Hongyu Ju, Li Cheng, Mengmeng Li, Kunrong Mei, Suhang He, Chuancheng Jia, Xuefeng Guo
In recent decades, there has been a significant increase in the application of single-molecule electrical analysis platforms in studying proteins and peptides. These advanced analysis methods have the potential for deep investigation of enzymatic working mechanisms and accurate monitoring of dynamic changes in protein configurations, which are often challenging to achieve in ensemble measurements. In this work, the prominent research progress in peptide and protein-related studies are surveyed using electronic devices with single-molecule/single-event sensitivity, including single-molecule junctions, single-molecule field-effect transistors, and nanopores...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)