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Spinal metastases surgery

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https://www.readbyqxmd.com/read/29764185/management-of-metastatic-spinal-cord-compression-among-veterans-health-administration-radiation-oncologists
#1
Ruchika Gutt, Sheeta Malhotra, Shruti Jolly, Drew Moghanaki, Alice V Cheuk, Helen Fosmire, Maria Kelly, Lori Hoffman-Hogg, Stephen Lutz, Mitchell Anscher, George Dawson
BACKGROUND: Optimal management of metastatic spinal cord compression (MSCC) improves functional outcomes in patients with metastatic disease. This survey study evaluated management of MSCC by Veterans Health Administration (VHA) radiation oncologists (ROs), to determine whether management of MSCC correlates with American College of Radiology (ACR) guidelines, and to compare times to initiation of treatment between surgery and radiotherapy (RT). METHODS: Surveys emailed to 79 VHA ROs included questions on steroid use, surgical care, palliative care, fractionation of irradiation, re-irradiation, and management of common MSCC case scenarios...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29759043/electrochemotherapy-of-spinal-metastases-using-transpedicular-approach-a-numerical-feasibility-study
#2
Helena Cindrič, Bor Kos, Giuseppe Tedesco, Matteo Cadossi, Alessandro Gasbarrini, Damijan Miklavčič
Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We developed a novel approach to treat spinal metastases, that is, transpedicular approach that combines electrochemotherapy with already established technologies for insertion of fixation screws in spinal surgery. In the transpedicular approach, needle electrodes are inserted into the vertebral body through pedicles and placed around the tumor...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29732436/the-c7-pedicle-as-a-superior-fixation-point-in-spinal-stabilization-for-spinal-metastatic-disease
#3
Harjot Thind, Andrew J Fabiano
Spinal metastatic disease (SMD) often requires spinal stabilization; however, the cervicothoracic junction can be a challenging area to instrument. An anterior approach may require division of the sternum. A posterior or posterolateral approach may rely on cervical lateral mass screws for superior construct fixation that are more prone to pullout than screws placed in a pedicle. The C7 pedicle is able to support pedicle screw fixation in most instances based on morphological features of the vertebra. When the C7 pedicle is used as a superior fixation point, it aligns with the thoracic pedicles below to create a streamlined posterior construct...
March 2018: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29729472/loss-of-local-tumor-control-after-index-surgery-for-spinal-metastases-a-prospective-cohort-study
#4
Bart Depreitere, Federico Ricciardi, Mark Arts, Laurent Balabaud, Jacob M Buchowski, Cody Bunger, Chun Kee Chung, Maarten H Coppes, Michael G Fehlings, Norio Kawahara, Chong-Suh Lee, YeeLing Leung, Juan A Martin-Benlloch, Eric M Massicotte, Christian Mazel, Meyer Bernhard, Fetullah C Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Christian Ulbricht, Jorrit J Verlaan, Michael Wang, Alan H Crockard, David Choi
BACKGROUND: As survival following treatment for symptomatic spinal metastases increases, the incidence of local tumor recurrence may also increase. However, data regarding incidence and timing of recurrence, or duration of survival after second surgeries are not readily available, and may help to inform clinicians when to perform second surgeries. OBJECTIVE: To identify features associated with loss of local control (LLC) at a previously treated or new spinal level...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29726364/contemporary-statewide-practice-pattern-assessment-of-the-palliative-treatment-of-bone-metastasis
#5
Daniel E Spratt, Brandon R Mancini, James A Hayman, Thomas Boike, Lori J Pierce, Jean M Moran, Michael M Dominello, Mark Fireman, Kent Griffith, Shruti Jolly
PURPOSE: Palliative radiation therapy for bone metastases is often viewed as a single entity, despite national guidelines providing input principally only for painful uncomplicated bone metastases. Data surrounding the treatment of bone metastases are often gleaned from questionnaires of what providers would theoretically do in practice or from population-based data lacking critical granular information. We investigated the real-world treatment of bone metastases with radiation therapy...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29715577/are-older-patients-with-solitary-spinal-metastases-fit-for-total-en-bloc-surgery
#6
Peng Liu, Libo Jiang, Yun Liang, Houlei Wang, Hao Zhou, Xilei Li, Hong Lin, Xiaogang Zhou, Jian Dong
OBJECTIVE: Due to radical resection, total en-bloc spondylectomy (TES) is associated with significant levels of surgical injury and spinal instability, particularly in elderly patients with solitary spinal metastases (SM), whether the possible benefits outweigh the risk requires intense consideration. Our aim was to compare and analyze the impact of age on patient prognosis. PATIENTS AND METHODS: This study investigated TES in 78 consecutive patients with solitary SM, who were divided into Group A (>65 years, n = 32) and group B (<60 years of age, n = 46)...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29709741/long-term-follow-up-of-patients-with-metastatic-epidural-spinal-cord-compression-mescc-from-solid-tumors-submitted-surgery-followed-by-radiation-therapy
#7
Federico Pessina, Pierina Navarria, Giulio Alberto Carta, Giuseppe Roberto D'Agostino, Elena Clerici, Marco Conti Nibali, Francesco Costa, Maurizio Fornari, Marta Scorsetti
OBJECTIVE: To evaluate the outcome of patients, with epidural spinal cord compression (MESCC) from different solid tumors, treated with a combined approach, surgery plus radiotherapy (RT), with a follow-up longer than 10 years. METHODS: Ninety-seven patients treated between 2002 and 2009 were included. Surgical treatment was performed in patients with good performance status, limited metastatic disease, life expectancy longer than 3 months and progressive neurologic deficit and/or intractable pain...
April 27, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29707552/minimally-invasive-versus-conventional-spine-surgery-for-vertebral-metastases-a-systematic-review-of-the-evidence
#8
REVIEW
Zach Pennington, A Karim Ahmed, Camilo A Molina, Jeffrey Ehresman, Ilya Laufer, Daniel M Sciubba
One of the major determinants of surgical candidacy in patients with symptomatic spinal metastases is the ability of the patient to tolerate the procedure-associated morbidity. In other pathologies, minimally invasive (MIS) procedures have been suggested to have lower intra-operative morbidity while providing similar outcomes. We conducted a systematic review of the PubMed library searching for articles that directly compared the operative and post-operative outcomes of patients treated for symptomatic spinal metastases...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29682016/neurological-outcome-following-surgical-treatment-of-spinal-metastases
#9
Abdelaal Abdelbaky, Hazem Eltahawy
Background: Spinal metastases lead to bony instability and spinal cord compression resulting in intractable pain and neurological deficits which affect ambulatory function and quality of life. The most appropriate treatment for spinal metastasis is still debated. Objective: The aim of this study is to evaluate clinical outcome, quality of life, complications, and survival after surgical treatment of spinal metastases. Methods: Retrospective review of patients with spinal metastases surgically treated at our facility between March 2008 and March 2013 was performed...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681425/epidemiology-and-national-trends-in-prevalence-and-surgical-management-of-metastatic-spinal-disease
#10
Samantha R Horn, Ekamjeet S Dhillon, Gregory W Poorman, Jared C Tishelman, Frank A Segreto, Cole A Bortz, John Y Moon, Omar Behery, Nicholas Shepard, Bassel G Diebo, Shaleen Vira, Peter G Passias
Surgical treatment for spinal metastasis has benefited from improvements in surgical techniques. However, the trends in treatment and outcomes for spinal metastasis surgery have not been well-established in a pediatric population. Patients <20 years old with metastatic spinal tumors undergoing spinal surgery were identified in the KID database. Trends for spinal metastases treatment and patient outcomes were analyzed using weight-adjusted ANOVAs. 333 patients were identified in the KID database. The top five primary diagnoses were metastatic brain/spinal cord tumor (19...
April 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29661205/comparison-between-minimally-invasive-spine-stabilization-with-and-without-posterior-decompression-for-the-management-of-spinal-metastases-a-retrospective-cohort-study
#11
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda, Masahiro Nakahashi, Hirokatsu Sawada, Enshi Nakayama, Hirotoki Soma
BACKGROUND: Posterior decompression and stabilization plays significant roles in palliative surgery for metastatic spinal tumor. However, the indication for addition of posterior decompression have not been examined. The purpose of this study was to investigate a retrospective cohort of outcomes of metastatic spinal tumor treated with minimally invasive spine stabilization (MISt) with or without posterior decompression. METHODS: The subjects were 40 patients who underwent MISt using percutaneous pedicle screws for metastatic spinal tumor, including 20 patients treated with stabilization alone (group A) and 20 patients with added posterior decompression (group B)...
April 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29652780/implication-of-biomarker-mutations-for-predicting-survival-in-patients-with-metastatic-lung-cancer-to-the-spine
#12
Bryan D Choi, Ganesh M Shankar, Ahilan Sivaganesan, Laura A Van Beaver, Kevin Oh, John H Shin
STUDY DESIGN: A retrospective cohort study. OBJECTIVE: We performed a retrospective study of patients treated at our institution over the last 7 years to ascertain whether gene expression signatures in patients with advanced metastatic disease are associated with survival, when the disease has progressed to the spine. SUMMARY OF BACKGROUND DATA: Spinal metastases are a major cause of morbidity in patients with cancer. Molecular profiling strategies to characterize lung cancer have identified several genetic biomarkers that may lead to more effective prognostication...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29650272/treatment-of-spinal-metastases-in-renal-cell-carcinoma-a-critical-review
#13
REVIEW
Diego Teyssonneau, Marine Gross-Goupil, Charlotte Domblides, Thibaud Haaser, Vincent Pointillart, Amaury Daste, Olivier Hauger, Alain Ravaud
Kidney cancer is the 9th most common cancer in men and the 14th most common in women worldwide. Renal cell carcinoma (RCC) constitutes 90% of all malignancies of the kidney. RCC, is known to be highly vascular and relatively radioresistant. Bone metastases are one of the most common metastatic sites and occur in around 30% of RCCs. They significantly impact the quality of life of patients causing pain and pathological fractures. Spinal metastases represent a particular case with regard to symptoms and treatment...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29625617/analysis-of-prognostic-factors-for-survival-in-patients-with-primary-spinal-chordoma-using-the-seer-registry-from-1973-to-2014
#14
Yue Pan, Lingyun Lu, Junquan Chen, Yong Zhong, Zhehao Dai
BACKGROUND: Spinal chordomas are rare primary osseous tumors that arise from the remnants of the notochord. They are commonly considered slow-growing, locally invasive neoplasms with little tendency to metastasize, but the high recurrent rate of spinal chordomas may seriously affect the survival rate and quality of life of patients. The aim of the study is to describe the epidemiological data and determine the prognostic factors for decreased survival in patients with primary spinal chordoma...
April 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29622504/effect-of-surgical-decompression-of-spinal-metastases-in-acute-treatment-predictors-of-neurological-outcome
#15
Christoph Hohenberger, Corinna Schmidt, Julius Höhne, Alexander Brawanski, Florian Zeman, Karl-Michael Schebesch
OBJECTIVE: Space-occupying spinal metastases (SM), commonly diagnosed because of acute neurological deterioration, consequently lead to immediate decompression with tumor removal or debulking. In this study, we analyzed a series of patients with surgically treated spinal metastases and explicitly sought to determine individual predictors of functional outcome. PATIENTS AND METHODS: 94 patients (26 women, 68 men; mean age 64.0 years) with spinal metastases, who had been surgically treated at our department, were included retrospectively...
April 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29619931/approaches-to-radiotherapy-in-metastatic-spinal-cord-compression
#16
Morten Hiul Suppl
Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29618107/incidence-and-time-of-onset-of-osseous-pseudoprogression-in-patients-with-metastatic-spine-disease-from-renal-cell-or-prostate-carcinoma-after-treatment-with-stereotactic-body-radiation-therapy
#17
Pejman Jabehdar Maralani, Kathleen Winger, Sean Symons, Matylda Machnowska, Chinthaka Heyn, Ali Helmi, Aimee Chan, Chia-Lin Tseng, Arjun Sahgal
BACKGROUND: Tumor osseous pseudoprogression (PP), defined as an imaging-based transient increase in tumor size following treatment, was recently described in patients with spinal metastases following stereotactic body radiation therapy. Distinguishing PP from true tumor progression is critical. OBJECTIVE: To describe the incidence, time of onset, and time range of PP following stereotactic body radiation therapy in patients treated for spinal metastases from either prostate cancer (PC) or renal cell carcinoma (RCC), and associated predictive factors...
March 29, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29590465/population-description-and-clinical-response-assessment-for-spinal-metastases-part-2-of-the-spine-response-assessment-in-neuro-oncology-spino-group-report
#18
Ilya Laufer, Simon S Lo, Eric L Chang, Jason Sheehan, Matthias Guckenberger, Moon-Jun Sohn, Samuel Ryu, Matthew Foote, Alexander Muacevic, Scott G Soltys, Samuel Chao, Sten Myrehaug, Peter C Gerszten, Eric Lis, Pejman Maralani, Mark Bilsky, Charles Fisher, Laurence Rhines, Jorrit-Jan Verlaan, David Schiff, Michael G Fehlings, Lijun Ma, Susan Chang, Wendy R Parelukar, Michael A Vogelbaum, Arjun Sahgal
Background: Approximately 40% of metastatic cancer patients will develop spinal metastases. The current report provides recommendations for standardization of metrics used for spinal oncology patient population description and outcome assessment beyond local control endpoints on behalf of the SPIne response assessment in Neuro-Oncology (SPINO) group. Methods: SPINO group survey was conducted in order to determine the preferences for utilization of clinician-based and patient-reported outcome measures for description of patients with spinal metastases...
March 24, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29581018/application-of-morphometrics-as-a-predictor-for-survival-in-patients-with-prostate-cancer-metastasis-to-the-spine
#19
Hesham Mostafa Zakaria, Lara Massie, Azam Basheer, Erinma Elibe, David Boyce-Fappiano, Lonni Shultz, Ian Lee, Brent Griffith, Farzan Siddiqui, Victor Chang
BACKGROUND: Surgery for spinal metastases can improve survival, but has high morbidity that can potentially diminish any benefit. New objective methods of predicting overall survival would be beneficial for surgical decision making. Morphometrics quantifies patient frailty and has been successfully used to predict overall survival in lung cancer patients with spine metastases. This study evaluates whether morphometrics can predict survival in patients with prostate cancer spinal metastases...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29572177/metastatic-spine-tumor-epidemiology-comparison-of-trends-in-surgery-across-two-decades-and-three-continents
#20
Ernest Wright, Federico Ricciardi, Mark Arts, Jacob M Buchowski, Chun Kee Chung, Maarten Coppes, Alan Crockard, Bart Depreitere, Michael Fehlings, Norio Kawahara, Chong Suh Lee, Yee Leung, Antonio Martin-Benlloch, Eric Massicotte, Christian Mazel, Cumhur Oner, Wilco Peul, Nasir Quraishi, Yasuaki Tokuhashi, Katsuro Tomita, Christian Ulbricht, Jorrit-Jan Verlaan, Mike Wang, David Choi
BACKGROUND: Indications for surgery for symptomatic spinal metastases have been better defined in recent years, and suitable outcome measures established, against a changing back-drop of patient characteristics, tumor behavior and oncological treatments. However variations still exist in the local management of patients with spinal metastases. The objective was to review global trends and habits in the surgical treatment of symptomatic spinal metastases, and how this has changed over the last 25 years...
March 20, 2018: World Neurosurgery
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