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https://www.readbyqxmd.com/read/28893613/genotoxic-effects-in-transformed-and-non-transformed-human-breast-cell-lines-after-exposure-to-silver-nanoparticles-in-combination-with-aluminium-chloride-butylparaben-or-di-n-butylphthalate
#1
J Roszak, K Domeradzka-Gajda, A Smok-Pieniążek, A Kozajda, S Spryszyńska, J Grobelny, E Tomaszewska, K Ranoszek-Soliwoda, M Cieślak, D Puchowicz, M Stępnik
In the present study genotoxic effects after combined exposure of human breast cell lines (MCF-10A, MCF-7 and MDB-MB-231) to silver nanoparticles (AgNP, citrate stabilized, 15 and 45nm by STEM, Ag15 and Ag45, respectively) with aluminium chloride, butylparaben, or di-n-butylphthalate were studied. In MCF-10A cells exposed for 24h to Ag15 at the concentration of 23.5μg/mL a statistically significant increase in DNA damage in comet assay (SSB) was observed. In the presence of the test chemicals the genotoxic effect was decreased to a level comparable to control values...
September 8, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28892627/the-sequence-dependence-of-photoinduced-single-strand-break-in-5-bromo-2-deoxyuridine-labeled-dna-supports-electron-transfer-to-be-responsible-for-the-damage
#2
Kinga Westphal, Samanta Makurat, Janusz Rak
The UVB irradiation of DNA labeled with 5-bromo-2'-deoxyuridine (BrdU) leads to single strand breaks (SSBs) as a major photochemical damage. Some time ago we demonstrated that SSB is a secondary damage forming due to thermal dissociation of 2'-deoxyribonolactone generated photochemically in DNA labeled with BrdU. For the first time, we study here the variation of the yield of UVB generated SSBs with the alteration of 3'-neighbour nucleobase of electron donor (2'-deoxyguanine (dG)) and acceptor (excited BrdU) in double stranded DNA...
September 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28890354/employment-changes-associated-with-the-introduction-of-taxes-on-sugar-sweetened-beverages-and-nonessential-energy-dense-food-in-mexico
#3
Carlos M Guerrero-López, Mariana Molina, M Arantxa Colchero
We assessed changes in employment in the manufacturing industry, the commercial sector and national unemployment rates, associated with the fiscal policies implemented in 2014 in Mexico: a 1 peso per liter excise tax to sugar-sweetened beverages (SSB) and an 8% tax on nonessential energy-dense food. We used data from three nationally representative surveys. Controlling for contextual variables, we used interrupted time series analyses to model changes in number of employees in the SSB and nonessential energy-dense food industry, in commercial establishments selling beverages and food and changes in national unemployment rates...
September 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28884973/a-novel-multiplex-pcr-assay-for-detection-of-both-hla-a-31-01-hla-b-15-02-alleles-which-confer-susceptibility-to-carbamazepine-induced-severe-cutaneous-adverse-reactions
#4
Dinh Van Nguyen, Christopher Vidal, Hieu Chi Chu, Nga Thi Quynh Do, Richard Fulton, Jamma Li, Suran L Fernando
HLA-A*31:01 and HLA-B*15:02 have been widely reported to confer genetic susceptibility to carbamazepine-induced severe cutaneous adverse reactions. Accordingly, the screening for these alleles has been highly recommended to prevent SCAR prior to introducing CBZ therapy. Although a number of methods are available for screening of HLA-A*31:01 or HLA-B*15:02 alleles separately, developing an assay that can detect both these alleles would be more clinically practical, cost-effective and less time-consuming. Therefore, in this study, a multiplex PCR using Taq°Man Probe was designed and validated to be able to detect HLA-A*31:01 and HLA-B*15:02...
September 8, 2017: HLA
https://www.readbyqxmd.com/read/28882121/evaluation-of-a-peer-education-program-on-student-leaders-energy-balance-related-behaviors
#5
B C Foley, V A Shrewsbury, L L Hardy, V M Flood, K Byth, S Shah
BACKGROUND: Few studies have reported energy balance-related behavior (EBRB) change for peer leaders delivering health promotion programs to younger students in secondary schools. Our study assessed the impact of the Students As LifeStyle Activists (SALSA) program on SALSA peer leaders' EBRBs, and their intentions regarding these behaviors. METHODS: We used a pre-post study design to assess changes in EBRBs and intentions of Year 10 secondary school students (15-16 year olds) who volunteered to be peer leaders to deliver the SALSA program to Year 8 students (13-14 year olds)...
September 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28878042/interactions-of-the-bacillus-subtilis-dnae-polymerase-with-replisomal-proteins-modulate-its-activity-and-fidelity
#6
Vasileios Paschalis, Emmanuelle Le Chatelier, Matthew Green, François Képès, Panos Soultanas, Laurent Janniere
During Bacillus subtilis replication two replicative polymerases function at the replisome to collectively carry out genome replication. In a reconstituted in vitro replication assay, PolC is the main polymerase while the lagging strand DnaE polymerase briefly extends RNA primers synthesized by the primase DnaG prior to handing-off DNA synthesis to PolC. Here, we show in vivo that (i) the polymerase activity of DnaE is essential for both the initiation and elongation stages of DNA replication, (ii) its error rate varies inversely with PolC concentration, and (iii) its misincorporations are corrected by the mismatch repair system post-replication...
September 2017: Open Biology
https://www.readbyqxmd.com/read/28869998/changes-in-consumption-of-added-sugars-from-age-13-to-30%C3%A2-years-a-systematic-review-and-meta-analysis-of-longitudinal-studies
#7
REVIEW
E M Winpenny, T L Penney, K Corder, M White, E M F van Sluijs
Added sugar intake during adolescence has been associated with weight gain and cardiometabolic risk factors. Moreover, dietary habits may persist into adulthood, increasing chronic disease risk in later life. This systematic review investigated changes in intake of added sugars between the ages of 13 and 30 years. Literature databases were searched for longitudinal studies of diet during adolescence or early adulthood. Retrieved articles were screened for studies including multiple measures of intake of sugars or sugary foods from cohort participants between the ages of 13 and 30...
September 4, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28864259/perceived-impact-of-smaller-compared-with-larger-sized-bottles-of-sugar-sweetened-beverages-on-consumption-a-qualitative-analysis
#8
Eleni Mantzari, Gareth J Hollands, Rachel Pechey, Susan Jebb, Theresa M Marteau
Sugar-sweetened beverage (SSB) consumption increases obesity risk and is linked to adverse health consequences. Large packages increase food consumption, but most evidence comes from studies comparing larger with standard packages, resulting in uncertainty regarding the impact of smaller packages. There is also little research on beverages. This qualitative study explores the experiences of consuming cola from smaller compared with larger bottles, to inform intervention strategies. Sixteen households in Cambridge, England, participating in a feasibility study assessing the impact of bottle size on in-home SSB consumption, received a set amount of cola each week for four weeks in one of four bottle sizes: 1500 ml, 1000 ml, 500 ml, or 250 ml, in random order...
August 31, 2017: Appetite
https://www.readbyqxmd.com/read/28862774/deinococcus-radiodurans-dr1088-is-a-novel-recf-interacting-protein-that-stimulates-single-stranded-dna-annealing
#9
Kaiying Cheng, Guangzhi Xu, Hong Xu, Ye Zhao, Yuejin Hua
RecF, together with the recombination mediators RecO and RecR, is required in the RecFOR homologous recombination repair pathway in bacteria. In this study, a recF-dr1088 operon, which is highly conserved in the Deinococcus-Thermus phylum, was identified in Deinococcus radiodurans. Interaction between DRRecF and DR1088 was confirmed by yeast two-hybrid and pull-down assays. DR1088 exhibited some RecO-like biochemical properties including single/double-stranded DNA binding activity, ssDNA binding protein (SSB) replacement ability and ssDNA (with or without SSB) annealing activity...
September 1, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28856770/genotoxic-effects-of-high-dose-rate-x-ray-and-low-dose-rate-gamma-radiation-in-apc-min-mice
#10
Anne Graupner, Dag M Eide, Dag A Brede, Michele Ellender, Elisabeth Lindbo Hansen, Deborah H Oughton, Simon D Bouffler, Gunnar Brunborg, Ann Karin Olsen
Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with respect to the application of the dose and dose rate effectiveness factor. As part of a study to investigate the development of colon cancer following chronic LDR vs. acute HDR radiation, this study presents the results of genotoxic effects in blood of exposed mice...
August 30, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28851621/pulmonary-arterial-hypertension-associated-with-systemic-lupus-erythematosus-results-from-the-french-pulmonary-hypertension-registry
#11
Eric Hachulla, Xavier Jais, Gaël Cinquetti, Pierre Clerson, Laurence Rottat, David Launay, Vincent Cottin, Gilbert Habib, Grégoire Prevot, Céline Chabanne, Eléna Foïs, Zahir Amoura, Luc Mouthon, Véronique Le Guern, David Montani, Gérald Simonneau, Marc Humbert, Vincent Sobanski, Olivier Sitbon
BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare complication of systemic lupus erythematosus (SLE). METHODS: We identified all patients with SLE and PAH (SLE-PAH) who were enrolled in the French Pulmonary Hypertension Registry with a diagnosis confirmed by right heart catheterization (RHC). A control group of 101 patients with SLE without known PAH was selected from SLE expert centers participating in the Pulmonary Hypertension Registry. Survival was estimated by the Kaplan-Meier method...
August 26, 2017: Chest
https://www.readbyqxmd.com/read/28844688/primary-sj%C3%A3-gren-s-syndrome-and-pregnancy-a-report-of-18-cases
#12
Julia Demarchi, Silvia B Papasidero, Diana Klajn, Paula Alba, Alejandra M Babini, Virginia Durigan, Carla Gobbi, Laura Raiti
Primary Sjögren's syndrome (pSS) is a condition that predominantly affects women. Reports of pregnancy outcome in these patients are limited and contradictory. OBJECTIVE: To describe pregnancy characteristics and outcomes and newborn morbidity in women with pSS. MATERIAL AND METHODS: We included women with pSS who became pregnant after the onset of the symptoms of the disease. Clinical and serological characteristics, risk factors and previous maternal comorbidities are described...
August 24, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28843719/incidence-risk-factors-and-mortality-of-neonatal-and-late-onset-dilated-cardiomyopathy-associated-with-cardiac-neonatal-lupus
#13
Nathalie Morel, Kateri Lévesque, Alice Maltret, Gabriel Baron, Mohamed Hamidou, Pauline Orquevaux, Jean-Charles Piette, François Barriere, Jérôme Le Bidois, Laurent Fermont, Olivier Fain, Arnaud Theulin, François Sassolas, Quentin Hauet, Gaëlle Guettrot-Imbert, Sophie Georgin-Lavialle, Christophe Deligny, Eric Hachulla, Luc Mouthon, Claire Le Jeunne, Philippe Ravaud, Delphine Le Mercier, Bénédicte Romefort, Elisabeth Villain, Damien Bonnet, Nathalie Costedoat-Chalumeau
BACKGROUND: Dilated cardiomyopathy (DCM), a well-known complication of cardiac neonatal lupus, is associated with high mortality rate. Its risk factors remain unclear. METHODS: We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB antibodies. RESULTS: Among 187 neonates with CHB, 35 (18.8%, one missing data) had DCM and 22 (11.8%) died during a median follow-up of 7years [range: birth-36years]...
August 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28843559/an-amplified-fluorescent-aptasensor-based-on-single-stranded-dna-binding-protein-copper-and-silica-nanoparticles-for-sensitive-detection-of-interferon-gamma
#14
Seyed Mohammad Taghdisi, Noor Mohammad Danesh, Mohammad Ramezani, Rezvan Yazdian-Robati, Khalil Abnous
It is great significance to identify interferon-gamma (IFN-γ), as a biological marker for diagnosis of latent tuberculosis, in serum samples. In this paper, a novel fluorescent aptasensor was fabricated and applied for sensitive and specific detection of IFN-γ. This biosensor was based on hairpin structure of oligonucleotide, single-stranded DNA-binding protein (SSB), copper nanoparticles (CuNPs) and silica nanoparticles coated with streptavidin (SNPs-Streptavidin). The presences of double-stranded DNA (dsDNA) region and poly thymine (T) in the hairpin structure of the oligonucleotide, SSB and SNPs-streptavidin caused IFN-γ determination with high selectivity and sensitivity...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28839447/hypokalemic-paralysis-a-hidden-card-of-several-autoimmune-diseases
#15
Yelitza Velarde-Mejía, Rocío Gamboa-Cárdenas, Manuel Ugarte-Gil, César Pastor Asurza
Acute hypokalemic paralysis is a rare and potentially fatal condition, with few related causes, one of which highlights distal renal tubular acidosis (dRTA). Distal renal tubular acidosis is a rare complication of several autoimmune diseases such as systemic lupus erythematosus, Sjögren's syndrome, and Hashimoto thyroiditis. We report a case of a lupic patient who presented rapidly progressive quadriparesis in the context of active renal disease. Research revealed severe refractory hypokalemia, metabolic acidosis, and alkaline urine suggestive of dRTA...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28832651/inhibition-of-the-bioavailability-of-heavy-metals-in-sewage-sludge-biochar-by-adding-two-stabilizers
#16
Zhujian Huang, Qin Lu, Jun Wang, Xian Chen, Xiaoyun Mao, Zhenli He
Agricultural application of sewage sludge (SS) after carbonization is a plausible way for disposal. Despite its benefits of improving soil fertility and C sequestration, heavy metals contained in sewage sludge biochars (SSB) are still a concern. In this study, two types of heavy metal stabilizers were chosen: fulvic acid (FA) and phosphogypsum (with CaSO4, CS, as the main component). The two stabilizers were incorporated into SS prior to 350°C carbonization for 1 h at the rates of 1%, 2%, or 4%. The obtained SSBs were then analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS)...
2017: PloS One
https://www.readbyqxmd.com/read/28805073/do-you-know-what-your-kids-are-drinking-evaluation-of-a-media-campaign-to-reduce-consumption-of-sugar-sweetened-beverages
#17
Amy Bleakley, Amy Jordan, Giridhar Mallya, Michael Hennessy, Jessica Taylor Piotrowski
OBJECTIVE: This study evaluates a citywide media campaign that targeted reducing sugar-sweetened beverage (SSB) consumption as a strategy for addressing obesity. DESIGN: Rolling cross-sectional survey data, collected before and during the media campaign, with 1367 parents to assess exposure to and effect of a televised public service advertisement (TV PSA) developed using a reasoned action approach. SETTING: Televised public service advertisement campaign created by the Philadelphia Department of Public Health and disseminated on cable television channels within the Philadelphia market...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28804786/health-impact-assessment-of-the-uk-soft-drinks-industry-levy-a-comparative-risk-assessment-modelling-study
#18
Adam D M Briggs, Oliver T Mytton, Ariane Kehlbacher, Richard Tiffin, Ahmed Elhussein, Mike Rayner, Susan A Jebb, Tony Blakely, Peter Scarborough
BACKGROUND: In March, 2016, the UK Government proposed a tiered levy on sugar-sweetened beverages (SSBs; high tax for drinks with >8 g of sugar per 100 mL, moderate tax for 5-8 g, and no tax for <5 g). We estimate the effect of possible industry responses to the levy on obesity, diabetes, and dental caries. METHODS: We modelled three possible industry responses: reformulation to reduce sugar concentration, an increase of product price, and a change of the market share of high-sugar, mid-sugar, and low-sugar drinks...
January 2017: Lancet. Public Health
https://www.readbyqxmd.com/read/28803573/the-school-environment-and-sugar-sweetened-beverage-consumption-among-guatemalan-adolescents
#19
Katelyn M Godin, Violeta Chacón, Joaquin Barnoya, Scott T Leatherdale
OBJECTIVE: The current study sought to examine Guatemalan adolescents' consumption of sugar-sweetened beverages (SSB), identify which individual-level characteristics are associated with SSB consumption and describe school characteristics that may influence students' SSB consumption. DESIGN: Within this observational pilot study, a questionnaire was used to assess students' consumption of three varieties of SSB (soft drinks, energy drinks, sweetened coffees/teas), as well as a variety of sociodemographic and behavioural characteristics...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28799445/molecular-efficacy-of-radio-and-chemotherapy-sequences-from-direct-dna-damage-measurements
#20
Yanfang Dong, Yunfeng Chen, Limei Zhou, Yu Shao, Xianzhi Fu, Yi Zheng
PURPOSE: To investigate the molecular aspects of the synergy between ionizing radiation and platinum (Pt) chemotherapeutic agents in cancer treatment with chemoradiation therapy (CRT) by measuring damages induced by low-energy electrons (LEE) to DNA bound to cisplatin. LEE are produced abundantly by any type of ionizing radiation and cisplatin represents a typical Pt-chemotherapeutic agents. MATERIALS AND METHODS: Our strategy involves two parallel administrations of cisplatin and irradiation with a 4...
September 1, 2017: International Journal of Radiation Biology
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