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FK506 induce hepatic injury after liver transplantation

Zhiying He, Haibin Zhang, Xin Zhang, Dongfu Xie, Yixin Chen, Kirk J Wangensteen, Stephen C Ekker, Meri Firpo, Changcheng Liu, Dao Xiang, Xiaoyuan Zi, Lijian Hui, Guangshun Yang, Xiaoyan Ding, Yiping Hu, Xin Wang
Functional human hepatocytes xeno-engrafted in mouse liver can be used as a model system to study hepatitis virus infection and vaccine efficacy. Significant liver xeno-repopulation has been reported in two kinds of genetically modified mice that have both immune deficiency and liver injury-induced donor hepatocyte selection: the uPA/SCID mice and Fah(-/-) Rag2(-/-)Il2rg(-/-) mice. The lack of hardy breeding and the overly elaborated technique in these two models may hinder the potential future application of these models to hepatitis virus infection and vaccination studies...
September 2010: American Journal of Pathology
Y Yamaguchi, K Okabe, F Matsumura, E Akizuki, T Matsuda, H Ohshiro, J Liang, S Yamada, K Mori, M Ogawa
The role of nitric oxide (NO) on tissue injury of hepatic allografts during rejection remains controversial. We investigated inducible nitric oxide synthase (iNOS) expression and formation of peroxynitrite in ACI rat liver grafts implanted in recipients. Animals were divided into four experimental groups: group I, isografts; group II, untreated hepatic allografts; group III, allografts treated with FK506; and group IV, allografts pretreated with donor-specific blood transfusion (DST). Serum nitrite/nitrate, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) concentrations increased significantly in group II rats after transplantation but were significantly lower in groups I, III, and IV...
March 1999: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
M Woo, D Przepiorka, C Ippoliti, D Warkentin, I Khouri, H Fritsche, M K├Ârbling
To determine how well tacrolimus (FK506) and cyclosporin A (CsA) are tolerated after HLA-identical blood stem cell transplantation, we performed a retrospective review of 87 adults transplanted consecutively who received FK506 (n = 40) or CsA (n = 47) in a nonrandomized fashion in combination with methylprednisolone for graft-versus-host disease (GVHD) prophylaxis and compared the incidences of complications potentially related to the immunosuppressive agents. Pre-transplant demographic characteristics, drug compliance and rates of acute GVHD were comparable for the two groups...
December 1997: Bone Marrow Transplantation
A J Demetris, J J Fung, S Todo, J McCauley, A Jain, S Takaya, M Alessiani, K Abu-Elmagd, D H Van Thiel, T E Starzl
The effect of conversion from cyclosporine-steroid immunosuppression to the new agent FK506 was studied in 96 liver allograft recipients who were experiencing graft dysfunction or cyclosporine toxicity. Patients were stratified according to the cause of graft dysfunction that ultimately led to conversion to FK506. Response to FK506 introduction was monitored pathologically and biochemically. The outcome of a switch from CsA to FK506 was highly favorable in patients experiencing acute and the early stages of chronic rejection, despite optimal conventional therapy...
May 1992: Transplantation
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