keyword
https://read.qxmd.com/read/38487022/application-of-dental-pulp-stem-cells-for-bone-regeneration
#21
REVIEW
Ye Liu, Wei Xiong, Junyi Li, Huixian Feng, Shuili Jing, Yonghao Liu, Heng Zhou, Duan Li, Dehao Fu, Chun Xu, Yan He, Qingsong Ye
Bone defects resulting from severe trauma, tumors, inflammation, and other factors are increasingly prevalent. Stem cell-based therapies have emerged as a promising alternative. Dental pulp stem cells (DPSCs), sourced from dental pulp, have garnered significant attention owing to their ready accessibility and minimal collection-associated risks. Ongoing investigations into DPSCs have revealed their potential to undergo osteogenic differentiation and their capacity to secrete a diverse array of ontogenetic components, such as extracellular vesicles and cell lysates...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38486824/static-magnetic-fields-in-regenerative-medicine
#22
REVIEW
Wenjing Xie, Chao Song, Ruowen Guo, Xin Zhang
All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38480735/combination-of-stem-cell-derived-secretome-from-human-exfoliated-deciduous-teeth-with-yemeni-sidr-honey-on-cell-viability-and-migration-an-in-vitro-study
#23
JOURNAL ARTICLE
Mona Abdulrahman Abdullah Al-Hadi
INTRODUCTION: Bone diseases have a profound global impact, especially when the body's innate regenerative capacity falls short in the face of extensive damage. Stem cells from human exfoliated deciduous teeth (SHEDs), discovered in 2003, offer a promising solution for tissue repair, as they self-renew naturally and are easily obtainable. Mesenchymal stem cells (MSCs), including SHEDs, are believed to promote tissue regeneration by releasing growth factors, collectively known as the secretome...
March 13, 2024: BDJ Open
https://read.qxmd.com/read/38474339/mechanobiology-of-dental-pulp-cells
#24
REVIEW
Natalia Bryniarska-Kubiak, Agnieszka Basta-Kaim, Andrzej Kubiak
The dental pulp is the inner part of the tooth responsible for properly functioning during its lifespan. Apart from the very big biological heterogeneity of dental cells, tooth microenvironments differ a lot in the context of mechanical properties-ranging from 5.5 kPa for dental pulp to around 100 GPa for dentin and enamel. This physical heterogeneity and complexity plays a key role in tooth physiology and in turn, is a great target for a variety of therapeutic approaches. First of all, physical mechanisms are crucial for the pain propagation process from the tooth surface to the nerves inside the dental pulp...
February 21, 2024: Cells
https://read.qxmd.com/read/38471313/characterization-of-cells-in-blood-evoked-from-periapical-tissues-in-immature-teeth-with-pulp-necrosis-and-their-potential-for-autologous-cell-therapy-in-regenerative-endodontics
#25
JOURNAL ARTICLE
Chengxiang Zheng, Peiru Jiang, Shan Hu, Yin Tang, Lei Dou
OBJECTIVE: The objectives of this study were to isolate, characterize progenitor cells from blood in the root canals of necrotic immature permanent teeth evoked from periapical tissues and evaluate the applicable potential of these isolated cells in Regenerative Endodontics. DESIGN: Ten necrotic immature permanent teeth from seven patients were included. Evoked bleeding from periapical tissues was induced after chemical instrumentation of the root canals. Cells were isolated from the canal blood and evaluated for cell surface marker expression, multilineage differentiation potential, proliferation ability, and target protein expression...
March 11, 2024: Archives of Oral Biology
https://read.qxmd.com/read/38470723/zirconia-hybrid-dental-implants-influence-the-biological-properties-of-neural-crest-derived-mesenchymal-stromal-cells
#26
JOURNAL ARTICLE
Nadia Tagliaferri, Alessandra Pisciotta, Giulia Orlandi, Giulia Bertani, Rosanna Di Tinco, Laura Bertoni, Paola Sena, Alice Lunghi, Michele Bianchi, Federica Veneri, Pierantonio Bellini, Jessika Bertacchini, Enrico Conserva, Ugo Consolo, Gianluca Carnevale
Dental implants are regularly employed in tooth replacement, the good clinical outcome of which is strictly correlated to the choice of an appropriate implant biomaterial. Titanium-based implants are considered the gold standard for rehabilitation of edentulous spaces. However, the insurgence of allergic reactions, cellular sensitization and low integration with dental and gingival tissues lead to poor osseointegration, affecting the implant stability in the bone and favoring infections and inflammatory processes in the peri-implant space...
February 20, 2024: Nanomaterials
https://read.qxmd.com/read/38463764/influence-of-a-pro-inflammatory-stimulus-on-the-mirna-and-lipid-content-of-human-dental-stem-cell-derived-extracellular-vesicles-and-their-impact-on-microglial-activation
#27
JOURNAL ARTICLE
Viridiane Gratpain, Axelle Loriot, Pauline Bottemanne, Ludovic d'Auria, Romano Terrasi, Valéry L Payen, Vincent van Pesch, Giulio G Muccioli, Anne des Rieux
Neuro-inflammation occurs in numerous disorders such as multiple sclerosis, Alzheimer's disease and Parkinson's disease. However, anti-inflammatory drugs for the central nervous system have failed to show significant improvement when compared to a placebo in clinical trials. Our previous work demonstrated that stem cells from the apical papilla (SCAP) can decrease neuro-inflammation and stimulate oligodendrocyte progenitor cell differentiation. One hypothesis is that the therapeutic effect of SCAP could be mediated by their secretome, including extracellular vesicles (EV)...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463053/evaluation-of-the-efficacy-of-using-dental-pulp-graft-in-the-healing-of-the-alveolar-bone-after-impacted-canine-extraction-a-prospective-cohort-study
#28
JOURNAL ARTICLE
Omar Aljarmakani, Mounzer Assad
SUMMARY: The purpose of this study was to evaluate the radiographic density of the alveolar bone of the maxilla after extraction of the impacted canines and using the pulp tissue as an autogenous graft. MATERIALS AND METHODS: This prospective cohort study recruited 14 patients (8 females and 6 males) between 2021 and 2023, with an average age of 35 years. All participants had palatally impacted maxillary canines. The impacted teeth were extracted surgically. The extracted teeth were then used for autogenous grafting...
March 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38460622/recent-advancements-in-hydrogels-as-novel-tissue-engineering-scaffolds-for-dental-pulp-regeneration
#29
REVIEW
Xiaofei Guo, Jiaxuan Li, Yong Wu, Laijun Xu
Although conventional root canal treatment offers an effective therapeutic solution, it negatively affects the viability of the affected tooth. In recent years, pulp regeneration technology has emerged as a novel method for treating irreversible pulpitis due to its ability to maintain tooth vitality. The successful implementation of this technique depends on scaffolds and transplantation of exogenous stem cells or recruitment of endogenous stem cells. Accordingly, the three-dimensional structure and viscoelastic characteristics of hydrogel scaffolds, which parallel those of the extracellular matrix, have generated considerable interest...
March 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38460171/harnessing-mechanical-stress-with-viscoelastic-biomaterials-for-periodontal-ligament-regeneration
#30
JOURNAL ARTICLE
Jiu-Jiu Zhang, Xuan Li, Yi Tian, Jie-Kang Zou, Dian Gan, Dao-Kun Deng, Chen Jiao, Yuan Yin, Bei-Min Tian, Rui-Xin Wu, Fa-Ming Chen, Xiao-Tao He
The viscoelasticity of mechanically sensitive tissues such as periodontal ligaments (PDLs) is key in maintaining mechanical homeostasis. Unfortunately, PDLs easily lose viscoelasticity (e.g., stress relaxation) during periodontitis or dental trauma, which disrupt cell-extracellular matrix (ECM) interactions and accelerates tissue damage. Here, Pluronic F127 diacrylate (F127DA) hydrogels with PDL-matched stress relaxation rates and high elastic moduli are developed. The hydrogel viscoelasticity is modulated without chemical cross-linking by controlling precursor concentrations...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38456006/the-3-dimensional-printing-for-dental-tissue-regeneration-the-state-of-the-art-and-future-challenges
#31
REVIEW
Fengxiao Zhao, Zhijun Zhang, Weihua Guo
Tooth loss or damage poses great threaten to oral and general health. While contemporary clinical treatments have enabled tooth restoration to a certain extent, achieving functional tooth regeneration remains a challenging task due to the intricate and hierarchically organized architecture of teeth. The past few decades have seen a rapid development of three-dimensional (3D) printing technology, which has provided new breakthroughs in the field of tissue engineering and regenerative dentistry. This review outlined the bioactive materials and stem/progenitor cells used in dental regeneration, summarized recent advancements in the application of 3D printing technology for tooth and tooth-supporting tissue regeneration, including dental pulp, dentin, periodontal ligament, alveolar bone and so on...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38455102/human-dental-pulp-stem-stromal-cells-in-clinical-practice
#32
EDITORIAL
Mohammed E Grawish
Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical concerns and can be successfully cryopreserved and thawed. The therapeutic effects of DPSCs derived from animal or human sources have been extensively studied through in-vitro and in-vivo animal experiments and the findings indicated that DPSCs are effective not only for dental diseases but also for systemic diseases...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38449629/effect-of-erbium-yttrium-aluminium-garnet-laser-dentin-conditioning-on-dental-pulp-stem-cells-viability
#33
JOURNAL ARTICLE
Aryan Jafari, Mehdi Vatanpour, Nooshin Barikrow, Pouyan Razavi, Sohrab Tour Savadkouhi
OBJECTIVE: This study aims to investigate the effect of dentin conditioning by subablative Er:YAG (erbium-doped yttrium aluminium garnet) laser on dental pulp stem cells (DPSCs) viability. METHODS: For this in-vitro experimental study, root fragments were longitudinally hemisected after decoronation of single-rooted extracted teeth and preparation of root canals. Prepared samples were randomly assigned to 2 experimental groups (n = 17) as follows; 1) laser conditioning: irradiation with Er:YAG laser beams (2940 nm, 50 mJ per pulse, 20 Hz) 2) Chemical conditioning: 1...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38447980/effects-of-vehicles-on-the-physical-properties-and-biocompatibility-of-premixed-calcium-silicate-cements
#34
JOURNAL ARTICLE
Gitae Son, Gyeung Mi Seon, Sang Hoon Choi, Hyeong-Cheol Yang
Premixed calcium silicate cements (pCSCs) contain vehicles which endow fluidity and viscosity to CSCs. This study aimed to investigate the effects of three vehicles, namely, polyethylene glycol (PEG), propylene glycol (PG), and dimethyl sulfoxide (DMSO), on the physicochemical properties and biocompatibility of pCSCs. The setting time, solubility, expansion rate, and mechanical strength of the pCSCs were evaluated, and the formation of calcium phosphate precipitates was assessed in phosphate-buffered saline (PBS)...
March 5, 2024: Dental Materials Journal
https://read.qxmd.com/read/38445444/peptide-kn-17-loaded-supramolecular-hydrogel-induces-the-regeneration-of-the-pulp-dentin-complex
#35
JOURNAL ARTICLE
Borui Zhao, Qian Zhang, Houzhi Yang, Shuipeng Yu, Rui Fu, Shurui Shi, Yuanyuan Wang, Wei Zhou, Yange Cui, Qingxiang Guo, Xi Zhang
Regenerating the pulp-dentin complex remains a decisive factor during apexification for immature permanent teeth. Peptide KN-17, which was modified based on the structure of cecropin B, could effectively interfere with bacterial growth and induce the migration of human bone marrow stromal cells (hBMSCs). This study aimed to investigate the effect of KN-17 on the tissue regeneration. To our surprise, KN-17 can significantly stimulate angiogenesis in vitro and in vivo, which may provide a guarantee for apical closure...
March 6, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38443654/osteoblastic-differentiation-and-changes-in-the-redox-state-in-pulp-stem-cells-by-laser-treatment
#36
JOURNAL ARTICLE
Lina M Escobar, Marggie Grajales, Zita Bendahan, Sully Jaimes, Paula Baldión
The aim of this study was to determine the effect of low-level laser therapy (LLLT) on cell proliferation, mitochondrial membrane potential changes (∆Ψm), reactive oxygen species (ROS), and osteoblast differentiation of human dental pulp stem cells (hDPSCs). These cells were irradiated with 660- and 940-nm lasers for 5 s, 50 s, and 180 s. Cell proliferation was assessed using the resazurin assay, cell differentiation by RUNX2 and BMP2 expression, and the presence of calcification nodules using alizarin-red S staining...
March 6, 2024: Lasers in Medical Science
https://read.qxmd.com/read/38443392/lin28-affects-the-proliferation-and-osteogenic-differentiation-of-human-dental-pulp-stem-cells-by-directly-inhibiting-let-7b-maturation
#37
JOURNAL ARTICLE
Liu Yan, Jing Sun, Yushan Wang, Xinxin Liu, Jiayi Hu, Mengxin Sun, Xi Suo, Rongquan Duan, Changyong Yuan
OBJECTIVE: Activation of Lin28 gene under certain conditions promotes tissue damage repair. However, it remains unknown whether conditional expression of Lin28 facilitates the recovery of damaged pulp tissue. In the study, we focus on exploring the effects and possible regulatory mechanisms of Lin28 on the proliferation and differentiation of human dental pulp stem cells (hDPSCs). MATERIALS AND METHODS: We adopted techniques such as the ethynyl-2'-deoxyuridine (EdU) incorporation assay, RNA-protein immunoprecipitation (RIP) analysis, and luciferase assays to study the regulation of hDPSCs by Lin28...
March 5, 2024: BDJ Open
https://read.qxmd.com/read/38441304/mechanism-underlying-the-anti-diabetic-potential-of-bee-venom-as-compared-to-bone-marrow-mesenchymal-stem-cells-in-the-diabetic-rat-tongue
#38
JOURNAL ARTICLE
Israa Ahmed Radwan, Dina Rady, Mohamed Ramadan, Sara El Moshy
BACKGROUND: Diabetes mellitus (DM) is a critical chronic metabolic disease. Several treatment modalities are currently under investigation. Both bee venom (BV) and bone marrow mesenchymal stem cells (BMSCs) can possibly offer an approach for treating type I diabetes. OBJECTIVES: The aim of the present study was to investigate the mechanism underlying the anti-diabetic effect of BV as compared to BMSCs on the tongue mucosa of diabetic rats. MATERIAL AND METHODS: A total of 52 male albino rats were used in the current study...
2024: Dental and Medical Problems
https://read.qxmd.com/read/38435089/periostin-is-a-candidate-regulator-of-the-host-microenvironment-in-regeneration-of-pulp-and-dentin-complex-and-periodontal-ligament-in-transplantation-with-stem-cell-conditioned-medium
#39
JOURNAL ARTICLE
Shintarou Sakatoku, Yuki Hayashi, Taku Futenma, Yoshihiko Sugita, Ryo Ishizaka, Hiroyuki Nawa, Koichiro Iohara
PURPOSE: The microenvironment is required for tissues to maintain their properties in vivo . This microenvironment encompasses the types and three-dimensional arrangement of cells forming the tissues, and their interactions with neighboring cells and extracellular matrices, as represented by the stem cell niche. Tissue regeneration depends not on the original tissue source of the transplanted cells, but on the microenvironment in which they are transplanted. We have previously reported pulp regeneration in a heterotopic root graft model by transplantation of conditioned medium alone, which suggests that host-derived cells expressing receptors for migration factors in conditioned medium migrate into the root canal and cause pulp regeneration...
2024: Stem Cells International
https://read.qxmd.com/read/38432951/bioactivity-of-human-dental-pulp-derived-stem-cells-with-boron-controlled-s-prg-filler-eluate-by-anion-exchange
#40
JOURNAL ARTICLE
Yusuke Tatsumi, Harumi Kawaki, Kohei Shintani, Kyohei Ueno, Masato Hotta, Nobuo Kondoh, Michael F Burrow, Toru Nikaido
Surface pre-reacted glass-ionomer (S-PRG) filler is a bioactive glass filler capable of releasing various ions. A culture medium to which was added an S-PRG filler eluate rich in boron was reported to enhance alkaline phosphatase (ALP) activity in human dental pulp-derived stem cells (hDPSC). To clarify the role of boron eluted from S-PRG fillers, the modified S-PRG filler eluate with different boron concentrations was prepared by using an anion exchange material. Therefore, elemental mapping analysis of anion exchange material, adsorption ratio, hDPSCs proliferation and ALP activity were evaluated...
March 1, 2024: Dental Materials Journal
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