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https://www.readbyqxmd.com/read/29141338/-spatial-and-temporal-clustering-characteristics-of-typhoid-and-paratyphoid-fever-and-its-change-pattern-in-3-provinces-in-southwestern-china-2001-2012
#1
L X Wang, B Yang, M Y Yan, Y Q Tang, Z C Liu, R Q Wang, S Li, L Ma, B Kan
Objective: To analyze the spatial and temporal clustering characteristics of typhoid and paratyphoid fever and its change pattern in Yunnan, Guizhou and Guangxi provinces in southwestern China in recent years. Methods: The incidence data of typhoid and paratyphoid fever cases at county level in 3 provinces during 2001-2012 were collected from China Information System for Diseases Control and Prevention and analyzed by the methods of descriptive epidemiology and geographic informatics. And the map showing the spatial and temporal clustering characters of typhoid and paratyphoid fever cases in three provinces was drawn...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141334/-human-exposure-to-live-poultry-among-residents-during-the-second-wave-of-avian-influenza-a-h7n9-epidemic-in-beijing-2013-2014
#2
S S Wu, P Yang, Q Y Wang, H Y Zhang, Y H Chu, H J Li, W Y Hua, Y Q Tang, C Li
Objective: To investigate human exposure to live poultry (poultry feeding and purchasing) in the residents in Beijing and related factors during the second wave of avian influenza A(H7N9) epidemic during 2013-2014, and provide scientific evidence for avian influenza prevention and control. Methods: A total of 7 366 adults aged ≥18 years were selected through multi-stage stratified sampling in Beijing for a questionnaire survey. Logistic regression model was used to analyze the influence factors of human exposure to live poultry...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141248/association-of-functional-genetic-variants-of-hotair-with-hepatocellular-carcinoma-hcc-susceptibility-in-a-chinese-population
#3
Hao Li, Xian-Mei Tang, Yangchen Liu, Weizhen Li, Qiaoyun Chen, Yan Pan
BACKGROUND/AIMS: The HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), plays an important role in the pathogenesis and progression of multiple tumors. The aim of the present study was to evaluate whether common single nucleotide polymorphisms (SNPs) in HOTAIR are related to hepatocellular carcinoma (HCC) susceptibility in a Chinese population. METHODS: We genotyped three SNPs of HOTAIR in a hepatocellular carcinoma (HCC) case-control study, including 482 cases and 520 control subjects...
November 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29141205/investigation-of-alimentary-canal-ultrastructure-following-knockdown-of-the-dicer-2-gene-in-planthoppers-reveals-the-potential-pathogenicity-of-southern-rice-black-streaked-dwarf-virus-to-its-insect-vector
#4
Yuyan Liu, Qianzhuo Mao, Hanhong Lan, Haitao Wang, Taiyun Wei, Qian Chen
An increasing number of studies are suggesting that plant viruses, including southern rice black-streaked dwarf virus (SRBSDV), can adversely affect biological characteristics of insect vectors by unknown mechanisms. To study the adverse effect of SRBSDV at cellular level on the insect vector, we promoted viral infection by the disruption of the small interfering RNA (siRNA) pathway. The transmission electron microscopy was utilized to describe the ultrastructural changes that occurred in insects when the core component of the siRNA pathway, Dicer-2, was knocked down...
November 12, 2017: Virus Research
https://www.readbyqxmd.com/read/29141197/medical-abortion-reversal-science-and-politics-meet
#5
Khadijah Z Bhatti, Antoinette T Nguyen, Gretchen S Stuart
Medical abortion is a safe, effective, and acceptable option for patients seeking an early non-surgical abortion. In 2014, medical abortion accounted for nearly one-third (31%) of all abortions performed in the United States. State-level attempts to restrict reproductive and sexual health have recently included bills that require physicians to inform women that a medical abortion is reversible. In this commentary, we will review the history, current evidence-based regimen, and regulation of medical abortion...
November 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29141125/elevated-proinflammatory-markers-in-22q11-2-deletion-syndrome-are-associated-with-psychosis-and-cognitive-deficits
#6
Ehud Mekori-Domachevsky, Michal Taler, Yehuda Shoenfeld, Michael Gurevich, Polina Sonis, Omri Weisman, Abraham Weizman, Doron Gothelf
OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals with 22q11...
November 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29141100/religiosity-and-psychological-resilience-in-patients-with-schizophrenia-and-bipolar-disorder-an-international-cross-sectional-study
#7
Y Mizuno, A Hofer, B Frajo-Apor, F Wartelsteiner, G Kemmler, S Pardeller, T Suzuki, M Mimura, W W Fleischhacker, H Uchida
OBJECTIVE: The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. METHOD: Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of 112 outpatients with paranoid schizophrenia, 120 with bipolar I disorder (DSM-IV), and 137 healthy controls. Religiosity was assessed in terms of attendance and importance of religious/spiritual activities, while resilience was assessed using the 25-item Resilience Scale...
November 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29141075/treatment-for-livedoid-vasculopathy-a-systematic-review
#8
Robert Micieli, Afsaneh Alavi
Importance: Livedoid vasculopathy is a painful, ulcerative condition of the lower extremities for which no established treatment exists. Current treatment paradigms rely on low levels of evidence, primarily case reports and case series. Objective: To systematically review the treatment for livedoid vasculopathy and synthesize the available clinical data. Evidence Review: A systematic review of the literature using Ovid MEDLINE (covering the period January 1, 1946, through June 9, 2017) and Ovid EMBASE (covering January 1, 1947, through June 9, 2017) databases was performed with a broad and inclusive search strategy along with a subsequent search of the references of retrieved articles...
November 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29141018/evaluation-of-the-proliferation-marker-ki-67-in-a-large-prostatectomy-cohort
#9
Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen, Nora Ness, Thea Grindstad, Ingeborg Movik, Tom Dønnem, Roy Bremnes, Lill-Tove Busund
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related outcomes of 535 patients treated with radical prostatectomy. The percentage of tumor epithelial cells expressing Ki-67 was determined by immunohistochemical assay, both digital image analysis and visual scoring by light microscope were used for quantification...
2017: PloS One
https://www.readbyqxmd.com/read/29140976/independent-degradation-in-genes-of-the-plastid-ndh-gene-family-in-species-of-the-orchid-genus-cymbidium-orchidaceae-epidendroideae
#10
Hyoung Tae Kim, Mark W Chase
In this paper, we compare ndh genes in the plastid genome of many Cymbidium species and three closely related taxa in Orchidaceae looking for evidence of ndh gene degradation. Among the 11 ndh genes, there were frequently large deletions in directly repeated or AT-rich regions. Variation in these degraded ndh genes occurs between individual plants, apparently at population levels in these Cymbidium species. It is likely that ndh gene transfers from the plastome to mitochondrial genome (chondriome) occurred independently in Orchidaceae and that ndh genes in the chondriome were also relatively recently transferred between distantly related species in Orchidaceae...
2017: PloS One
https://www.readbyqxmd.com/read/29140972/long-noncoding-rna-profiling-revealed-differentially-expressed-lncrnas-associated-with-disease-activity-in-pbmcs-from-patients-with-rheumatoid-arthritis
#11
Min Yuan, Shujun Wang, Lijie Yu, Bo Qu, Liming Xu, Lining Liu, Huanxia Sun, Chunxian Li, Yanjun Shi, Huaxiang Liu
Long noncoding RNAs (lncRNAs) have recently emerged as important biological regulators, and the aberrant expression of lncRNAs has been reported in numerous diseases. However, the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) in rheumatoid arthritis (RA) has not been well documented. We applied a microarray analysis to profile the lncRNA and mRNA expression in 3 pairs of samples. Each sample was mixed with equivalent PBMCs from 9 female RA patients and 9 corresponding healthy controls, and the data were validated via qPCR using another cohort that comprised 36 RA patients and 24 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/29140961/cervical-foraminal-epidural-blood-patch-for-the-targeted-treatment-of-refractory-cerebrospinal-fluid-leakage-from-a-dural-sleeve
#12
Nuj Tontisirin, Pannawit Benjhawaleemas, Sasikaan Nimmaanrat, Pornchai Sathirapanya, Teeranan Laohawiriyakamol, De Q Tran, Roderick J Finlayson
Epidural blood patches (EBPs) are routinely used to treat symptoms (eg, headaches) associated with spontaneous intracranial hypotension. Although cerebrospinal fluid leakage commonly involves the periforaminal areas of the cervical or thoracic spine, EBPs have been historically performed at the lumbar level. Recent evidence suggests that targeting the causative spinal segment may provide greater clinical benefits. While previous reports have targeted foraminal leaks with segmental thoracic or cervical injections, we present a case report detailing the novel use of a navigable epidural catheter to perform a selective EBP at the C7/T1 foramen...
November 14, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29140957/beneficial-effects-of-angiotensin-1-7-on-cd34-cells-from-heart-failure-patients
#13
Colleen T Cole-Jeffrey, Carl J Pepine, Michael J Katovich, Maria B Grant, Mohan K Raizada, Sugata Hazra
The dysfunctional nature of CD34 cells from heart failure (HF) patients makes them unsuitable for autologous stem cell therapy. In view of evidence that the vasoprotective axis of the renin-angiotensin system (RAS) improves CD34 cell functions, we hypothesized that CD34 cells from HF patients will be dysfunctional and that Angiotensin-(1-7) [Ang-(1-7)] would improve their function. Peripheral blood was collected from NYHA class II-IV HF patients (n=31) and reference subjects (n=16). CD34 cell numbers from HF patients were reduced by 47% (p<0...
November 8, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29140953/contemporary-management-of-rectal-injuries-at-level-i-trauma-centers-the-results-of-an-american-association-for-the-surgery-of-trauma-multi-institutional-study
#14
Carlos V R Brown, Pedro G Teixeira, Elisa Furay, John P Sharpe, Tashinga Musonza, John Holcomb, Eric Bui, Brandon Bruns, H Andrew Hopper, Michael S Truitt, Clay C Burlew, Morgan Schellenberg, Jack Sava, John VanHorn, Brian Eastridge, Alicia M Cross, Richard Vasak, Gary Vercruysse, Eleanor E Curtis, James Haan, Raul Coimbra, Phillip Bohan, Stephen Gale, Peter G Bendix
INTRODUCTION: Rectal injuries have been historically treated with a combination of modalities including direct repair, resection, proximal diversion, presacral drainage, and distal rectal washout. We hypothesized that intraperitoneal rectal injuries may be selectively managed without diversion and the addition of distal rectal washout and pre-sacral drainage in the management of extraperitoneal injuries are not beneficial. METHODS: This is an American Association for the Surgery of Trauma multi-institutional retrospective study from 2004-2015 of all patients who sustained a traumatic rectal injury and were admitted to one of the 22 participating centers...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29140897/psychological-and-psychophysiological-effects-of-recuperative-music-postexercise
#15
Costas I Karageorghis, Andrew C Bruce, Suzanne T Pottratz, Rebecca C Stevens, Marcelo Bigliassi, Mark Hamer
PURPOSE: Few studies have examined the psychological and psychophysiological effects of recuperative music following exhaustive exercise. The main purpose of the present study was to examine the effects of two music conditions compared with a no-music control on psychological and psychophysiological recovery processes post-exercise. METHODS: A randomized, fully counterbalanced, crossover design was used. Core affect, salivary cortisol, heart rate, and blood pressure were measured before exhaustive exercise, immediately after, and in 10-, 20-, and 30-min intervals during passive recovery (21 women and 21 men; 20...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29140881/pdgfb-rearrangements-in-dermatofibrosarcoma-protuberans-of-the-vulva-a-study-of-11-cases-including-myxoid-and-fibrosarcomatous-variants
#16
Khadijeh Jahanseir, Deyin Xing, Patricia T Greipp, William R Sukov, Gary L Keeney, Brooke E Howitt, J Kenneth Schoolmeester
Dermatofibrosarcoma protuberans (DFSP) is a low-grade fibroblastic sarcoma that tends to arise in young to middle age adults and involve the trunk and proximal extremities. Rare examples of vulvar DFSP have been reported, including myxoid, myoid, and fibrosarcomatous variants, but detection of the characteristic t(17;22)(q22;q13) that produces COL1A1-PDGFB gene fusion has not been evaluated in a large series of primary vulvar tumors. The clinical, morphologic, immunohistochemical, and molecular cytogenetic features of 11 cases were examined...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140765/quantitative-weight-of-evidence-assessment-of-higher-tier-studies-on-the-toxicity-and-risks-of-neonicotinoids-in-honeybees-2-imidacloprid
#17
Gladys L Stephenson, Keith R Solomon
A quantitative weight of evidence (QWoE) methodology was used to assess higher-tier studies on the effects of imidacloprid (IMI) on honeybees. Assessment endpoints were population size and viability of commercially managed bees and quantity of hive products. A colony-level no-observed-adverse effect concentration (NOAEC) of 25 µg IMI/kg syrup, equivalent to an oral no-observed-adverse-effect-dose of 7.3 ng/bee/d for all responses, was measured. The overall weight of evidence indicates that there is minimal risk to honeybees from exposure to IMI from its use as a seed treatment...
November 15, 2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29140738/do-outcomes-of-osteochondral-allograft-transplantation-differ-based-on-age-and-sex-a-comparative-matched-group-analysis
#18
Rachel M Frank, Eric J Cotter, Simon Lee, Sarah Poland, Brian J Cole
BACKGROUND: The effect of patient age or sex on outcomes after osteochondral allograft transplantation (OCA) has not been assessed. PURPOSE: To determine clinical outcomes for male and female patients aged ≥40 years undergoing OCA compared with a group of patients aged <40 years. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A review of prospectively collected data of consecutive patients who underwent OCA by a single surgeon with a minimum follow-up of 2 years was conducted...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29140733/proinflammatory-dietary-intake-is-associated-with-increased-risk-of-colorectal-cancer-results-of-a-case-control-study-in-argentina-using-a-multilevel-modeling-approach
#19
Camila Niclis, Sonia A Pou, Nitin Shivappa, James R Hébert, Susan E Steck, María Del Pilar Díaz
Little evidence regarding the inflammatory potential of diet and its effect on colorectal cancer exists in Latin American countries. The aim of the present study was to evaluate the association between the Dietary Inflammatory Index (DII®) and colorectal cancer (CRC) risk in Córdoba, Argentina. A frequency-matched case-control study (N = 446, including 144 (32.3%) CRC cases and 302 (67.7%) controls was conducted in Córdoba (Argentina) from 2008 through 2015. DII® scores were computed based on dietary intake assessed by a validated food frequency questionnaire (FFQ)...
November 15, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29140585/timap-the-versatile-protein-phosphatase-1-regulator-in-endothelial-cells
#20
REVIEW
Anita Boratkó, Csilla Csortos
Transforming growth factor (TGF)-β inhibited membrane associated protein, TIMAP, is the member of the myosin phosphatase targeting protein (MYPT) family of protein phosphatase 1 (PP1) regulatory subunits. The N-terminal part of TIMAP has a typical MYPT family structure with a sequence element called MyPhone (myosin phosphatase N-terminal element), a putative bipartite nuclear localization signal, a PP1 catalytic subunit binding motif, and five ankyrin repeats. The C-terminal half of TIMAP is intrinsically disordered, but ends with a functional CAAX box for lipid modification which allows localization of TIMAP at the plasma membrane...
November 15, 2017: IUBMB Life
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