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https://www.readbyqxmd.com/read/29028588/formation-of-struvite-urinary-stones-and-approaches-towards-the-inhibition-a-review
#1
REVIEW
Poppy Das, Gaurav Gupta, Vinodhini Velu, Rajendra Awasthi, Kamal Dua, Himaja Malipeddi
BACKGROUND: Struvite is one of the most common urinary/kidney stones, composed of magnesium ammonium phosphate (MgNHPO4·H2O). They are also termed as infection stones as these are associated with urinary tract infections. Numerous studies have been carried out to examine the growth and inhibition of struvite stones. OBJECTIVE: This review summarizes various reports on the factors responsible for inducing struvite stones in the kidney and gives a detailed account of studies on inhibition of growth of struvite crystals...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29027695/shear-wave-elastographic-alterations-in-the-kidney-after-extracorporeal-shock-wave-lithotripsy
#2
Rustu Turkay, Ercan Inci, Derya Bas, Arda Atar
OBJECTIVES: Extracorporeal shock wave lithotripsy (ESWL) is a method used frequently for the treatment of renal stone disease. Although its safety is proven, there are still concerns about its unwanted effects on kidneys. In this prospective study, we aimed to evaluate renal tissue alterations with shear wave elastography (SWE) after ESWL. We also studied the correlation between SWE and resistive index (RI) changes. METHODS: The study included 59 patients who underwent ESWL treatment for renal stone disease...
October 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29025381/adenovirus-infection-as-a-cause-of-fever-of-unknown-origin-and-allograft-dysfunction-in-a-kidney-transplant-recipient
#3
Michelle Saliba, Hala Kfoury Assouf, Souodod Abbas, Pierre Abi Hanna, Gaby Kamel, Antoine Barbari
With the recent introduction of more potent modern immunosuppressive regimens in solid-organ transplant, new types of viral infections such as adenovirus are emerging as a potential cause for graft dysfunction and loss. We report a case of 41-year-old male patient with end-stage renal disease from recurrent kidney stones who underwent kidney transplant from a deceased 12-year-old female donor. He developed adenoviral infection with acute cystitis, microscopic hematuria, and necrotizing interstitial nephritis associated with graft dysfunction within the first month of the postoperative period...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29023532/risk-factors-for-gallstones-and-kidney-stones-in-a-cohort-of-patients-with-inflammatory-bowel-diseases
#4
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz
BACKGROUND: Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. OBJECTIVES: Identifying risk factors for gallstones and kidney stones in IBD patients. METHODS: Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses...
2017: PloS One
https://www.readbyqxmd.com/read/29019063/statin-prescribing-in-the-elderly-special-considerations
#5
REVIEW
M Leya, N J Stone
PURPOSE OF REVIEW: Our aim was to examine the current evidence behind prescribing statins to individuals over 65 years of age with emphasis on those older than 75. Individuals over 75 years of age may often have multiple comorbidities and take many medications. Additionally, they are often underrepresented in randomized controlled trials (RCTs) of statins in older populations. While results of RCTs demonstrate the benefit of statin therapy in both primary and secondary prevention patients, clinicians must more carefully consider adverse effects and drug-drug interactions before prescribing statin therapy as well as determining the intensity in older individuals...
October 11, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28994037/pathophysiology-diagnosis-and-treatment-of-inherited-distal-renal-tubular-acidosis
#6
REVIEW
Nilufar Mohebbi, Carsten A Wagner
Distal renal tubular acidosis (dRTA) is a tubular disorder with a primary defect of urinary acidification and acid excretion in the collecting duct system. Consequently, patients develop hyperchloremic metabolic acidosis with an inappropriately alkaline urine. Inherited forms of dRTA are due to mutations in at least three distinct genes: SLC4A1, ATP6V1B1, ATP6V0A4. Mutations in SLC4A1-(AE1) are inherited either in an autosomal dominant manner or in a recessive one. ATP6V1B and ATP6V0A4 mutations affect two different subunits of the vacuolar H(+)-ATPase proton-pump, the B1 and a4 subunits, and are inherited in an autosomal recessive manner...
October 9, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28992566/quantification-of-xanthine-and-uric-acid-related-compounds-in-urine-using-a-dilute-and-shoot-technique-coupling-ultra-high-performance-liquid-chromatography-and-high-resolution-orbitrap-mass-spectrometry
#7
Adrian Rodriguez, Rosa Maria Gomila, Gabriel Martorell, Antonia Costa-Bauza, Felix Grases
Quantitative analysis of relevant metabolites in biofluids such as urine is often a tedious procedure, since it usually requires extraction, purification or preconcentration. For instance, in the analysis of methylxanthines in urine, a solid-phase extraction is often required. In the current work, a rapid and highly sensitive "dilute-and-shoot" method combining ultra-high-performance liquid chromatography and high-resolution mass spectrometry (UHPLC/HRMS) was validated for urinary determination of twelve analytes: uric acid, hypoxanthine, xanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, theophylline, theobromine, paraxanthine and caffeine...
October 2, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28992172/points-to-consider-in-renal-involvement-in-systemic-sclerosis
#8
REVIEW
Felice Galluccio, Ulf Müller-Ladner, Daniel E Furst, Dinesh Khanna, Marco Matucci-Cerinic
This article discusses points to consider when undertaking a clinical trial to test therapy for renal involvement in SSc, not including scleroderma renal crisis. Double-blind, randomized controlled trials vs placebo or standard background therapy should be strongly considered. Inclusion criteria should consider a pre-specified range of renal functions or stratification of renal function. Gender and age limitations are probably not necessary. Concomitant medications including vasodilators, immunosuppressants and endothelin receptor antagonists and confounding illnesses such as diabetes, kidney stones, hypertension and heart failure need to be considered...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28990356/thalidomide-embryopathy-as-possible-cause-of-anterior-sacral-meningocele-a-case-report
#9
Davide Marco Croci, Martina Dalolio, Stefan Schaeren, Morten G Wasner, Luigi Mariani, Gregory F Jost
A 54-year-old male presented with a sudden burning sensation during urination and left flank pain. Apart from having congenital facial palsy and malformation of the inner right ear that was linked to thalidomide embryopathy, the patient has always been in good health. Urine examination showed the presence of a urinary tract infection. An abdominal ultrasound revealed a large cyst in the lower abdomen, which on MRI corresponded to a large anterior sacral meningocele (ASM) with sacral agenesis at S1/S2. After antibiotic treatment and the spontaneous passage of a kidney stone, the symptoms resolved...
October 9, 2017: Birth defects research
https://www.readbyqxmd.com/read/28981413/characterizing-the-acoustic-output-of-an-ultrasonic-propulsion-device-for-urinary-stones
#10
Bryan W Cunitz, Barbrina Dunmire, Michael R Bailey
A non-invasive ultrasound system to facilitate the passage of small kidney stones has been developed. The device incorporates a software based ultrasound platform programmed with B-mode and Doppler for visualizing stones, plus long duration focused pulses for repositioning stones using the same transducer. This paper characterizes the acoustic outputs of the ultrasonic propulsion device. Though the application and outputs are unique, measurements were performed based on regulatory standards for both diagnostic ultrasound and extracorporeal lithotripters...
October 2, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28981230/-diagnosis-and-treatment-of-nephrolithiasis-and-prevention-of-recurrences
#11
I Simon, F Legrand, J M Des Grottes, F Cotton, J Nortier, T Roumeguère
despite fluctuations, the prevalence of nephrolithiasis has significantly increased during the last decades in industrialized nations worldwide (1 to 15 %), which has a significant impact on the cost of healthcare. This increased prevalence is mainly explained by diet modifications. Environmental, metabolic and genetic factors may also influence the formation of kidney stones. As a consequence, the medical management of this disease is preferentially multidisciplinary and involves urologists, nephrologists, radiologists, biologists and dietitians...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28980082/accuracy-of-daily-fluid-intake-measurements-using-a-smart-water-bottle
#12
Michael S Borofsky, Casey A Dauw, Nadya York, Colin Terry, James E Lingeman
High fluid intake is an effective preventative strategy against recurrent kidney stones but is known to be challenging to achieve. Recently, a smart water bottle (Hidrate Spark™, Minneapolis, MN) was developed as a non-invasive fluid intake monitoring system. This device could help patients who form stones from low urine volume achieve sustainable improvements in hydration, but has yet to be validated in a clinical setting. Hidrate Spark™ uses capacitive touch sensing via an internal sensor. It calculates volume measurements by detecting changes in water level and sends data wirelessly to users' smartphones through an application...
October 4, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28977105/flexible-ureterorenoscopy-in-position-or-fusion-anomaly-is-it-feasible
#13
Rafael Haddad Astolfi, Gustavo Freschi, Fernando Figueiredo Berti, Nelson Gattas, Wilson Rica Molina, Alex Meller
OBJECTIVE: To analyze the results of flexible ureterorenoscopy (F-URS) with holmium laser in the treatment of kidney stones with ectopic and fusion anomalies (horseshoe kidney and rotation anomalies). METHOD: We reviewed data from 13 patients with fusion and ectopic renal anomalies that underwent F-URS from April 2011 to April 2017. We analyzed demographic and clinical data (age, gender, BMI, anatomical abnormality, location and dimension of the renal calculi) and perioperative data (method of treatment, stone-free rate, number of days with DJ catheter and perioperative complications)...
August 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28976497/kidney-cancer-activation-of-oncogenes-driven-by-vhl-loss-in-ccrcc
#14
Louise Stone
No abstract text is available yet for this article.
October 4, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28975110/nephrolithiasis-as-a-common-urinary-system-manifestation-of-inflammatory-bowel-diseases-a-clinical-review-and-meta-analysis
#15
REVIEW
Mahboube Ganji-Arjenaki, Hamid Nasri, Mahmoud Rafieian-Kopaei
CONTEXT: The extra-intestinal manifestations of inflammatory bowel disease (IBD) are common and involve other organs or systems for example; urinary system. EVIDENCE ACQUISITIONS: For this review, we used a variety of sources by searching through Web of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ). RESULTS: Urinary complications may occur in up to 22% of patients and nephrolithiasis or renal/kidney stones have been suggested to be a common manifestation of disease in forms of uric acid, calcium phosphate or calcium oxalate...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28975090/chronic-dietary-oxalate-nephropathy-after-intensive-dietary-weight-loss-regimen
#16
Gebran Khneizer, Ahmad Al-Taee, Meher S Mallick, Bahar Bastani
BACKGROUND: Hyperoxaluria has been associated with nephrolithiasis as well as acute and chronic kidney disease. We present a case of end stage renal failure caused by excessive dietary oxalate intake in a dietary weight loss regimen. CASE PRESENTATION: A 51-year-old Caucasian male with the past medical history of type 2 diabetes mellitus, gout, hypertension and morbid obesity was referred to the primary care clinic after being found pale and easily fatigued. The patient had lost 36 kg over a 7-month period by implementing exercise and intense dietary measures that included 6 meals of spinach, kale, berries, and nuts...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28974672/a-non-classical-view-on-calcium-oxalate-precipitation-and-the-role-of-citrate
#17
Encarnación Ruiz-Agudo, Alejandro Burgos-Cara, Cristina Ruiz-Agudo, Aurelia Ibañez-Velasco, Helmut Cölfen, Carlos Rodriguez-Navarro
Although calcium oxalates are relevant biominerals, their formation mechanisms remain largely unresolved. Here, we investigate the early stages of calcium oxalate formation in pure and citrate-bearing solutions. Citrate is used as a well-known oxalate precipitation inhibitor; moreover, it resembles the functional domains of the biomolecules that modulate biomineralization. Our data suggest that calcium oxalate forms after Ca(2+) and C2O4(2-) association into polynuclear stable complexes that aggregate into larger assemblies, from which amorphous calcium oxalate nucleates...
October 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28970593/occupations-and-the-risk-of-bladder-cancer-in-yazd-province-a-case-control-study
#18
Fatemeh Farzaneh, Amir Houshang Mehrparvar, Mohammad Hassan Lotfi
BACKGROUND: Bladder cancer is the most common cancer of the urinary tract, with known occupational causes. The most effective way to prevent occupational cancers of the urinary tract is to prevent exposure to known carcinogens. OBJECTIVE: To examine the relationship between occupation and the risk of bladder cancer. METHODS: This case-control study was performed on 200 patients with bladder cancer and 200 healthy individuals in Yazd. Data were collected using a researcher-made questionnaire and based on interviews with patients and controls...
October 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28969396/epidemiologic-study-of-urolithiasis-in-seven-countries-of-south-eastern-europe-s-e-g-u-r-1-study
#19
Andreas Karagiannis, Andreas Skolarikos, Emanuel Alexandrescu, Dragoslav Basic, Petrisor Geavlete, Alessandro Maletta, A Yaser Muslumanoglu, Athanasios Papatsoris, Kremena Petkova, Skender Saidi, Aleksandar Skakic, Iliya Saltirov, Kemal Sarica, Sotir Stavridis, Omer Yilmaz, Alberto Trinchieri
OBJECTIVE: To investigate some epidemiological aspects of kidney stones in the South- Eastern European area. MATERIALS AND METHODS: From September 2015 to December 2015, 538 consecutive patients were treated and evaluated for reno-ureteral stones in eight departments in Bulgaria, Greece, Italy, FYR Macedonia, Romania, Serbia and Turkey. RESULTS: The age of onset was lower in Turkey and higher in Italy. The rate of recurrent patients was higher in Romania and Serbia, while first renal stone formers were more frequent in Italy...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28966756/preventive-kidney-stones-continue-medical-education
#20
REVIEW
Farahnak Assadi, Mastaneh Moghtaderi
Nephrolithiasis is a common health problem across the globe with a prevalence of 15%-20%. Idiopathic hypercalciuria is the most common cause of nephrolithiasis, and calcium oxalate stones are the most common type of stones in idiopathic hypercalciuric patients. Calcium phosphate stones are frequently associated with other diseases such as renal tubular acidosis type 1, urinary tract infections, and hyperparathyroidism. Compared with flat abdominal film and renal sonography, a noncontrast helical computed tomography scan of the abdomen is the diagnostic procedure of choice for detection of small and radiolucent kidney stones with sensitivity and specificity of nearly 100%...
2017: International Journal of Preventive Medicine
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