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https://www.readbyqxmd.com/read/29458214/effect-of-tetrahedral-dna-nanostructures-on-proliferation-and-osteo-odontogenic-differentiation-of-dental-pulp-stem-cells-via-activation-of-the-notch-signaling-pathway
#1
Mi Zhou, Nan-Xin Liu, Si-Rong Shi, Yong Li, Qi Zhang, Quan-Quan Ma, Tao-Ran Tian, Wen-Juan Ma, Xiao-Xiao Cai, Yun-Feng Lin
Dental pulp stem cells (DPSCs) derived from the human dental pulp tissue have multiple differentiation capabilities, such as osteo/odontogenic differentiation. Therefore, DPSCs are deemed as ideal stem cell sources for tissue regeneration. As new nanomaterials based on DNA, tetrahedral DNA nanostructures (TDNs) have tremendous potential for biomedical applications. Here, the authors aimed to explore the part played by TDNs in proliferation and osteo/odontogenic differentiation of DPSCs, and attempted to investigate if these cellular responses could be driven by activating the canonical Notch signaling pathway...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29453987/the-role-of-foxq1-in-proliferation-of-human-dental-pulp-stem-cell
#2
Shaoqin Tu, Junming Zheng, Xin Gao, Chenyu Guan, Bin Cai, Lusai Xiang
This study aimed to investigate the role for Foxq1 in proliferation activity regulation of dental pulp stem cells (DPSCs). Proliferation of DPSC was induced by calcium hydroxide, then expression alteration of Foxq1 was evaluated. Lentivirus was employed to manipulate Foxq1 level in DPSC, and proliferation activities were evaluated. To look into mechanism regulating Foxq1 level after calcium hydroxide stimulation, expressions of various microRNAs were evaluated, then bioinformatics study and dual-luciferase study were carried out to confirm targeting relationship between microRNA and Foxq1...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29452287/dental-pulp-stem-cell-derived-chondrogenic-cells-demonstrate-differential-cell-motility-in-type-i-and-type-ii-collagen-hydrogels
#3
Li Yao, Nikol Flynn
BACKGROUND CONTEXT: Advances in the development of biomaterials and stem cell therapy provide a promising approach to regenerating degenerated discs. The normal nucleus pulposus (NP) cells exhibit the similar phenotype as chondrocytes. Because dental pulp stem cells (DPSCs) can be differentiated into chondrogenic cells, the DPSCs and DPSCs-derived chondrogenic cells encapsulated in type I and type II collagen hydrogels can potentially be transplanted into degenerated nucleus pulposus (NP) to repair damaged tissue...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29451421/bionanocomposite-scaffolds-based-on-chitosan-gelatin-and-nanodimensional-bioactive-glass-particles-in-vitro-properties-and-in-vivo-bone-regeneration
#4
Cristian Covarrubias, Monserrat Cádiz, Miguel Maureira, Isabel Celhay, Felipe Cuadra, Alfredo von Marttens
Bone repair bionanocomposite scaffolds were produced by incorporating dense bioactive glass nanoparticles or mesoporous bioactive glass nanospheres into a chitosan-gelatin polymer blend. The in vitro bioactivity of the scaffolds was assessed in simulated body fluid, and cell viability and osteogenic differentiation assays were performed with dental pulp stem cells. Bone regeneration properties of the scaffold materials were in vivo assessed by using a critical-sized femoral defect model in rat. The scaffold nanocomposites showed excellent cytocompatibility and ability to accelerate the crystallization of bone-like apatite in vitro...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29450735/n-acetyl-l-cysteine-protects-dental-tissue-stem-cells-against-oxidative-stress-in-vitro
#5
Jasmina Martacic, Milica Kovacevic Filipovic, Suncica Borozan, Zorica Cvetkovic, Tamara Popovic, Aleksandra Arsic, Marija Takic, Vesna Vucic, Maria Glibetic
OBJECTIVES: The aim of our study was to investigate whether N-acetyl-L-cysteine (NAC) could protect stem cells from exfoliated deciduous teeth (SHED) against oxidative damage, during in vitro cultivation, to preserve regenerative potential of these cells. Accordingly, we examined the potential of cell culture supplementation with NAC in prevention of lipid peroxidation, unfavorable changes of total lipids fatty acid composition, and the effects on the activity of antioxidant enzymes. MATERIAL AND METHODS: We analyzed the extent of oxidative damage in SHED after 48 h treatment with different NAC concentrations...
February 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29449086/progress-in-the-use-of-dental-pulp-stem-cells-in-regenerative-medicine
#6
REVIEW
Eduardo Anitua, María Troya, Mar Zalduendo
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. Their high plasticity and multipotential capacity to differentiate into a large array of tissues can be explained by its neural crest origin, which supports applications beyond the scope of oral tissues...
February 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29442525/comparative-analysis-of-mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-dental-pulp-as-sources-of-cell-therapy-for-zone-of-stasis-burns
#7
Ozan Luay Abbas, Orhan Özatik, Zeynep Burçin Gönen, Serdal Öğüt, Fikriye Yasemin Özatik, Hasan Salkın, Ahmet Musmul
INTRODUCTION: The implantation of mesenchymal stem cells (MSCs) has been shown to exert benefits for the survival of the zone-of-stasis. However, the clinical experience indicates the importance of selecting the right source and type of stem cells. Therefore, we planned the current study to perform a quantitative comparison of MSCs isolated from three different sources to provide information useful in selection of the optimal source and to see whether critical mechanisms are conserved between different populations...
February 14, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29442285/diverse-effect-of-bmp-2-homodimer-on-mesenchymal-progenitors-of-different-origin
#8
Edit Hrubi, László Imre, Agnieszka Robaszkiewicz, László Virág, Farkas Kerényi, Krisztina Nagy, Gábor Varga, Attila Jenei, Csaba Hegedüs
Bone morphogenetic protein-2 (BMP-2), is a potential factor to enhance osseointegration of dental implants. However, the appropriate cellular system to investigate the osteogenic effect of BMP-2 in vitro in a standardized manner still needs to be defined. The aim of this study was to examine the effect of BMP-2 on the cell proliferation and osteogenic differentiation of human osteogenic progenitors of various origins: dental pulp stem cells (DPSC), human osteosarcoma cell line (Saos-2) and human embryonic palatal mesenchymal cell line (HEPM)...
February 13, 2018: Human Cell
https://www.readbyqxmd.com/read/29442020/tnf-%C3%AE-was-involved-in-calcium-hydroxide-promoted-osteogenic-differentiation-of-human-dpscs-through-nf-%C3%AE%C2%BAb-p38mapk-wnt-pathway
#9
Y M Cui, X H Han, Y Y Lin, W W Lv, Y L Wang
It has been reported that calcium hydroxide can induce proliferation, migration, and mineralization in dental pulp stem cells (DPSCs), but the underlying molecular mechanisms are still unclear. In this study, we sought to explore the role of calcium hydroxide in the cell proliferation and directional differentiation of DPSCs and to study the regulatory effect of NF-κB, p38MAPK, and Wnt signaling on differentiation of DPSCs. CCK8 cell assay, Wound Healing Assay, and Alkaline Phosphatase Staining Assay were respectively used to determine the proliferation rate, migration and ALP expression of DPSCs...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29435765/inflammation-mesenchymal-stem-cells-and-bone-regeneration
#10
REVIEW
Hongrui Liu, Dongfang Li, Yi Zhang, Minqi Li
Achieving satisfactory reconstruction of bone remains an important goal in orthopedic and dental conditions such as bone trauma, osteoporosis, arthritis, osteonecrosis, and periodontitis. Appropriate temporal and spatial differentiation of mesenchymal stem cells (MSCs) is essential for postnatal bone regeneration. Additionally, an acute inflammatory response is crucial at the onset of bone repair, while an adaptive immune response has important implications during late bone remodeling. Various reports have indicated bidirectional interactions between MSCs and inflammatory cells or molecules...
February 12, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29434225/mechanical-stretch-induced-osteogenic-differentiation-of-human-jaw-bone-marrow-mesenchymal-stem-cells-hjbmmscs-via-inhibition-of-the-nf-%C3%AE%C2%BAb-pathway
#11
Xiaoyan Chen, Yuan Liu, Wanghui Ding, Jiejun Shi, Shenglai Li, Yali Liu, Mengjie Wu, Huiming Wang
Severe malocclusion can contribute to several serious dental and physical conditions, such as digestive difficulties, periodontal disease, and severe tooth decay. Orthodontic treatment is mainly used to treat malocclusion. Forces in orthodontic tooth results in bone resorption on the pressure side and bone deposition on the tension side. Osteoblasts have been considered as the key component in bone regeneration on the tension side. However, the underlying mechanisms remain unclear. In this study, we focus on how mechanical stretch regulates the osteogenesis during orthodontic treatment...
February 12, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29429515/mice-dental-pulp-and-periodontal-ligament-endothelial-cells-exhibit-different-proangiogenic-properties
#12
Mohammad Ali Saghiri, Armen Asatourian, Christine M Sorenson, Nader Sheibani
Dental pulp is a highly vascularized tissue with a high regenerative capacity. This is attributed to its unique blood supply and the presence of progenitor or postnatal dental pulp stem cells. Here we aimed to isolate and compare the angiogenic properties of endothelial cells (EC) prepared from mouse dental pulp and periodontal ligament (PDL). EC were isolated from 4-week-old wild type immorto mice. Mice were sacrificed and after mandible isolation, the molar and incisor teeth and the PDL from molar teeth were dissected...
February 2018: Tissue & Cell
https://www.readbyqxmd.com/read/29426646/effect-of-3-bioceramic-materials-on-stem-cells-of-the-apical-papilla-proliferation-and-differentiation-using-a-dentin-disk-model
#13
Amber A Miller, Koyo Takimoto, James Wealleans, Anibal Diogenes
INTRODUCTION: There is a complex interaction between biomaterials placed as a coronal barrier with stem cells and dentin in regenerative procedures. In this study, the effect of Biodentine (BD; Septodont, Saint-Maurdes-Fossés, France), Endosequence BC Root Repair Material-Putty (ES; Brasseler, Savannah, GA), Endosequence BC Root Repair Material-Putty Fast set (ES-fast, Brasseler), and ProRoot (Dentsply Tulsa Dental Specialties, Johnson City, TN) mineral trioxide aggregate (MTA) on the viability and differentiation of stem cells of the apical papilla (SCAP) was evaluated using an ex vivo dentin disk model...
February 6, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29423132/significant-transcriptional-changes-in-15q-duplication-but-not-angelman-syndrome-deletion-stem-cell-derived-neurons
#14
Nora Urraca, Kevin Hope, A Kaitlyn Victor, T Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges, Lawrence T Reiter
Background: The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level. Method: Here, we use dental pulp stem cells (DPSC) from AS deletion, 15q Duplication, and neurotypical control subjects for whole transcriptome analysis. We identified 20 genes unique to AS neurons, 120 genes unique to 15q duplication, and 3 shared transcripts that were differentially expressed in DPSC neurons vs controls...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29417177/stem-cells-from-human-apical-papilla-decrease-neuro-inflammation-and-stimulate-oligodendrocyte-progenitor-differentiation-via-activin-a-secretion
#15
Pauline De Berdt, Pauline Bottemanne, John Bianco, Mireille Alhouayek, Anibal Diogenes, Amy Llyod, Jose Gerardo-Nava, Gary A Brook, Véronique Miron, Giulio G Muccioli, Anne des Rieux
Secondary damage following spinal cord injury leads to non-reversible lesions and hampering of the reparative process. The local production of pro-inflammatory cytokines such as TNF-α can exacerbate these events. Oligodendrocyte death also occurs, followed by progressive demyelination leading to significant tissue degeneration. Dental stem cells from human apical papilla (SCAP) can be easily obtained at the removal of an adult immature tooth. This offers a minimally invasive approach to re-use this tissue as a source of stem cells, as compared to biopsying neural tissue from a patient with a spinal cord injury...
February 7, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29415969/osteoblastic-differentiating-potential-of-dental-pulp-stem-cells-in-vitro-cultured-on-a-chemically-modified-microrough-titanium-surface
#16
Marianna De Colli, Milena Radunovic, Vincenzo L Zizzari, Viviana di Giacomo, Chiara Di Nisio, Adriano Piattelli, José L Calvo Guirado, Barbara Zavan, Amelia Cataldi, Susi Zara
Titanium surface modification is critical for dental implant success. Our aim was to determine surfaces influence on dental pulp stem cells (DPSCs) viability and differentiation. Implants were divided into sandblasted/acid-etched (control) and sandblasted/acid-etched coated with calcium and magnesium ions (CaMg), supplied as composite, (test). Proliferation was evaluated by MTT, differentiation checking osteoblastic gene expression, PGE2 secretion and matrix formation, inflammation by Interleukin 6 (IL-6) detection...
February 8, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29412734/chemically-defined-conditions-mediate-an-efficient-induction-of-mesodermal-lineage-from-human-umbilical-cord-and-bone-marrow-mesenchymal-stem-cells-and-dental-pulp-pluripotent-like-stem-cells
#17
Ashraf Al Madhoun, Sarah Alkandari, Hamad Ali, Neus Carrio, Maher Atari, Milad S Bitar, Fahd Al-Mulla
The human umbilical cord Wharton's Jelly- and the bone marrow- mesenchymal stem cells (WJ-MSCs and BM-MSCs, respectively) and the newly identified dental pulp pluripotent-like stem cells (DPPSCs) are new sources for stem cells with prospective use in cell regeneration and therapy. These cells are self-renewable, can be differentiated into several lineages, and can potentiate the immune responses. We hypothesized that three-dimensional (3D) culture conditions and directed differentiation using specific signaling regulators will enhance an efficient generation of mesoderm (MD) lineage independent from the origin or source of the stem cells...
February 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29412365/effects-of-mineral-trioxide-aggregate-biodentinetm-and-calcium-hydroxide-on-viability-proliferation-migration-and-differentiation-of-stem-cells-from-human-exfoliated-deciduous-teeth
#18
Leandro Borges Araújo, Leopoldo Cosme-Silva, Ana Paula Fernandes, Thais Marchini de Oliveira, Bruno das Neves Cavalcanti, João Eduardo Gomes Filho, Vivien Thiemy Sakai
The aim of the study was to evaluate the effects of the capping materials mineral trioxide aggregate (MTA), calcium hydroxide (CH) and BiodentineTM (BD) on stem cells from human exfoliated deciduous teeth (SHED) in vitro. SHED were cultured for 1 - 7 days in medium conditioned by incubation with MTA, BD or CH (1 mg/mL), and tested for viability (MTT assay) and proliferation (SRB assay). Also, the migration of serum-starved SHED towards conditioned media was assayed in companion plates, with 8 μm-pore-sized membranes, for 24 h...
February 1, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29407749/differentiation-of-stem-cells-from-human-deciduous-and-permanent-teeth-into-spiral-ganglion-neuron-like-cells
#19
Thanasup Gonmanee, Charoensri Thonabulsombat, Kutkao Vongsavan, Hathaitip Sritanaudomchai
OBJECTIVE: Stem cells from pulp tissue are a promising cell-based therapy for neurodegenerative patients based on their origin in the neural crest. The aim of this study was to differentiate and evaluate the ability of human dental pulp stem cells from permanent teeth (DPSC) and stem cells from human exfoliated deciduous teeth (SHED) to differentiate into spiral ganglion neurons. DESIGN: After isolation and characterization of mesenchymal stem cell properties, DPSC and SHED were treated with the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and glial cell-derived neurotrophic factor (GDNF)...
February 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29407636/comparative-proteomic-profiling-of-human-dental-pulp-stem-cells-and-periodontal-ligament-stem-cells-under-in-vitro-osteogenic-induction
#20
He Wang, Dandan Ma, Xiaoyi Zhang, Shuaimei Xu, Tingting Ning, Buling Wu
OBJECTIVE: This study aimed to compare the proteomic profiling of human dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) under in vitro osteogenic induction, which imitates the microenvironment during osteo-/odontogenesis of DPSCs and PDLSCs. DESIGN: The proteomic profiles of osteoinduced DPSCs and PDLSCs from a single donor were compared using the isobaric tag for relative and absolute quantitation (iTRAQ) technique and subsequent bioinformatics analysis...
February 3, 2018: Archives of Oral Biology
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