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Cartilage repaire

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https://www.readbyqxmd.com/read/28333779/impact-of-chronic-suppurative-otitis-media-in-pediatric-cochlear-implant-recipients-insight-into-the-challenges-from-a-tertiary-referral-center-in-uk
#1
Paramita Baruah, Kate Hanvey, Richard Irving, Konstance Tzifa
OBJECTIVE: Analyze the presentation and evolution of chronic suppurative otitis media (CSOM) in children with cochlear implants (CI) and explore the merit of early intervention. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral hospital and cochlear implant programme. PATIENTS: Children with a CI who developed CSOM. INTERVENTION: Tympanoplasty. MAIN OUTCOME MEASURES: Disease control, recurrence of cholesteatoma, cochlear implant preservation...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28333539/age-is-not-a-contraindication-for-cartilage-surgery-a-critical-analysis-of-standardized-outcomes-at-long-term-follow-up
#2
Giuseppe Filardo, Luca Andriolo, Andrea Sessa, Francesca Vannini, Alberto Ferruzzi, Maurilio Marcacci, Elizaveta Kon
BACKGROUND: Age is commonly accepted as a negative prognostic factor in cartilage surgery, and cutoff values of 30 to 40 years have been previously suggested as treatment indication. However, the lower outcome scores documented in older patients do not take in consideration the decreasing requirements of an aging joint. PURPOSE: To analyze the real effect of age in terms of recovery with respect to the functional level expected for different age categories of patients treated for cartilage lesions...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28332587/bioreactor-mechanically-guided-3d-mesenchymal-stem-cell-chondrogenesis-using-a-biocompatible-novel-thermo-reversible-methylcellulose-based-hydrogel
#3
A Cochis, S Grad, M J Stoddart, S Farè, L Altomare, B Azzimonti, M Alini, L Rimondini
Autologous chondrocyte implantation for cartilage repair represents a challenge because strongly limited by chondrocytes' poor expansion capacity in vitro. Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. Moreover, MSC supporting material selection is fundamental to allow for an active interaction with cells. Here, we tested a novel thermo-reversible hydrogel composed of 8% w/v methylcellulose (MC) in a 0...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330431/fabrication-and-characterization-of-biphasic-silk-fibroin-scaffolds-for-tendon-ligament-to-bone-tissue-engineering
#4
Sònia Font Tellado, Walter Bonani, Elizabeth Rosado Balmayor, Peter Föhr, Antonella Motta, Claudio Migliaresi, Martijn van Griensven
Tissue engineering is an attractive strategy for tendon/ligament-to-bone interface repair. The structure and extracellular matrix composition of the interface are complex and allow for a gradual mechanical stress transfer between tendons/ligaments and bone. Thus, scaffolds mimicking the structural features of the native interface may be able to better support functional tissue regeneration. In this study, we fabricated biphasic silk fibroin scaffolds designed to mimic the gradient in collagen molecule alignment present at the interface...
March 23, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28325693/surgical-technique-and-clinical-outcomes-of-retrograde-osteochondral-autograft-transfer-for-osteochondral-lesions-of-the-tibial-plateau
#5
Hiromitsu Yabumoto, Yasuaki Nakagawa, Shogo Mukai, Takahiko Saji, Takashi Nakamura
PURPOSE: To present the surgical technique, clinical outcomes, and poor prognostic factors of arthroscopic retrograde osteochondral autograft transfer of the tibial plateau. METHODS: Twelve patients (6 men, 6 women; mean age, 38.7 years) with tibial plateau osteochondral lesions underwent surgery. The primary diseases were osteonecrosis in 4 cases, cartilage injuries in 6, and postfractures of the tibial plateau in 2. Clinical outcomes were evaluated preoperatively and postoperatively according to the International Knee Documentation Committee score and the Japanese Orthopaedic Association score...
March 18, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28325151/adipose-tissue-derived-pericytes-for-cartilage-tissue-engineering
#6
Jin Xin Zhang, Chun Yan Du, Wei Min Guo, Pan Li, Shu Yun Liu, Zhi Guo Yuan, Jian Hua Yang, Xun Sun, He Yong Yin, Quan Yi Guo, Chen Fu Zhou
Mesenchymal stem cells (MSCs) represent a promising alternative source for cartilage tissue engineering. However, MSC culture is labor-intensive, so these cells cannot be applied immediately to regenerate cartilage for clinical purposes. Risks during the ex vivo expansion of MSCs, such as infection and immunogenicity, can be a bottleneck in their use in clinical tissue engineering. As a novel stem cell source, pericytes are generally considered to be the origin of MSCs. Pericytes do not have to undergo time-consuming ex vivo expansion because they are uncultured cells...
March 21, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28324152/good-clinical-results-with-autologous-matrix-induced-chondrogenesis-amic-technique-in-large-knee-chondral-defects
#7
Alfredo Schiavone Panni, Chiara Del Regno, Giuseppe Mazzitelli, Rocco D'Apolito, Katia Corona, Michele Vasso
PURPOSE: Autologous matrix-induced chondrogenesis (AMIC) is a treatment for focal full-thickness cartilage defects combining microfracturing with an exogenous I/III collagen matrix (Chondro-Gide). The aim of the present study was to determine the 7 years outcomes of patients treated with the AMIC technique for knee chondral defects larger than 2 cm(2). The hypothesis was that the positive short-term outcomes achieved in the previous series would not deteriorate at a 7-year follow-up...
March 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28321429/intermediate-to-long-term-results-of-combined-anterior-cruciate-ligament-reconstruction-and-autologous-chondrocyte-implantation
#8
Andrew N Pike, Tim Bryant, Takahiro Ogura, Tom Minas
BACKGROUND: Cartilage injury associated with anterior cruciate ligament (ACL) ruptures is common; however, relatively few reports exist on concurrent cartilage repair with ACL reconstruction. Autologous chondrocyte implantation (ACI) has been utilized successfully for treatment of moderate to large chondral defects. HYPOTHESIS: ACL insufficiency with relatively large chondral defects may be effectively managed with concurrent ACL reconstruction and ACI. STUDY DESIGN: Case series; Level of evidence, 4...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28319418/autologous-cartilage-chip-transplantation-improves-repair-tissue-composition-compared-with-marrow-stimulation
#9
Bjørn Borsøe Christensen, Morten Lykke Olesen, Martin Lind, Casper Bindzus Foldager
BACKGROUND: Repair of chondral injuries by use of cartilage chips has recently demonstrated clinical feasibility. PURPOSE: To investigate in vivo cartilage repair outcome of autologous cartilage chips compared with marrow stimulation in full-thickness cartilage defects in a minipig model. STUDY DESIGN: Controlled laboratory study. METHODS: Six Göttingen minipigs received two 6-mm chondral defects in the medial and lateral trochlea of each knee...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28318324/subchondral-bone-response-to-injected-adipose-derived-stromal-cells-for-treating-osteoarthritis-using-an-experimental-rabbit-model
#10
A Parrilli, G Giavaresi, A Ferrari, F Salamanna, G Desando, B Grigolo, L Martini, M Fini
Although articular cartilage is the target of osteoarthritis (OA), its deterioration is not always clearly associated with patient symptoms. Because a functional interaction between cartilage and bone is crucial, the pathophysiology of OA and its treatment strategy must focus also on subchondral bone. We investigated whether adipose-derived stromal cells (ASCs) injected into a joint at two different concentrations could prevent subchondral bone damage after the onset of mild OA in a rabbit model. We measured both volumetric and densitometric aspects of bone remodeling...
March 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28318168/-research-progress-of-mechanism-of-hypoxia-inducible-factor-1%C3%AE-signaling-pathway-in-condylar-cartilage-growth-and-remodeling
#11
Xu Gaoli, Wu Lili, Wu Zhiwu, Gu Zhiyuan
The condylar cartilage was adapted to hypoxic conditions in vivo. However, condylar cartilage cells exposed in normoxia in vitro affect the chondrocyte phenotype and cartilage matrix formation. This condition also resulted in great difficulty in chondrocyte research. Culturing chondrocyte should be simulated in in vivo hypoxia environment as much as possible. The hypoxia-inducible factor-1α (HIF-1α) demonstrates an important transcription factor of adaptive response to hypoxic conditions. HIF-1α also plays an active role in maintaining homeostasis and function of chondrocytes...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28302318/regional-differences-of-tibial-and-femoral-cartilage-in-the-chondrocyte-gene-expression-immunhistochemistry-and-composite-in-different-stages-of-osteoarthritis
#12
A Lahm, D Dabravolski, H Spank, H Merk, J Esser, R Kasch
The function of articular cartilage as an avascular tissue is mainly served by collagen type II and proteoglycan molecules. Within this matrix homeostasis between production and breakdown of the matrix is exceptionally sensitive. The current study was conducted to identify regional differences in specific alterations in cartilage composition during the osteoarthritic process of the human knee joint. Therefor the changes in the expression of the key molecules of the extracellular matrix were measured in dependence of the anatomical side (femoral vs tibial) and associated with immunohistochemistry and quantitative measurement...
February 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28301627/single-staged-tunneled-cheek-interpolation-flap-with-cartilage-batten-graft-for-repair-of-nasal-ala-defect
#13
Tatyana A Petukhova, Jayne S Joo, Daniel B Eisen
<p>Surgical defects located within 5 mm of the nasal alar margin are at risk for alar elevation or collapse of the external nasal valve during wound healing. To reduce the chance of such complications, free cartilage grafts may be used as part of the reconstruction. However, if the defect is large enough so that the free cartilage graft does not fill most of the defect, wound contraction can still lead to alar displacement. In these situations, skin may need to be recruited from either the forehead or cheek in the form of an interpolation flap to cover both the free cartilage graft and the residual cutaneous defect...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300491/dynamic-regulation-of-twist1-expression-during-chondrogenic-differentiation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#14
Mairéad A Cleary, Roberto Narcisi, Anna Albiero, Florien Jenner, Laurie M G de Kroon, Wendy J L M Koevoet, Pieter A J Brama, Gerjo J V M van Osch
Human bone marrow-derived mesenchymal stem cells (BMSCs) are clinically promising to repair damaged articular cartilage. This study investigated TWIST1, an important transcriptional regulator in mesenchymal lineages, in BMSC chondrogenesis. We hypothesized that downregulation of TWIST1 expression is required for in vitro chondrogenic differentiation. Indeed, significant downregulation of TWIST1 was observed in murine skeletal progenitor cells during limb development (N = 3 embryos), and during chondrogenic differentiation of culture-expanded human articular chondrocytes (N = 3 donors) and isolated adult human BMSCs (N = 7 donors), consistent with an inhibitory effect of TWIST1 expression on chondrogenic differentiation...
March 16, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28300264/integration-of-stem-cell-derived-exosomes-with-in-situ-hydrogel-glue-as-a-promising-tissue-patch-for-articular-cartilage-regeneration
#15
Xiaolin Liu, Yunlong Yang, Yan Li, Xin Niu, Bizeng Zhao, Yang Wang, Chunyan Bao, Zongping Xie, Qiuning Lin, Linyong Zhu
The regeneration of articular cartilage, which scarcely shows innate self-healing ability, is a great challenge in clinical treatment. Stem cell-derived exosomes (SC-Exos), an important type of extracellular nanovesicle, exhibit great potential for cartilage regeneration to replace stem cell-based therapy. Cartilage regeneration often takes a relatively long time and there is currently no effective administration method to durably retain exosomes at cartilage defect sites to effectively exert their reparative effect...
March 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28298062/traumatic-patellar-dislocation-and-cartilage-injury
#16
Essi E Salonen, Teemu Magga, Petri J Sillanpää, Tommi Kiekara, Heikki Mäenpää, Ville M Mattila
BACKGROUND: Patellofemoral cartilage deterioration and osteoarthritis are reported to be associated with recurrent patellar dislocation. However, the association between first-time traumatic patellar dislocation and cartilage deterioration is unknown. PURPOSE: The aim of this study was to assess long-term cartilage deterioration in the patellofemoral and tibiofemoral joint after conservatively treated traumatic lateral patellar dislocation. STUDY DESIGN: Case series; Level of evidence, 4...
February 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28297584/improvement-of-in-vitro-three-dimensional-cartilage-regeneration-by-a-novel-hydrostatic-pressure-bioreactor
#17
Jie Chen, Zhaoyuan Yuan, Yu Liu, Rui Zheng, Yao Dai, Ran Tao, Huitang Xia, Hairong Liu, Zhiyong Zhang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou
In vitro three-dimensional (3D) cartilage regeneration is a promising strategy for repair of cartilage defects. However, inferior mechanical strength and tissue homogeneity greatly restricted its clinical translation. Simulation of mechanical stress through a bioreactor is an important approach for improving in vitro cartilage regeneration. The current study developed a hydrostatic pressure (HP) bioreactor based on a novel pressure-transmitting mode achieved by slight deformation of a flexible membrane in a completely sealed stainless steel device...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28296552/enhanced-socs3-in-osteoarthiritis-may-limit-both-proliferation-and-inflammation
#18
T Gui, B S He, Q Gan, C Yang
Osteoarthritis (OA) is a degenerative joint disease that is characterized by localized inflammatory and secondary proliferative changes. Suppressor of cytokine signaling 3 (SOCS3) is elevated during OA development. We investigated the effects of this protein on human chondrocyte survival in OA and the inflammatory response together with the mechanisms of these effects. Small interfering RNA (siRNA) was used to knock down the expression of SOCS3 in interleukin(IL)-1β-induced primary human osteoarthritic chondrocytes...
2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28295381/upper-lateral-cartilage-composite-flap-for-closure-of-complicated-septal-perforations
#19
David F Smith, Monirah Albathi, Andrew Lee, Linda N Lee, Kofi D Boahene
OBJECTIVES/HYPOTHESIS: To present a novel technique for the repair of large complicated nasal septal perforations using an upper lateral cartilage composite flap. STUDY DESIGN: This is a case series of five patients with large septal perforations seen at an academic tertiary care center, who have failed previous treatment measures and were selected to undergo this novel reconstruction for closure of their defects. METHODS: Patients were followed clinically to determine the success of the repair...
March 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28291955/change-of-chondral-lesions-and-predictive-factors-after-medial-open-wedge-high-tibial-osteotomy-with-a-locked-plate-system
#20
Kang-Il Kim, Min-Chul Seo, Sang-Jun Song, Dae-Kyung Bae, Duk-Hyun Kim, Sang Hak Lee
BACKGROUND: Although cartilage regeneration after medial open-wedge high tibial osteotomy (HTO) has been described, there is a paucity of reports regarding which factors influence cartilage regeneration. PURPOSE: To document whether cartilage regeneration occurs in the previously degenerated medial compartment of arthritic knees after medial open-wedge HTO without concomitant cartilage procedures and to assess which predictive factors influence regeneration after HTO...
March 1, 2017: American Journal of Sports Medicine
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