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Spine metastases

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https://www.readbyqxmd.com/read/28816829/treatment-outcome-of-metastatic-spine-tumor-in-lung-cancer-patients-did-the-treatments-improve-their-outcomes
#1
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda
STUDY DESIGN: A retrospective, single-center study. OBJECTIVE: Investigation of the changes in the treatment outcomes of patients with lung cancer-derived metastatic spine tumors SUMMARY OF BACKGROUND DATA.: Metastatic spine tumors derived from lung cancer had been progressive, and their prognosis is poor. It has recently been reported that the use of molecularly targeted drugs and bone-modifying agents (BMA) improved the treatment outcomes of patients with lung cancer, but no detailed information about the treatment of metastatic spine tumors has been reported...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28815357/carbon-fiber-reinforced-peek-fixation-system-in-the-treatment-of-spine-tumors-a-preliminary-report
#2
Stefano Boriani, Giuseppe Tedesco, Lu Ming, Riccardo Ghermandi, Maurizio Amichetti, Piero Fossati, Marco Krengli, Loredana Mavilla, Alessandro Gasbarrini
BACKGROUND: Protocols including combination of surgery and radiotherapy are more and more frequent in the treatment of bone tumors of the spine. In metastatic disease, combination of surgery and radiotherapy is since long time accepted, as based on clinical evidence. In primary tumors, combination of surgery and radiotherapy can be considered in all the cases in which a satisfactory oncological margin cannot be achieved: high-grade malignancies, recurrent tumors, huge tumors expanding in an extracompartimental area, and when tumor-free margin requires unacceptable functional sacrifices...
August 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28815098/osteoblastic-metastases-mimickers-on-contrast-enhanced-ct
#3
Fahad Al-Lhedan, Sam Samaan, Wanzhen Zeng
Secondary osseous involvement in lymphoma is more common compared to primary bone lymphoma. The finding of osseous lesion can be incidentally discovered during the course of the disease. However, osseous metastases are infrequently silent. Detection of osseous metastases is crucial for accurate staging and optimal treatment planning of lymphoma. The aim of imaging is to identify the presence and extent of osseous disease and to assess for possible complications such as pathological fracture of the load-bearing bones and cord compression if the lesion is spinal...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/28811991/systematic-review-of-the-outcomes-of-surgical-treatment-of-prostate-metastases-to-the-spine
#4
REVIEW
Michelle J Clarke, Camilo A Molina, Daryl R Fourney, Charles G Fisher, Ziya L Gokaslan, Meic H Schmidt, Laurence D Rhines, Michael G Fehlings, Ilya Laufer, Shreyaskumar R Patel, Y Raja Rampersaud, Jeremy Reynolds, Dean Chou, Chetan Bettegowda, Ehud Mendel, Michael H Weber, Daniel M Sciubba
STUDY DESIGN: Systematic review. OBJECTIVE: Surgical decompression and reconstruction of symptomatic spinal metastases has improved the quality of life in cancer patients. However, most data has been collected on cohorts of patients with mixed tumor histopathology. We systematically reviewed the literature for prognostic factors specific to the surgical treatment of prostate metastases to the spine. METHODS: A systemic review of the literature was conducted to answer the following questions: Question 1...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811847/a-rare-case-of-adult-rhabdomyosarcoma
#5
Benjamin Sparreboom, Brendan Litton, Julian Yaxley
BACKGROUND: Rhabdomyosarcoma is a rare, soft tissue malignancy, diagnosed particularly in adults. It commonly metastasizes to the bone marrow. We present a rare case of an adult rhabdomyosarcoma which illustrates the importance of magnetic resonance imaging in identifying early changes in the internal bone structure. CASE REPORT: A 50-year-old male presented with acute urinary retention. The patient initially had a CT scan of the lumbar spine which only revealed a protrusion of the L5-S1 intervertebral disc and no apparent cause for the patient's symptoms...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28808607/surgically-treated-spinal-metastases-do-prognostic-scores-have-a-role
#6
Afifa Afsar, Mohsin Qadeer, Salman Sharif
BACKGROUND: The outcome for patients with metastatic disease in spine is difficult to predict. Multiple scoring systems were utilized in this study to determine their effectiveness in predicting long-term prognoses. METHODS: A retrospective analysis of surgically treated patients of spinal metastasis was performed between 2005 and 2016. Data were collected prospectively during which 8 patients were lost to follow-up. Ultimately, data from 63 patients were reviewed...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28760030/cervical-vertebroplasty-for-osteolytic-metastases-as-a-minimally-invasive-therapeutic-option-in-oncological-surgery-outcome-in-14-cases
#7
Martin Stangenberg, Lennart Viezens, Sven O Eicker, Malte Mohme, Klaus C Mende, Marc Dreimann
OBJECTIVE The treatment of cervical spinal metastases represents a controversial issue regarding the type, extent, and invasiveness of interventions. In the lumbar and thoracic spine, kypho- and vertebroplasties have been established as minimally invasive procedures for patients with metastases to the vertebral bodies and without neurological deficit. These procedures show good results with respect to pain reduction and low complication rates. However, limited data are available for kypho- and vertebroplasties for cervical spinal metastases...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28755383/solid-bone-tumors-of-the-spine-diagnostic-performance-of-apparent-diffusion-coefficient-measured-using-diffusion-weighted-mri-using-histology-as-a-reference-standard
#8
Grazia Pozzi, Domenico Albano, Carmelo Messina, Salvatore Alessio Angileri, Asma'a Al-Mnayyis, Fabio Galbusera, Alessandro Luzzati, Giuseppe Perrucchini, Gennaro Scotto, Antonina Parafioriti, Alberto Zerbi, Luca Maria Sconfienza
PURPOSE: To assess the diagnostic performance of mean apparent diffusion coefficient (mADC) in differentiating benign from malignant bone spine tumors, using histology as a reference standard. Conventional magnetic resonance imaging (MRI) sequences have good reliability in evaluating spinal bone tumors, although some features of benign and malignant cancers may overlap, making the differential diagnosis challenging. MATERIALS AND METHODS: In all, 116 patients (62 males, 54 females; mean age 59...
July 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28750274/medical-treatment-of-advanced-chordomas
#9
REVIEW
Vittoria Colia, Silvia Stacchiotti
Chordoma is a very rare bone sarcoma that can arise from any site along the spine and from the skull base. Enbloc resection is the gold standard for treatment while radiation therapy has been shown to provide both curative and palliative benefit. Unfortunately, local recurrences are common, even after a complete surgical resection, and up to 40% of patients suffer from distant metastases, while salvage treatments are challenging. Patients carrying an advanced disease need a systemic treatment. Unluckily, conventional chordoma are insensitive to cytotoxic chemotherapy that is considered the standard treatment option in patients with metastatic sarcoma...
July 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28749856/evaluation-of-prognostic-factors-and-proposed-changes-to-the-modified-tokuhashi-score-in-patients-with-spinal-metastases-from-breast-cancer
#10
Kimberly-Anne Tan, Jiong Hao Tan, Aye Sandar Zaw, Joel Yong Hao Tan, Hwee Weng Dennis Hey, Naresh Kumar
STUDY DESIGN: A retrospective study of all patients with histologically-confirmed breast cancer spinal metastases presenting to a single instituition between May 2001-April 2012. OBJECTIVES: To investigate if the 2014mT is more accurate than the 2005mT. SUMMARY OF BACKGROUND DATA: The commonly used 2005 modified Tokuhashi score (2005mT) has become more inaccurate as oncologists move towards treating tumours according to their molecular and genomic profile, rather than their tissue-of-origin...
July 26, 2017: Spine
https://www.readbyqxmd.com/read/28741325/continuous-pain-and-swelling-after-humerus-fracture-in-an-86-years-old-woman
#11
M Herrera-Pérez, J Boluda-Mengod, R Muñoz-Ortus, M J Gutiérrez-Morales, J Pais-Brito
Metastases to bone are the most frequent cause of destructive lesions to the skeleton in adults . The tumours that are most likely to metastasize to bone are prostate (32%), breast (22%), kidney (16%), lung and thyroid. The typical distribution of metastatic lesions are to the spine, ribs, pelvis, and proximal limb girdles. The humerus is the second most common site for long bone metastases, behind only the femur in its frequency of involvement . It represents the 20% of all bony metastases. We present a clinical case of an 86 yo woman with a previous diagnosis of myofibroblastic sarcoma of the maxillaris who suffers a pathological fracture of the humeral shaft secondary to metastasis and was misdiagnosed and treated for a typical humeral fracture using and intramedullary pinning (Hackethal technique), producing the progression of the disease within the humeral shaft...
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28740742/radical-surgery-of-only-the-anterior-elements-of-the-spine-at-the-posterior-element-fusion-level-due-to-metastatic-thyroid-cancer
#12
Ryuto Tsuchiya, Kazuki Fujimoto, Kazuhide Inage, Sumihisa Orita, Yasuhiro Shiga, Hiroto Kamoda, Kazuyo Yamauchi, Miyako Suzuki, Jun Sato, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Junichi Nakamura, Kazuhisa Takahashi, Seiji Ohtori
Spinal metastasis of differentiated thyroid cancer can have a favorable prognosis if radical surgery is performed. We encountered a case of spinal metastasis involving three anterior vertebral bodies at the posterior element fusion level and successfully achieved adequate stability by radical surgery involving only the anterior elements. A 67-year-old woman who had numbness and muscle weakness in the lower limbs caused by metastatic spinal tumor at the posterior element fusion level of L1-L3 vertebrae was treated with radical surgery of only the anterior element to gain stability...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28734793/hardware-failure-in-patients-with-metastatic-cancer-to-the-spine
#13
Rachel Pedreira, Nancy Abu-Bonsrah, A Karim Ahmed, Rafael De la Garza-Ramos, C Rory Goodwin, Ziya L Gokaslan, Justin Sacks, Daniel M Sciubba
BACKGROUND: The spine is the most common site of skeletal metastases, affecting approximately 30% of individuals with cancer. The aim of surgical treatment for metastatic spine disease is generally palliative to address pain and/or neurologic compromise, significantly improving patients' quality of life. Patients with metastatic spine disease, however, represent a vulnerable cohort and may have comorbidities or previous treatments that impair the structural integrity of spinal hardware...
July 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28731393/the-impact-of-decompression-with-instrumentation-on-local-failure-following-spine-stereotactic-radiosurgery
#14
Jacob A Miller, Ehsan H Balagamwala, Camille A Berriochoa, Lilyana Angelov, John H Suh, Edward C Benzel, Alireza M Mohammadi, Todd Emch, Anthony Magnelli, Andrew Godley, Peng Qi, Samuel T Chao
OBJECTIVE Spine stereotactic radiosurgery (SRS) is a safe and effective treatment for spinal metastases. However, it is unknown whether this highly conformal radiation technique is suitable at instrumented sites given the potential for microscopic disease seeding. The authors hypothesized that spinal decompression with instrumentation is not associated with increased local failure (LF) following SRS. METHODS A 2:1 propensity-matched retrospective cohort study of patients undergoing SRS for spinal metastasis was conducted...
July 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28727717/percutaneous-vertebroplasty-for-primary-non-hodgkin-s-lymphoma-of-the-thoracic-spine-case-report-and-review-of-the-literature
#15
Pu Jia, JinJun Li, Hao Chen, Li Bao, Fei Feng, Hai Tang
Primary non-Hodgkin's lymphoma of the vertebra is rare in the spine of the elderly. The clinical presentation and radiological features are unspecific, which make it more difficult for diagnosis. We report a case of a 79-year-old woman complaining of serious backache without any injury. The magnetic resonance imaging (MRI) showed invasion of the fifth thoracic vertebra with the posterior vertebral body wall defect. There was a high suspicion that the patient had a metastatic tumor of the vertebra. A percutaneous vertebroplasty was performed under fluoroscopic guidance, which was used to treat the osteoporotic vertebral compression fracture, vertebral metastases, verte-bral hemangioma, and multiple myeloma...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28719452/treatment-of-spinal-tumors-in-a-high-volume-center-has-direct-impact-on-local-recurrence-morbidity-and-mortality
#16
Ran Lador, Stefano Bandiera, Alessandro Gasbarrini, Riccardo Ghermandi, Stefano Boriani
OBJECTIVE OF THE STUDY: En bloc resections of spine tumors aim at locally controlling the disease for both improving the patient's quality of life as well as improving mortality. The purpose of this study was to compare the outcome between patients who were initially treated in a high volume specialized center, and patients who initially underwent either invasive diagnostic procedure or an initial surgical attempt to treat the disease in a different center. MATERIALS AND METHODS: A retrospective study of 1681 patients affected by spine tumors-treated from 1990 to 2015 by the same team...
July 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28708043/reirradiation-spine-stereotactic-body-radiation-therapy-for-spinal-metastases-systematic-review
#17
Sten Myrehaug, Arjun Sahgal, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martinez, Ian Paddick, Jean Régis, Samuel Ryu, Ben Slotman, Antonio De Salles
OBJECTIVE Spinal metastases that recur after conventional palliative radiotherapy have historically been difficult to manage due to concerns of spinal cord toxicity in the retreatment setting. Spine stereotactic body radiation therapy (SBRT), also known as stereotactic radiosurgery, is emerging as an effective and safe means of delivering ablative doses to these recurrent tumors. The authors performed a systematic review of the literature to determine the clinical efficacy and safety of spine SBRT specific to previously irradiated spinal metastases...
July 14, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28705700/incidental-primary-intradural-carcinoid-tumor-in-a-patient-with-lumbar-radiculopathy
#18
Stavros Koustais, Philip O'Halloran, Alfrazdaq Hassan, Francesca Brett, Steven Young
BACKGROUND: Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Central nervous system involvement is rare. The reported cases include metastases to brain or spinal cord, as well as primary skeletal or extradural disease resulting in compressive myelo-radiculopathy. There are two previously reported cases of primary intradural extramedullary carcinoid tumor, presenting with compressive symptoms. We report the first case of primary incidental intradural extramedullary carcinoid tumor...
July 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28704910/late-developing-metastatic-malignant-melanoma-in-the-thoracic-spine-originating-from-choroidal-melanoma
#19
Jun Kyu Hwang, Kyung Hyun Kim, Ji Sup Kim, Sung Jun Ahn, Sung Uk Kuh
A 54-year-old woman visited Gangnam Severance Hospital for left side flank pain. She had a history of total removal of malignant melanoma on the left eye ball 20 years prior. No evaluation had been performed since then. A paravertebral mass at thoracic ninth level (T9) was discovered on spinal magnetic resonance imaging, and pathology confirmed malignant melanoma. Following positron emission tomography-computed tomography, no other metastasis was discovered. After removal of the paravertebral mass, palliative chemotherapy (dacabarzine + tamoxifene) was administered in 3 cycles over 2 months...
June 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28704338/analysis-of-metastatic-involvement-in-bone-using-anatomical-and-functional-information-from-18f-fdg-pet-ct
#20
Omer Demirkaya, Mohammed AlQahtani, Abdulaziz Alsugair, Omer Aras, Mohei-Eldin Abouzied
PURPOSE: Although the overall incidence of bone metastasis is not known, over one-half of the people who die of cancer in the USA every year are thought to have bone involvement. In this study we have developed a method to quantify the metabolic and anatomic changes induced by different types of bone metastases in cancer patients using PET/CT images. PATIENTS AND MATERIALS: Seventy-three cancer patients with no previous history of chemotherapy or radiotherapy who had definite bone metastases documented by PET/CT and other conventional modalities were selected for this study...
July 12, 2017: Nuclear Medicine Communications
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