Víctor M García Nieto, Xochitl Illian Pérez Bastida, María Salvador Cañibano, Victoria E García Rodríguez, Margarita Monge Zamorano, María Isabel Luis Yanes
BACKGROUND: Various genetic and environmental factors are involved in urolithiasis. The 2 most common metabolic abnormalities are the increase in urinary calcium and low urinary citrate excretion. The ratio calculated between the concentrations of both substances is a good risk marker for the formation of calcium stones. OBJECTIVES: To determine whether the risk of urinary calcium stone formation changes throughout the day in the same patient. METHODS: We studied 56 children (23V, 33M) to check if they had prelithiasis...
February 14, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29452705/the-changing-incidence-and-presentation-of-urinary-stones-over-3-decades
#3
Wonngarm Kittanamongkolchai, Lisa E Vaughan, Felicity T Enders, Tsering Dhondup, Ramila A Mehta, Amy E Krambeck, Cynthia H McCollough, Terri J Vrtiska, John C Lieske, Andrew D Rule
OBJECTIVE: To evaluate trends in the incidence of kidney stones and characteristics associated with changes in the incidence rate over 3 decades. PATIENTS AND METHODS: Adult stone formers in Olmsted County, Minnesota, from January 1, 1984, to December 31, 2012, were validated and characterized by age, sex, stone composition, and imaging modality. The incidence of kidney stones per 100,000 person-years was estimated. Characteristics associated with changes in the incidence rate over time were assessed using Poisson regression models...
February 6, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29449452/evolution-and-kidney-development-a-rosetta-stone-for-nephrology
#4
EDITORIAL
Robert L Chevalier
No abstract text is available yet for this article.
February 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29447949/protective-effects-of-alpinae-oxyphyllae-fructus-extracts-on-lipopolysaccharide-induced-animal-model-of-alzheimer-s-disease
#5
Yunlong Wang, Mengshi Wang, Kaiyue Fan, Tongde Li, Tingxu Yan, Bo Wu, Kaishun Bi, Ying Jia
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinae Oxyphyllae Fructus (AOF) with warming and tonifying the kidney and spleen, anti-salivation, anti-polyuria and anti-diarrhea functions is the dried ripe fruits of Alpinia oxyphylla Miq. (Zingiberaceae). As a traditional Chinese medicine, its application history is very long. AIMS OF THE STUDY: The purpose of our study is to investigate the effects of different solvent extracts from AOF on lipopolysaccharide (LPS)-induced animal model of Alzheimer's disease (AD) to elucidate the traditional medical theories with modern pharmacological methods and provide a reference for further clarifying its active components and mechanisms...
February 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29447770/efficacy-and-safety-of-dual-antiplatelet-therapy-after-coronary-stenting-in-patients-with-chronic-kidney-disease
#6
Doyeon Hwang, Kyung Woo Park, Joo Myung Lee, Tae-Min Rhee, Myeong-Ki Hong, Yangsoo Jang, Marco Valgimigli, Antonio Colombo, Martine Gilard, Tullio Palmerini, Gregg W Stone, Hyo-Soo Kim
BACKGROUND: We compared efficacy and safety of short- (3 or 6 months) versus long-term (≥12 months) dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation, according to the presence of chronic kidney disease (CKD). METHODS: Patient-level pooled analysis was performed with 7242 patients (87.2% with 2nd generation DES) from 5 randomized controlled trials. RESULTS: In both CKD (1273 patients) and non-CKD (5969 patients) population, the rates of patient-oriented composite outcomes at 1-year (POCO, all-cause death, any myocardial infarction [MI], stroke and TIMI major bleeding) were not different between the short- and long-term DAPT (hazard ratio [HR] 1...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29444579/-quality-of-nephrolithiasis-surgical-treatment-what-is-it-influenced-by
#7
V Kováčik, M Maciak, P Bujdák, V Baláž, R Školka, M Rusňák
INTRODUCTION: Identifying factors effecting the quality of nephrolithiasis surgical treatment could improve medical care for patients suffering from kidney stone disease. The objective of the article is to identify factors influencing reintervention rate after surgical treatment of kidney stone disease either by percutaneous nephrolitholapaxy or flexible ureterorenoscopy. METHOD: A retrospective study was conducted on 149 patients who underwent a surgery for a kidney stone disease at the Urological department of F...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29443696/intravenous-lidocaine-for-intractable-renal-colic-unresponsive-to-standard-therapy
#8
Billy Sin, John Cao, David Yang, Karen Ambert, Sheena Punnapuzha
CLINICAL FEATURES: Renal colic is defined as a flank pain radiating to the groin caused by kidney stones in the ureter (urolithiasis). Renal colic is a frequent cause of Emergency Department visits. Most renal colic cases present as acute distress and severe back and/or abdominal pain that require prompt treatment with analgesics. THERAPEUTIC CHALLENGE: Nonsteroidal anti-inflammatory drugs and opioids are traditionally used for renal colic in the Emergency Department...
February 13, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29440373/calcium-supplementation-in-osteoporosis-useful-or-harmful
#9
Iacopo Chiodini, Mark J Bolland
Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality. It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis...
February 12, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29437013/topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#10
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29435125/inhibition-of-autophagy-attenuated-calcium-oxalate-crystal-induced-renal-tubular-epithelial-cell-injury-in-vivo-and-in-vitro
#11
Yunlong Liu, Derong Li, Ziqi He, Quan Liu, Jihua Wu, Xiaofeng Guan, Zhiwei Tao, Yaoliang Deng
Accumulating evidence suggests that autophagy is involved in the pathophysiological processes of kidney diseases. However, the role of autophagy in the formation of calcium oxalate (CaOx) nephrolithiasis remains unclear. In this study, we investigated the effects of autophagy on renal tubular epithelial cell injury induced by CaOx crystals in vivo and in vitro . We first observed that the expression levels of LC3-II and BECN1 and number of autophagic vacuoles were markedly increased in the renal tissue of CaOx stone patients...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434824/clinical-importance-of-chemokines-and-inflammatory-cytokines-for-patient-care-following-percutaneous-nephrolithotripsy
#12
Junrong Wang, Wei Wang, Wei Guo, Yanru Ma, Tianhui Ji, Baodi Zhang
Chemokines are a class of proteins with low molecular weight that serve important roles in the progression of inflammation. Percutaneous nephrolithotripsy is a surgical technique in which lasers or ultrasound are utilized to break down and/or remove kidney stones. In order to ensure a full recovery following surgery, effective patient care and nursing are required. In the present study, a total of 348 patients with kidney stones were recruited and the clinical importance of chemokines and inflammatory cytokines for the nursing of patients during perioperative period was investigated...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29428801/hipk2-polymorphisms-rs2058265-rs6464214-and-rs7456421-were-associated-with-kidney-stone-disease-in-chinese-males-not-females
#13
Haisong Lin, Xiujuan Zhu, Jun Long, Yang Chen, Yuanliang Xie, Ming Liao, Jianxin Chen, Jiarong Tian, Shengzhu Huang, Ruiqiang Tang, Xiaoying Xian, Suchun Wei, Qiuyan Wang, Zengnan Mo
BACKGROUND AND AIM: Recent studies have shown that genetic factors are involved in the development of kidney stone disease (KSD). A case-control association analysis was performed to investigate the association between homeodomain-interacting protein kinase 2 (HIPK2; OMIM *606868) polymorphisms and KSD. METHODS: A total of 890 KSD patients and 920 healthy subjects were analyzed. Polymorphisms were genotyped using SNPscanTM high-throughput SNP classification technology...
February 8, 2018: Gene
https://www.readbyqxmd.com/read/29428569/a-continuum-of-mineralization-from-human-renal-pyramid-to-stones-on-stems
#14
Benjamin A Sherer, Ling Chen, Misun Kang, Alex R Shimotake, Scott V Wiener, Tom Chi, Marshall L Stoller, Sunita P Ho
The development of new modalities for kidney stone prevention rests upon understanding the progression of mineralization within the renal pyramid. The progression from small foci of mineralization within the renal pyramid to larger interstitial plaques that ultimately lead to the formation of clinically detectable calcium-based stones on calcium phosphate stems will be presented through correlative microscopy approach. High resolution X-ray computed tomography (micro-XCT), electron microscopy, and energy dispersive X-ray (EDX) compositional analyses of interstitial plaques, stems, and attached stones were performed...
February 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29424333/pathogenesis-of-proteus-mirabilis-infection
#15
Chelsie E Armbruster, Harry L T Mobley, Melanie M Pearson
Proteus mirabilis , a Gram-negative rod-shaped bacterium most noted for its swarming motility and urease activity, frequently causes catheter-associated urinary tract infections (CAUTIs) that are often polymicrobial. These infections may be accompanied by urolithiasis, the development of bladder or kidney stones due to alkalinization of urine from urease-catalyzed urea hydrolysis. Adherence of the bacterium to epithelial and catheter surfaces is mediated by 17 different fimbriae, most notably MR/P fimbriae...
February 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29423204/practical-approaches-to-the-management-of-autosomal-dominant-polycystic-kidney-disease-patients-in-the-era-of-tolvaptan
#16
Roman-Ulrich Müller, Christian S Haas, John A Sayer
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease worldwide. The renal phenotype is characterized by progressive cystic enlargement of the kidneys leading to a decline in renal function, hypertension and often end-stage renal disease (ESRD). Supportive care with blood pressure control and management of pain, urinary infections and renal stone disease has, until recently, been the mainstay of treatment. With the recent approval of tolvaptan for use in ADPKD, the disease progression may now be targeted specifically...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29422481/investigation-of-adipose-tissue-fatty-acid-composition-in-men-with-uronephrolithiasis-and-metabolic-syndrome
#17
Inga Bikulčienė, Laima Vasiliauskaitė, Zita Aušrelė Kučinskienė, Arvydas Kaminskas, Vaiva Hendrixson
BACKGROUND Fatty acids (FA) and their metabolites are closely related to some mechanisms involved in the development of uronephrolithiasis. The aim of this study was to evaluate the relationship between FA composition and type of kidney stones. MATERIAL AND METHODS Abdominal adipose tissue fatty acid methyl esters of 71 men with nephrolithiasis were identified by GC/MS, and the type of kidney stones was identified using FTIR infrared spectroscopy. Patients were divided into groups according to diagnosis of metabolic syndrome (MS) and type of kidney stone...
February 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29421299/impact-of-statin-intake-on-kidney-stone-formation
#18
Andrew J Cohen, Melanie A Adamsky, Charles U Nottingham, Jaclyn Pruitt, Brittany Lapin, Chi H Wang, Sangtae Park
OBJECTIVES: To determine whether statin intake affects nephrolithiasis risk, and whether higher lipid levels correlate with stone risk. Dyslipidemia is a known independent risk factor for urolithiasis, and emerging evidence suggests common biological pathways. Previous work has suggested that statins protect against new stone formation, but these findings have not been verified by other investigators. METHODS: We queried our Institution's Electronic Data Warehouse for all patients who were newly diagnosed with hyperlipidemia between 2009 and 2011, and had never taken a statin drug...
February 5, 2018: Urology
https://www.readbyqxmd.com/read/29416282/incidence-and-characteristics-of-kidney-stones-in-patients-with-horseshoe-kidney-a-systematic-review-and-meta-analysis
#19
Aditya S Pawar, Charat Thongprayoon, Wisit Cheungpasitporn, Ankit Sakhuja, Michael A Mao, Stephen B Erickson
Introduction: The horseshoe kidney (HSK) is the most common type of renal fusion anomaly. The incidence and characteristics of kidney stones in patients with HSK are not well studied. The aim of this meta-analysis was to evaluate the incidence and types of kidney stones in patients with HSK. Methods: A systematic literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from the databases' inception through November 2016...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29411942/libs-raman-an-effective-complementary-approach-to-analyze-renal-calculi
#20
K M Muhammed Shameem, Arun Chawla, Madhukar Mallya, Bijay Kumar Barik, V K Unnikrishnan, V B Kartha, C Santhosh
Presence of renal calculi (kidney stones) in human urethra is being increasingly diagnosed over the last decade and is considered as one of the most painful urological disorders. Accurate analysis of such stones plays a vital role in the evaluation of urolithiasis patients and in turn helps the clinicians toward exact etiologies. Two highly complementary laser-based analytical techniques; Laser Induced Breakdown Spectroscopy (LIBS) and micro-Raman spectroscopy have been used to identify the chemical composition of different types of renal calculi...
February 7, 2018: Journal of Biophotonics
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