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https://www.readbyqxmd.com/read/28648678/single-plane-illumination-microscopy-as-a-tool-for-studying-nucleome-dynamics
#1
Jörg Langowski
Single plane illumination microscopy (SPIM) is a new optical method that has become extremely important in recent years. It is based on the formation of a "light slice" in the specimen in which fluorescently tagged molecules are observed. The spatial resolution is close to that of confocal optics, but without the disadvantages inherent to scanning or high laser irradiation doses. A recent development is light sheet fluctuation microscopy, which exploits the dynamic information contained in the fluorescence intensity fluctuations of each image pixel...
June 22, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28641092/nuclear-mechanotransduction-sensing-the-force-from-within
#2
REVIEW
Avathamsa Athirasala, Nivi Hirsch, Amnon Buxboim
The cell nucleus is a hallmark of eukaryotic evolution, where gene expression is regulated and the genome is replicated and repaired. Yet, in addition to complex molecular processes, the nucleus has also evolved to serve physical tasks that utilize its optical and mechanical properties. Nuclear mechanotransduction of externally applied forces and extracellular stiffness is facilitated by the physical connectivity of the extracellular environment, the cytoskeleton and the nucleoskeletal matrix of lamins and chromatin...
June 19, 2017: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/28640750/in-vivo-monitoring-of-infection-via-implantable-microsensors-a-pilot-study
#3
Andrej Ring, Heiko Sorg, Andreas Weltin, Daniel J Tilkorn, Jochen Kieninger, Gerald Urban, Jörg Hauser
The most common complication after implantation of foreign material is infection, leading to implant failure and severe patient discomfort. Smoldering-infections proceed inapparently and might not get verified by radiological diagnostics. Early identification of this type of infection might significantly reduce the rate of complications. Therefore, we manufactured a microsensor strip in a hybrid of thin-film and laminate technology in a wafer-level process. It comprises electrochemical, amperometric microsensors for glucose, oxygen and lactate as well as an integrated reference electrode...
June 22, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28637992/ten-year-clinical-observation-of-a-porcelain-laminate-veneer-seated-with-biological-tissue-adaptation-bta-technique
#4
Kenji Tsubota
This clinical report describes the use of biological tissue adaptation technique for placement of a porcelain laminate veneer in a 50-year-old woman. The author developed this prosthetic technique to facilitate alignment of gingival levels for esthetic purposes. The laminate veneer was seated on the maxillary central incisor with an adhesive system. Although the margin of the restoration overhangs, no gingival inflammation or recession has been observed during a follow-up period of 10 years and 9 months.
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28637946/basal-cell-adenocarcinoma-in-the-gland-of-the-third-eyelid-of-a-brown-bear-ursus-arctos
#5
Hiroki Sakai, Minami Goto, Takeshi Komatsu
The right third eyelid of an adult female brown bear (Ursus arctos) was swollen and removed. Histopathology revealed a tumor exhibiting proliferation with mild infiltration, consisting of multi-stratified glandular structures of the innermost laminal neoplastic cells and the basaloid neoplastic cells, and with eosinophilic thick basal lamina material around the glandular structures. Both types of neoplastic cells exhibited moderate anisokaryosis, and mitotic figures were observed in the basaloid neoplastic cells...
June 22, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28637768/vrk2a-is-an-a-type-lamin-dependent-nuclear-envelope-kinase-that-phosphorylates-baf
#6
K C Birendra, Danielle G May, Benjamin V Benson, Dae In Kim, Winnie G Shivega, Manaal H Ali, Randolph S Faustino, Alexandre R Campos, Kyle J Roux
The nuclear envelope (NE) is critical for numerous fundamental cellular functions and mutations in several NE constituents can lead to a heterogeneous spectrum of diseases. We used proximity biotinylation to uncover new constituents of the inner nuclear membrane (INM) by comparative BioID analysis of lamin-A, Sun2 and a minimal INM-targeting motif. These studies identified vaccinia-related kinase-2 (VRK2) as a candidate constituent of the INM. We determined that the transmembrane VRK2A isoform is retained at the NE by association with A-type lamins...
June 21, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28635493/the-structure-of-lamin-filaments-in-somatic-cells-as-revealed-by-cryo-electron-tomography
#7
Y Turgay, O Medalia
Metazoan nuclei are equipped with nuclear lamina - a thin layer of intermediate filaments (IFs) mostly built of nuclear lamins facing the inner nuclear membrane (INM). The nuclear lamina serves as an interaction hub for INM-proteins, soluble nuclear factors and DNA. It confers structural and mechanical stability to the nucleus, transduces mechanical forces and biochemical signals across the nuclear envelope (NE) and regulates the organization of chromatin. By utilizing cryo-electron tomography (cryo-ET), we recently provided an unprecedented view into the 3D organization of lamin filaments within the lamina meshwork in mammalian somatic cells...
June 21, 2017: Nucleus
https://www.readbyqxmd.com/read/28632157/development-of-a-novel-transparent-flexible-capacitive-micromachined-ultrasonic-transducer
#8
Da-Chen Pang, Cheng-Min Chang
This paper presents the world's first transparent flexible capacitive micromachined ultrasonic transducer (CMUT) that was fabricated through a roll-lamination technique. This polymer-based CMUT has advantages of transparency, flexibility, and non-contacting detection which provide unique functions in display panel applications. Comprising an indium tin oxide-polyethylene terephthalate (ITO-PET) substrate, SU-8 sidewall and vibrating membranes, and silver nanowire transparent electrode, the transducer has visible-light transmittance exceeding 80% and can operate on curved surfaces with a 40 mm radius of curvature...
June 20, 2017: Sensors
https://www.readbyqxmd.com/read/28632130/the-laminar-organization-of-the-drosophila-ellipsoid-body-is-semaphorin-dependent-and-prevents-the-formation-of-ectopic-synaptic-connections
#9
Xiaojun Xie, Masashi Tabuchi, Matthew P Brown, Sarah P Mitchell, Mark N Wu, Alex L Kolodkin
The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function remain unknown. We show here that the EB is sequentially innervated by small-field and large-field neurons, and that early-developing EB neurons play an important regulatory role in EB laminae formation...
June 20, 2017: ELife
https://www.readbyqxmd.com/read/28631480/fully-transparent-quantum-dot-light-emitting-diode-with-a-laminated-top-graphene-anode
#10
Li Yao, Xin Fang, Wei Gu, Wenhao Zhai, Yi Wan, Xixi Xie, Wanjin Xu, Xiaodong Pi, Guangzhao Ran, Guogang Qin
A new method to employ graphene as top electrode was introduced, and based on that, fully transparent quantum dot light emitting diodes (T-QLEDs) were sucessfully fabribated through a lamination process. We adopted the widely used wet transfer method to transfer bilayer graphene (BG) on polydimethylsiloxane/polyethylene terephthalate (PDMS/PET) substrate. The sheet resistance of graphene reduced to ~540 Ω/□ through transferring BG for 3 times on the PDMS/PET. The T-QLED has an inverted device structure of glass/Indium tin oxide (ITO)/ZnO nanoparticles (NPs)/(CdSSe/ZnS quantum dots (QDs))/ 1,1-bis[(di-4-tolylamino)phenyl] cyclohexane (TAPC)/MoO3/ graphene/PDMS/PET...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28627136/enhancer-of-rudimentary-homologue-interacts-with-scaffold-attachment-factor-b-at-the-nuclear-matrix-to-regulate-sr-protein-phosphorylation
#11
Sotiria Drakouli, Aggeliki Lyberopoulou, Maria Papathanassiou, Ilias Mylonis, Eleni Georgatsou
Scaffold Attachment Factor B1 (SAFB1) is an integral component of the nuclear matrix of vertebrate cells.It binds to DNA on scaffold/matrix attachment region (S/MAR) elements, to RNA, and to a multitude of different proteins, affecting, as has been extensively substantiated, basic cellular activities such as transcription, splicing and DNA damage repair (DDR). In this study, we show that Enhancer of Rudimentary Homologue (ERH) is a new molecular partner of SAFB1 and its 70% homologous paralogue, Scaffold Attachment Factor B2 (SAFB2)...
June 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28623920/ketamine-induced-apoptosis-in-the-mouse-cerebral-cortex-follows-similar-characteristic-of-physiological-apoptosis-and-can-be-regulated-by-neuronal-activity
#12
Qi Wang, Feng-Yan Shen, Rong Zou, Jing-Jing Zheng, Xiang Yu, Ying-Wei Wang
The effects of general anesthetics on inducing neuronal apoptosis during early brain development are well-documented. However, since physiological apoptosis also occurs during this developmental window, it is important to determine whether anesthesia-induced apoptosis targets the same cell population as physiological apoptosis or different cell types altogether. To provide an adequate plane of surgery, ketamine was co-administered with dexmedetomidine. The apoptotic neurons in the mouse primary somatosensory cortex (S1) were quantitated by immunohistochemistry...
June 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28621919/insights-on-tuning-the-nanostructure-of-rgo-laminate-membranes-for-low-pressure-osmosis-process
#13
Qiuze Wang, Cyril Aubry, Yaxin Chen, Huaihe Song, Linda Zou
In this research, rGO laminates were prepared by a controlled partial reduction step, aimed to avoid aggregation and tune the interlayer spacing (d) between the rGO layers. The mild reducing agent vitamin C (L-AA) and cross-linker polycarboxilic acids were used to improve the stability of the assembled rGO laminate membranes. AFM was used for the first time to further investigate the statistical size distribution of spacing between rGO layers. Topographical images of the edges of the rGO layers were obtained with an AFM instrument, interlayer spacing profiles were extracted and then the data was plotted and fitted with Gaussian curves...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28620549/lamination-of-microfibrous-plga-fabric-by-electrospinning-a-layer-of-collagen-hydroxyapatite-composite-nanofibers-for-bone-tissue-engineering
#14
Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung, Inn-Kyu Kang
BACKGROUND: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen-hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28619888/response-to-comment-on-xist-recruits-the-x-chromosome-to-the-nuclear-lamina-to-enable-chromosome-wide-silencing
#15
Chun-Kan Chen, Amy Chow, Mason Lai, Mitchell Guttman
Wang et al question whether Lamin B receptor is required for Xist-mediated silencing because they claim that our cells contain an inversion rather than a deletion. We present evidence that these cells contain a proper deletion and that the confusion is caused by DNA probes used in the experiment. Accordingly, the points raised have no effect on the conclusions in our paper.
June 16, 2017: Science
https://www.readbyqxmd.com/read/28619887/comment-on-xist-recruits-the-x-chromosome-to-the-nuclear-lamina-to-enable-chromosome-wide-silencing
#16
Chen-Yu Wang, John E Froberg, Roy Blum, Yesu Jeon, Jeannie T Lee
Chen et al (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported genotypes of mutants are not supported by the sequencing data. These inconsistencies preclude assessment of the role of LBR in Xist spreading.
June 16, 2017: Science
https://www.readbyqxmd.com/read/28617352/equivalent-circuit-model-of-low-frequency-magnetoelectric-effect-in-disk-type-terfenol-d-pzt-laminate-composites-considering-a-new-interface-coupling-factor
#17
Guofeng Lou, Xinjie Yu, Shihua Lu
This paper describes the modeling of magnetoelectric (ME) effects for disk-type Terfenol-D (Tb0.3Dy0.7Fe1.92)/PZT (Pb(Zr,Ti)O₃) laminate composite at low frequency by combining the advantages of the static elastic model and the equivalent circuit model, aiming at providing a guidance for the design and fabrication of the sensors based on magnetoelectric laminate composite. Considering that the strains of the magnetostrictive and piezoelectric layers are not equal in actual operating due to the epoxy resin adhesive bonding condition, the magnetostrictive and piezoelectric layers were first modeled through the equation of motion separately, and then coupled together with a new interface coupling factor kc, which physically reflects the strain transfer between the phases...
June 15, 2017: Sensors
https://www.readbyqxmd.com/read/28615691/human-myogenic-reserve-cells-are-quiescent-stem-cells-that-contribute-to-muscle-regeneration-after-intramuscular-transplantation-in-immunodeficient-mice
#18
Thomas Laumonier, Flavien Bermont, Pierre Hoffmeyer, Vincent Kindler, Jacques Menetrey
Satellite cells, localized within muscles in vivo, are Pax7(+) muscle stem cells supporting skeletal muscle growth and regeneration. Unfortunately, their amplification in vitro, required for their therapeutic use, is associated with reduced regenerative potential. In the present study, we investigated if human myogenic reserve cells (MRC) obtained in vitro, represented a reliable cell source for muscle repair. For this purpose, primary human myoblasts were freshly isolated and expanded. After 2 days of differentiation, 62 ± 2...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28612607/stereoselective-cyclopropanation-to-homoquinones-from-phenacyl-carbenes-obtained-through-quinone-electrogenerated-bases
#19
Kaouthar Hamrouni, Fructuoso Barba, Mohamed Lamine Benkhoud, Belen Batanero
A series of new (E) and (Z)-benzoyl-homoquinones have been prepared in good yield by the parent quinone-electrogenerated base (EGB) in the presence of α-bromoacetophenones or α-bromopropiophenone. The EGB, obtained when electrolysis of p-benzoquinone, or 1,4-naphthoquinone, is carried out at the reduction potential of their first voltammetric peak, conducted to electrogenerated phenacyl carbenes after halide evolution on the first obtained bromo-enolates. The stereoselectivity of the [2 + 2]cycloaddition of the carbene to the quinoid substrate is highly dependent on the electrode nature...
June 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28610487/establishment-of-novel-meniscal-scaffold-structures-using-polyglycolic-and-poly-l-lactic-acids
#20
Tomohiko Murakami, Shuhei Otsuki, Kosuke Nakagawa, Yoshinori Okamoto, Tae Inoue, Yuki Sakamoto, Hideki Sato, Masashi Neo
The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue...
January 1, 2017: Journal of Biomaterials Applications
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