Annemarie Lang, Emily A Eastburn, Mousa Younesi, Madhura Nijsure, Carly Siciliano, Annapurna Pranatharthi Haran, Christopher J Panebianco, Elizabeth Seidl, Rui Tang, Eben Alsberg, Nick J Willett, Riccardo Gottardi, Dongeun Huh, Joel D Boerckel
Compromised vascular supply and insufficient neovascularization impede bone repair, increasing risk of non-union. Cyr61, Cysteine-rich angiogenic inducer of 61kD (also known as CCN1), is a matricellular growth factor that is regulated by mechanical cues during fracture repair. Here, we map the distribution of endogenous Cyr61 during bone repair and evaluate the effects of recombinant Cyr61 delivery on vascularized bone regeneration. In vitro, Cyr61 treatment did not alter chondrogenesis or osteogenic gene expression, but significantly enhanced angiogenesis...
April 6, 2024: bioRxiv