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FK506-induced hepatotoxicity

Chien-Chao Chiu, Yen-Te Huang, Hsiao-Li Chuang, Hans Hsien-Chuan Chen, Tung-Ching Chung
Pseudomonas aeruginosa Exotoxin A (PEA) induces hepatotoxicity in experimental animals. Lipopolysaccharide (LPS) interacts synergistically with xenotoxics to induce severe organ injury. We examined the combination of non-injurious doses of LPS and sub-hepatotoxic PEA in the induction of multiple organ injury (MOI). Rats treated with 20 or 40 microg/kg LPS plus 10 microg/kg PEA developed severe liver, kidney, and lung injury; elevation of TNF-alpha, IFN-gamma, and IL-2; and high mortality. Depletion of Kupffer cells or T-cells by pretreatment with Gadolinium Chloride or FK506, respectively, attenuated MOI...
2009: Immunopharmacology and Immunotoxicology
A Fisher, E Mor, P Hytiroglou, S Emre, P Boccagni, L Chodoff, P Sheiner, M Schwartz, S N Thung, C Miller
No abstract text is available yet for this article.
June 15, 1995: Transplantation
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