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Kyung-A Hwang, Jeong Eun Kwon, YooHun Noh, BongKyun Park, Yong Joon Jeong, Sun-Mee Lee, Se-Young Kim, InHye Kim, Se Chan Kang
Degenerative arthritis, also known as osteoarthritis (OA), is the most common type of arthritis, which is caused by degenerative damage of the cartilage, which primarily protects the joints, leading to inflammation and pain. The objective of this study was to investigate the in vivo and in vitro effects of treatment with ZPE-LR (90% EtOH extract of Zanthoxylum piperitum) on pain severity and inflammation. When using an in vivo OA model MIA (monosodiumidoacetate-induced arthritis) rats, ZPE-LR (100 mg/kg) oral-administratio significantly inhibited MIA-induced change in loaded weight ratio on the left foot, and articular cartilage thickness...
June 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Ivan Capo, Dusan Lalosević
INTRODUCTION: Findings of dark neurons is still a big controversy. Do they represent a simple artifact or neuropatological findings? The aim is to explain the appearance of "dark" neurons in different experimental animal models. MATERIAL AND METHODS: The experiments included three experimental models. Neuroischemia: where in postmortal fixed rat brain after 10', 30', 45', 1.5h, 3h, 6h, 12h, 24h histologically was examined the appearance of dark neurons; intoxication: after 28 days of oral administratio AlCl3 in rats analyse changes in the brain; neuroinfection: where hamsters perorally given culture larvae T...
January 2011: Medicinski Pregled
No abstract text is available yet for this article.
1962: Bulletin de la Société des Amis des Sciences et des Lettres de Poznań. Séria C: Médecine
R W Chesney, B S Kaplan, E Colle, C R Scriver, R R McInnes, C H Dupont, K N Drummond
Various metabolic studies were performed in a patient with the idiopathic Fanconi syndrome in whom constant ketonuria suggested that organic acidemia might contribute to the metabolic acidosis. Glucose intolerance with a diminished insulin release was found after PO or IV glucose loads and after glucagon administratio. An insulinopenic "diabetes-like" state has not previously been described in such patients. The patient had impaired galactose-glucose interconversion, elevated blood lactate levels, reduced pyruvate levels, and an increased lactate:pyruvate ratio...
March 1980: Pediatric Research
R Roeper, K Hupe
No abstract text is available yet for this article.
December 1966: Bruns' Beiträge Für Klinische Chirurgie
G A Grant, J A Barlow, K E Leach
The administratio prior to irradiation of adenosine triphosphate (ATP) or other adenosine nucleotides, singly or in combination, increased the radioresistance of mice. Post-irradiation treatment with the adenosine nucleotides had no effect on the survival of the irradiated mice. Dose reduction factors of 2.32 could be obtained by pretreatment of mice with the following combination of protective agents: S-2(4-aminobutylamino)ethyl phosphorothioic acid(WR 2822), cysteamine (MEA) and ATP. Since cyclic AMP levels were unchangd in the spleen or gut by administration of cysteamine and other protectors it is unlikely that the increase in preotection was due to changes in cyclic AMP levles...
September 1976: Strahlentherapie
W M Dairman, L Juhasz
The effectiveness of benzodiazepines and anticholinergics administered alone or in combination in preventing restraint-immersion and forced exertion-induced gastric mucosal erosion was investigated in mice. The benzodiazepines used were diazepam and chlordiazepoxide HCI and the anticholinergics were propantheline bromide and clidinium bromide. The administratio of a benzodiazepine with an anticholinergic resulted in additive or supra-additive protective effects in both systems. In the restraint-immersion system, diazepam combined with propantheline bromide at a ratio of 1 to 13...
1978: Pharmacology
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