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Traumatic brain injury in children

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https://www.readbyqxmd.com/read/28212177/neurocognitive-outcomes-for-acute-global-acquired-brain-injury-in-children
#1
Fenella J Kirkham
PURPOSE OF REVIEW: In children, acute global brain injury from traumatic brain injury (TBI) and nontraumatic coma has a substantial cost to the child, the family, and the society. There have historically been relatively few studies looking at long-term cognition and behavioural outcomes. RECENT FINDINGS: Long-term follow-up studies, population-based studies, and meta-analyses are now available for TBI in children as well as adults and suggest that there is a significant cognitive cost, particularly for processing speed, working memory, and intelligence quotient (IQ) in severe TBI...
February 15, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28207570/international-survey-of-critically-ill-children-with-acute-neurologic-insults-the-prevalence-of-acute-critical-neurological-disease-in-children-a-global-epidemiological-assessment-study
#2
Ericka L Fink, Patrick M Kochanek, Robert C Tasker, John Beca, Michael J Bell, Robert S B Clark, Jamie Hutchison, Monica S Vavilala, Anthony Fabio, Derek C Angus, R Scott Watson
OBJECTIVE: The international scope of critical neurologic insults in children is unknown. Our objective was to assess the prevalence and outcomes of children admitted to PICUs with acute neurologic insults. DESIGN: Prospective study. SETTING: Multicenter (n = 107 PICUs) and multinational (23 countries, 79% in North America and Europe). PATIENTS: Children 7 days to 17 years old admitted to the ICU with new traumatic brain injury, stroke, cardiac arrest, CNS infection or inflammation, status epilepticus, spinal cord injury, hydrocephalus, or brain mass...
February 15, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28196142/moderate-injury-in-motor-sensory-cortex-causes-behavioral-deficits-accompanied-by-electrophysiological-changes-in-mice-adulthood
#3
Wei Ouyang, Qichao Yan, Yu Zhang, Zhiheng Fan
Moderate traumatic brain injury (TBI) in children often happen when there's a sudden blow to the frontal bone, end with long unconscious which can last for hours and progressive cognitive deficits. However, with regard to the influences of moderate TBI during children adulthood, injury-induced alterations of locomotive ability, long-term memory performance, and hippocampal electrophysiological firing changes have not yet been fully identified. In this study, lateral fluid percussion (LFP) method was used to fabricate moderate TBI in motor and somatosensory cortex of the 6-weeks-old mice...
2017: PloS One
https://www.readbyqxmd.com/read/28195957/ecological-assessment-of-everyday-executive-functioning-at-home-and-at-school-following-childhood-traumatic-brain-injury-using-the-brief-questionnaire
#4
Mathilde Chevignard, Bernadette Kerrouche, Agata Krasny-Pacini, Aude Mariller, Emmanuelle Pineau-Chardon, Pauline Notteghem, Julie Prodhomme, Didier Le Gall, Jean-Luc Roulin, Nathalie Fournet, Arnaud Roy
OBJECTIVES: To describe dysexecutive symptoms in children with traumatic brain injury (TBI) using the Behavior Rating Inventory of Executive Function (BRIEF); to compare parent- and teacher-ratings, to analyze the differential impairment in the BRIEF subscales, and factors influencing outcome. PARTICIPANTS: Children aged 5 to 18 years 11 months, referred to a rehabilitation department following TBI. OUTCOME MEASURES: Parent- and teacher reports of the BRIEF...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28192567/development-and-internal-validation-of-a-clinical-risk-score-for-treating-children-with-mild-head-trauma-and-intracranial-injury
#5
Jacob K Greenberg, Yan Yan, Christopher R Carpenter, Angela Lumba-Brown, Martin S Keller, Jose A Pineda, Ross C Brownson, David D Limbrick
Importance: The appropriate treatment of children with mild traumatic brain injury (mTBI) and intracranial injury (ICI) on computed tomographic imaging remains unclear. Evidence-based risk assessments may improve patient safety and reduce resource use. Objective: To derive a risk score predicting the need for intensive care unit observation in children with mTBI and ICI. Design, Setting, and Participants: This retrospective analysis of the prospective Pediatric Emergency Care Applied Research Network (PECARN) head injury cohort study included patients enrolled in 25 North American emergency departments from 2004 to 2006...
February 13, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28185504/artificial-cooling-can-increase-risk-of-death-in-children
#6
(no author information available yet)
Therapeutic hypothermia is proven to reduce the effects of traumatic brain injuries (TBIs) in adults. Researchers of this study found these benefits do not extend to children, however, and that the practice can even increase the likelihood of death.
February 10, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28181102/cerebrospinal-fluid-nlrp3-is-increased-after-severe-traumatic-brain-injury-in-infants-and-children
#7
Jessica S Wallisch, Dennis W Simon, Hülya Bayır, Michael J Bell, Patrick M Kochanek, Robert S B Clark
BACKGROUND: Inflammasome-mediated neuroinflammation may cause secondary injury following traumatic brain injury (TBI) in children. The pattern recognition receptors NACHT domain-, Leucine-rich repeat-, and PYD-containing Protein 1 (NLRP1) and NLRP3 are essential components of their respective inflammasome complexes. We sought to investigate whether NLRP1 and/or NLRP3 abundance is altered in children with severe TBI. METHODS: Cerebrospinal fluid (CSF) from children (n = 34) with severe TBI (Glasgow coma scale score [GCS] ≤8) who had externalized ventricular drains (EVD) placed for routine care was evaluated for NLRP1 and NLRP3 at 0-24, 25-48, 49-72, and >72 h post-TBI and was compared to infection-free controls that underwent lumbar puncture to rule out CNS infection (n = 8)...
February 8, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28177265/social-competence-at-2-years-following-child-traumatic-brain-injury
#8
Vicki Anderson, Miriam Helen Beauchamp, Keith Owen Yeates, Louise Crossley, Nicholas Peter Ryan, Stephen J C Hearps, Cathy Catroppa
Children with traumatic brain injury (TBI) are at risk of social impairment, but research is yet to document the trajectory of these skills post-injury and factors that may predict social problems. The study addressed these gaps in knowledge, reporting on findings from a prospective, longitudinal follow-up study which investigated social outcomes post injury and explored factors contributing to these outcomes at 2 years post-injury. The sample included 113 children, 74 with TBI and 39 typically developing (TD) controls...
February 8, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28170143/prevalence-of-brain-injuries-and-recurrence-of-seizures-in-children-with-post-traumatic-seizures
#9
Mohamed K Badawy, Peter S Dayan, Michael G Tunik, Frances M Nadel, Kathleen A Lillis, Michelle Miskin, Dominic A Borgialli, Michael C Bachman, Shireen M Atabaki, John D Hoyle, James F Holmes, Nathan Kuppermann
OBJECTIVES: Computed tomography (CT) is often used in the emergency department (ED) evaluation of children with post-traumatic seizures (PTS); however, the frequency of traumatic brain injuries (TBI) and short-term seizure recurrence is lacking. Our main objective was to evaluate the frequency of TBI on CT and short-term seizure recurrence in children with PTS. We also aimed to determine the associations between the likelihood of TBI on CT with the timing of onset of PTS after the traumatic event and duration of PTS...
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28162033/high-density-electroencephalographic-recordings-during-sleep-in-children-and-adolescents-with-acquired-brain-injury
#10
Anne-Laure Mouthon, Andreas Meyer-Heim, Salome Kurth, Maya Ringli, Fiona Pugin, Hubertus J A van Hedel, Reto Huber
BACKGROUND: Acquired brain injuries (ABI) such as traumatic brain injury (TBI) or stroke can result in motor, language, or cognitive impairments. Although a considerable number of studies have investigated functional recovery, underlying brain reorganization remains poorly understood. Accumulating evidence indicates that plastic processes in the brain are linked to changes in electroencephalographic (EEG) slow wave activity (SWA) during deep sleep (EEG spectral power 1-4.5 Hz). OBJECTIVE: We investigated sleep SWA in children and adolescents with ABI...
February 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28159872/utilization-of-mental-health-services-after-mild-pediatric-traumatic-brain-injury
#11
Nathalia Jimenez, Alex Quistberg, Monica S Vavilala, Kenneth M Jaffe, Frederick P Rivara
BACKGROUND: Mild traumatic brain injury injuries (mTBIs), including concussions, represent >2 million US pediatric emergency department visits annually. Post-mTBI mental health symptoms are prominent and often attributed to the mTBI. This study examined whether individuals seeking post-mTBI mental health care had previous mental health diagnoses or a new onset of such disorders, and determined if mental health care utilization differed by race/ethnicity. METHODS: Retrospective cohort study, using the Medicaid Marketscan claims national dataset (2007-2012)...
February 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28158951/neuronal-biomarker-ubiquitin-c-terminal-hydrolase-uch-l1-detects-traumatic-intracranial-lesions-on-ct-in-children-and-youth-with-mild-traumatic-brain-injury
#12
Linda Papa, Manoj K Mittal, Jose Ramirez, Salvatore Silvestri, Philip Giordano, Carolina F Braga, Ciara Natasha S Tan, Neema J Ameli, Marco Lopez, Crystal A Haeussler, Diego Mendez Giordano, Mark R Zonfrillo
: This study examined the performance of serum Ubiquitin C-terminal Hydrolase (UCH-L1) in detecting traumatic intracranial lesions on CT scan (+CT) in children and youth with mild and moderate TBI (MMTBI) and assessed its performance in trauma control patients without head trauma. This prospective cohort study enrolled children and youth presenting to three Level 1 Trauma Centers following blunt head trauma and a GCS 9-15 as well as trauma control patients with GCS 15 that did not have blunt head trauma...
February 3, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28145660/playground-equipment-related-injuries-in-preschool-aged-children-emergency-department-based-injury-in-depth-surveillance
#13
Sohyun Bae, Ji Sook Lee, Kyung Hwan Kim, Junseok Park, Dong Wun Shin, Hyunjong Kim, Joon Min Park, Hoon Kim, Woochan Jeon
In this study, we investigated playground equipment related injuries in preschool-aged children. This was a retrospective observational study using Emergency Department based Injury In-depth Surveillance, (2011-2014). We included the preschool-aged children with playground equipment related injuries. We surveyed the mechanism and incidence of injuries, and estimated the odds ratio (OR) of traumatic brain injury (TBI) and upper/lower extremities fracture. There were 6,110 patients, mean age was 4.14 ± 1.95 years old...
March 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28144880/use-of-stimulants-in-bipolar-disorder
#14
REVIEW
Giulio Perugi, Giulia Vannucchi, Fulvio Bedani, Ettore Favaretto
Several international guidelines indicate stimulants, including methylphenidate (MPH), amphetamines and derivatives, modafinil, and armodafinil among the second-third-line choices for bipolar depression. Efficacy of stimulants has been also reported for the management of residual depressive symptoms such as fatigue and sleepiness and for the management of affective, cognitive, and behavioral symptoms in children and adult bipolar patients with comorbid ADHD. Few case reports show positive results with MPH in the treatment of resistant mania...
January 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28131925/prevalence-and-impact-of-admission-acute-traumatic-coagulopathy-on-treatment-intensity-resource-utilization-and-mortality-an-evaluation-of-956-severely-injured-children-and-adolescents
#15
Ioannis N Liras, Henry W Caplan, Jakob Stensballe, Charles E Wade, Charles S Cox, Bryan A Cotton
INTRODUCTION: Acute coagulopathy of trauma in children are of potential importance to clinical outcome, but knowledge is limited and has only been investigated using conventional coagulation testing (CCT). The purpose of this study was to assess the prevalence and impact of arrival coagulopathy, determined by viscoelastic hemostatic testing, in severely injured children. METHODS: Pediatric patients (<17 years of age) who were admitted 01/2010-05/2016 and met highest-level trauma activation were included...
January 25, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28126353/auditing-access-to-outpatient-rehabilitation-services-for-children-with-traumatic-brain-injury-and-public-insurance-in-washington-state
#16
Molly M Fuentes, Leah Thompson, D Alex Quistberg, Wren L Haaland, Karin Rhodes, Deborah Kartin, Cheryl Kerfeld, Susan Apkon, Ali Rowhani-Rahbar, Frederick P Rivara
OBJECTIVE: Identify insurance-based disparities in access to outpatient pediatric neurorehabilitation services. DESIGN: Audit study, with paired calls where callers posed as a mother seeking services for a simulated child with history of severe traumatic brain injury (TBI) and public or private insurance. SETTING: Outpatient rehabilitation clinics in Washington State PARTICIPANTS: 195 physical therapy clinics (PTc), 109 occupational therapy clinics (OTc), 102 speech therapy clinics (STc) and 11 rehabilitation medicine clinics INTERVENTIONS: None MAIN OUTCOME MEASURES: Acceptance of public insurance, business days until the next available appointment...
January 23, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28123622/full-outline-of-unresponsiveness-score-and-the-glasgow-coma-scale-in-prediction-of-pediatric-coma
#17
Atahar Jamal, Naveen Sankhyan, Murlidharan Jayashree, Sunit Singhi, Pratibha Singhi
BACKGROUND: This study was done to compare the admission Full Outline of Unresponsiveness (FOUR) score and Glasgow Coma Scale (GCS) as predictors of outcome in children with impaired consciousness. METHODS: In this observational study, children (5-12 years) with impaired consciousness of <7 days were included. Children with traumatic brain injury, on sedatives or neuromuscular blockade; with pre-existing cerebral palsy, mental retardation, degenerative brain disease, vision/hearing impairment; and seizure within last 1 hour were excluded...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28122475/the-relationship-between-olfactory-dysfunction-and-executive-function-in-children-with-traumatic-brain-injury
#18
Kathleen Bakker, Cathy Catroppa, Vicki Anderson
INTRODUCTION: Olfactory dysfunction (OD) has been suggested as a possible marker of executive function (EF) deficits after traumatic brain injury (TBI) in adults. Little is known about the relationship between EF and OD in pediatric TBI (pTBI). This study aimed to investigate EF, explore the relationship between OD and EF, and determine the utility of olfactory performance as a marker of later EF in pTBI. It was hypothesized that (i) children with TBI would perform more poorly on EF measures relative to normative expectation; (ii) children with OD would perform more poorly on tests of EF than those with normal olfaction after TBI; and (iii) acute olfactory function would predict later EF for children with TBI...
January 25, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28121973/emergency-department-care-of-young-children-at-risk-for-traumatic-brain-injury-what-are-we-doing-and-do-parents-understand
#19
Caroline Reilly, Nanhua Zhang, Lynn Babcock, Shari L Wade, Tara Rhine
OBJECTIVES: The aims of the study were to describe emergency department (ED) management of young children with head injury and to assess parental comfort level and perceptions of ED care. METHODS: This was a prospective observational study of children younger than 5 years who presented to a pediatric ED after head injury. Children were eligible if clinical observation was an appropriate ED management option per the Pediatric Emergency Care Academic Research Network's neuroimaging clinical decision rule...
January 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28114784/long-term-brain-injury-specific-effects-following-preschool-mild-tbi-a-study-of-theory-of-mind
#20
Jenny Bellerose, Annie Bernier, Cindy Beaudoin, Jocelyn Gravel, Miriam H Beauchamp
OBJECTIVE: A previous study conducted by our group found theory of mind (ToM) differences in preschool children who sustained mild traumatic brain injury (mTBI) compared with typically developing peers, 6 months postinjury. The goals of the current longitudinal study were to determine whether these findings are the result of a brain-injury-specific effect or rather a general-injury effect, to examine the long-term evolution of ToM skills following preschool mTBI, as well as to investigate the links between ToM abilities and general social functioning...
January 23, 2017: Neuropsychology
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