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https://www.readbyqxmd.com/read/28223366/la-deletion-from-mouse-brain-alters-pre-trna-metabolism-and-accumulation-of-pre-5-8s-rrna-with-neuron-death-and-reactive-astrocytosis
#1
Nathan H Blewett, James R Iben, Sergei Gaidamakov, Richard J Maraia
Human La antigen (Sjögren's syndrome antigen B, SSB) is an abundant multifunctional RNA-binding protein. In the nucleoplasm, La binds to and protects from 3' exonucleases, the ends of precursor-tRNAs and other transcripts synthesized by RNA polymerase III, and facilitates their maturation, while a nucleolar isoform has been implicated in rRNA biogenesis by multiple independent lines of evidence. We showed earlier that conditional La knockout (La cKO) from mouse cortex neurons results in defective tRNA processing although pathway(s) involved in neuronal loss thereafter was unknown...
February 21, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28215974/a-systematic-approach-to-evaluate-parameter-consistency-in-the-inlet-stream-of-source-separated-biowaste-composting-facilities-a-case-study-in-colombia
#2
E R Oviedo-Ocaña, P Torres-Lozada, L F Marmolejo-Rebellon, W A Torres-López, I Dominguez, D Komilis, A Sánchez
Biowaste is commonly the largest fraction of municipal solid waste (MSW) in developing countries. Although composting is an effective method to treat source separated biowaste (SSB), there are certain limitations in terms of operation, partly due to insufficient control to the variability of SSB quality, which affects process kinetics and product quality. This study assesses the variability of the SSB physicochemical quality in a composting facility located in a small town of Colombia, in which SSB collection was performed twice a week...
February 16, 2017: Waste Management
https://www.readbyqxmd.com/read/28210632/increased-interleukin-17f-is-associated-with-elevated-autoantibody-levels-and-more-clinically-relevant-than-interleukin-17a-in-primary-sj%C3%A3-gren-s-syndrome
#3
Yuzhou Gan, Xiaozhen Zhao, Jing He, Xu Liu, Yun Li, Xiaolin Sun, Zhanguo Li
Th17 related immune response is pathogenic in primary Sjögren's syndrome (pSS). However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined. We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays. White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28205602/a-new-joint-blade-sense-reconstruction-for-accelerated-propeller-mri
#4
Mengye Lyu, Yilong Liu, Victor B Xie, Yanqiu Feng, Hua Guo, Ed X Wu
PROPELLER technique is widely used in MRI examinations for being motion insensitive, but it prolongs scan time and is restricted mainly to T2 contrast. Parallel imaging can accelerate PROPELLER and enable more flexible contrasts. Here, we propose a multi-step joint-blade (MJB) SENSE reconstruction to reduce the noise amplification in parallel imaging accelerated PROPELLER. MJB SENSE utilizes the fact that PROPELLER blades contain sharable information and blade-combined images can serve as regularization references...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204891/low-titer-isolated-anti-ro-ssa-60-kd-antibodies-is-correlated-with-positive-pregnancy-outcomes-in-women-at-risk-of-congenital-heart-block
#5
Marta Tonello, Ariela Hoxha, Elena Mattia, Alessandra Zambon, Silvia Visentin, Alessia Cerutti, Anna Ghirardello, Ornella Milanesi, Amelia Ruffatti
Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study...
February 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28196498/children-s-sugar-sweetened-beverages-consumption-associations-with-family-and-home-related-factors-differences-within-ethnic-groups-explored
#6
V M van de Gaar, A van Grieken, W Jansen, H Raat
BACKGROUND: The consumption of sugar-sweetened beverages (SSB) may contribute to the development of overweight among children. The present study aimed to evaluate associations between family and home-related factors and children's SSB consumption. We explored associations within ethnic background of the child. METHODS: Cross-sectional data from the population-based 'Water Campaign' study were used. Parents (n = 644) of primary school children (6-13 years) completed a questionnaire on socio-demographic characteristics, family and home-related factors and child's SSB intake...
February 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28173882/efficacy-of-school-based-interventions-aimed-at-decreasing-sugar-sweetened-beverage-consumption-among-adolescents-a-systematic-review
#7
Lydi-Anne Vézina-Im, Dominique Beaulieu, Ariane Bélanger-Gravel, Danielle Boucher, Caroline Sirois, Marylène Dugas, Véronique Provencher
OBJECTIVE: To verify the efficacy of school-based interventions aimed at reducing sugar-sweetened beverage (SSB) consumption among adolescents in order to develop or improve public health interventions. DESIGN: Systematic review of interventions targeting adolescents and/or the school environment. SETTING: The following databases were investigated: MEDLINE/PubMed, PsycINFO, CINAHL and EMBASE. Proquest Dissertations and Theses was also investigated for unpublished trials...
February 8, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28166540/effect-of-tobacco-smoking-on-the-clinical-histopathological-and-serological-manifestations-of-sj%C3%A3-gren-s-syndrome
#8
Donald U Stone, Dustin Fife, Michael Brown, Keith E Earley, Lida Radfar, C Erick Kaufman, David M Lewis, Nelson L Rhodus, Barbara M Segal, Daniel J Wallace, Michael H Weisman, Swamy Venuturupalli, Michael T Brennan, Christopher J Lessard, Courtney G Montgomery, R Hal Scofield, Kathy L Sivils, Astrid Rasmussen
OBJECTIVES: To assess the association of smoking habits with the clinical, serological, and histopathological manifestations of Sjögren's syndrome (SS) and non-Sjögren's sicca (non-SS sicca). METHODS: Cross-sectional case-control study of 1288 patients with sicca symptoms (587 SS and 701 non-SS sicca) evaluated in a multi-disciplinary research clinic. Smoking patterns were obtained from questionnaire data and disease-related clinical and laboratory data were compared between current, past, ever, and never smokers...
2017: PloS One
https://www.readbyqxmd.com/read/28165771/predicting-sugar-sweetened-behaviours-with-theory-of-planned-behaviour-constructs-outcome-and-process-results-from-the-sipsmarter-behavioural-intervention
#9
Jamie M Zoellner, Kathleen J Porter, Yvonnes Chen, Valisa E Hedrick, Wen You, Maja Hickman, Paul A Estabrooks
OBJECTIVE: Guided by the theory of planned behaviour (TPB) and health literacy concepts, SIPsmartER is a six-month multicomponent intervention effective at improving SSB behaviours. Using SIPsmartER data, this study explores prediction of SSB behavioural intention (BI) and behaviour from TPB constructs using: (1) cross-sectional and prospective models and (2) 11 single-item assessments from interactive voice response (IVR) technology. DESIGN: Quasi-experimental design, including pre- and post-outcome data and repeated-measures process data of 155 intervention participants...
February 6, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28157953/rapidly-and-continuously-frequency-scanning-opto-electronic-oscillator
#10
Qizhuang Cen, Yitang Dai, Feifei Yin, Yue Zhou, Jianqiang Li, Jian Dai, Lan Yu, Kun Xu
An opto-electronic oscillator (OEO) scheme which operates at "chirp oscillation" mode and generates low-phase-noise, frequency-swept microwave is proposed and experimentally demonstrated. This frequency-swept OEO is achieved by embedding a rapidly frequency-scanning microwave filter in an opto-electronic cavity. The filter has fixed passband while its center frequency scans rapidly and periodically at cavity round-trip time, covering a large frequency range (~GHz). Experimentally, the generated frequency-swept microwave is linear frequency-modulated continuous wave (FMCW) which centers at 7 GHz with 1-GHz bandwidth...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28148755/work-disability-in-newly-diagnosed-patients-with-primary-sj%C3%A3-gren-syndrome
#11
Thomas Mandl, Tanja Schjødt Jørgensen, Marie Skougaard, Peter Olsson, Lars-Erik Kristensen
OBJECTIVE: To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjögren syndrome (pSS). METHODS: Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were included in the study. For each patient we randomly selected 4 reference subjects from the general population and matched for age, sex, and area of residence...
February 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28148578/hypokalaemia-in-sj%C3%A3-gren-s-syndrome-the-missing-piece
#12
Umer Farooq Khan, Lee Chun Tsu, Kong-Bing Tan, Jingxiang Huang, Audrey LiAnn Wong
A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0.32 mmol/L) with rhabdomyolysis and electrocardiogram changes, without other concurrent biochemical abnormalities. Immediate intravenous and oral potassium and phosphate replacement was initiated with objective improvement in weakness with replenished electrolyte levels. Urine studies confirmed renal potassium wasting...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28147328/autoantibody-to-mdm2-a-potential-serological-marker-of-primary-sjogren-s-syndrome
#13
Yuan Liu, Xining Liao, Ying Wang, Shiju Chen, Yuechi Sun, Qingyan Lin, Guixiu Shi
INTRODUCTION: Primary Sjogren's Syndrome (pSS) is one of the autoimmune diseases characterized by polyclonal autoantibody production. The human homologue of the mouse double minute 2 (MDM2) is an important negative regulator of p53. Our previous study indicated that autoantibody to MDM2 can be detected in systemic lupus erythematosus patients. The purpose of this study is to study anti-MDM2 autoantibody in pSS patients. METHODS: Anti-MDM2 autoantibody in sera from 100 pSS patients and 74 normal controls was investigated by ELISA...
January 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28143794/home-sweet-home-parent-and-home-environmental-factors-in-adolescent-consumption-of-sugar-sweetened-beverages
#14
Laura M Bogart, Marc N Elliott, Allison J Ober, David J Klein, Jennifer Hawes-Dawson, Burton O Cowgill, Kimberly Uyeda, Mark A Schuster
OBJECTIVE: Sugar-sweetened beverages (SSBs) are key contributors to obesity among youth. We investigated associations among parental and home-related factors (parental attitudes and consumption; home availability) regarding three types of SSBs-soda, sports drinks, and fruit-flavored drinks-with consumption of each type of SSB in a general school-based sample of adolescents. METHODS: Data were collected across three school semesters, from 2009-2011. A total of 1,313 seventh-grade student-parent dyads participated...
January 28, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28138914/obstetric-and-perinatal-outcome-in-anti-ro-ssa-positive-pregnant-women-a-prospective-cohort-study
#15
Nuria Martínez-Sánchez, Sergio Pérez-Pinto, Ángel Robles-Marhuenda, Francisco Arnalich-Fernández, María Martín Cameán, Edurne Hueso Zalvide, Jose Luis Bartha
: Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed...
January 30, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28137763/monocyte-siglec-14-expression-is-upregulated-in-patients-with-systemic-lupus-erythematosus-and-correlates-with-lupus-disease-activity
#16
Susannah I Thornhill, Anselm Mak, Bernett Lee, Hui Yin Lee, Michael Poidinger, John E Connolly, Anna-Marie Fairhurst
OBJECTIVE: Siglecs are sialic acid-binding immunoglobulin-like lectins expressed on the surface of immune cells, which participate in the discrimination of self and non-self. We investigated myeloid CD33-related Siglec expression in a cohort of patients with SLE. METHODS: Cell surface expression of Siglec-5/14, Siglec-9 and Siglec-10 on peripheral myeloid subsets were analysed from 39 SLE patients using flow cytometry. Genotyping of the Siglec-5/14 locus was also performed...
January 29, 2017: Rheumatology
https://www.readbyqxmd.com/read/28134563/zenit-ra-evaluation-a-solid-phase-chemiluminescence-immunoassay-for-detection-of-anti-cellular-antibodies
#17
Enrique Melguizo Madrid, Concepción González-Rodríguez, María de Gracia Ávila-García, Teresa Arrobas-Velilla, Patricia Fernández-Riejos
AIM: The objective was to compare Zenit RA chemiluminescent immunoassay (CLIA) from Menarini Diagnostics and ELISA from INOVA Diagnostics for the presence of specific anti-Ro/SS-A, anti-La/SS-B, anti-U1snRNP, anti-Sm, anti-Scl-70, anti-Jo-1 antibodies. Results/methodology: We studied 501 samples (178 connective autoimmune disease, 150 other autoimmune or inflammatory disease and 173 other disease or healthy). All samples were analyzed using CLIA and ELISA. The Kappa agreement was excellent for anti-SSA/Ro (0...
January 30, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28133360/dietary-patterns-in-infancy-are-associated-with-child-diet-and-weight-outcomes-at-6-years
#18
C M Rose, L L Birch, J S Savage
OBJECTIVE: To assess whether patterns of dietary exposures at 9 months are associated with child diet and weight at 6 years. METHODS: Data for this study were from the Infant Feeding Practices Study II and Year 6 Follow-Up Studies. All data were self-reported monthly. Results of a previous latent class analysis revealed 5 dietary patterns varying in milk and solid food intake. These 5 infant dietary patterns were used in the current study to predict child diet and weight outcomes at 6 years, while controlling for confounding variables...
January 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28127816/the-idl-of-e-coli-ssb-links-ssdna-and-protein-binding-by-mediating-protein-protein-interactions
#19
Piero R Bianco, Sasheen Pottinger, Hui Yin Tan, Trong Nguyenduc, Kervin Rex, Umesh Varshney
The E. coli single strand DNA binding protein (SSB) is essential to viability where it functions in two seemingly disparate roles: it binds to single stranded DNA (ssDNA) and to target proteins that comprise the SSB interactome. The link between these roles resides in a previously under-appreciated region of the protein known as the intrinsically disordered linker (IDL). We present a model wherein the IDL is responsible for mediating protein-protein interactions critical to each role. When interactions occur between SSB tetramers, cooperative binding to ssDNA results...
February 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28126491/the-relative-reinforcing-value-of-sweet-versus-savory-snack-foods-after-consumption-of-sugar-or-non-nutritive-sweetened-beverages
#20
Shanon L Casperson, LuAnn Johnson, James N Roemmich
The effects of sugar-sweetened (SSB) and non-nutritive sweetened (NSB) beverages on the regulation of appetite, energy intake and body weight regulation remain controversial. Using a behavioral choice paradigm, we sought to determine the effects of consuming a SSB or NSB on appetite and the reinforcing value of sweet relative to salty/savory snack foods. In a randomized crossover study, 21 healthy weight adults consumed 360 ml of SSB (sucrose; 31 g) or NSB (sucralose; 4 g) with a standardized meal. Hedonic ratings for the sweet and salty/savory snack foods used for the reinforcement task were assessed prior to the start of the study...
January 23, 2017: Appetite
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