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JOURNAL ARTICLE
Colby R Slezak, Erik J Blomberg, Amber M Roth, Liam A Berigan, Alexander C Fish, Rachel Darling, Sarah J Clements, Greg Balkcom, Bobbi Carpenter, Gary Costanzo, Jeffrey Duguay, Clayton L Graham, William Harvey, Michael Hook, Douglas L Howell, Seth Maddox, Shawn W Meyer, Theodore C Nichols, J Bruce Pollard, Christian Roy, Joshua C Stiller, Jacob N Straub, Mathieu Tetreault, Reina Tyl, Lisa Williams, Jennifer E Kilburn, Scott R McWilliams
Conventional life-history theory predicts that energy-demanding events such as reproduction and migration must be temporally segregated to avoid resource limitation. Here, we provide, to our knowledge, the first direct evidence of 'itinerant breeding' in a migratory bird, an incredibly rare breeding strategy (less than 0.1% of extant bird species) that involves the temporal overlap of migratory and reproductive periods of the annual cycle. Based on GPS-tracking of over 200 female American woodcock, most female woodcock (greater than 80%) nested more than once (some up to six times) with short re-nest intervals, and females moved northwards on average 800 km between first and second nests, and then smaller distances ( ca 200+ km) between subsequent nesting attempts...
April 30, 2024: Proceedings. Biological Sciences
#2
JOURNAL ARTICLE
Giuseppe Troisi, Roy Small, Roman Chestnov, Diana Andreasyan, Henrik Khachatryan, Erwin Arthur Phillips, Taraleen Malcolm, Hero Kol, Nargiza Khodjaeva, Mussie Gebremichael, Addisu Worku Tessema, Asmamaw Bezabeh Workneh, Tamu Davidson, Michelle Harris, Nurgul Ibraeva, Aigul Nurmatova, Aliina Altymysheva, John Juliard Go, Anna Kontsevaya, Krisada Hanbunjerd, Sushera Bunluesin, Olivia Nieveras, Banu Ekinci, Bekir Keskinkiliç, Toker Erguder, Oyoo Charles Akiya, Hafisa Kasule, Aidah Nakanjako, Shukhrat Shukurov, Nazokat Kasymova, Patrick Banda, Ernest Kakoma, Nathan N Bakyaita, Alexey Kulikov, Dudley Tarlton, Nadia Putoud, Scott Chiossi, Douglas Webb, Nicholas Banatvala
Non-communicable diseases (NCDs) are a leading health and development challenge worldwide. Since 2015, WHO and the United Nations Development Programme have provided support to governments to develop national NCD investment cases to describe the socioeconomic dimensions of NCDs. To assess the impact of the investment cases, semistructured interviews and a structured process for gathering written feedback were conducted between July and October 2022 with key informants in 13 countries who had developed a national NCD investment case between 2015 and 2020...
April 10, 2024: BMJ Global Health
#3
JOURNAL ARTICLE
Scott Rickert, David Chi, Mark Gerber, Soham Roy, Doug Sidell, Steven E Sobol, Julie Wei
No abstract text is available yet for this article.
April 6, 2024: International Journal of Pediatric Otorhinolaryngology
#4
COMMENT
Rachel V Aaron, Scott G Ravyts
Commentary on: Darnall BD, Burns JW, Hong J, Roy A, Slater K, Poupore-King H, Ziadni MS, You DS, Jung C, Cook KF, Lorig K, Tian L, Mackey SC. Empowered relief, cognitive behavioral therapy and health education for people with chronic pain: a comparison of outcomes at 6-month follow-up for a randomized controlled trial. PAIN Reports 2024;9:e1116.
June 2024: Pain Reports
#5
JOURNAL ARTICLE
Arjun K Raj, Scott J Pedersen, Casey Mainsbridge, Chythra R Rao, Sohini Roy, Baskaran Chandrasekaran
Prolonged sitting is postulated to influence musculoskeletal performance (cervical flexor endurance, balance, and agility), discomfort and alter cervical spine angles during work-based computer use. Stair climbing breaks may be a great addition at typical and home offices however remain unexplored for its impact on musculoskeletal performance. In our counterbalanced pilot crossover trial, 24 adults were randomised to three interventions: (1) prolonged sitting, (2) interrupted by 2 min of self-paced, and (3) externally paced stair climbing for 2 h...
April 3, 2024: Ergonomics
#6
REVIEW
Soumyajit Roy, Gagan Fervaha, Daniel E Spratt, Yilun Sun, Amar U Kishan, Andrew Loblaw, Shawn Malone, Michael Ong, Fred Saad, Christopher J D Wallis, Scott C Morgan
BACKGROUND AND OBJECTIVE: The utility of prostate radiotherapy (RT) is unclear in men with metastatic hormone-sensitive prostate cancer (mHSPC) receiving intensified systemic therapy with androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPIs). We performed a network meta-analysis of randomized controlled trials (RCTs) to investigate the role of prostate RT in low-volume mHSPC. METHODS: Bibliographic databases and conference proceedings were searched through July 2023 for RCTs evaluating the addition of ARPIs or prostate RT to standard of care (SOC) systemic therapy, defined as ADT or ADT plus docetaxel, for the initial treatment of mHSPC...
April 2, 2024: European Urology
#7
Alexandra G Bardon, Jesus J Ballesteros, Scott L Brincat, Jefferson E Roy, Meredith K Mahnke, Yumiko Ishizawa, Emery N Brown, Earl K Miller
Many different anesthetics cause loss of responsiveness despite having diverse underlying molecular and circuit actions. To explore the convergent effects of these drugs, we examined how ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, and dexmedetomidine, an α2 adrenergic receptor agonist, affected neural oscillations in the prefrontal cortex of nonhuman primates. Previous work has shown that anesthesia increases phase locking of low-frequency local field potential activity across cortex...
March 20, 2024: bioRxiv
#8
JOURNAL ARTICLE
Mithuna Srinivasan, Amber Scott, Jackie Soo, Meera Sreedhara, Shena Popat, Kincaid Lowe Beasley, Tiara N Jackson, Amena Abbas, W Alexander Keaton, Christine Holmstedt, Jillian Harvey, Ryan Kruis, Shay McLeod, Roy Ahn
OBJECTIVE: To examine the relationship between stroke care infrastructure and stroke quality-of-care outcomes at 29 spoke hospitals participating in the <name concealed for blinding purposes> hub-and-spoke telestroke network. MATERIALS AND METHODS: Encounter-level data from <name concealed for blinding purposes> telestroke patient registry were filtered to include encounters during 2015-2022 for patients aged 18 and above with a clinical diagnosis of acute ischemic stroke, and who received intravenous tissue plasminogen activator...
March 29, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#9
JOURNAL ARTICLE
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil Chung, Abeer Al-Battashi, Agnes Reschke, Alex Lion, Alia Ahmad, Alvaro Lassaletta, Alyssa T Reddy, Amir F Al-Darraji, Amish C Shah, An Van Damme, Anne Bendel, Aqeela Rashid, Ashley S Margol, Bethany L Kelly, Bojana Pencheva, Brandie Heald, Brianna Lemieux-Anglin, Bruce Crooks, Carl Koschmann, Catherine Gilpin, Christopher C Porter, David Gass, David Samuel, David S Ziegler, Deborah T Blumenthal, Dennis John Kuo, Dima Hamideh, Donald Basel, Dong-Anh Khuong-Quang, Duncan Stearns, Enrico Opocher, Fernando Carceller, Hagit Baris Feldman, Helen Toledano, Ira Winer, Isabelle Scheers, Ivana Fedorakova, Jack M Su, Jaime Vengoechea, Jaroslav Sterba, Jeffrey Knipstein, Jordan R Hansford, Julieta Rita Gonzales-Santos, Kanika Bhatia, Kevin J Bielamowicz, Khurram Minhas, Kim E Nichols, Kristina A Cole, Lynette Penney, Magnus Aasved Hjort, Magnus Sabel, Maria Joao Gil-da-Costa, Matthew J Murray, Matthew Miller, Maude L Blundell, Maura Massimino, Maysa Al-Hussaini, Mazin F Al-Jadiry, Melanie A Comito, Michael Osborn, Michael P Link, Michal Zapotocky, Mithra Ghalibafian, Najma Shaheen, Naureen Mushtaq, Nicolas Waespe, Nobuko Hijiya, Noemi Fuentes-Bolanos, Olfat Ahmad, Omar Chamdine, Paromita Roy, Pavel N Pichurin, Per Nyman, Rachel Pearlman, Rebecca C Auer, Reghu K Sukumaran, Rejin Kebudi, Rina Dvir, Robert Raphael, Ronit Elhasid, Rose B McGee, Rose Chami, Ryan Noss, Ryuma Tanaka, Salmo Raskin, Santanu Sen, Scott Lindhorst, Sebastien Perreault, Shani Caspi, Shazia Riaz, Shlomi Constantini, Sophie Albert, Stanley Chaleff, Stefan Bielack, Stefano Chiaravalli, Stuart Louis Cramer, Sumita Roy, Suzanne Cahn, Suzanne Penna, Syed Ahmer Hamid, Tariq Ghafoor, Uzma Imam, Valerie Larouche, Vanan Magimairajan Issai, William D Foulkes, Yi Yen Lee, Paul C Nathan, Yosef E Maruvka, Mary-Louise C Greer, Carol Durno, Adam Shlien, Birgit Ertl-Wagner, Anita Villani, David Malkin, Cynthia Hawkins, Eric Bouffet, Anirban Das, Uri Tabori
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD. METHODS: In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries...
March 26, 2024: Lancet Oncology
#10
JOURNAL ARTICLE
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine A Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven by the inactivation of a subunit of SWI/SNF (also known as BAF) chromatin-remodelling complexes. Here, to generate mechanistic insights into the consequences of SMARCB1 mutation and to identify vulnerabilities, we contributed 14 SMARCB1-mutant cell lines to a near genome-wide CRISPR screen as part of the Cancer Dependency Map Project1-3 ...
March 27, 2024: Nature
#11
COMMENT
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sánchez, Betty R Vohr, Karen J Johnson, Dianne E Herron, Abhik Das, Margaret M Crawford, Michele C Walsh, Rosemary D Higgins, Barbara J Stoll, Namisavayam Ambalavanan, Myra H Wyckoff, Carl T D'Angio, George W Bugg, Robin K Ohls, Anne Marie Reynolds, Gregory M Sokol, Abbot R Laptook, Steven L Olsen, Jessica R White, Sudarshan R Jadcherla, Monika Bajaj, Prabhu S Parimi, Barbara Schmidt, Matthew M Laughon, John Barks, Kimberley A Fisher, Anna Maria Hibbs, Myriam Peralta-Carcelen, Noah Cook, Roy J Heyne, Brenna Cavanaugh, Ira Adams-Chapman, Janell Fuller, Michelle E Hartley-McAndrew, Heidi M Harmon, Andrea F Duncan, Abbey C Hines, Howard W Kilbride, Laurie A Richards, Nathalie L Maitre, Girija Natarajan, Andrea N Trembath, Martha D Carlson, William F Malcolm, Deanne E Wilson-Costello
IMPORTANCE: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. OBJECTIVE: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk...
February 20, 2024: JAMA
#12
JOURNAL ARTICLE
Aaron Adler, Joel S Bader, Brian Basnight, Benjamin W Booth, Jitong Cai, Elizabeth Cho, Joseph H Collins, Yuchen Ge, John Grothendieck, Kevin Keating, Tyler Marshall, Anton Persikov, Helen Scott, Roy Siegelmann, Mona Singh, Allison Taggart, Benjamin Toll, Kenneth H Wan, Daniel Wyschogrod, Fusun Yaman, Eric M Young, Susan E Celniker, Nicholas Roehner
Synthetic biology is creating genetically engineered organisms at an increasing rate for many potentially valuable applications, but this potential comes with the risk of misuse or accidental release. To begin to address this issue, we have developed a system called GUARDIAN that can automatically detect signatures of engineering in DNA sequencing data, and we have conducted a blinded test of this system using a curated Test and Evaluation (T&E) data set. GUARDIAN uses an ensemble approach based on the guiding principle that no single approach is likely to be able to detect engineering with perfect accuracy...
March 12, 2024: ACS Synthetic Biology
#13
JOURNAL ARTICLE
Patrick G Pilie, Virginia Giuliani, Wei-Lien Wang, Daniel J McGrail, Christopher A Bristow, Natalie Y L Ngoi, Keith Kyewalabye, Khalida M Wani, Hung Le, Erick Campbell, Nora S Sánchez, Dong Yang, Jinesh S Gheeya, Rohit Vivek Goswamy, Vijaykumar Holla, Kenna Rael Shaw, Funda Meric-Bernstam, Chiu-Yi Liu, XiaoYan Ma, Ningping Feng, Annette A Machado, Jennifer P Bardenhagen, Christopher P Vellano, Joseph R Marszalek, Eeson Rajendra, Desiree Piscitello, Timothy I Johnson, Maria Likhatcheva, Elias Elinati, Jayesh Majithiya, Joana Neves, Vera Grinkevich, Marco Ranzani, Marina Roy-Luzarraga, Marie Boursier, Lucy Armstrong, Lerin Geo, Giorgia Lillo, Wai Yiu Tse, Alexander J Lazar, Scott E Kopetz, Mary K Geck Do, Sarah Lively, Michael G Johnson, Helen M R Robinson, Graeme C M Smith, Christopher L Carroll, M Emilia Di Francesco, Philip Jones, Timothy P Heffernan, Timothy A Yap
PURPOSE: Mutations in the ATM gene are common in multiple cancers, but clinical studies of therapies targeting ATM aberrant cancers have yielded mixed results. Refinement of ATM loss of function (LOF) as a predictive biomarker of response is urgently needed. EXPERIMENTAL DESIGN: We present the first disclosure and preclinical development of a novel, selective ATR inhibitor, ART0380, and test its antitumor activity in multiple preclinical cancer models. To refine ATM LOF as a predictive biomarker, we performed a comprehensive pan-cancer analysis of ATM variants in patient tumors, and then assessed the ATM variant-to-protein relationship...
February 28, 2024: Clinical Cancer Research
#14
JOURNAL ARTICLE
Brandon J Beddingfield, Kenneth S Plante, Jessica A Plante, Scott C Weaver, Sarah Bose, Clara Krzykwa, Nicole Chirichella, Rachel K Redmann, Stephanie Z Seiler, Jason Dufour, Robert V Blair, Kathrin Endt, Ariane Volkmann, Nicholas J Maness, Chad J Roy
MVA-based monovalent eastern equine encephalitis virus (MVA-BN-EEEV) and multivalent western, eastern, and Venezuelan equine encephalitis virus (MVA-BN-WEV) vaccines were evaluated in the cynomolgus macaque aerosol model of EEEV infection. Macaques vaccinated with two doses of 5 × 108 infectious units of the MVA-BN-EEEV or MVA-BN-WEV vaccine by the intramuscular route rapidly developed robust levels of neutralizing antibodies to EEEV that persisted at high levels until challenge at day 84 via small particle aerosol delivery with a target inhaled dose of 107 PFU of EEEV FL93-939...
February 27, 2024: NPJ Vaccines
#15
Amish N Raval, Eric G Schmuck, Sushmita Roy, Yukihiro Saito, Tianhua Zhou, James Conklin, Timothy A Hacker, Chad Koonce, Meghan Boyer, Kristin Stack, Ellen Hebron, Scott K Nagle, Patrick C H Hsieh, Timothy J Kamp
BACKGROUND: The adult human heart following a large myocardial infarction is unable to regenerate heart muscle and instead forms scar with the risk of progressive heart failure. Large animal studies have shown that intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) following a myocardial infarction result in cell grafts but also ventricular arrhythmias. We hypothesized that intramyocardial injection of committed cardiac progenitor cells (CCPs) derived from iPSCs, combined with cardiac fibroblast-derived extracellular matrix (cECM) to enhance cell retention will: i) form cardiomyocyte containing functional grafts, ii) be free of ventricular arrhythmias and iii) restore left ventricular contractility in a post-myocardial infarction (MI) cardiomyopathy swine model...
February 17, 2024: bioRxiv
#16
Maria Koromina, Ashvin Ravi, Georgia Panagiotaropoulou, Brian M Schilder, Jack Humphrey, Alice Braun, Tim Bidgeli, Chris Chatzinakos, Brandon Coombes, Jaeyoung Kim, Xiaoxi Liu, Chikashi Terao, Kevin S O 'Connell, Mark Adams, Rolf Adolfsson, Martin Alda, Lars Alfredsson, Till F M Andlauer, Ole A Andreassen, Anastasia Antoniou, Bernhard T Baune, Susanne Bengesser, Joanna Biernacka, Michael Boehnke, Rosa Bosch, Murray Cairns, Vaughan J Carr, Miquel Casas, Stanley Catts, Sven Cichon, Aiden Corvin, Nicholas Craddock, Konstantinos Dafnas, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Arianna Di Florio, Dimitris Dikeos, Frederike Tabea Fellendorf, Panagiotis Ferentinos, Andreas J Forstner, Liz Forty, Mark Frye, Janice M Fullerton, Micha Gawlik, Ian R Gizer, Katherine Gordon-Smith, Melissa J Green, Maria Grigoroiu-Serbanescu, José Guzman-Parra, Tim Hahn, Frans Henskens, Jan Hillert, Assen V Jablensky, Lisa Jones, Ian Jones, Lina Jonsson, John R Kelsoe, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Manolis Kogevinas, Mikael Landén, Marion Leboyer, Melanie Lenger, Jolanta Lissowska, Christine Lochner, Carmel Loughland, Donald MacIntyre, Nicholas G Martin, Eirini Maratou, Carol A Mathews, Fermin Mayoral, Susan L McElroy, Nathaniel W McGregor, Andrew McIntosh, Andrew McQuillin, Patricia Michie, Vihra Milanova, Philip B Mitchell, Paraskevi Moutsatsou, Bryan Mowry, Bertram Müller-Myhsok, Richard Myers, Igor Nenadić, Markus M Nöthen, Claire O'Donovan, Michael O'Donovan, Roel A Ophoff, Michael J Owen, Chris Pantelis, Carlos Pato, Michele T Pato, George P Patrinos, Joanna M Pawlak, Roy H Perlis, Evgenia Porichi, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Andreas Reif, Eva Z Reininghaus, Marta Ribasés, Marcella Rietschel, Ulrich Schall, Thomas G Schulze, Laura Scott, Rodney J Scott, Alessandro Serretti, Cynthia Shannon Weickert, Jordan W Smoller, Maria Soler Artigas, Dan J Stein, Fabian Streit, Claudio Toma, Paul Tooney, Eduard Vieta, John B Vincent, Irwin D Waldman, Thomas Weickert, Stephanie H Witt, Kyung Sue Hong, Masashi Ikeda, Nakao Iwata, Beata Świątkowska, Hong-Hee Won, Howard J Edenberg, Stephan Ripke, Towfique Raj, Jonathan R I Coleman, Niamh Mullins
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci, and prioritized 22 likely causal SNPs for BD. We mapped these SNPs to genes, and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci, and results from rare variant exome sequencing in BD...
February 13, 2024: medRxiv
#17
JOURNAL ARTICLE
Anna H Ou, Sara B Rosenthal, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Martin Alda, Azmeraw T Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Michael Bauer, Bernhard T Baune, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M Biernacka, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Clarissa R Dantas, Alexandre Dayer, Maria Del Zompo, Franziska Degenhardt, J Raymond DePaulo, Bruno Étain, Peter Falkai, Frederike Tabea Fellendorf, Ewa Ferensztajn-Rochowiak, Andreas J Forstner, Louise Frisén, Mark A Frye, Janice M Fullerton, Sébastien Gard, Julie S Garnham, Fernando S Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, Sarah Kittel-Schneider, Barbara König, Po-Hsiu Kuo, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Glenda MacQueen, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Francis J McMahon, Philip B Mitchell, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Markus M Nöthen, Tomas Novák, Urban Ösby, Norio Ozaki, Sergi Papiol, Roy H Perlis, Claudia Pisanu, James B Potash, Andrea Pfennig, Daniela Reich-Erkelenz, Andreas Reif, Eva Z Reininghaus, Marcella Rietschel, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, K Oliver Schubert, Thomas G Schulze, Barbara W Schweizer, Florian Seemüller, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Eduard Vieta, Julia Volkert, Stephanie Witt, Naomi R Wray, Adam Wright, L Trevor Young, Peter P Zandi, John R Kelsoe
Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study...
February 23, 2024: Translational Psychiatry
#18
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#19
JOURNAL ARTICLE
Émilie Degagné, Paul D Donohoue, Suparna Roy, Jessica Scherer, Tristan W Fowler, Ryan T Davis, Gustavo A Reyes, George Kwong, Morena Stanaway, Vanina Larroca Vicena, Devin Mutha, Raymond Guo, Leslie Edwards, Benjamin Schilling, McKay Shaw, Stephen C Smith, Bryan Kohrs, Heinrich J Kufeldt, Glen Churchward, Finey Ruan, David B Nyer, Kyle McSweeney, Matthew J Irby, Christopher K Fuller, Lynda Banh, Mckenzi S Toh, Matthew Thompson, Arthur L G Owen, Zili An, Scott Gradia, Justin Skoble, Mara Bryan, Elizabeth Garner, Steven B Kanner
Allogeneic chimeric antigen receptor (CAR) T-cell therapies hold the potential to overcome many of the challenges associated with patient-derived (autologous) CAR T cells. Key considerations in the development of allogeneic CAR T-cell therapies include prevention of GvHD and suppression of allograft rejection. Here we describe preclinical data supporting the ongoing first-in-human clinical study, the CaMMouflage trial (NCT05722418), evaluating CB-011 in patients with relapsed/refractory multiple myeloma. CB-011 is a hypoimmunogenic, allogeneic anti-B cell maturation antigen (BCMA) CAR T-cell therapy candidate...
February 9, 2024: Cancer Immunology Research
#20
JOURNAL ARTICLE
Sara B DeMauro, Scott A McDonald, Roy J Heyne, Betty R Vohr, Andrea F Duncan, Jamie E Newman, Abhik Das, Susan R Hintz
OBJECTIVE: To evaluate changes in prevalence and severity of cerebral palsy (CP) among surviving children born at <27 weeks of gestation over time and to determine associations between CP and other developmental domains, functional impairment, medical morbidities, and resource utilization among two-year old children who were born extremely preterm. STUDY DESIGN: Retrospective cohort study using prospective registry data, conducted at 25 centers of the Eunice Kennedy Shriver NICHD Neonatal Research Network...
February 7, 2024: Journal of Pediatrics
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