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https://www.readbyqxmd.com/read/27900999/evaluating-anti-smd1-amino-acid-83-119-peptide-reactivity-in-children-with-systemic-lupus-erythematosus-and-other-immunological-diseases
#1
Hai-Ou Yang, Xiao-Qing Zhang, Qi-Hua Fu
BACKGROUND: SmD1-amino-acid 83-119 peptide (SmD183-119) is the major epitope of Smith (Sm) antigen, which is specific for adult systemic lupus erythematosus (SLE). The anti-SmD183-119 antibody has exhibited higher sensitivity and specificity than anti-Sm antibody in diagnosing adult SLE. However, the utility of anti-SmD183-119antibodies remains unclear in children with SLE (cSLE). This study aimed to assess the characteristics of anti-SmD183-119antibody in the diagnosis of cSLE. METHODS: Samples from 242 children with different rheumatological and immunological disorders, including autoimmune diseases (SLE [n = 46] and ankylosing spondylitis [AS, n = 11]), nonautoimmune diseases (Henoch-Schonlein purpura [HSP, n = 60], idiopathic thrombocytopenia purpura [n = 27], hematuria [n = 59], and arthralgia [n = 39]) were collected from Shanghai Children's Medical Center from March 6, 2012 to February 27, 2014...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27886383/permanent-tooth-loss-and-sugar-sweetened-beverage-intake-in-u-s-young-adults
#2
Sunkyung Kim, Sohyun Park, Mei Lin
OBJECTIVE: In young adults, sugar-sweetened beverage (SSB) intake is associated with dental caries, which in turn is a major contributor to tooth loss. The independent role of SSB intake on tooth loss, however, has not been well-described. This cross-sectional study examined associations between tooth loss and SSB intake among U.S. young adults. METHODS: The outcome was number of permanent teeth lost because of dental caries or periodontal disease (0, 1-5, ≥6 teeth)...
November 25, 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/27882919/interaction-of-the-cotranslational-hsp70-ssb-with-ribosomal-proteins-and-rrna-depends-on-its-lid-domain
#3
Andrea Gumiero, Charlotte Conz, Genís Valentín Gesé, Ying Zhang, Felix Alexander Weyer, Karine Lapouge, Julia Kappes, Ulrike von Plehwe, Géza Schermann, Edith Fitzke, Tina Wölfle, Tamás Fischer, Sabine Rospert, Irmgard Sinning
Cotranslational chaperones assist in de novo folding of nascent polypeptides in all organisms. In yeast, the heterodimeric ribosome-associated complex (RAC) forms a unique chaperone triad with the Hsp70 homologue Ssb. We report the X-ray structure of full length Ssb in the ATP-bound open conformation at 2.6 Å resolution and identify a positively charged region in the α-helical lid domain (SBDα), which is present in all members of the Ssb-subfamily of Hsp70s. Mutational analysis demonstrates that this region is strictly required for ribosome binding...
November 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27881980/comparative-genomics-of-dna-recombination-and-repair-in-cyanobacteria-biotechnological-implications
#4
REVIEW
Corinne Cassier-Chauvat, Théo Veaudor, Franck Chauvat
Cyanobacteria are fascinating photosynthetic prokaryotes that are regarded as the ancestors of the plant chloroplast; the purveyors of oxygen and biomass for the food chain; and promising cell factories for an environmentally friendly production of chemicals. In colonizing most waters and soils of our planet, cyanobacteria are inevitably challenged by environmental stresses that generate DNA damages. Furthermore, many strains engineered for biotechnological purposes can use DNA recombination to stop synthesizing the biotechnological product...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27881859/friends-and-social-contexts-as-unshared-environments-a-discordant-sibling-analysis-of-obesity-and-health-related-behaviors-in-young-adolescents
#5
S- Salvy, D M Feda, L H Epstein, J N Roemmich
OBJECTIVE: This study examines the contribution of best friends' weight and the peer social context (time spent alone versus with friends) as sources of unshared environment associated with variability in weight and health behaviors among weight-discordant siblings. METHODS: Pairs of same-sex biologic siblings (N=40 pairs; ages 13-17) were originally recruited as part of a study evaluating putative factors contributing to differences in adiposity among weight-discordant siblings...
November 24, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27878170/absolute-cross-sections-for-dna-strand-breaks-and-crosslinks-induced-by-low-energy-electrons
#6
Wenzhuang Chen, Shiliang Chen, Yanfang Dong, Pierre Cloutier, Yi Zheng, Léon Sanche
Absolute cross sections (CSs) for the interaction of low energy electrons with condensed macromolecules are essential parameters to accurately model ionizing radiation induced reactions. To determine CSs for various conformational DNA damage induced by 2-20 eV electrons, we investigated the influence of the attenuation length (AL) and penetration factor (f) using a mathematical model. Solid films of supercoiled plasmid DNA with thicknesses of 10, 15 and 20 nm were irradiated with 4.6, 5.6, 9.6 and 14.6 eV electrons...
November 23, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27871042/is-trade-liberalisation-a-vector-for-the-spread-of-sugar-sweetened-beverages-a-cross-national-longitudinal-analysis-of-44-low-and-middle-income-countries
#7
Ana Mendez Lopez, Rachel Loopstra, Martin McKee, David Stuckler
Does trade and investment liberalisation increase the growth in sales of sugar-sweetened beverages (SSBs)? Here, for the first time to our knowledge, we test this hypothesis using a unique data source on SSB-specific trade flows. We test whether lower tariffs effectively increase imports of SSBs, and whether a higher level of imports increase sales of SSBs. Cross-national fixed effects models were used to evaluate the association between SSBs sales and trade liberalisation. SSBs per capita sales data were taken from EuroMonitor, covering 44 low- and middle-income countries from 2001 to 2014, SSBs import data were from TradeMap, Foreign Direct Investment data were from EuroMonitor, and data on applied tariffs on SSB from the World Trade Organisation tariffs database, all 2015 editions...
November 4, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27864697/characteristics-of-primary-sj%C3%A3-gren-s-syndrome-patients-with-igg4-positive-plasma-cells-infiltration-in-the-labial-salivary-glands
#8
Chang Liu, Huayong Zhang, Genhong Yao, Yunxia Hu, Jingjing Qi, Yan Wang, Weiwei Chen, Xiaojun Tang, Wenchao Li, Liwei Lu, Luo Gu, Lingyun Sun
The purpose of this study was to investigate the characteristics of primary Sjögren's syndrome (pSS) patients with IgG4 positive (IgG4(+)) plasma cell infiltration in labial salivary glands (LSGs). Paraffin sections of LSGs from 336 pSS patients were stained with IgG4 and IgG monoclonal antibodies. According to the infiltration of IgG4(+) plasma cells, patients were divided and clinical and serological characteristics were analyzed and compared. Based on the infiltration of IgG4(+) plasma cells in the LSGs, patients were divided into three subgroups, low IgG4, moderate IgG4, and high IgG4 groups...
November 18, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27864072/racial-and-gender-disparities-in-sugar-consumption-change-efficacy-among-first-year-college-students
#9
Marino A Bruce, Bettina M Beech, Roland J Thorpe, Krista Mincey, Derek M Griffith
Reducing excess dietary sugar intake among emerging adults involves replacing sugar sweetened beverages (SSBs) and sugary snacks (SSN) with healthier options. Few studies have assessed the perceived degree of difficulty associated with making lifestyle modifications among a diverse group of emerging adults. The purpose of this study was to assess race and gender disparities in SSB and SSN behavioral modification efficacy among African American and White first year college students. A self-administered, cross-sectional survey was completed by a subsample of freshmen (n = 499) at a medium-sized southern university...
November 15, 2016: Appetite
https://www.readbyqxmd.com/read/27862861/the-overexpression-of-insect-endogenous-small-rnas-in-transgenic-rice-inhibits-growth-and-delays-pupation-of-striped-stem-borer-chilo-suppressalis
#10
Shan Jiang, Hao Wu, Haoju Liu, Jie Zheng, Yongjun Lin, Hao Chen
BACKGROUND: Striped stem borer (Chilo suppressalis Walker, SSB) is a major rice insect pest worldwide. RNA interference (RNAi) has become a promising strategy for developing insect-resistant crops. In a previous study, five double-stranded RNAs (dsRNAs) targeting important SSB housekeeping genes were overexpressed in rice, but none of the acquired dsRNA-transgenic rice plants showed significant effects on SSB. RESULTS: Thirteen selected SSB endogenous small RNAs, predicted as SSB novel microRNAs (miRNAs), were overexpressed in rice using artificial miRNA (amiRNA) expression technology...
November 11, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27862026/unusual-presentation-of-sj%C3%A3-gren-associated-neuropathy-with-plasma-cell-rich-infiltrate
#11
Elie Naddaf, Sarah E Berini, P James B Dyck, Ruple S Laughlin
INTRODUCTION: Sjögren syndrome is thought to be a lymphocyte-driven process. Peripheral nervous system involvement occurs in about 20-25% of patients. A sensory predominant, large fiber peripheral neuropathy is most common, and it is usually associated with a subacute to chronic presentation. METHODS: We report a rare case of an acute Sjögren-associated, sensory predominant, length-dependent peripheral neuropathy mimicking Guillain-Barré syndrome. The patient presented with sensory ataxia preceded by fever and polyarthralgia...
November 16, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27857169/mobile-phone-signal-exposure-triggers-a-hormesis-like-effect-in-atm-and-atm-mouse-embryonic-fibroblasts
#12
Chuan Sun, Xiaoxia Wei, Yue Fei, Liling Su, Xinyuan Zhao, Guangdi Chen, Zhengping Xu
Radiofrequency electromagnetic fields (RF-EMFs) have been classified by the International Agency for Research on Cancer as possible carcinogens to humans; however, this conclusion is based on limited epidemiological findings and lacks solid support from experimental studies. In particular, there are no consistent data regarding the genotoxicity of RF-EMFs. Ataxia telangiectasia mutated (ATM) is recognised as a chief guardian of genomic stability. To address the debate on whether RF-EMFs are genotoxic, we compared the effects of 1,800 MHz RF-EMF exposure on genomic DNA in mouse embryonic fibroblasts (MEFs) with proficient (Atm(+/+)) or deficient (Atm(-/-)) ATM...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27829397/design-and-methods-for-a-community-based-intervention-to-reduce-sugar-sweetened-beverage-consumption-among-youth-h2go-study
#13
Monica L Wang, Stephenie C Lemon, Kristian Clausen, Julie Whyte, Milagros C Rosal
BACKGROUND: Reducing sugar-sweetened beverage (SSB) intake is an important dietary target among underserved children at high risk for obesity and associated morbidities. Community-based approaches to reduce SSB intake are needed. The use of narrative-based approaches (presenting messages within the context of a story) can facilitate connection with target health messages and empower children as behavior change agents within their families. The H2GO! program is a community-based behavioral intervention that integrates narrative-based strategies to reduce SSB consumption and promote water intake among school-age youth and parents...
November 9, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27828954/prion-associated-toxicity-is-rescued-by-elimination-of-cotranslational-chaperones
#14
Kathryn M Keefer, Heather L True
The nascent polypeptide-associated complex (NAC) is a highly conserved but poorly characterized triad of proteins that bind near the ribosome exit tunnel. The NAC is the first cotranslational factor to bind to polypeptides and assist with their proper folding. Surprisingly, we found that deletion of NAC subunits in Saccharomyces cerevisiae rescues toxicity associated with the strong [PSI+] prion. This counterintuitive finding can be explained by changes in chaperone balance and distribution whereby the folding of the prion protein is improved and the prion is rendered nontoxic...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27828350/simple-and-reconfigured-single-sideband-ofdm-rof-system
#15
Yuming Xu, Xinying Li, Jianjun Yu, Gee-Kung Chang
We propose a simple and reconfigured dispersion-tolerant single sideband (SSB) orthogonal frequency division multiplexing (OFDM) radio over fiber (RoF) system enabled by digital signal processing (DSP), one in-phase/quadrature (I/Q) modulator and direct-detection. The generated radio frequency (RF) is based on DSP and the frequency can be flexibly adjusted, which can be employed in the future software-defined radio access network (RAN). Based on our proposed system, we have experimentally demonstrated 16-ary quadrature amplitude modulation (16QAM) 21...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27827398/factors-associated-with-sugar-intake-and-sugar-sources-in-european-children-from-1-to-8-years-of-age
#16
I Pawellek, V Grote, M Theurich, R Closa-Monasterolo, A Stolarczyk, E Verduci, A Xhonneux, B Koletzko
BACKGROUND/OBJECTIVES: The World Health Organization recommends to limit intake of free sugars to 5% of total energy per day because of the great impact of high sugar intake on body fat deposition, adiposity and dental caries. However, little data exist about total intake and sources of sugar in European children. Therefore, this paper aims to describe sugar intake and dietary sugar sources and associated factors. SUBJECTS/METHODS: Three-day weighed dietary records were obtained at eight time points from children 1 to 8 years of age (n=995) in five European countries...
November 9, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27803305/clinical-relevance-of-ror%C3%AE-positive-and-negative-subsets-of-cd161-cd4-t-cells-in-primary-sj%C3%A3-gren-s-syndrome
#17
Linlin Zhao, Gaetane Nocturne, Scott Haskett, Saida Boudaoud, Thierry Lazure, Christine Le Pajolec, Xavier Mariette, Michael Mingueneau, Daliya Banerjee
OBJECTIVE: The relevance of the Th17 pathway in primary SS (pSS) is unclear. Published studies have relied on restimulating circulating CD161(+) T cells in vitro for quantitation of IL-17-producing cells. While CD161 marks all IL-17(+) T cells, it is also expressed by other Th subsets. The aim of this study was to directly analyse retinoic acid receptor-related orphan nuclear receptor (ROR)-γ expressing and non-expressing subsets of CD161(+) T cells to determine the relevance of the Th17 pathway in pSS...
November 1, 2016: Rheumatology
https://www.readbyqxmd.com/read/27802278/projected-impact-of-mexico-s-sugar-sweetened-beverage-tax-policy-on-diabetes-and-cardiovascular-disease-a-modeling-study
#18
Luz Maria Sánchez-Romero, Joanne Penko, Pamela G Coxson, Alicia Fernández, Antoinette Mason, Andrew E Moran, Leticia Ávila-Burgos, Michelle Odden, Simón Barquera, Kirsten Bibbins-Domingo
BACKGROUND: Rates of diabetes in Mexico are among the highest worldwide. In 2014, Mexico instituted a nationwide tax on sugar-sweetened beverages (SSBs) in order to reduce the high level of SSB consumption, a preventable cause of diabetes and cardiovascular disease (CVD). We used an established computer simulation model of CVD and country-specific data on demographics, epidemiology, SSB consumption, and short-term changes in consumption following the SSB tax in order to project potential long-range health and economic impacts of SSB taxation in Mexico...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27795684/pyramiding-and-evaluation-of-both-a-foreign-bacillus-thuringiensis-and-a-lysine-rich-protein-gene-in-the-elite-indica-rice-9311
#19
Xin Liu, Cuicui Zhang, Xiaogang Li, Jumin Tu
Gene pyramiding is an efficient approach for the genetic improvement of multiple agronomic traits simultaneously. In this study, we pyramided two foreign genes, cry1Ac driven by the rice Actin I promoter, and lysine-rich protein (LRP), driven by the endosperm-specific GLUTELIN1 (GT1) promoter, into the elite indica cultivar 9311. These two genes were chosen in an attempt to enhance insect-resistance and Lysine (Lys) content. In the pyramided line, the foreign gene cry1Ac was efficiently expressed in the leaves and stems, and exhibited highly efficient resistance to striped stem borer (SSB, Chilo suppressalis Walker) in the laboratory and rice leaf folder (RLF, Cnaphalocrocis medinalis Guenee) in the field...
September 2016: Breeding Science
https://www.readbyqxmd.com/read/27793508/dna-maintenance-following-bleomycin-induced-strand-breaks-does-not-require-poly-adp-ribosyl-ation-activation-in-drosophila-s2-cells
#20
Layal Ishak, Amandine Moretton, Isabelle Garreau-Balandier, Mathilde Lefebvre, Serge Alziari, Philippe Lachaume, Frédéric Morel, Géraldine Farge, Patrick Vernet, Pascal Dubessay
BACKGROUND: Poly-ADP ribosylation (PARylation) is a post translational modification, catalyzed by Poly(ADP-ribose)polymerase (PARP) family. In Drosophila, PARP-I (human PARP-1 ortholog) is considered to be the only enzymatically active isoform. PARylation is involved in various cellular processes such as DNA repair in case of base excision and strand-breaks. OBSERVATIONS: Strand-breaks (SSB and DSB) are detrimental to cell viability and, in Drosophila, that has a unique PARP family organization, little is known on PARP involvement in the control of strand-breaks repair process...
October 21, 2016: DNA Repair
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