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Cartilage repaire

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https://www.readbyqxmd.com/read/28808811/construction-and-biocompatibility-of-a-thin-type-i-ii-collagen-composite-scaffold
#1
Long Han, Zhong-Wen Zhang, Bo-He Wang, Zhen-Kun Wen
Articular cartilage injury is a common type of damage observed in clinical practice. A matrix-induced autologous chondrocyte implant was developed to repair articular cartilage as an advancement on the autologous chondrocyte implant procedure. Here, we establish a thin double layer of collagen as a novel and effective bioscaffold for the regeneration of cartilaginous lesions. We created a collagen membrane with double layers using a cover slip, a cover slip, and the collagen was then freeze-dried under vacuum...
August 14, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28808630/systematic-review-on-the-use-of-autologous-matrix-induced-chondrogenesis-for-the-repair-of-articular-cartilage-defects-in-patients
#2
Nafisa Shaikh, Matthew K T Seah, Wasim S Khan
AIM: To systematically review the results of studies looking at autologous matrix-induced chondrogenesis (AMIC) in humans. METHODS: A literature search was performed, adhering to the PRISMA guidelines, to review any studies using such techniques in humans. Our initial search retrieved 297 articles listed on MEDLINE, Google Scholar, CINHal and EMBASE. From these studies, 15 studies meeting the eligibility criteria were selected and formed the basis of our systematic review...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28806310/the-prevention-of-recurrent-cholesteatoma-in-cwu-surgery-the-use-of-titanium-sheeting
#3
Bruce Black, Ian Gutteridge
OBJECTIVE: Assessment of the outcomes of a technique of prevention of recurrent cholesteatoma in canal wall up (CWU) mastoidectomy, using titanium sheeting to repair the external auditory canal wall. PATIENTS: Sixty four cholesteatoma cases were managed during a period from 2007 to 2015. The cases were unselected; the surgery was performed by the senior author. Cholesteatoma Patterns Were: Forty two attic, nine pars tensa, seven combined attic-pars tensa, three congenital, and three other...
August 10, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28804984/3d-bioprinting-for-cartilage-and-osteochondral-tissue-engineering
#4
REVIEW
Andrew C Daly, Fiona E Freeman, Tomas Gonzalez-Fernandez, Susan E Critchley, Jessica Nulty, Daniel J Kelly
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28801718/stentless-endoscopic-repair-of-congenital-choanal-atresia-is-it-enough-for-maintaining-choanal-patency
#5
Emel Çadallı Tatar, Bülent Öcal, Esra Doğan, Ömer Bayır, Cem Saka, Ali Özdek, Mehmet Hakan Korkmaz
The aim of choanal atresia (CA) surgery is to achieve bilateral nasal patency. Among the different methods of CA repair, the endoscopic transnasal approach has gained recent popularity with the advent of endoscopic instruments and techniques. This article describes our experience regarding CA repair that was done either using or not using a stent in different periods of time in our department. Between February 2006 and February 2016, a total of 29 patients aged 2 days-53 years underwent endoscopic transnasal CA repair...
August 11, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28801212/intraoperative-validation-of-quantitative-t2-mapping-in-patients-with-articular-cartilage-lesions-of-the-knee
#6
Stefan Soellner, Axel Goldmann, Daniel Muelheims, Goetz H Welsch, Milena Pachowsky
OBJECTIVE: The aim of this study was to compare T2 relaxation times of knee cartilage with intraoperative results for the assessment of early osteoarthritis (OA) and to define T2 values for the differentiation between healthy and degenerated cartilage. DESIGN: Twenty-one patients with cartilage lesions or moderate OA were examined using 3T MRI. In this prospective study, a total of 882 regions of interest (ROIs) were examined by a sagittal, multi-echo, spin-echo T2 sequence and a morphological high-resolution three-dimensional, fat-saturated proton-density space sequence...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28800402/extracellular-matrix-cartilage-allograft-and-particulate-cartilage-allograft-for-osteochondral-lesions-of-the-knee-and-ankle-joints-a-systematic-review
#7
Dexter Seow, Youichi Yasui, Eoghan T Hurley, Andrew W Ross, Christopher D Murawski, Yoshiharu Shimozono, John G Kennedy
BACKGROUND: Extracellular matrix cartilage allografts (EMCAs) and particulate cartilage allografts (PCAs) are relatively new biologics that may improve the quality of cartilage regeneration after bone marrow stimulation. The increasing popularity of these novel biologics in the treatment of osteochondral lesions (OCLs) of the knee and ankle joints prompts a systematic evaluation of their efficacies. PURPOSE: The purpose of this systematic review was to clarify the effectiveness of EMCAs and PCAs on cartilage regeneration...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28798993/decellularization-and-recellularization-of-cartilage
#8
Catherine A Bautista, Bahar Bilgen
Decellularization of cartilage enables the use of cartilage allografts or xenografts as natural scaffolds for repair and regeneration of injured cartilage. The preservation of the extracellular matrix ultrastructure of the graft makes this a promising tool for cartilage tissue engineering. We have optimized the decellularization protocol by enzymatically digesting proteoglycans while preserving the native collagen architecture. Here we describe our methods for cartilage decellularization and cell labeling for the tracking of infiltration for recellularization in detail...
August 11, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28797874/factors-affecting-articular-cartilage-repair-after-open-wedge-high-tibial-osteotomy
#9
Chang-Wan Kim, Seung-Suk Seo, Chang-Rack Lee, Heui-Chul Gwak, Jung-Han Kim, Sun-Gyu Jung
BACKGROUND: To evaluate the factors that affect articular cartilage repair after open-wedge high tibial osteotomy (OWHTO) and the relationship between regeneration of articular cartilage repair and clinical outcomes. METHODS: Among the cases of OWHTO that were performed from March 2005 to February 2012, the patients who followed up for >2years and received a second-look arthroscopy were retrospectively reviewed. For clinical evaluation, the Knee Society scores and Western Ontario and McMaster Universities Osteoarthritis Index score were measured...
August 8, 2017: Knee
https://www.readbyqxmd.com/read/28795641/fixation-of-hydrogel-constructs-for-cartilage-repair-in-the-equine-model-a-challenging-issue
#10
Irina A D Mancini, Rafael Angel Vindas Bolanos, Harold Brommer, Miguel Castilho, Alexandro Ribeiro, J P A M van Loon, Anneloes Mensinga, Mattie H P Van Rijen, Jos Malda, René van Weeren
<u><b>Objective</b></u> To evaluate the use of commercial and autologous fibrin glue and of an alternative method based on a 3D-printed polycaprolactone (PCL) anchor for the fixation of hydrogel-based scaffolds in an equine model for cartilage repair. <u><b>Methods</b></u> In a first study, three different hydrogel-based materials were orthotopically implanted in nine horses for 1-4 weeks in 6mm diameter full thickness cartilage defects in the medial femoral trochlear ridge and fixated with commercially available fibrin glue (CFG)...
August 10, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28792637/modulation-of-chondrocyte-motility-by-tetrahedral-dna-nanostructures
#11
Sirong Shi, Shiyu Lin, Xiaoru Shao, Qianshun Li, Zhang Tao, Yunfeng Lin
OBJECTIVES: Contemporarily, a highly increasing attention was paid to nanoconstructs, particularly DNA nanostructures possessing precise organization, functional manipulation, biocompatibility and biodegradability. Amongst these DNA nanomaterials, tetrahedral DNA nanostructures (TDNs) are a significantly ideal bionanomaterials with focusing on the property that can be internalized into cytoplasm in the absence of transfection. Therefore, the focus of this study was on investigating the influence of TDNs on the chondrocytes locomotion...
August 9, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28792423/novel-%C3%AE-tcp-pva-bilayered-hydrogels-with-considerable-physical-and-bio-functional-properties-for-osteochondral-repair
#12
Hang Yao, Junpei Kang, Weichang Li, Jian Liu, Renjian Xie, Yingjun Wang, Sa Liu, Dong An Wang, Li Ren
Cartilage repairing graft had been widely studied and the osteochondral replacement hydrogels were proved to be an excellent method in research and clinical. However, it was difficult to solve three main issues in osteochondral replacement preparation at one time: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study...
August 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28791817/binder-syndrome-clinical-findings-and-surgical-treatment-of-18-patients-at-the-department-of-plastic-surgery-in-polanica-zdr%C3%A3-j
#13
Piotr H Drozdowski, Ireneusz Łątkowski, Mateusz G Zachara, Piotr Wójcicki
BACKGROUND: Binder syndrome (BS) is an uncommon congenital underdevelopment of the maxilla and nasal skeleton. Other clinical features include a hypoplastic or absent anterior nasal spine; a short, flat nose with short columella; an acute nasolabial angle; a convex upper lip and class III malocclusion. OBJECTIVES: The aim of the study was to outline the major characteristics of BS and to present a variety of surgical treatment methods. MATERIAL AND METHODS: The study included 18 patients treated in the authors' department from 1989 to 2013...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28782725/the-bio-in-the-ink-cartilage-regeneration-with-bioprintable-hydrogels-and-articular-cartilage-derived-progenitor-cells
#14
Riccardo Levato, William R Webb, Iris A Otto, Anneloes Mensinga, Yadan Zhang, Mattie van Rijen, René van Weeren, Ilyas M Khan, Jos Malda
Cell-laden hydrogels are the primary building blocks for bioprinting, and, also termed bioinks, are the foundations for creating structures that can potentially recapitulate the architecture of articular cartilage. To be functional, hydrogel constructs need to unlock the regenerative capacity of encapsulated cells. The recent identification of multipotent articular cartilage-resident chondroprogenitor cells (ACPCs), which share important traits with adult stem cells, represents a new opportunity for cartilage regeneration...
August 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28777662/clinical-and-radiological-regeneration-of-large-and-deep-osteochondral-defects-of-the-knee-by-bone-augmentation-combined-with-matrix-guided-autologous-chondrocyte-transplantation
#15
Johannes Zellner, Stephan Grechenig, Christian G Pfeifer, Werner Krutsch, Matthias Koch, Goetz Welsch, Madeleine Scherl, Johannes Seitz, Florian Zeman, Michael Nerlich, Peter Angele
BACKGROUND: Large osteochondral defects of the knee are a challenge for regenerative treatment. While matrix-guided autologous chondrocyte transplantation (MACT) represents a successful treatment for chondral defects, the treatment potential in combination with bone grafting by cancellous bone or bone block augmentation for large and deep osteochondral defects has not been evaluated. PURPOSE: To evaluate 1- to 3-year clinical outcomes and radiological results on magnetic resonance imaging (MRI) after the treatment of large osteochondral defects of the knee with bone augmentation and MACT...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28777076/cnt-decellularized-cartilage-hybrids-for-tissue-engineering-applications
#16
Toktam Ghassemi, Nasser Saghatolslami, Maryam M Matin, Reza Gheshlaghi, Ali Moradi
An optimized scaffold with adaptable architectural and biochemical properties is a goal for articular cartilage (AC) repair. Mechanically enhanced decellularized AC can be an optimistic ECM-derived scaffold. In this study, reinforced decellularized bovine AC was evaluated for a potential scaffold for cartilage repair applications. Individually dispersed single-wall carbon nanotubes (CNTs) were incorporated into chemically decellularized bovine AC samples. The mechanical and thermodynamic properties as well as biocompatibility of the samples were evaluated through compressive test, SEM, AFM, FTIR, TGA, DSC, and resazurin test...
August 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28772550/a-dual-bonded-approach-for-improving-hydrogel-implant-stability-in-cartilage-defects
#17
Yan Liu, Yuxuan Wu, Lei Zhou, Zhengao Wang, Cong Dai, Chengyun Ning, Guoxin Tan
Integration and stability of hydrogels and surrounding cartilage/bone tissue is crucial for both immediate functionality and long-term performance of the tissue. In this work, chondroitin sulphate (CS) a polysaccharide found in cartilage and other tissues was used to synthesize a tough hydrogel that was chemically functionalized with methacrylate and aldehyde groups, bonding to surrounding tissue via a dual-bonded approach. The hydrogel can not only chemically anchor onto implanted titanium at the subchondral bone, but also on cartilage tissue via the Schiff-base reaction...
February 16, 2017: Materials
https://www.readbyqxmd.com/read/28772498/3d-printing-of-cytocompatible-water-based-light-cured-polyurethane-with-hyaluronic-acid-for-cartilage-tissue-engineering-applications
#18
Ming-You Shie, Wen-Ching Chang, Li-Ju Wei, Yu-Hsin Huang, Chien-Han Chen, Cheng-Ting Shih, Yi-Wen Chen, Yu-Fang Shen
Diseases in articular cartilages have affected millions of people globally. Although the biochemical and cellular composition of articular cartilages is relatively simple, there is a limitation in the self-repair ability of the cartilage. Therefore, developing strategies for cartilage repair is very important. Here, we report on a new liquid resin preparation process of water-based polyurethane based photosensitive materials with hyaluronic acid with application of the materials for 3D printed customized cartilage scaffolds...
February 8, 2017: Materials
https://www.readbyqxmd.com/read/28770483/evaluation-of-reproducibility-of-the-mocart-score-in-patients-with-osteochondral-lesions-of-the-talus-repaired-using-the-autologous-matrix-induced-chondrogenesis-technique
#19
Domenico Albano, Nicolò Martinelli, Alberto Bianchi, Antonino Giacalone, Luca Maria Sconfienza
PURPOSE: To evaluate the applicability and reproducibility of magnetic resonance observation of cartilage repair tissue (MOCART) score for morphological evaluation of osteochondral lesions of the talus (OLT) repaired using autologous matrix-induced chondrogenesis (AMIC) technique. METHODS: Two radiologists (R1-R2) and two orthopaedists (O1-O2) independently reviewed 26 ankle MRIs performed on 13 patients (6 females; age: 38.9 ± 15.9, 14-63) with OLT repaired using AMIC...
August 2, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28769981/human-suprapatellar-fat-pad-derived-mesenchymal-stem-cells-induce-chondrogenesis-and-cartilage-repair-in-a-model-of-severe-osteoarthritis
#20
Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution...
2017: Stem Cells International
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