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https://www.readbyqxmd.com/read/29145292/recurrent-spinal-primitive-neuroectodermal-tumor-with-brain-and-bone-metastases-a-case-report
#1
Frank Chen, Shyh-Shin Chiou, Sheng-Fung Lin, Ann-Shung Lieu, Yi-Ting Chen, Chih-Jen Huang
RATIONALE: Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment. PATIENT CONCERNS: A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143901/combined-vertebral-augmentation-and-radiofrequency-ablation-in-the-management-of-spinal-metastases-an-update
#2
REVIEW
Ning Mao Kam, Julian Maingard, Hong Kuan Kok, Dinesh Ranatunga, Duncan Brooks, William C Torreggiani, Peter L Munk, Michael J Lee, Ronil V Chandra, Hamed Asadi
Spinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1 year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stability...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29135471/first-patients-treated-with-a-1-5-t-mri-linac-clinical-proof-of-concept-of-a-high-precision-high-field-mri-guided-radiotherapy-treatment
#3
B W Raaymakers, I M Jürgenliemk-Schulz, G H Bol, M Glitzner, A N T J Kotte, B van Asselen, J C J de Boer, J J Bluemink, S L Hackett, M A Moerland, S J Woodings, J W H Wolthaus, H M van Zijp, M E P Philippens, R Tijssen, J G M Kok, E N de Groot-van Breugel, I Kiekebosch, L T C Meijers, C N Nomden, G G Sikkes, P A H Doornaert, W S C Eppinga, N Kasperts, L G W Kerkmeijer, J H A Tersteeg, K J Brown, B Pais, P Woodhead, J J W Lagendijk
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unrivalled, online and real-time, soft-tissue visualization of the tumour and the surroundings for more precise radiation delivery. The proof of concept of this device was given in 2009 by demonstrating simultaneous irradiation and MR imaging on phantoms, since then the device has been further developed and commercialized by Elekta...
November 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29134357/apparent-diffusion-coefficient-of-vertebral-haemangiomas-allows-differentiation-from-malignant-focal-deposits-in-whole-body-diffusion-weighted-mri
#4
Jessica M Winfield, Gabriele Poillucci, Matthew D Blackledge, David J Collins, Vallari Shah, Nina Tunariu, Martin F Kaiser, Christina Messiou
OBJECTIVES: The aim of this study was to identify apparent diffusion coefficient (ADC) values for typical haemangiomas in the spine and to compare them with active malignant focal deposits. METHODS: This was a retrospective single-institution study. Whole-body magnetic resonance imaging (MRI) scans of 106 successive patients with active multiple myeloma, metastatic prostate or breast cancer were analysed. ADC values of typical vertebral haemangiomas and malignant focal deposits were recorded...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29129354/surgical-management-and-outcomes-of-patients-with-bone-metastases-in-germ-cell-tumors-a-case-series
#5
Alessandro Nini, Marcus Konieczny, Christian Winter, Achim Lusch, Rüdiger Krauspe, Peter Albers
OBJECTIVE: To report perioperative and oncological outcomes of patients with nodal and bone involvement treated with postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) and simultaneous bone resection (BR). PATIENTS AND METHODS: Between 2008 and 2016, 14 consecutive unselected TC patients with nodal and bone involvement underwent PC-RPLND and BR. Surgery was performed together with orthopedic surgeons. Standard PC-RPLNDs were performed in 4 patients...
November 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29112473/percutaneous-thermal-ablation-of-spinal-metastases-recent-advances-and-review
#6
Anderanik Tomasian, Afshin Gangi, Adam N Wallace, Jack W Jennings
OBJECTIVE: The purpose of this study was to review the available armamentarium and most recent advances in minimally invasive, image-guided percutaneous thermal ablation for treatment of spinal metastases. CONCLUSION: Minimally invasive percutaneous spine thermal ablation technologies have proved safe and effective in management of selected patients with spinal metastases. Special attention to procedure techniques including choice of ablation modality, thermoprotection, adequacy of treatment, and postablation imaging is essential for improved patient outcomes...
November 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#7
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
November 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29106668/usim-a-new-device-and-app-for-case-specific-intraoperative-ultrasound-simulation-and-rehearsal-in-neurosurgery-a-preliminary-study
#8
Alessandro Perin, Francesco Ugo Prada, Michela Moraldo, Andrea Schiappacasse, Tommaso Francesco Galbiati, Enrico Gambatesa, Piergiorgio d'Orio, Nicole Irene Riker, Curzio Basso, Matteo Santoro, Torstein Ragnar Meling, Karl Schaller, Francesco DiMeco
BACKGROUND: Intraoperative ultrasound (iUS) is an excellent aid for neurosurgeons to perform better and safer operations thanks to real time, continuous, and high-quality intraoperative visualization. OBJECTIVE: To develop an innovative training method to teach how to perform iUS in neurosurgery. METHODS: Patients undergoing surgery for different brain or spine lesions were iUS scanned (before opening the dura) in order to arrange a collection of 3-dimensional, US images; this set of data was matched and paired to preoperatively acquired magnetic resonance images in order to create a library of neurosurgical cases to be studied offline for training and rehearsal purposes...
June 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29097953/a-young-female-athlete-with-acute-low-back-pain-caused-by-stage-iv-breast-cancer
#9
Evan A Kahn
Objective: The purpose of this case report is to describe the case of a young female athlete with low back pain caused by metastatic breast cancer. Clinical Features: A 27-year-old woman presented with low back pain after striking a ball during kickball 3 days earlier. Because of the mechanism of injury and onset, the patient was originally diagnosed with a lumbar spine sprain/strain. Intervention/Outcome: After radiographs were obtained and were read as unremarkable, a 2-week trial of care was initiated that included soft-tissue mobilizations, anti-inflammatory medications from her primary care physician, and therapeutic rehabilitation exercises...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29095674/bone-marrow-metastases-t2-weighted-dixon-spin-echo-fat-images-can-replace-t1-weighted-spin-echo-images
#10
Yaël Maeder, Vincent Dunet, Raphael Richard, Fabio Becce, Patrick Omoumi
Purpose To test the potential of Dixon T2-weighted fat-only sequences to replace T1-weighted sequences for the detection of bone metastases, with the hypothesis that diagnostic performance with an alternative magnetic resonance (MR) imaging protocol (sagittal spin-echo Dixon T2-weighted fat-only and water-only imaging) would not be inferior to that with the standard protocol (sagittal spin-echo T1-weighted and spin-echo Dixon T2-weighted water-only imaging). Materials and Methods A total of 121 consecutive whole-spine MR imaging examinations (63 men; mean age ± standard deviation, 61...
November 2, 2017: Radiology
https://www.readbyqxmd.com/read/29095319/malignant-pheochromocytoma-with-multiple-vertebral-metastases-causing-acute-incomplete-paralysis-during-pregnancy-literature-review-with-one-case-report
#11
REVIEW
Shuzhong Liu, An Song, Xi Zhou, Xiangyi Kong, William A Li, Yipeng Wang, Yong Liu
RATIONALE: We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The clinical manifestations, imaging results, pathological characteristics, treatment and prognosis of the case were analyzed. PATIENT CONCERNS: A 26-year-old pregnant woman with a history of paroxysmal hypertension during the second trimester presented with lower extremity weakness, numbness, urinary incontinence, and back pain...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29081018/treatment-for-malignant-pheochromocytomas-and-paragangliomas-5%C3%A2-years-of-progress
#12
REVIEW
Paola Jimenez, Claudio Tatsui, Aaron Jessop, Sonali Thosani, Camilo Jimenez
PURPOSE OF REVIEW: The purpose of this manuscript is to review the progress in the field of therapeutics for malignant pheochromocytomas and sympathetic paraganglioma (MPPG) over the past 5 years. RECENT FINDINGS: The manuscript will describe the clinical predictors of survivorship and their influence on the first TNM staging classification for pheochromocytomas and sympathetic paragangliomas, the treatment of hormonal complications, and the rationale that supports the resection of the primary tumor and metastases in patients with otherwise incurable disease...
October 28, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29076897/a-case-of-anaplastic-oligodendroglioma-with-extensive-extraneural-metastases-imaged-with-fdg-pet
#13
Emily B Ambinder, Steven P Rowe
A 28-year-old man with history of anaplastic oligodendroglimoma in the left frontal lobe presented with worsening right leg weakness 2 months after surgical resection. MRI of the brain and spine demonstrated a new mass in the left parietal lobe, as well as extraneural osseous metastases. FDG PET scan subsequently showed widespread extraneural metastatic disease. Extraneural metastases from primary brain tumors are a rare occurrence, although anaplastic oligodendroglioma has a propensity for spreading in such a manner...
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29071122/diagnostic-algorithm-prognostic-factors-and-surgical-treatment-of-metastatic-cancer-diseases-of-the-long-bones-and-spine
#14
REVIEW
Miklós Szendrői, Imre Antal, Attila Szendrői, Áron Lazáry, Péter Pál Varga
Oncological management of skeletal metastases has changed dramatically in the last few decades. A significant number of patients survive for many years with their metastases.Surgeons are more active and the technical repertoire is broader, from plates to intramedullary devices to (tumour) endoprostheses.The philosophy of treatment should be different in the case of a trauma-related fracture and a pathological fracture. A proper algorithm for establishing a diagnosis and evaluation of prognostic factors helps in planning the surgical intervention...
September 2017: EFORT open reviews
https://www.readbyqxmd.com/read/29051709/effect-of-androgen-deprivation-therapy-on-bone-mineral-density-in-a-prostate-cancer-cohort-in-new-zealand-a-pilot-study
#15
Alice Wang, Nishi Karunasinghe, Lindsay Plank, Shuotun Zhu, Sue Osborne, Karen Bishop, Charis Brown, Tiffany Schwass, Jonathan Masters, Michael Holmes, Roger Huang, Christine Keven, Lynnette Ferguson, Ross Lawrenson
INTRODUCTION: Reduction in bone mineral density (BMD) is a common side effect of androgen deprivation therapy (ADT). We aimed to examine the cross-sectional and longitudinal variation in BMD and associated bone markers in patients with nonmetastatic prostate cancer (PCa) managed with and without ADT. METHODS: Bone mineral density of the total body, lumbar spine, femoral neck, ultradistal forearm, and one-third distal radius was measured in 88 patients with PCa without bone metastases at baseline and at 6 months...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29039785/prospective-comparison-of-f-18-choline-pet-ct-scan-versus-axial-mri-for-detecting-bone-metastasis-in-biochemically-relapsed-prostate-cancer-patients
#16
Wouter Huysse, Frédéric Lecouvet, Paolo Castellucci, Piet Ost, Valerie Lambrecht, Carlos Artigas, Marie-Laurence Denis, Kathia De Man, Louke Delrue, Lennart Jans, Aurélie De Bruycker, Filip De Vos, Gert De Meerleer, Karel Decaestecker, Valerie Fonteyne, Bieke Lambert
We compared fluor-18 choline positron emission tomography/computed tomography (PET/CT) and axial skeleton magnetic resonance imaging (MRI) prospectively obtained for the detection of bone metastases in non-castrated patients with biochemically recurrent prostate cancer following primary treatment. PET/CT was performed 45 min post-injection of 3-4 MBq/kg F-18 methyl choline. MRI included T1- and fluid sensitive T2-weighted images of the spine and pelvis. Readers were initially blinded from other results and all scans underwent independent double reading...
October 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/29038086/radiosurgery-for-treatment-of-renal-cell-metastases-to-spine-a-systematic-review-of-the-literature
#17
Brandon W Smith, Jacob R Joseph, Yamaan S Saadeh, Frank La Marca, Nicholas J Szerlip, Thomas C Schermerhorn, Daniel E Spratt, Kelly C Younge, Paul Park
BACKGROUND: The incidence of renal cell carcinoma (RCC) continues to rise, and the spine is the most common site for bony metastasis. Radiation therapy is one treatment for spinal RCC metastasis. Stereotactic body radiotherapy (SBRT) is a newer treatment that reportedly has benefits over conventional external beam radiotherapy (cEBRT). This study systematically reviewed the current literature on SBRT for metastatic RCC to spine. METHODS: A search of PubMed, Embase, and Scopus databases was conducted in accordance with PRISMA guidelines...
October 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29036016/exercise-preserves-physical-function-in-prostate-cancer-patients-with-bone-metastases
#18
Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann, James Denham, Michael Baker, Robert U Newton
PURPOSE: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. METHODS: Between 2012 and 2015, 57 prostate cancer patients (70.0±8.4 years; BMI 28.7±4.0 kg/m) with bone metastases (pelvis 75...
October 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29031992/assessing-the-utility-of-a-prognostication-model-to-predict-1-year-mortality-in-patients-receiving-radiation-therapy-for-spinal-metastases
#19
Diana D Shi, Yu-Hui Chen, Tai Chung Lam, Dana Leonard, Tracy Anne Balboni, Andrew Schoenfeld, Sonia Skamene, Daniel N Cagney, John H Chi, Charles H Cho, Mitchel Harris, Marco L Ferrone, Lauren M Hertan
BACKGROUND CONTEXT: Predicting survival outcomes after radiation therapy alone for metastatic disease of the spine is a challenging task that is important to guiding treatment decisions (e.g., determining dose fractionation and intensity). The New England Spinal Metastasis Score (NESMS) was recently introduced and validated in independent cohorts as a tool to predict 1-year survival following surgery for spinal metastases. This metric is composed of 3 factors: pre-operative albumin, ambulatory status, and modified Bauer score, with the total score ranging from 0 to 3...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29029886/heterogeneity-in-treatment-response-of-spine-metastases-to-spine-stereotactic-radiosurgery-within-radiosensitive-subtypes
#20
Vincent Bernard, Andrew J Bishop, Pamela K Allen, Behrang Amini, Xin A Wang, Jing Li, Claudio E Tatsui, Laurence D Rhines, Paul D Brown, Amol J Ghia
PURPOSE: To characterize outcomes of metastatic colorectal and non-small cell lung cancer (NSCLC) histologies, compared with other radiosensitive histologies, treated with spine stereotactic radiosurgery with regard to local control, overall survival, and predictors of response. METHODS AND MATERIALS: A total of 127 patients with 148 spine stereotactic radiosurgery-treated metastatic lesions at our institution between 2003 and 2013 were reviewed. We assessed clinical endpoints in relation to histologic type, including local control (LC) and overall survival (OS), using univariate and multivariate analyses...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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