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https://www.readbyqxmd.com/read/28805073/do-you-know-what-your-kids-are-drinking-evaluation-of-a-media-campaign-to-reduce-consumption-of-sugar-sweetened-beverages
#1
Amy Bleakley, Amy Jordan, Giridhar Mallya, Michael Hennessy, Jessica Taylor Piotrowski
OBJECTIVE: This study evaluates a citywide media campaign that targeted reducing sugar-sweetened beverage (SSB) consumption as a strategy for addressing obesity. DESIGN: Rolling cross-sectional survey data, collected before and during the media campaign, with 1367 parents to assess exposure to and effect of a televised public service advertisement (TV PSA) developed using a reasoned action approach. SETTING: Televised public service advertisement campaign created by the Philadelphia Department of Public Health and disseminated on cable television channels within the Philadelphia market...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28804786/health-impact-assessment-of-the-uk-soft-drinks-industry-levy-a-comparative-risk-assessment-modelling-study
#2
Adam D M Briggs, Oliver T Mytton, Ariane Kehlbacher, Richard Tiffin, Ahmed Elhussein, Mike Rayner, Susan A Jebb, Tony Blakely, Peter Scarborough
BACKGROUND: In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened beverages (SSBs; high tax for drinks with >8 g of sugar per 100 mL, moderate tax for 5-8 g, and no tax for <5 g). We estimate the effect of possible industry responses to the levy on obesity, diabetes, and dental caries. METHODS: We modelled three possible industry responses: reformulation to reduce sugar concentration, an increase of product price, and a change of the market share of high-sugar, mid-sugar, and low-sugar drinks...
January 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28803573/the-school-environment-and-sugar-sweetened-beverage-consumption-among-guatemalan-adolescents
#3
Katelyn M Godin, Violeta Chacón, Joaquin Barnoya, Scott T Leatherdale
OBJECTIVE: The current study sought to examine Guatemalan adolescents' consumption of sugar-sweetened beverages (SSB), identify which individual-level characteristics are associated with SSB consumption and describe school characteristics that may influence students' SSB consumption. DESIGN: Within this observational pilot study, a questionnaire was used to assess students' consumption of three varieties of SSB (soft drinks, energy drinks, sweetened coffees/teas), as well as a variety of sociodemographic and behavioural characteristics...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28799445/molecular-efficacy-of-radio-and-chemotherapy-sequences-from-direct-dna-damages-measurements
#4
Yanfang Dong, Yunfeng Chen, Limei Zhou, Yu Shao, Xianzhi Fu, Yi Zheng
PURPOSE: To investigate the molecular aspects of the synergy of between ionizing radiation and platinum (Pt) chemotherapeutic agents in cancer treatment with chemoradiation therapy (CRT), by measuring damages induced by low-energy electrons (LEE) to DNA bound to cisplatin. LEE are produced abundantly by any types of ionizing radiation and cisplatin represents a typical Pt-chemotherapeutic agents. MATERIALS AND METHODS: Our strategy involves two parallel administrations of cisplatin and irradiation with a 4...
August 11, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28793268/characterizing-expression-and-processing-of-precursor-and-mature-human-trnas-by-hydro-trnaseq-and-par-clip
#5
Tasos Gogakos, Miguel Brown, Aitor Garzia, Cindy Meyer, Markus Hafner, Thomas Tuschl
The participation of tRNAs in fundamental aspects of biology and disease necessitates an accurate, experimentally confirmed annotation of tRNA genes and curation of tRNA sequences. This has been challenging because RNA secondary structure, nucleotide modifications, and tRNA gene multiplicity complicate sequencing and mapping efforts. To address these issues, we developed hydro-tRNAseq, a method based on partial alkaline RNA hydrolysis that generates fragments amenable for sequencing. To identify transcribed tRNA genes, we further complemented this approach with photoactivatable crosslinking and immunoprecipitation (PAR-CLIP) of SSB/La, a conserved protein involved in pre-tRNA processing...
August 8, 2017: Cell Reports
https://www.readbyqxmd.com/read/28789721/sociodemographic-lifestyle-and-behavioural-factors-associated-with-consumption-of-sweetened-beverages-among-adults-in-cambridgeshire-uk-the-fenland-study
#6
Peter Barrett, Fumiaki Imamura, Søren Brage, Simon J Griffin, Nicholas J Wareham, Nita G Forouhi
OBJECTIVE: We aimed to identify sociodemographic, lifestyle and behavioural determinants of consumption of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) among adults in Cambridgeshire, UK. DESIGN: Cross-sectional data were obtained from a cohort of 9991 adults born between 1950 and 1975. An FFQ was used to assess consumption of beverages and other dietary factors. Multivariable logistic regression was used to examine potential determinants of consuming SSB and ASB (≥1 serving/d)...
August 9, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28789696/long-term-follow-up-in-primary-sj%C3%A3-gren-s-syndrome-reveals-differences-in-clinical-presentation-between-female-and-male-patients
#7
Jorge I Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson, Thomas Mandl, Katrine Brække Norheim, Svein Joar Johnsen, Daniel Hammenfors, Malin V Jonsson, Kathrine Skarstein, Johan G Brun, Lars Rönnblom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Eva Baecklund, Elke Theander, Roald Omdal, Roland Jonsson, Gunnel Nordmark, Marie Wahren-Herlenius
BACKGROUND: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjögren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. METHODS: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers...
August 8, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28783737/salivary-gland-ultrasonography-as-a-predictor-of-clinical-activity-in-sj%C3%A3-gren-s-syndrome
#8
Tania Fidelix, Adriano Czapkowski, Sergio Azjen, Adagmar Andriolo, Virginia F M Trevisani
PURPOSE: Primary Sjögren's syndrome is a multisystem autoimmune disease characterized by hypofunction of salivary and lacrimal glands and possible multi-organ system manifestations. Over the past 15 years, three sets of diagnostic criteria have been proposed, but none has included salivary gland ultrasonography. However, recent studies support its role in the diagnosis and prognostic evaluation of patients with Sjögren's syndrome. This study aimed to determine the value of salivary gland ultrasonography in the diagnosis and prognosis of Sjögren's syndrome by relating ultrasonography severity scores to clinical and laboratory data...
2017: PloS One
https://www.readbyqxmd.com/read/28783171/the-pdgfr%C3%AE-laminin-b1-keratin-19-cascade-drives-tumor-progression-at-the-invasive-front-of-human-hepatocellular-carcinoma
#9
O Govaere, M Petz, J Wouters, Y-P Vandewynckel, E J Scott, B Topal, F Nevens, C Verslype, Q M Anstee, H Van Vlierberghe, W Mikulits, T Roskams
Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and laminin beta 1 (LAMB1) expression. PDGFRα has been reported to induce de novo synthesis of LAMB1 protein in a Sjogren syndrome antigen B (La/SSB)-dependent manner in a murine metastasis model. However, the role of this cascade in human HCC remains unclear. This study focused on the functional role of the PDGFRα-La/SSB-LAMB1 pathway and its molecular link to K19 expression in human HCC...
August 7, 2017: Oncogene
https://www.readbyqxmd.com/read/28782560/glutamate-promotes-ssb-protein-protein-interactions-via-intrinsically-disordered-regions
#10
Alexander G Kozlov, Min Kyung Shinn, Elizabeth A Weiland, Timothy M Lohman
E. coli single strand (ss) DNA binding protein (SSB) is an essential protein that binds to ssDNA intermediates formed during genome maintenance. SSB homotetramers bind ssDNA in several modes that differ in occluded site size and cooperativity. High "unlimited" cooperativity is associated with the 35 site size ((SSB)35) mode at low [NaCl], whereas the 65 site size ((SSB)65) mode formed at higher [NaCl] (> 200mM), where ssDNA wraps completely around the tetramer, displays "limited" cooperativity forming dimers of tetramers...
August 3, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28774355/funding-quality-pre-kindergarten-slots-with-philadelphia-s-new-sugary-drink-tax-simulating-effects-of-using-an-excise-tax-to-address-a-social-determinant-of-health
#11
Brent A Langellier, Félice Lê-Scherban, Jonathan Purtle
OBJECTIVE: Philadelphia passed a 1·5-cent-per-ounce sweetened beverage tax (SBT). Revenue will fund 10 000 quality pre-kindergarten slots for poor children. It is imperative to understand how revenue from SBT can be used to fund programmes to address education and other social determinants of health. The objective of the present study was to simulate quality pre-kindergarten attendance, educational achievement and sugar-sweetened beverage (SSB) consumption among Philadelphia children and adolescents under six intervention scenarios: (i) no intervention; (ii) 10 000 additional quality pre-kindergarten slots; (iii) a 1·5-cent-per-ounce SBT; (iv) expanded pre-kindergarten and 1·5-cent-per-ounce SBT; (v) a 3-cent-per-ounce SBT; and (vi) expanded pre-kindergarten and 3-cent-per-ounce SBT...
August 4, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28772105/transient-endothelial-dysfunction-induced-by-sugar-sweetened-beverage-consumption-may-be-attenuated-by-a-single-bout-of-aerobic-exercise
#12
Pia Varsamis, Guillaume Walther, Bianca Share, Frances Taylor, Simon Stewart, Christian Lorenzen, Jordan Loader
BACKGROUND: This study assessed whether aerobic exercise would attenuate microvascular endothelial dysfunction induced by commercial sugar-sweetened beverage (SSB) consumption. METHODS: Eleven healthy males participated in this randomized, single-blind crossover study. Cutaneous microvascular endothelial function was assessed using laser speckle contrast imaging coupled with post-occlusive reactive hyperemia before and after a) consumption of water; b) consumption of a commercial SSB; c) 30min of aerobic exercise followed by water consumption; and d) 30 minutes of aerobic exercise followed by SSB consumption...
July 31, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28771464/two-chaperones-locked-in-an-embrace-structure-and-function-of-the-ribosome-associated-complex-rac
#13
REVIEW
Ying Zhang, Irmgard Sinning, Sabine Rospert
Chaperones, which assist protein folding are essential components of every living cell. The yeast ribosome-associated complex (RAC) is a chaperone that is highly conserved in eukaryotic cells. The RAC consists of the J protein Zuo1 and the unconventional Hsp70 homolog Ssz1. The RAC heterodimer stimulates the ATPase activity of the ribosome-bound Hsp70 homolog Ssb, which interacts with nascent polypeptide chains to facilitate de novo protein folding. In addition, the RAC-Ssb system is required to maintain the fidelity of protein translation...
August 3, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28770708/the-interaction-between-anti-ro-ssa-and-anti-la-ssb-autoantibodies-and-anti-infectious-antibodies-in-a-wide-spectrum-of-auto-immune-diseases-another-angle-of-the-autoimmune-mosaic
#14
Nancy Agmon-Levin, Amir Dagan, Yogev Peri, Juan-Manuel Anaya, Carlo Selmi, Angela Tincani, Nicola Bizzaro, Ljudmila Stojanovich, Jan Damoiseaux, Jan Willem Cohen Tervaert, Marta Mosca, Ricard Cervera, Yehuda Shoenfeld
OBJECTIVES: The presence of anti-Ro/SSA and anti-La/SSB antibodies has been linked with autoimmunity in general and with several autoimmune diseases (AID) in particular. In the current study we evaluated these antibodies in a wide spectrum of AID as well as the links between them and anti-infectious antibodies. METHODS: We examined 2082 sera from patients with 16 different AID compared to 524 sera from geographically-matched healthy controls, for the presence and titres of anti-Ro/SSA and anti-La/SSB...
July 6, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28763128/chemical-tagging-with-t-butyl-and-trimethylsilyl-groups-for-measuring-intermolecular-noes-in-a-large-protein-ligand-complex
#15
Shereen Jabar, Luke Adams, Yao Wang, Luigi Aurelio, Bim Graham, Gottfried Otting
Intermolecular 1H-1H nuclear Overhauser effects (NOE) present a powerful tool to assess contacts between proteins and binding partners, but are difficult to identify for complexes of high molecular weight. We show that intermolecular NOEs can readily be observed following chemical labeling with t-butyl or trimethylsilyl groups. Proteins can be furnished with t-butyl or TMS groups site-specifically using genetically encoded unnatural amino acids or by chemical modification of single cysteine residues. No isotope labeling is required...
August 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28760797/sugar-sweetened-beverage-consumption-correlates-and-interventions-among-australian-aboriginal-and-torres-strait-islander-communities-a-scoping-review-protocol
#16
Jodie C Avery, Jacqueline A Bowden, Joanne Dono, Odette R Gibson, Aimee Brownbill, Wendy Keech, David Roder, Caroline L Miller
INTRODUCTION: Aboriginal and Torres Strait Islander communities of Australia experience poorer health outcomes in the areas of overweight and obesity, diabetes and cardiovascular disease. Contributing to this burden of disease in the Australian community generally and in Aboriginal and Torres Strait Islander communities, is the consumption of sugar-sweetened beverages (SSBs). We have described a protocol for a review to systematically scope articles that document use of SSBs and interventions to reduce their consumption with Aboriginal and Torres Strait Islander people...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28751241/flexibility-assessment-of-the-unfused-thoracic-segments-above-the-potential-upper-instrumented-vertebra-using-the-supine-side-bending-radiographs-in-lenke-5-and-6-curves-for-adolescent-idiopathic-scoliosis-patients
#17
Mun Keong Kwan, Chee Kidd Chiu, Teik Seng Chan, Siti Mariam Abd Gani, Tan Shurn Heng, Chris Yin Wei Chan
BACKGROUND CONTEXT: Selection of UIV for Lenke 5 and 6 curves remains debatable, and several authors had described different selection strategies. OBJECTIVE: This study analyzed the flexibility of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' (T1 to T12) and its compensatory ability in Lenke 5 and 6 curves using supine side bending (SSB) radiographs. STUDY DESIGN: Retrospective study PATIENT SAMPLE: 100 patients OUTCOME MEASURES: The ability of the unfused thoracic segments above the 'potential upper instrumented vertebrae (UIV)' i...
July 24, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28750050/staphylococcus-aureus-single-stranded-dna-binding-protein-ssba-can-bind-but-cannot-stimulate-pria-helicase
#18
Yen-Hua Huang, Hong-Hsiang Guan, Chun-Jung Chen, Cheng-Yang Huang
Single-stranded DNA-binding protein (SSB) and PriA helicase play important roles in bacterial DNA replication restart process. The mechanism by which PriA helicase is bound and stimulated by SSB in Escherichia coli (Ec) has been established, but information on this process in Gram-positive bacteria are limited. We characterized the properties of SSB from Staphylococcus aureus (SaSsbA, a counterpart of EcSSB) and analyzed its interaction with SaPriA. The gel filtration chromatography analysis of purified SaSsbA showed a stable tetramer in solution...
2017: PloS One
https://www.readbyqxmd.com/read/28732309/zebularine-induces-replication-dependent-double-strand-breaks-which-are-preferentially-repaired-by-homologous-recombination
#19
Manuel Luis Orta, Nuria Pastor, Estefanía Burgos-Morón, Inmaculada Domínguez, José Manuel Calderón-Montaño, Carlos Huertas Castaño, Miguel López-Lázaro, Thomas Helleday, Santiago Mateos
Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that preferentially target cancer cells. It acts primarily as a trap for DNA methyl transferases (DNMTs) protein by forming covalent complexes between DNMT protein and zebularine-substrate DNA. It's well documented that replication-blocking DNA lesions can cause replication fork collapse and thereby to the formation of DNA double-strand breaks (DSB). DSB are dangerous lesions that can lead to potentially oncogenic genomic rearrangements or cell death...
July 12, 2017: DNA Repair
https://www.readbyqxmd.com/read/28731385/kids-sip-smarter-a-feasibility-study-to-reduce-sugar-sweetened-beverage-consumption-among-middle-school-youth-in-central-appalachia
#20
Hannah Lane, Kathleen J Porter, Erin Hecht, Priscilla Harris, Vivica Kraak, Jamie Zoellner
PURPOSE: To test the feasibility of Kids SIP smartER, a school-based intervention to reduce consumption of sugar-sweetened beverages (SSBs). DESIGN: Matched-contact randomized crossover study with mixed-methods analysis. SETTING: One middle school in rural, Appalachian Virginia. PARTICIPANTS: Seventy-four sixth and seventh graders (5 classrooms) received Kids SIP smartER in random order over 2 intervention periods. Feasibility outcomes were assessed among 2 teachers...
January 1, 2017: American Journal of Health Promotion: AJHP
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