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https://www.readbyqxmd.com/read/27916873/the-effect-of-low-dose-iron-and-zinc-intake-on-child-micronutrient-status-and-development-during-the-first-1000-days-of-life-a-systematic-review-and-meta-analysis
#1
REVIEW
Nicolai Petry, Ibironke Olofin, Erick Boy, Moira Donahue Angel, Fabian Rohner
Adequate supply of micronutrients during the first 1000 days is essential for normal development and healthy life. We aimed to investigate if interventions administering dietary doses up to the recommended nutrient intake (RNI) of iron and zinc within the window from conception to age 2 years have the potential to influence nutritional status and development of children. To address this objective, a systematic review and meta-analysis of randomized and quasi-randomized fortification, biofortification, and supplementation trials in women (pregnant and lactating) and children (6-23 months) delivering iron or zinc in doses up to the recommended nutrient intake (RNI) levels was conducted...
November 30, 2016: Nutrients
https://www.readbyqxmd.com/read/27873429/low-association-between-fasting-and-ogtt-stimulated-glucose-levels-with-hba1c-in-overweight-children-and-adolescents
#2
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
BACKGROUND: Diabetes and prediabetes are defined based on different methods such as fasting glucose, glucose at 2-hour in oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). These parameters probably describe different deteriorations in glucose metabolism limiting the exchange between each other in definitions of diabetes. OBJECTIVE: To investigate the relationship between OGTT and HbA1c in overweight and obese children and adolescents living in Germany...
November 22, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27740930/progression-from-impaired-glucose-tolerance-to-type-2-diabetes-in-obese-children-and-adolescents-a-3-6-year-cohort-study-in-southern-thailand
#3
Somchit Jaruratanasirikul, Sudarat Thammaratchuchai, Maneerat Puwanant, Ladda Mo-Suwan, Hutcha Sriplung
BACKGROUND: Childhood obesity is associated with abnormal glucose metabolism and type 2 diabetes mellitus (T2DM). This study evaluated the prevalence of abnormal glucose metabolism in asymptomatic obese children and adolescents, and determined the percentage of T2DM development after 3-6 years of follow-up. METHODS: During 2007-2013, 177 obese children and adolescents who had normal fasting plasma glucose (FPG<100 mg/dL) were given an oral glucose tolerance test (OGTT)...
November 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27671736/plasmodium-falciparum-infection-in-febrile-congolese-children-prevalence-of-clinical-malaria-10-years-after-introduction-of-artemisinin-combination-therapies
#4
Mandingha Kosso Etoka-Beka, Francine Ntoumi, Michael Kombo, Julia Deibert, Pierre Poulain, Christevy Vouvoungui, Simon Charles Kobawila, Felix Koukouikila-Koussounda
OBJECTIVES: To investigate the proportion of malaria infection in febrile children consulting a paediatric hospital in Brazzaville, to determine the prevalence of submicroscopic malaria infection, to characterise Plasmodium falciparum infection and compare the prevalence of uncomplicated P. falciparum malaria according to haemoglobin profiles. METHODS: Blood samples were collected from children aged <10 years with an axillary temperature ≥37.5 °C consulting the paediatric ward of Marien Ngouabi Hospital in Brazzaville...
December 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27590789/the-syndrome-of-inappropriate-secretion-of-anti-diuretic-hormone-siadh-and-brucellosis
#5
Keziban Aslı Bala, Murat Doğan, Sultan Kaba, Sinan Akbayram, Oktay Aslan, Selami Kocaman, Gülsüm İclal Bayhan, Lokman Üstyol, Nihat Demir
BACKGROUND Our study aimed to demonstrate the frequency of the syndrome of inappropriate ADH secretion (SIADH) and associated factors during the course of brucellosis in children and adolescents. MATERIAL AND METHODS The study included children and adolescents aged 0-18 years old diagnosed with brucellosis between 2012 and 2014. The data were collected from patient charts. The diagnosis of brucellosis was made based on titrations >1:160 in standard Wright tube agglutination tests and/or positive culture tests...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27353561/the-role-of-osteopontin-in-the-pathogenesis-and-complication-of-type-1-diabetes-mellitus-in-children-and-adolescents
#6
Mohamed Talat, Laila Sherief, Hosam El-Saadany, Anwar Ahmed, Rabab M Saleh, Maha Sakr
OBJECTIVE: To investigate the levels of serum osteopontin in pediatric patients with type1 diabetes mellitus (T1DM) and to explored if it has a role in the prediction of diabetes complications. METHODS: This was a case-control study conducted at endocrinology unit, children's Hospital, Zagazig University, Egypt, from October 2014 to December 2015. Sixty patients with T1DM and 60 healthy subjects were enrolled. All the children were subjected to detailed medical history; full clinical examination, ophthalmoscopy ; laboratory estimation for fasting blood glucose, hemoglobin A1c (HbA1c), urine albumin / creatinine ratio and serum osteopontin...
June 29, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27275343/metabolic-syndrome-and-cardiovascular-risk-factors-in-obese-adolescent
#7
Manal Mansour, Yasser E Nassef, Mones Abu Shady, Ali Abdel Aziz, Heba A El Malt
BACKGROUND: Childhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this study was to determine the prevalence of cardiovascular risk factor abnormalities and metabolic syndrome in a sample of obese adolescent as prevalence data might be helpful in improving engagement with obesity treatment in future. The high blood lipid levels and obesity are the main risk factors for cardio vascular diseases...
March 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27265160/serum-leptin-as-a-nutritional-biomarker-in-children-with-cerebral-palsy
#8
Chavarin Amarase, Soarawit Weerasopone, Phatcharapa Osateerakun, Sittisak Honsawek, Noppachart Limpaphayom
Adequate nutrition is crucial for children with cerebral palsy (CCP). However, conventional nutritional assessments may be inadequate for defining undernourished CCP. Leptin, an adipocyte hormone controlling energy expenditure, could be a useful marker. Objectives of this cross-sectional analytic study were to explore correlations between serum leptin level and nutritional status, anthropometric measurements, and biochemical parameters in 86 CCP (aged 9 ± 2 years). Subscapular (SST) and triceps (TST) skinfold thicknesses, weight, and calculated height were obtained...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27262832/iron-deficiency-without-anemia-a-common-yet-under-recognized-diagnosis-in-young-women-with-heavy-menstrual-bleeding
#9
Stephen Johnson, Abigail Lang, Mollie Sturm, Sarah H O'Brien
STUDY OBJECTIVE: To assess the proportion of iron deficiency that is not detected with a screening hemoglobin or complete blood count (CBC) alone in young women with heavy menstrual bleeding. DESIGN: Retrospective review of electronic medical records SETTING: Nationwide Children's Hospital in Columbus, Ohio PARTICIPANTS: 114 young women ages 9-19 years consecutively referred to a Young Women's Hematology Clinic with a complaint of heavy menstrual bleeding RESULTS: Fifty-eight (50...
June 1, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27222704/severe-anemia-and-helicobacter-pylori-infection-in-school-age-children-a-case-reports
#10
Sh Gheibi, M Noroozi, S Hejazi, M Karamyyar, H Farrokh-Eslamlou
BACKGROUND: Iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. However, in a fraction of patients an underlying cause is never found during routine investigation. Recent studies have suggested an association between Helicobacter pylori (H. Pylori) infection and iron-deficiency anemia. CASE PRESENTATION: Here is reported four school aged children (two male, two female) with refractory severe iron-deficiency anemia associated H...
2016: Iranian Journal of Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27212845/amino-terminal-pro-brain-natriuretic-peptide-in-children-with-latent-rheumatic-heart-disease
#11
Justin P Zachariah, Twalib Aliku, Amy Scheel, Babar S Hasan, Peter Lwabi, Craig Sable, Andrea Z Beaton
BACKGROUND: Rheumatic heart disease (RHD) is a global cause of early heart failure. Early RHD is characterized by valvar regurgitation, leading to ventricular distention and possible elaboration of amino-terminal pro-brain natriuretic peptide (NT-proBNP). We investigated the ability of NT-proBNP to distinguish cases of latent RHD detected by echocardiographic screening from the controls. MATERIALS AND METHODS: Ugandan children (N = 44, 36% males, mean age: 12 ± 2 years) with latent RHD (cases) and siblings (controls) by echocardiography were enrolled...
May 2016: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/27199624/response-of-iron-deficiency-anemia-to-intravenous-iron-sucrose-in-pediatric-inflammatory-bowel-disease
#12
Istvan Danko
OBJECTIVES: The objective of this retrospective study was to evaluate the safety and efficacy of intravenous iron sucrose (IS) in iron deficient children with inflammatory bowel disease (IBD) in remission. METHODS: Electronic medical records at a university based pediatric children's hospital were searched for patients in age range 0 to 18 years with diagnosis of IBD and treatment with IS over a 1-year period. Response to IS treatment was assessed by posttreatment changes in ferritin, hemoglobin (Hb), and mean corpuscular volume (MCV)...
March 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27182231/gaucher-disease-in-iraqi-children-clinical-diagnostic-therapeutic-aspects
#13
Rabab Farhan Thejeal, Ausama Jamal Kadhum
BACKGROUND AND OBJECTIVE: Gaucher disease is the most common inherited lysosomal storage disorder. It is a multi organ disease affecting bone marrow, liver, spleen, lungs, and other organs contributes to pancytopenia and massive hepatosplenomegaly. This study aimed to spotlight on clinical and laboratory characteristics of children with Gaucher disease to raise awareness among physicians about the disease and to evaluate the outcome of enzyme replacement therapy (ERT). METHODS: Clinical courses were reviewed in 30 patients with age (2-22 years) with Gaucher disease...
March 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27154417/correlation-between-hemoglobin-levels-of-mothers-and-children-on-exclusive-breastfeeding-in-the-first-six-months-of-life
#14
Rosa de Fátima da Silva Vieira Marques, José Augusto de Aguiar Carrazedo Taddei, Tulio Konstantyner, Affonso Celso Vieira Marques, Josefina Aparecida Pellegrini Braga
OBJECTIVE: To evaluate the correlation between hemoglobin levels of mothers and their children on exclusive breastfeeding in the first six months of life. METHODS: Cross-sectional study with 221 binomials (mother-child) enrolled in a breastfeeding support program, who were stratified into six groups according to the children's age group. The sample consisted of children born at term with normal weight, with no neonatal complications and whose mothers did not have anemia or infectious disease at the time of data collection...
September 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27028343/osteoprotegerin-rankl-adma-and-fetuin-a-serum-levels-in-children-with-type-i-diabetes-mellitus
#15
Dionisios Chrysis, Alexandra Efthymiadou, Alexandra Mermigka, Dimitra Kritikou, Bessie E Spiliotis
INTRODUCTION: Patients with type I diabetes mellitus (T1DM) have increased incidence of atherosclerosis and cardiovascular disease. Although these complications are unusual in children with T1DM, prevention, and early intervention could decrease morbidity and mortality. Osteoprotegerin (OPG), asymmetric dimethylarginine (ADMA), and Fetuin-A have been associated with increased cardiovascular risk (CVR). Increased OPG and ADMA, and decreased or increased Fetuin-A serum levels have been associated with increased CVR...
March 29, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/26986124/diagnostic-difficulties-in-a-pediatric-insulinoma-a-case-report
#16
Ingrith Miron, Smaranda Diaconescu, Gabriel Aprodu, Ileana Ioniuc, Mihai Radu Diaconescu, Lucian Miron
Insulinomas are functional neuroendocrine pancreatic tumors rarely encountered in pediatric pathology. Insulinomas are usually solitary and sporadic, but may occur in association with multiple endocrine neoplasia type 1. Whipple's triad-hypoglycemia, simultaneous compatible adrenergic and/or neurological signs, and relief of symptoms upon the administration of glucose-remains the fundamental diagnostic tool. We report a case of insulinoma in an 11-year-old boy with malnutrition and mild psychic retardation...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26934063/impaired-hemorheological-parameters-and-increased-carotid-intima-media-thickness-in-children-with-subclinical-hypothyroidism
#17
Yasemin Isik-Balci, Sebahat Agladioglu, Kadir Agladioglu, Emine Kilic-Toprak, Ozgen Kilic-Erkek, Bayram Ozhan, Aziz Polat, Melek Bor-Kucukatay
BACKGROUND: Subclinical hypothyroidism (SH) is defined as elevated serum thyroid-stimulating hormone (TSH) concentration associated with normal serum-free thyroxine levels. Effects of hypothyroidism on hemorheology had widely attracted the attention of researchers during the last decade. OBJECTIVE: The purpose of this study is to determine alterations in hemorheological parameters and carotid intima-media thickness (CIMT) in children with SH. METHODS: Fifty-three SH children and 31 healthy controls were enrolled...
2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26931143/maternal-fetal-and-perinatal-alterations-associated-with-obesity-overweight-and-gestational-diabetes-an-observational-cohort-study-preobe
#18
Staffan K Berglund, Luz García-Valdés, Francisco J Torres-Espinola, M Teresa Segura, Cristina Martínez-Zaldívar, María J Aguilar, Ahmad Agil, Jose A Lorente, Jesús Florido, Carmen Padilla, Signe Altmäe, Acensión Marcos, M Carmen López-Sabater, Cristina Campoy
BACKGROUND: Maternal overweight, obesity, and gestational diabetes (GD) have been negatively associated with offspring development. Further knowledge regarding metabolic and nutritional alterations in these mother and their offspring are warranted. METHODS: In an observational cohort study we included 331 pregnant women from Granada, Spain. The mothers were categorized into four groups according to BMI and their GD status; overweight (n:56), obese (n:64), GD (n:79), and healthy normal weight controls (n:132)...
March 1, 2016: BMC Public Health
https://www.readbyqxmd.com/read/26864718/iron-deficiency-anemia-in-newly-diagnosed-celiac-disease-in-children
#19
Maria T Sanseviero, Giuseppe A Mazza, Maria N Pullano, Antonella C Oliveiro, Federica Altomare, Luca Pedrelli, Bruno Dattilo, Roberto Miniero, Gianfranco Meloni, Laura Giancotti, Valentina Talarico
BACKGROUND: Celiac disease (CD) in children may occur with a wide spectrum of clinical manifestations: anemia is the most frequent extraintestinal manifestation, iron deficiency anemia (IDA) is the common presentation. In our study we aimed to assess IDA condition in a large cohort of pediatric patients with newly diagnosed CD. METHODS: Our study includes a cohort of 518 children (340 females and 178 males), 6 months-18 years old, joined between January 1990 and January 2013...
February 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/26847470/urinary-%C3%AE-1-microglobulin-and-albumin-excretion-in-children-and-adolescents-with-type-1-diabetes
#20
Aasem Saif, Neveen Soliman
BACKGROUND: The present study investigated the correlation between urinary α1 -microglobulin as a marker of tubular dysfunction and albumin excretion in children and adolescents with type 1 diabetes (T1D). METHODS: Ninety-two Egyptian patients with T1D were included in the study (mean [± SD] age 14.14 ± 5.13 years). The duration of diabetes in all patients was >5 years (mean [± SD] duration 8.28 ± 2.62 years) and all had normal renal function...
January 2017: Journal of Diabetes
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