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Cartilage repaire

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https://www.readbyqxmd.com/read/28534942/gene-expression-analysis-of-growth-factor-receptors-in-human-chondrocytes-in-monolayer-and-3d-pellet-cultures
#1
Anika Witt, Achim Salamon, Diana Boy, Doris Hansmann, Andreas Büttner, Andreas Wree, Rainer Bader, Anika Jonitz-Heincke
The main goal of cartilage repair is to create functional tissue by enhancing the in vitro conditions to more physiological in vivo conditions. Chondrogenic growth factors play an important role in influencing cartilage homeostasis. Insulin‑like growth factor (IGF)‑1 and transforming growth factor (TGF)‑β1 affect the expression of collagen type II (Col2) and glycosaminoglycans (GAGs) and, therefore, the targeted use of growth factors could make chondrogenic redifferentiation more efficient. In the present study, human chondrocytes were postmortally isolated from healthy articular cartilage and cultivated as monolayer or 3D pellet cultures either under normoxia or hypoxia and stimulated with IGF‑1 and/or TGF‑β1 to compare the impact of the different growth factors...
May 18, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28532603/matrix-replenishing-by-bmscs-is-beneficial-for-osteoarthritic-temporomandiblar-joint-cartilage
#2
Mian Zhang, Hongxu Yang, Lei Lu, Xianghong Wan, Jing Zhang, Hongyun Zhang, Xiaodong Liu, Xiaofeng Huang, Guozhi Xiao, Meiqing Wang
OBJECTIVES: The present goal was to explore whether matrix replenishment is the primary requirement for osteoarthritic (OA) cartilage. METHODS: Cells isolated from the superficial and deep zone cartilage of a pig temporomandibular joint (TMJ) were exposed to fluid flow shear stress (FFSS). Differences in matrix production and cellular differentiation were detected. Unilateral anterior crossbite (UAC) was applied to C57BL/6J female mice. Green fluorescent protein-labelled exogenous bone marrow stromal cells (GFP-BMSCs) were injected weekly into TMJs, starting from 3 weeks of UAC stimulation and continuing for 4-, 8- and 12-weeks...
May 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28532101/sonochemical-synthesis-of-fructose-1-6-bisphosphate-dicalcium-porous-microspheres-and-their-application-in-promotion-of-osteogenic-differentiation
#3
Chao Qi, Ding Zhou, Ying-Jie Zhu, Tuan-Wei Sun, Feng Chen, Chang-Qing Zhang
Human bone mesenchymal stem cells (hBMSCs) have the ability to differentiate into bone and cartilage for clinical bone regeneration. Biomaterials with an innate ability to stimulate osteogenic differentiation of hBMSCs into bone and cartilage are considered attractive candidates for the applications in bone tissue engineering and regeneration. In this paper, we synthesized fructose 1,6-bisphosphate dicalcium (Ca2FBP) porous microspheres by the sonochemical method, and investigated the ability of Ca2FBP for the promotion of the osteogenic differentiation of hBMSCs...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529661/slipped-capital-femoral-epiphysis-management-and-the-arthroscope
#4
F Accadbled, O May, C Thévenin-Lemoine, J Sales de Gauzy
BACKGROUND: In situ pinning of slipped capital femoral epiphysis (SCFE) results in various degrees of deformity of the femoral head-neck junction. Repetitive trauma from cam-type femoroacetabular impingement (FAI) can lead to labral tears and injury to the articular cartilage causing loss of function. Arthroscopic osteoplasty is an alternative to open procedure and to Southwick/Imhäuser-type osteotomies in symptomatic selected cases. SURGICAL TECHNIQUE: The amount of bone to be resected has to be carefully planned pre-operatively...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28529106/engineered-cartilage-regeneration-from-adipose-tissue-derived-mesenchymal-stem-cells-a-morphomolecular-study-on-osteoblast-chondrocyte-and-apoptosis-evaluation
#5
Marta Anna Szychlinska, Paola Castrogiovanni, Houda Nsir, Michelino Di Rosa, Claudia Guglielmino, Rosalba Parenti, Giovanna Calabrese, Elisabetta Pricoco, Lucia Salvatorelli, Gaetano Magro, Rosa Imbesi, Ali Mobasheri, Giuseppe Musumeci
The poor self-repair capacity of cartilage tissue in degenerative conditions, such as osteoarthritis (OA), has prompted the development of a variety of therapeutic approaches, such as cellular therapies and tissue engineering based on the use of mesenchymal stem cells (MSCs). The aim of this study is to demonstrate, for the first time, that the chondrocytes differentiated from rat adipose tissue derived-MSCs (AMSCs), are able to constitute a morphologically and biochemically healthy hyaline cartilage after 6 weeks of culture on a Collagen Cell Carrier (CCC) scaffold...
May 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28528301/selective-laser-sintering-scaffold-with-hierarchical-architecture-and-gradient-composition-for-osteochondral-repair-in-rabbits
#6
Yingying Du, Haoming Liu, Qin Yang, Shuai Wang, Jianglin Wang, Jun Ma, Insup Noh, Antonios G Mikos, Shengmin Zhang
Osteochondral defects cannot be adequately self-repaired due to the presence of the sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the major challenges remaining in this field is the structural design of a biomimetic scaffold that satisfies the specific requirements for osteochondral repair. To address this hurdle, a bio-inspired multilayer osteochondral scaffold that consisted of the poly(ε-caprolactone) (PCL) and the hydroxyapatite (HA)/PCL microspheres, was constructed via selective laser sintering (SLS) technique...
May 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28525525/morphological-observation-on-critical-sized-cranial-defect-repaired-by-icariin-and-autologous-concentrate-growth-factors-in-rabbits
#7
Gang Li, Jie Wang, Guiyun Ren, Fuliang Hao, Yanning Zhang, Peikai Shi, Xiao Liu, Fusheng Dong
BACKGROUND Morphological changes repaired by icariin and autologous concentrate growth factors (ACGF) in critical-sized cranial defect were observed and their promoting effects were investigated. MATERIAL AND METHODS Seventy-two New Zealand white rabbits weighing 1.8~2.0kg were used to build a critical-sized cranial defect model and were randomly divided into 3 groups. X-ray, HE staining, general and histological observation, and immunohistochemistry were used to describe the changes caused by normal saline, icariin, and ACGF...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28523266/stimulating-fracture-healing-in-ischemic-environments-does-oxygen-direct-stem-cell-fate-during-fracture-healing
#8
REVIEW
Katherine R Miclau, Sloane A Brazina, Chelsea S Bahney, Kurt D Hankenson, Thomas K Hunt, Ralph S Marcucio, Theodore Miclau
Bone fractures represent an enormous societal and economic burden as one of the most prevalent causes of disability worldwide. Each year, nearly 15 million people are affected by fractures in the United States alone. Data indicate that the blood supply is critical for fracture healing; as data indicate that concomitant bone and vascular injury are major risk factors for non-union. However, the various role(s) that the vasculature plays remains speculative. Fracture stabilization dictates stem cell fate choices during repair...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28518137/nerve-growth-factor-from-chinese-cobra-venom-stimulates-chondrogenic-differentiation-of-mesenchymal-stem-cells
#9
Zhenhui Lu, Danqing Lei, Tongmeng Jiang, Lihui Yang, Li Zheng, Jinmin Zhao
Growth factors such as transforming growth factor beta1 (TGF-β1), have critical roles in the regulation of the chondrogenic differentiation of mesenchymal stem cells (MSCs), which promote cartilage repair. However, the clinical applications of the traditional growth factors are limited by their high cost, functional heterogeneity and unpredictable effects, such as cyst formation. It may be advantageous for cartilage regeneration to identify a low-cost substitute with greater chondral specificity and easy accessibility...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28515058/tissue-engineered-cartilage-constructed-by-a-biotin-conjugated-anti-cd44-avidin-binding-technique-for-the-repairing-of-cartilage-defects-in-the-weight-bearing-area-of-knee-joints-in-pigs
#10
H Lin, J Zhou, L Cao, H R Wang, J Dong, Z R Chen
OBJECTIVES: The lack of effective treatment for cartilage defects has prompted investigations using tissue engineering techniques for their regeneration and repair. The success of tissue-engineered repair of cartilage may depend on the rapid and efficient adhesion of transplanted cells to a scaffold. Our aim in this study was to repair full-thickness defects in articular cartilage in the weight-bearing area of a porcine model, and to investigate whether the CD44 monoclonal antibody biotin-avidin (CBA) binding technique could provide satisfactory tissue-engineered cartilage...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28513840/histomorphology-and-innate-immunity-during-the-progression-of-osteoarthritis-does-synovitis-affect-cartilage-degradation
#11
Huan Wang, Qingguo Wang, Meijuan Yang, Lili Yang, Weili Wang, Haobin Ding, Dong Zhang, Jing Xu, Xuezhang Tang, Haitao Ding, Qingfu Wang
Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological stages of the disease. In the present study, our aim was to assess changes in innate immunity during the pathological processes of OA in articular cartilage (AC) and the synovial membrane (SM), which are the major structures in joints, and to systematically examine the histological changes in AC and SM in mild, moderate and severe cases of OA, in order to further speculate about the manner in which the interactions of AC and SM are facilitated by innate immunity...
May 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28512850/in-situ-handheld-3d-bioprinting-for-cartilage-regeneration
#12
Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong
Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ 3D printing is an exciting and innovative bio-fabrication technology that enables the surgeon to deliver tissue- engineering techniques at the time and location of need. We have created a hand- held 3D printing device (Biopen) that allows the simultaneous co-axial extrusion of bioscaffold and cultured cells directly into the cartilage defect in vivo in a single session surgery. This pilot study assesses the ability of the Biopen to repair a full thickness chondral defect and the early outcomes in cartilage regeneration, and compares these results to other treatments in a large animal model...
May 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28511868/tunnel-malpositions-in-anterior-cruciate-ligament-risk-cartilaginous-changes-and-bucket-handle-meniscal-tear-arthroscopic-survey-in-both-primary-and-revision-surgery
#13
Daisuke Chiba, Eiichi Tsuda, Harehiko Tsukada, Kohei Iio, Yasuyuki Ishibashi
OBJECTIVES: There are not many chances to arthroscopically reassess how graft tunnel malpositions in primary anterior cruciate ligament reconstruction (ACLR) associate with intra-articular degeneration in revision ACLR. This study was aimed to evaluate whether radiographic tunnel position in primary ACLR affect cartilaginous changes and bucket-handle meniscus tears in revision ACLR. METHODS: Thirty-five patients who underwent revision ACLR were recruited; their primary surgeries were single-bundle reconstructions...
May 13, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28508891/joint-morphogenetic-cells-in-the-adult-mammalian-synovium
#14
Anke J Roelofs, Janja Zupan, Anna H K Riemen, Karolina Kania, Sharon Ansboro, Nathan White, Susan M Clark, Cosimo De Bari
The stem cells that safeguard synovial joints in adulthood are undefined. Studies on mesenchymal stromal/stem cells (MSCs) have mainly focused on bone marrow. Here we show that lineage tracing of Gdf5-expressing joint interzone cells identifies in adult mouse synovium an MSC population largely negative for the skeletal stem cell markers Nestin-GFP, Leptin receptor and Gremlin1. Following cartilage injury, Gdf5-lineage cells underpin synovial hyperplasia through proliferation, are recruited to a Nestin-GFP(high) perivascular population, and contribute to cartilage repair...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28508007/five-year-outcomes-after-treatment-for-acute-instability-of-the-tibiofibular-syndesmosis-using-a-suture-button-fixation-system
#15
Paul F Förschner, Knut Beitzel, Andreas B Imhoff, Stefan Buchmann, Georg Feuerriegel, Felix Hofmann, Dimitrios C Karampinos, Pia Jungmann, Jonas Pogorzelski
BACKGROUND: Suture-button repair is a widely accepted surgical treatment for acute and isolated ankle syndesmosis injuries. To our knowledge, midterm results have not previously been reported. PURPOSE: To evaluate the clinical, qualitative, and quantitative radiological midterm outcomes of suture-button repair after acute isolated ankle syndesmosis injuries. STUDY DESIGN: Retrospective case series; Level of evidence, 4. METHODS: Clinical outcomes were measured using the Foot and Ankle Disability Index (FADI) and the American Orthopaedic Foot and Ankle Society (AOFAS) score...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28508006/early-osteoarthritis-after-untreated-anterior-meniscal-root-tears-an-in-vivo-animal-study
#16
Brett D Steineman, Robert F LaPrade, Kelly S Santangelo, Brent T Warner, Laurie R Goodrich, Tammy L Haut Donahue
BACKGROUND: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. PURPOSE: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28501713/an-in-situ-photocrosslinkable-platelet-rich-plasma-complexed-hydrogel-glue-with-growth-factor-controlled-release-ability-to-promote-cartilage-defect-repair
#17
Xiaolin Liu, Yunlong Yang, Xin Niu, Qiuning Lin, Bizeng Zhao, Yang Wang, Linyong Zhu
The repair of articular cartilage injury is a great clinical challenge. Platelet-rich plasma (PRP) has attracted much attention for the repair of articular cartilage injury, because it contains various growth factors that are beneficial for wound repair. However, current administration methods of PRP face many shortcomings, such as unstable biological fixation and burst release of growth factors, all of which will bring troubles to its application in the repair of articular cartilage and compromise its therapeutic efficacy...
May 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28499502/sesamin-encouraging-effects-on-chondrogenic-differentiation-of-human-amniotic-fluid-derived-mesenchymal-stem-cells
#18
Suteera Narakornsak, Sirinda Aungsuchawan, Peeraphan Pothacharoen, Runchana Markmee, Waleephan Tancharoen, Tanongsak Laowanitwattana, Chawapon Thaojamnong, Lamaiporn Peerapapong, Nonglak Boonma, Witoon Tasuya, Junjira Keawdee, Naree Poovachiranon
Worldwide, the most recognized musculoskeletal degenerative disease is osteoarthritis (OA). Sesamin, a major abundant lignan compound present in Sesamun Indicum Linn, has been described for its various pharmacological effects and health benefits. However, the promoting effects of sesamin on chondrogenic differentiation have not yet been observed. Herein, the aim of this study was to investigate the effects of sesamin on cell cytotoxicity and the potent supporting effects on chondrogenic differentiation of human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28499496/relationships-between-quantitative-pulse-echo-ultrasound-parameters-from-the-superficial-zone-of-the-human-articular-cartilage-and-changes-in-surface-roughness-collagen-content-or-collagen-orientation-caused-by-early-degeneration
#19
Wataru Kiyan, Akira Ito, Yasuaki Nakagawa, Shogo Mukai, Koji Mori, Tatsuo Arai, Eiichiro Uchino, Yasushi Okuno, Hiroshi Kuroki
We aimed to quantitatively investigate the relationship between amplitude-based pulse-echo ultrasound parameters and early degeneration of the knee articular cartilage. Twenty samples from six human femoral condyles judged as grade 0 or 1 according to International Cartilage Repair Society grading were assessed using a 15-MHz pulsed-ultrasound 3-D scanning system ex vivo. Surface roughness (Rq), average collagen content (A1) and collagen orientation (A12) in the superficial zone of the cartilage were measured via laser microscopy and Fourier transform infrared imaging spectroscopy...
May 9, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28496944/current-state-of-cartilage-tissue-engineering-using-nanofibrous-scaffolds-and-stem-cells
#20
REVIEW
Somaieh Kazemnejad, Manijeh Khanmohammadi, Nafiseh Baheiraei, Shaghayegh Arasteh
Cartilage is an avascular, aneural, and alymphatic connective tissue with a limited capacity caused by low mitotic activity of its resident cells, chondrocytes. Natural repair of full thickness cartilage defects usually leads to the formation of fibrocartilage with lower function and mechanical force compared with the original hyaline cartilage and further deterioration can occur. Tissue engineering and regenerative medicine is a promising strategy to repair bone and articular cartilage defects and rehabilitate joint functions by focusing on the optimal combination of cells, material scaffolds, and signaling molecules...
April 2017: Avicenna Journal of Medical Biotechnology
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