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Calcium Neuroimaging

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https://www.readbyqxmd.com/read/27764521/fahr-s-syndrome-and-clinical-correlation-a-case-series-and-literature-review
#1
M Pistacchi, M Gioulis, F Sanson, S M Marsala
INTRODUCTION: Fahr's disease is characterized by bilateral calcium deposition within the basal ganglia, cerebellar dentate nucleus and subcortical brain white matter. The main clinical manifestations are rigid or hyperkinetic syndrome, mood disorders and cognitive impairment. The correlation between neurological impairment and symmetrical basal ganglia calcification is not so frequent. Aim of the study was to report the results of neurological assessment of three sporadic cases of Fahr's disease highlighting a correlation between the clinical syndrome and neuroimaging...
2016: Folia Neuropathologica
https://www.readbyqxmd.com/read/27721780/the-need-for-a-rational-approach-to-vasoconstrictive-syndromes-transcranial-doppler-and-calcium-channel-blockade-in-reversible-cerebral-vasoconstriction-syndrome
#2
Elisabeth B Marsh, Wendy C Ziai, Rafael H Llinas
INTRODUCTION: Reversible cerebral vasoconstriction syndrome (RCVS) typically affects young patients and left untreated can result in hemorrhage or ischemic stroke. Though the disorder has been well characterized in the literature, the most appropriate way to diagnose, treat, and evaluate therapeutic response remains unclear. In previous studies, transcranial Doppler ultrasound (TCD) has shown elevated velocities indicative of vasospasm. This imaging modality is noninvasive and inexpensive; an attractive option for diagnosis and therapeutic monitoring if it is sensitive enough to detect changes in the acute setting given that RCVS often affects the distal vessels early in the course of disease...
May 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27597561/teaching-video-neuroimages-p-q-type-voltage-gated-calcium-channel-associated-paraneoplastic-elliptical-nystagmus
#3
Eva A Mistry, Andrew G Lee, Eugene C Lai
No abstract text is available yet for this article.
September 6, 2016: Neurology
https://www.readbyqxmd.com/read/27477722/nano-theranostics-and-nitroxyl-radical-labeled-antitumor-agents-for-magnetic-resonance-imaging
#4
Ichio Aoki
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDS) is opening new pathways to understanding pathophysiology using magnetic resonance imaging (MRI). Nitroxyl radical compounds are promising functional contrast agents for redox evaluation. We have developed a novel nitroxyl radical theranostic compound for noninvasive real-time imaging of blood-brain barrier-permeable antitumor drugs. Divalent manganese ions (Mn(2+)) can also be used as an intracellular functional MRI contrast agent...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27468266/older-age-results-in-differential-gene-expression-after-mild-traumatic-brain-injury-and-is-linked-to-imaging-differences-at-acute-follow-up
#5
Young-Eun Cho, Lawrence L Latour, Hyungsuk Kim, L Christine Turtzo, Anlys Olivera, Whitney S Livingston, Dan Wang, Christiana Martin, Chen Lai, Ann Cashion, Jessica Gill
Older age consistently relates to a lesser ability to fully recover from a traumatic brain injury (TBI); however, there is limited data to explicate the nature of age-related risks. This study was undertaken to determine the relationship of age on gene-activity following a TBI, and how this biomarker relates to changes in neuroimaging findings. A young group (between the ages of 19 and 35 years), and an old group (between the ages of 60 and 89 years) were compared on global gene-activity within 48 h following a TBI, and then at follow-up within 1-week...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27076413/molecular-fmri
#6
REVIEW
Benjamin B Bartelle, Ali Barandov, Alan Jasanoff
UNLABELLED: Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Here we discuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling...
April 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26807800/reversible-cerebral-vasoconstriction-syndrome-presenting-with-visual-field-defects
#7
Meisha L Raven, Alexander L Ringeisen, Angela R McAllister, Daniel W Knoch
A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clinical course and neuroimaging findings were consistent with reversible cerebral vasoconstriction syndrome...
June 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26791806/nonlinear-association-criterion-nonlinear-granger-causality-and-related-issues-with-applications-to-neuroimage-studies
#8
Chenyang Tao, Jianfeng Feng
BACKGROUND: Quantifying associations in neuroscience (and many other scientific disciplines) is often challenged by high-dimensionality, nonlinearity and noisy observations. Many classic methods have either poor power or poor scalability on data sets of the same or different scales such as genetical, physiological and image data. NEW METHOD: Based on the framework of reproducing kernel Hilbert spaces we proposed a new nonlinear association criteria (NAC) with an efficient numerical algorithm and p-value approximation scheme...
March 15, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/26691497/a-44-year-old-man-with-eye-kidney-and-brain-dysfunction
#9
Ivana Vodopivec, Derek H Oakley, Cory A Perugino, Nagagopal Venna, E Tessa Hedley-Whyte, John H Stone
Retinal vasculopathy with cerebral leukodystrophy (RVCL) is a rare, autosomal dominant condition caused by mutations of TREX1 (3-prime repair exonuclease-1). The phenotypic expressions range from isolated retinal involvement to varying degrees of retinopathy, cerebral infarction with calcium depositions, nephropathy, and hepatopathy. We report a case of RVCL caused by a novel TREX1 mutation. This patient's multisystem presentation, retinal involvement interpreted as "retinal vasculitis," and improvement of neuroimaging abnormalities with dexamethasone led to the accepted diagnosis of a rheumatologic disorder resembling Behçet disease...
April 2016: Annals of Neurology
https://www.readbyqxmd.com/read/26358822/calcium-neuroimaging-in-behaving-zebrafish-larvae-using-a-turn-key-light-field-camera
#10
Carlos Cruz Perez, Antonella Lauri, Panagiotis Symvoulidis, Michele Cappetta, Arne Erdmann, Gil Gregor Westmeyer
Reconstructing a three-dimensional scene from multiple simultaneously acquired perspectives (the light field) is an elegant scanless imaging concept that can exceed the temporal resolution of currently available scanning-based imaging methods for capturing fast cellular processes. We tested the performance of commercially available light field cameras on a fluorescent microscopy setup for monitoring calcium activity in the brain of awake and behaving reporter zebrafish larvae. The plenoptic imaging system could volumetrically resolve diverse neuronal response profiles throughout the zebrafish brain upon stimulation with an aversive odorant...
September 2015: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/26342528/profiling-neuronal-ion-channelopathies-with-non-invasive-brain-imaging-and-dynamic-causal-models-case-studies-of-single-gene-mutations
#11
Jessica R Gilbert, Mkael Symmonds, Michael G Hanna, Raymond J Dolan, Karl J Friston, Rosalyn J Moran
Clinical assessments of brain function rely upon visual inspection of electroencephalographic waveform abnormalities in tandem with functional magnetic resonance imaging. However, no current technology proffers in vivo assessments of activity at synapses, receptors and ion-channels, the basis of neuronal communication. Using dynamic causal modeling we compared electrophysiological responses from two patients with distinct monogenic ion channelopathies and a large cohort of healthy controls to demonstrate the feasibility of assaying synaptic-level channel communication non-invasively...
January 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26310517/cerebrovascular-correlates-of-vitamin-d-deficiency-in-older-adults-living-near-the-equator-results-from-the-atahualpa-project
#12
Oscar H Del Brutto, Robertino M Mera, Jorge Macias, Gabriela Morales, Mauricio Zambrano
All studies attempting to find an association between vitamin D deficiency and cerebrovascular diseases have been conducted at latitudes far away from the Equator, where living conditions, cardiovascular risk factors, and sunshine exposure are different from tropical regions. We aimed to assess cerebrovascular correlates of vitamin D deficiency in community-dwelling older adults living in Atahualpa, a village located in rural coastal Ecuador. Out of 267 individuals enrolled in the neuroimaging substudy of the Atahualpa Project, 220 (82%) signed the informed consent...
December 2015: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26135580/saccadic-palsy-following-cardiac-surgery-possible-role-of-perineuronal-nets
#13
Scott D Z Eggers, Anja K E Horn, Sigrun Roeber, Wolfgang Härtig, Govind Nair, Daniel S Reich, R John Leigh
OBJECTIVE: Perineuronal nets (PN) form a specialized extracellular matrix around certain highly active neurons within the central nervous system and may help to stabilize synaptic contacts, promote local ion homeostasis, or play a protective role. Within the ocular motor system, excitatory burst neurons and omnipause neurons are highly active cells that generate rapid eye movements - saccades; both groups of neurons contain the calcium-binding protein parvalbumin and are ensheathed by PN...
2015: PloS One
https://www.readbyqxmd.com/read/26098958/patterns-of-spontaneous-local-network-activity-in-developing-cerebral-cortex-relationship-to-adult-cognitive-function
#14
Alejandro Peinado, Charles K Abrams
Detecting neurodevelopμental disorders of cognition at the earliest possible stages could assist in understanding them mechanistically and ultimately in treating them. Finding early physiological predictors that could be visualized with functional neuroimaging would represent an important advance in this regard. We hypothesized that one potential source of physiological predictors is the spontaneous local network activity prominent during specific periods in development. To test this we used calcium imaging in brain slices and analyzed variations in the frequency and intensity of this early activity in one area, the entorhinal cortex (EC), in order to correlate early activity with level of cognitive function later in life...
2015: PloS One
https://www.readbyqxmd.com/read/26016546/practical-radiosynthesis-and-preclinical-neuroimaging-of-11c-isradipine-a-calcium-channel-antagonist
#15
Benjamin H Rotstein, Steven H Liang, Vasily V Belov, Eli Livni, Dylan B Levine, Ali A Bonab, Mikhail I Papisov, Roy H Perlis, Neil Vasdev
In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. Desmethyl isradipine (4-(benzo[c][1,2,5]oxadiazol-4-yl)-5-(isopropoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine -3-carboxylic acid) was reacted with [11C]CH3I in the presence of tetrabutylammonium hydroxide in DMF in an HPLC injector loop to produce the radiotracer in a good yield (6 ± 3% uncorrected radiochemical yield) and high specific activity (143 ± 90 GBq·µmol-1 at end-of-synthesis)...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/25976633/cacna1c-rs1006737-genotype-and-bipolar-disorder-focus-on-intermediate-phenotypes-and-cardiovascular-comorbidity
#16
REVIEW
Xiao Ou, David E Crane, Bradley J MacIntosh, L Trevor Young, Paul Arnold, Stephanie Ameis, Benjamin I Goldstein
Recently, multiple genome-wide association studies have identified a genetic polymorphism (CACNA1C rs1006737) that appears to confer susceptibility for BD. This article aims to summarize the existing literature regarding the impact of rs1006737 on functional and structural neuroimaging intermediate phenotypes. Twenty eight articles, representing 2486 healthy participants, 369 patients with BD and 104 healthy first-degree relatives of patients with BD, are incorporated. Multiple studies have demonstrated structural differences, functional differences associated with emotion-related and frontal-executive tasks, and/or differences in behavioral task performance in risk allele carriers (AA or AG)...
August 2015: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/25836837/in-vivo-neuroimaging-through-the-highly-scattering-tissue-via-iterative-multi-photon-adaptive-compensation-technique
#17
Lingjie Kong, Meng Cui
For in vivo deep tissue imaging, high order wavefront measurement and correction is needed for handling the severe wavefront distortion. Towards such a goal, we have developed the iterative multi-photon adaptive compensation technique (IMPACT). In this work, we explore using IMPACT to perform calcium imaging of neocortex through the intact skull of adult mice, and to image through the highly scattering white matter on the hippocampus surface.
March 9, 2015: Optics Express
https://www.readbyqxmd.com/read/25634049/-cognitive-function-and-calcium-molecular-neuroimaging-and-calcium
#18
REVIEW
Makoto Higuchi
Neurodegenerative dementias exemplified by Alzheimer's disease are neuropathologically characterized by deposition of protein aggregates such as amyloid β peptide (Aβ), tau protein. Aβ is known to act as a scaffold to promote clustering of metabotropic glutamate receptor type 5 (mGluR5) at the synaptic compartment, and tau is also supposed to mediate phosphorylation of N-methyl-D-aspartate (NMDA) receptor at the excitatory postsynapse. These pathologic changes reinforce coupling of mGluR5 and NMDA receptor, and induce influx of calcium into dendritic spines...
February 2015: Clinical Calcium
https://www.readbyqxmd.com/read/25614220/vitamin-d-related-changes-in-intracranial-volume-in-older-adults-a-quantitative-neuroimaging-study
#19
Cedric Annweiler, Robert Bartha, Sandy Goncalves, Spyridon N Karras, Pascal Millet, Francois Féron, Olivier Beauchet
OBJECTIVES: Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlation between 25OHD concentration and intracranial volume also occurred in older adults. STUDY DESIGN: Cross-sectional study. MAIN OUTCOME MEASURES: One hundred and ten Caucasian older community-dwellers (mean, 71...
March 2015: Maturitas
https://www.readbyqxmd.com/read/25388414/increased-risk-for-intracranial-arterial-stenosis-in-subjects-with-coronary-artery-calcification
#20
Hyung-Geun Oh, Pil-Wook Chung, Eun-Jung Rhee
BACKGROUND AND PURPOSE: Intracranial arterial stenosis (ICAS) is considered an important cause of stroke in Asians. Coronary artery calcification (CAC) is a surrogate marker for subclinical atherosclerosis. We aimed to analyze the association of ICAS assessed by transcranial Doppler ultrasonography and CAC in middle-aged Korean population. METHODS: This study included 10 550 participants (81.3% men, mean age 43 years) from a health screening program, in whom transcranial Doppler ultrasonography was used to detect >50% intracranial stenosis based on criteria modified from the stroke outcomes and neuroimaging of intracranial atherosclerosis trial...
January 2015: Stroke; a Journal of Cerebral Circulation
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