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Spinal metastases surgery

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https://www.readbyqxmd.com/read/29143901/combined-vertebral-augmentation-and-radiofrequency-ablation-in-the-management-of-spinal-metastases-an-update
#1
REVIEW
Ning Mao Kam, Julian Maingard, Hong Kuan Kok, Dinesh Ranatunga, Duncan Brooks, William C Torreggiani, Peter L Munk, Michael J Lee, Ronil V Chandra, Hamed Asadi
Spinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1 year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stability...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29136257/risk-factors-for-pathological-fracture-and-metastatic-epidural-spinal-cord-compression-in-patients-with-spinal-metastases
#2
Catherine S Hibberd, Gerald M Y Quan
Vertebral pathological fracture and metastatic epidural spinal cord compression (MESCC) due to metastatic cancer inevitably cause pain, neurological deficit, impaired function, and decreased quality of life and are indications for surgery. In such cases, earlier surgical intervention has the potential to prevent permanent neurological deficit and disability and to maintain function and quality of life. Therefore, the aim of this study was to identify and evaluate risk factors for pathological fracture and MESCC in patients with spinal metastases...
November 11, 2017: Orthopedics
https://www.readbyqxmd.com/read/29123990/the-skeletal-related-events-of-denosumab-versus-zoledronic-acid-in-patients-with-bone-metastases-a-meta-analysis-of-randomized-controlled-trials
#3
Zhicai Zhang, Feifei Pu, Zengwu Shao
Objective: The meta-analysis was used to evaluate the skeletal-related events (SREs) and efficacy of denosumab versus zoledronic acid (ZA) in patients with bone metastases. Methods: The data of this meta-analysis study were searched from PUBMED, EMBASE, Cochrane Library, Web of Science with Conference Proceedings, Elsevier and China National Knowledge Infrastructure (CNKI) databases till August 2017. Two independent reviewers reviewed the reference lists of relevant articles...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29113903/long-term-follow-up-of-metastatic-epidural-spinal-cord-compression-mescc-patients-from-breast-cancer-treated-with-surgery-followed-by-radiotherapy
#4
Federico Pessina, Pierina Navarria, Marco Riva, Davide Franceschini, Marco Conti Nibali, Maurizio Fornari, Marta Scorsetti
BACKGROUND: Aim of this study was to evaluate the role of surgery plus radiotherapy in Metastatic Epidural Spinal Cord Compression (MESCC) breast cancer (BC) patients with a follow-up longer than 10 years. METHODS: Twenty-three patients treated between 2004 and 2008 were included. Surgical treatment was performed in patients with good performance status, limited metastatic disease and progressive neurologic deficit and/or intractable pain. RT was performed delivering a median total dose of 30 Gy in 10 fractions...
November 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29110129/real-life-management-and-outcome-of-thyroid-carcinoma-related-bone-metastases-results-from-a-nationwide-multicenter-experience
#5
G Mazziotti, A M Formenti, M B Panarotto, E Arvat, A Chiti, A Cuocolo, M E Dottorini, C Durante, L Agate, S Filetti, F Felicetti, A Filice, L Pace, T Pellegrino, M Rodari, M Salvatori, C Tranfaglia, A Versari, D Viola, S Frara, A Berruti, A Giustina, R Giubbini
PURPOSE AND PATIENTS: The M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11-87) with differentiated thyroid carcinoma (DTC). RESULTS: Radio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47...
November 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29106668/usim-a-new-device-and-app-for-case-specific-intraoperative-ultrasound-simulation-and-rehearsal-in-neurosurgery-a-preliminary-study
#6
Alessandro Perin, Francesco Ugo Prada, Michela Moraldo, Andrea Schiappacasse, Tommaso Francesco Galbiati, Enrico Gambatesa, Piergiorgio d'Orio, Nicole Irene Riker, Curzio Basso, Matteo Santoro, Torstein Ragnar Meling, Karl Schaller, Francesco DiMeco
BACKGROUND: Intraoperative ultrasound (iUS) is an excellent aid for neurosurgeons to perform better and safer operations thanks to real time, continuous, and high-quality intraoperative visualization. OBJECTIVE: To develop an innovative training method to teach how to perform iUS in neurosurgery. METHODS: Patients undergoing surgery for different brain or spine lesions were iUS scanned (before opening the dura) in order to arrange a collection of 3-dimensional, US images; this set of data was matched and paired to preoperatively acquired magnetic resonance images in order to create a library of neurosurgical cases to be studied offline for training and rehearsal purposes...
June 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29100167/early-identification-and-intervention-matters-a-comprehensive-review-of-current-evidence-and-recommendations-for-the-monitoring-of-bone-health-in-patients-with-cancer
#7
REVIEW
Thomas Brodowicz, Peyman Hadji, Daniela Niepel, Ingo Diel
Bone metastases are common in patients with advanced solid tumors, and many individuals experience debilitating skeletal-related events (SREs; e.g. pathologic fracture, hypercalcemia, radiotherapy or surgery to bone, and spinal cord compression). These events substantially affect disease outcomes, including survival and quality of life, and healthcare systems. Plain radiography is the most widely used imaging modality for the detection of bone metastases; skeletal scintigraphy, computed tomography, positron emission tomography and magnetic resonance imaging offer greater sensitivity but their use in routine practice is restricted by high costs and limited availability...
October 18, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29095319/malignant-pheochromocytoma-with-multiple-vertebral-metastases-causing-acute-incomplete-paralysis-during-pregnancy-literature-review-with-one-case-report
#8
REVIEW
Shuzhong Liu, An Song, Xi Zhou, Xiangyi Kong, William A Li, Yipeng Wang, Yong Liu
RATIONALE: We present a rare case of malignant pheochromocytoma with thoracic metastases during pregnancy that presented with symptoms of myelopathy and was treated with circumferential decompression, stabilization, and radiation. The management of this unique case is not well documented. The clinical manifestations, imaging results, pathological characteristics, treatment and prognosis of the case were analyzed. PATIENT CONCERNS: A 26-year-old pregnant woman with a history of paroxysmal hypertension during the second trimester presented with lower extremity weakness, numbness, urinary incontinence, and back pain...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29073497/therapeutic-approaches-for-protecting-bone-health-in-patients-with-breast-cancer
#9
REVIEW
Diana Lüftner, Daniela Niepel, Guenther G Steger
Improvements in the survival of patients with breast cancer, together with a better understanding of the pathology of the disease, have led to the emergence of bone health as a key aspect of patient management. Patients with breast cancer are typically at risk of skeletal complications throughout their disease course. The receptor activator of nuclear factor κ B ligand (RANKL) inhibitor denosumab and bisphosphonates (e.g. zoledronic acid) are approved in Europe for the prevention of skeletal-related events (pathologic fracture, radiation or surgery to bone, and spinal cord compression) in adults with bone metastases secondary to solid tumours...
October 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29071122/diagnostic-algorithm-prognostic-factors-and-surgical-treatment-of-metastatic-cancer-diseases-of-the-long-bones-and-spine
#10
REVIEW
Miklós Szendrői, Imre Antal, Attila Szendrői, Áron Lazáry, Péter Pál Varga
Oncological management of skeletal metastases has changed dramatically in the last few decades. A significant number of patients survive for many years with their metastases.Surgeons are more active and the technical repertoire is broader, from plates to intramedullary devices to (tumour) endoprostheses.The philosophy of treatment should be different in the case of a trauma-related fracture and a pathological fracture. A proper algorithm for establishing a diagnosis and evaluation of prognostic factors helps in planning the surgical intervention...
September 2017: EFORT open reviews
https://www.readbyqxmd.com/read/29057359/spinal-metastases-of-two-different-grade-oligodendrogliomas-a-case-report-and-review-of-literature
#11
Carlos Enrique Maiguel Carrizosa, Maria Gabriela Sanchez Paez, Andreina Martinez Amado, Andrea Gonzalez Gutierrez, Maria Emma Garcia Ardila
Oligodendrogliomas (OGD) are glial tumors, together with mixed oligoastrocytoma constituting 5-20% of all gliomas, which occur predominantly in younger populations and are managed with surgery and chemotherapy with good long-term prognosis after treatment and additionally present with low rates of metastases. We present the case of a 46-year-old patient with intracranial right frontal subcortical OGD [World Health Organisation (WHO) grade II] managed at the Neurosurgery Department in Foscal Clinic, Floridablanca, Colombia...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29040130/volume-outcome-relationship-in-surgical-interventions-for-spinal-metastases
#12
Andrew J Schoenfeld, Marco L Ferrone, Daniel J Sturgeon, Mitchel B Harris
BACKGROUND: Surgery for spinal metastases is challenging and carries a high risk of perioperative morbidity and mortality. Procedures with such characteristics often exhibit a volume-outcome relationship. This has not been previously characterized for spinal metastasis surgery to our knowledge. METHODS: The Florida State Inpatient Database (2011 through 2014) was queried to identify patients who had undergone surgery for spinal metastases. Surgeon and hospital surgical volumes were compared with 90-day complication and readmission rates to develop procedural cut-points used to define high and low-volume providers...
October 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29031992/assessing-the-utility-of-a-prognostication-model-to-predict-1-year-mortality-in-patients-receiving-radiation-therapy-for-spinal-metastases
#13
Diana D Shi, Yu-Hui Chen, Tai Chung Lam, Dana Leonard, Tracy Anne Balboni, Andrew Schoenfeld, Sonia Skamene, Daniel N Cagney, John H Chi, Charles H Cho, Mitchel Harris, Marco L Ferrone, Lauren M Hertan
BACKGROUND CONTEXT: Predicting survival outcomes after radiation therapy alone for metastatic disease of the spine is a challenging task that is important to guiding treatment decisions (e.g., determining dose fractionation and intensity). The New England Spinal Metastasis Score (NESMS) was recently introduced and validated in independent cohorts as a tool to predict 1-year survival following surgery for spinal metastases. This metric is composed of 3 factors: pre-operative albumin, ambulatory status, and modified Bauer score, with the total score ranging from 0 to 3...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29023215/cost-effectiveness-analysis-of-monthly-zoledronic-acid-zoledronic-acid-every-3-months-and-monthly-denosumab-in-women-with-breast-cancer-and-skeletal-metastases-calgb-70604-alliance
#14
Charles L Shapiro, James P Moriarty, Stacie Dusetzina, Andrew L Himelstein, Jared C Foster, Stephen S Grubbs, Paul J Novotny, Bijan J Borah
Purpose Skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, or the necessity for radiation or surgery to bone metastasis cause considerable morbidity, decrements in quality of life, and costs to the health care system. The results of a recent large randomized trial (Cancer and Leukemia Group B/Alliance for Clinical Trials in Oncology [CALGB/Alliance 70604]) showed that zoledronic acid (ZA) every 3 months was noninferior to monthly ZA in reducing the risks of SREs. We sought to determine the cost-effectiveness (CE) of monthly ZA, ZA every 3 months, and monthly denosumab in women with breast cancer and skeletal metastases...
October 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29021669/is-there-a-correlation-between-the-spinal-instability-neoplastic-score-and-mechanical-pain-in-patients-with-metastatic-spinal-cord-compression-a-prospective-cohort-study
#15
Rodrigo Ac Cavalcante, Yvens B Fernandes, Romulo Al Marques, Vinícius G Santos, Edésio Martins, Vladimir A Zaccariotti, João B Arruda, Claúdio E Tatsui, Andrei F Joaquim
INTRODUCTION: The decision for selecting patients for surgical treatment of metastatic spinal cord compression (MSCC) is challenging even for experienced surgeons. Recently, the spinal instability neoplastic score (SINS) has been proposed to help surgeons in the evaluation of spinal stability in the setting of spinal metastases. This study aimed to evaluate the correlation between SINS and preoperative visual analog scale (VAS), as well as the pre- and post-operative association of the VAS and neurological function...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#16
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28987846/surgery-and-radiotherapy-for-symptomatic-spinal-metastases-is-more-cost-effective-than-radiotherapy-alone-a-cost-utility-analysis-in-a-u-k-spinal-center
#17
Isobel Turner, Joanne Kennedy, Stephen Morris, Alan Crockard, David Choi
BACKGROUND: Surgery for symptomatic spinal metastases is effective at prolonging ambulation and life, but it can appear costly at first glance. We have studied the difference between the cost of surgery and reimbursement received, and the cost-effectiveness of surgery in a U.K. tertiary referral spinal center. METHODS: A cost-versus-reimbursement and cost-utility analysis was performed in a prospective cohort of patients admitted for surgical treatment of spinal metastases...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28967088/uncommon-somatic-mutations-in-metastatic-nut-midline-carcinoma
#18
Stefano Cavalieri, Anastasios Stathis, Alessandra Fabbri, Angelica Sonzogni, Federica Perrone, Elena Tamborini, Giuseppe Pelosi, Filippo de Braud, Marco Platania
INTRODUCTION: NUT midline carcinoma (NMC) is a rare and aggressive epithelial cancer arising from median organs. It is driven by chromosomal translocation t(15;19) involving the rearrangement of NUT (nuclear protein in testis) and BRD4 (bromodomain 4) genes leading to fusion oncoprotein BRD4-NUT. CASE PRESENTATION: We report the case of a woman who was previously treated with induction chemotherapy, surgery, radiotherapy and adjuvant trastuzumab for HER-2 positive invasive ductal carcinoma of the breast...
September 25, 2017: Tumori
https://www.readbyqxmd.com/read/28937455/palliative-surgery-for-spinal-metastases-using-posterior-decompression-and-fixation-combined-with-intraoperative-vertebroplasty
#19
Liang Dong, Mingsheng Tan, Di Wu, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the clinical outcome of palliative surgery using posterior decompression and fixation combined with intraoperative vertebroplasty (PDFIV) for the treatment of spinal metastases, and analyze the indications for PDFIV using a neurological, oncologic, mechanical, and systemic framework. SUMMARY OF BACKGROUND DATA: Palliative surgery is widely used to spinal metastatic patients with poor condition for enough postoperative recovery...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28918384/systematic-review-and-meta-analysis-of-effectiveness-of-preoperative-embolization-in-surgery-for-metastatic-spine-disease
#20
Panya Luksanapruksa, Jacob M Buchowski, Sasima Tongsai, Weerasak Singhatanadgige, Jack W Jennings
BACKGROUND: Preoperative embolization (PE) may decrease intraoperative blood loss (IBL) in decompressive surgery of hypervascular spinal metastases. However, no consensus has been found in other metastases and no meta-analysis which reviewed the benefit of PE in spinal metastases has been conducted. OBJECTIVE: To assess IBL in spinal metastases surgery in a randomized controlled trial (RCT) and cohort studies comparing PE and a control group of non-embolized patients...
September 16, 2017: Journal of Neurointerventional Surgery
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