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Spine metastases

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https://www.readbyqxmd.com/read/29325524/posterior-decompression-and-occipitocervical-fixation-followed-by-intraoperative-vertebroplasty-for-metastatic-involvement-of-the-axis
#1
Xinjie Wu, Mingsheng Tan, Yingna Qi, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
BACKGROUND: Metastases to the upper cervical spine were rarely reported in the literature. However, metastases to this area may cause spinal instability and cord compression, which in turn can result in respiratory failure and neurological dysfunction. The present study investigated the efficacy and safety of posterior decompression and occipitocervical fixation followed by intraoperative vertebroplasty for this disease. METHODS: This was a retrospective study that included 10 patients with metastatic involvement of the axis from March 2002 to May 2014...
January 11, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29324909/effect-of-hypoparathyroid-on-bone-mineral-density-of-lumber-spine-in-postmenopausal-women-with-differentiated-thyroid-cancinoma
#2
Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29303926/technetium-99m-bone-scintigraphy-in-the-detection-of-cervical-spine-metastases-in-oncological-patients-methodological-issues-on-diagnostic-value
#3
Siamak Sabour, Somayeh Derakhshan
No abstract text is available yet for this article.
January 4, 2018: Spine
https://www.readbyqxmd.com/read/29299738/recursive-partitioning-analysis-is-predictive-of-overall-survival-for-patients-undergoing-spine-stereotactic-radiosurgery
#4
Ehsan H Balagamwala, Jacob A Miller, Chandana A Reddy, Lilyana Angelov, John H Suh, Muhammad B Tariq, Erin S Murphy, Kailin Yang, Toufik Djemil, Anthony Magnelli, Alireza M Mohammadi, Sherry Soeder, Samuel T Chao
Spine stereotactic radiosurgery (SRS) offers excellent radiographic and pain control for patients with spine metastases. We created a prognostic index using recursive partitioning analysis (RPA) to allow better patient selection for spine SRS. Patients who underwent single-fraction spine SRS for spine metastases were included. Primary histologies were divided into favorable (breast/prostate), radioresistant (renal cell/sarcoma/melanoma) and other. Cox proportional hazards regression was done to identify factors associated with overall survival (OS)...
January 3, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29287022/inflammatory-pseudotumor-like-follicular-dendritic-cell-sarcoma-of-the-spleen-computed-tomography-imaging-characteristics-in-5-patients
#5
Xiumei Li, Zhenshan Shi, Ruixiong You, Yueming Li, Dairong Cao, Renjie Lin, Xinming Huang
OBJECTIVES: The purpose of this study was to retrospectively review the computed tomography (CT) and clinicopathological characteristics of inflammatory pseudotumor (IPT)-like follicular dendritic cell sarcoma (FDCS) of the spleen in 5 patients. METHODS: Clinical, pathologic, and CT imaging findings of 5 patients with IPT-like FDCS of the spleen were reviewed and analyzed. Computed tomography imaging and pathologic features were compared. RESULTS: Abdominal unenhanced CT revealed a well-defined hypodense mass in the spleen with complex internal architecture with focal necrosis and/or speckle-strip calcification...
December 28, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29286966/isolated-scapular-metastasis-in-a-patient-with-malignant-struma-ovarii-a-case-report
#6
Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D'Almeida Costa, Américo Delgado Brilhante
CASE: We report the case of a 38-year-old woman who presented with a lytic bone lesion in the left scapula. A biopsy showed a tumor with the histologic appearance of thyroid tissue. She also was found to have a thyroid nodule and an enlarged ovary, both of which were excised. The thyroid nodule turned out to be a benign colloid nodule, and the ovary contained a monodermal teratoma composed of thyroid tissue (struma ovarii). The lesion in the scapula eventually was proven to be metastatic malignant struma ovarii...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29284779/adsorption-rheological-properties-of-blood-serum-in-lung-cancer-patients
#7
Y V Dumanskiy, O Y Stoliarova, O V Syniachenko, M F Giulmamedova, Y A Potapov
The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. PATIENTS AND METHODS: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29283901/vertebroplasty-and-kyphoplasty-for-metastatic-spinal-lesions-a-systematic-review
#8
Mohsen Sadeghi-Naini, Shahram Aarabi, Farhad Shokraneh, Leila Janani, Alexander R Vaccaro, Vafa Rahimi-Movaghar
INTRODUCTION: The spine is the most common site of bone metastases. Vertebroplasty (VP) and kyphoplasty (KP) have been proposed as potential minimally invasive therapeutic options for metastatic spinal lesion (MSL) pain. However, the efficacy of VP and KP on MSL pain is currently unclear. OBJECTIVE: The aim of this study was to assess the effects of VP and KP compared with each other, usual care, or other treatments on pain, disability, and quality of life following MSL...
December 27, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29281479/abscopal-effect-of-radiation-on-bone-metastases-of-breast-cancer-a-case-report
#9
Henry Wc Leung, Shyh-Yau Wang, Huang Jin-Jhih, Agnes Lf Chan
The abscopal effect is defined as the clearance of distant tumors after applying localized irradiation to a particular tumor site. It has been proposed that a mechanism for the abscopal effect might be the activation of the immune system, which leads to immunogenic tumor cell death. Here, we describe a woman with advanced breast cancer that received modified ablative radiation therapy that targeted her primary breast tumor. She experienced an apparent regression of metastatic mass in the thoracic spine. This case supported the hypothesis that the abscopal effect might be attributable to an activation of the systemic immune response...
December 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29245363/nasopharyngeal-carcinoma-with-central-nervous-system-metastases-two-case-reports-and-a-review-of-the-literature
#10
Chunying Shen, Hongmei Ying, Xueguan Lu, Chaosu Hu
RATIONALE: Central nervous system (CNS) metastases are rarely seen in patients with nasopharyngeal carcinoma (NPC). PATIENT CONCERNS: Two NPC patients developed CNS metastases were collected in Fudan University Shanghai Cancer Center. The medical records were reviewed to document patients' characteristics, treatment, and outcomes. In addition, we also provide an overview of the literature concerning this scenario. DIAGNOSES: Both patients were staged T4N1M0 with pathologically confirmed CNS metastases from nasopharyngeal carcinoma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29236139/-notochordal-tumors-benign-notochordal-tumors-and-chordomas
#11
REVIEW
T F E Barth, A von Witzleben, P Möller, S Scheil-Bertram
Benign notochordal tumors (BNCT) and chordomas are primary bone tumors of the spine with a predominant localization in the sacrum and clival region followed by the vertebral bodies. Besides the most common variant (NOS [not otherwise specified] with hepatoid or renal carcinoma cell-like differentiation) chordomas with chondroid, and polymorphic to anaplastic morphology are described. An unfavorable variant are pediatric chordomas with a loss of INI-1. BNCT and chordomas are characterized by the following immunohistological profile: vimentin+, cytokeratin+/-, epithelial membrane antigen (EMA)+/-, S100 protein+/-, brachyury+...
December 13, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29223525/case-series-of-rare-thymoma-metastases-to-the-spine-and-complete-literature-review
#12
Rebecca L Achey, Bryan S Lee, Swetha Sundar, Edward C Benzel, Ajit A Krishnaney
BACKGROUND: We report a series of three cases of metastatic thymoma to the spine with spinal cord compression. An extensive literature review of thymic metastases to the spine was completed in order to provide a comprehensive appraisal of current prognostic indicators and potential treatment algorithms to help guide clinicians in treatment management. CASE DESCRIPTIONS: Between 2000 and 2017, three patients were diagnosed with thymic metastases to the spine at our institution...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29219779/metastases-of-spinal-myxopapillary-ependymoma-unique-characteristics-and-clinical-management
#13
Theresa Kraetzig, Lily McLaughlin, Mark H Bilsky, Ilya Laufer
OBJECTIVE Myxopapillary ependymoma is a benign WHO Grade I tumor most commonly located in the conus-cauda equina region of the spine. Although this tumor is defined by an overall excellent survival, dissemination throughout the whole neuraxis occurs frequently. The current study evaluated the clinical characteristics and significance of myxopapillary ependymoma metastases. METHODS Patients who underwent surgery from 2005 to 2015 for treatment of spinal myxopapillary ependymoma were included in the study. Charts were reviewed for primary tumor symptoms and initial treatment, local recurrence, response to salvage therapy, and presence and behavior of distant metastases...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29208438/an-integrated-multidisciplinary-algorithm-for-the-management-of-spinal-metastases-an-international-spine-oncology-consortium-report
#14
REVIEW
Daniel E Spratt, Whitney H Beeler, Fabio Y de Moraes, Laurence D Rhines, Joseph J Gemmete, Neeraj Chaudhary, David B Shultz, Sean R Smith, Alejandro Berlin, Max Dahele, Ben J Slotman, Kelly C Younge, Mark Bilsky, Paul Park, Nicholas J Szerlip
Spinal metastases are becoming increasingly common because patients with metastatic disease are living longer. The close proximity of the spinal cord to the vertebral column limits many conventional therapeutic options that can otherwise be used to treat cancer. In response to this problem, an innovative multidisciplinary approach has been developed for the management of spinal metastases, leveraging the capabilities of image-guided stereotactic radiosurgery, separation surgery, vertebroplasty, and minimally invasive local ablative approaches...
December 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29198417/the-significance-of-spinal-fixation-in-palliative-surgery-for-spinal-metastases
#15
Shurei Sugita, Takahiro Hozumi, Kiyofumi Yamakawa, Takahiro Goto
The purpose of this study is to assess appropriate fixation methods for surgical spinal stabilization for spinal metastases. 191 patients who underwent spine surgery for spinal metastases are included in this study. The surgeries included 1) posterior decompression only (29), 2) posterior decompression and fixation (153), and 3) decompression and circumferential fixation (9). We evaluated and compared all cases based upon 1) use of fixation, 2) number of levels included in the fixation, 3) type of fixation, 4) use of bone graft, 5) presence of preoperative collapse of involved vertebrae, and 6) involved area of vertebrae according to Kostuik classification...
November 29, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29189958/surgical-treatment-of-spinal-metastases-from-renal-cell-carcinoma-effects-of-preoperative-embolization-on-intraoperative-blood-loss
#16
Matthias Reitz, Klaus Christian Mende, Christopher Cramer, Theresa Krätzig, ZSuzsanna Nagy, Eik Vettorazzi, Sven Oliver Eicker, Marc Dreimann
The objective of this paper is analyzing the effects of preoperative embolization on intraoperative blood loss in spinal surgery for renal cell carcinoma (RCC) metastasis and identifying factors contributing to an increased blood loss in the surgical procedure. A retrospective analysis was performed in patients who were treated in for spinal metastasis from RCC between 2011 and 2016. Factors analyzed were reduction of tumor blush, timing of embolization, selective vs. superselective approach, surgical factors, and tumor volume and localization...
November 30, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29178305/en-bloc-resection-with-the-assistance-of-video-assisted-thoracoscopy-for-left-lower-lung-cancer-invading-thoracic-vertebrae-and-rib-a-case-report
#17
Yun Liang, Peng Liu, Xiao-Gang Zhou, Xi-Lei Li, Hong Lin, Nong Chen, Di Ge, Jian Dong
Lung cancer invading the spine was previously considered unresectable and fatal and, consequently, there are few reports focusing on tumors located in the lower lung lobe and invading the spine. With the development of spinal instrumentation and surgical techniques, and wider acceptance of spondylectomy by surgeons, radical surgical resection has become feasible. Here, we present a case of a male patient with a left lower lung cancer invading thoracic vertebrae who underwent complete resection with sagittal en bloc hemivertebrectomy with video-assisted thoracoscopy...
November 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29145292/recurrent-spinal-primitive-neuroectodermal-tumor-with-brain-and-bone-metastases-a-case-report
#18
Frank Chen, Shyh-Shin Chiou, Sheng-Fung Lin, Ann-Shung Lieu, Yi-Ting Chen, Chih-Jen Huang
RATIONALE: Primary spinal primitive neuroectodermal tumor (PNET) is relatively rare in all age groups, and the prognosis in most cases of spinal PNETs appears to be poor, with a median patient survival of 1 to 2 years. We present a case with recurrent spinal PNET with brain and bone metastases that was successfully treated by multimodality treatment. PATIENT CONCERNS: A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143901/combined-vertebral-augmentation-and-radiofrequency-ablation-in-the-management-of-spinal-metastases-an-update
#19
REVIEW
Ning Mao Kam, Julian Maingard, Hong Kuan Kok, Dinesh Ranatunga, Duncan Brooks, William C Torreggiani, Peter L Munk, Michael J Lee, Ronil V Chandra, Hamed Asadi
Spinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1 year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stability...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29135471/first-patients-treated-with-a-1-5-t-mri-linac-clinical-proof-of-concept-of-a-high-precision-high-field-mri-guided-radiotherapy-treatment
#20
B W Raaymakers, I M Jürgenliemk-Schulz, G H Bol, M Glitzner, A N T J Kotte, B van Asselen, J C J de Boer, J J Bluemink, S L Hackett, M A Moerland, S J Woodings, J W H Wolthaus, H M van Zijp, M E P Philippens, R Tijssen, J G M Kok, E N de Groot-van Breugel, I Kiekebosch, L T C Meijers, C N Nomden, G G Sikkes, P A H Doornaert, W S C Eppinga, N Kasperts, L G W Kerkmeijer, J H A Tersteeg, K J Brown, B Pais, P Woodhead, J J W Lagendijk
The integration of 1.5 T MRI functionality with a radiotherapy linear accelerator (linac) has been pursued since 1999 by the UMC Utrecht in close collaboration with Elekta and Philips. The idea behind this integrated device is to offer unrivalled, online and real-time, soft-tissue visualization of the tumour and the surroundings for more precise radiation delivery. The proof of concept of this device was given in 2009 by demonstrating simultaneous irradiation and MR imaging on phantoms, since then the device has been further developed and commercialized by Elekta...
November 14, 2017: Physics in Medicine and Biology
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