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https://www.readbyqxmd.com/read/28329479/apremilast-for-treatment-of-recurrent-erythema-multiforme
#1
Tinley Chen, Jacob Levitt, Lauren Geller
Recurrent erythema multiforme with oralinvolvement is therapeutically challenging.Apremilast has been used with success in resolvingthe oral aphthae of Behçet disease, prompting theuse of the drug in patients with oral erosions fromerythema multiforme. Three patients with oralerythema multiforme were given apremilast at dosesof 30-60mg daily. Complete clearance of the lesionswere observed in all three patients, including thoserefractory to other standard therapies. Apremilast maypresent an effective option for recurrent erythemamultiforme for patients who have failed trials antiviraland immunosuppressive therapies...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28326169/circulating-ll37-targets-plasma-extracellular-vesicles-to-immune-cells-and-intensifies-beh%C3%A3-et-s-disease-severity
#2
Tamer Kahraman, Gozde Gucluler, Ismail Simsek, Fuat Cem Yagci, Muzaffer Yildirim, Can Ozen, Ayhan Dinc, Mayda Gursel, Lolai Ikromzoda, Tolga Sutlu, Stephen Gay, Ihsan Gursel
Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) to immune cells, thereby leading to enhanced immune activation aggravating BD pathology. Notably, disease activity was correlated with elevated levels of circulating LL37 and EV plasma concentration...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28321337/salivary-distinctiveness-and-modifications-in-males-with-diabetes-and-beh%C3%A3-et-s-disease
#3
Loai Aljerf, Iyad Alhaffar
Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to Behçet disease (BD) on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca(2+) and Mg(2+)) compared to healthy males and age-matched controls...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28299006/characteristics-of-macular-edema-in-behcet-disease-after-intravitreal-bevacizumab-injection
#4
Fariba Ghassemi, Sohrab Afshari Mirak, Hormoz Chams, Siamak Sabour, Mehdi Nilli Ahmadabadi, Fereidoun Davatchi, Farhad Shahram
PURPOSE: To investigate the effect of intravitreal bevacizumab (IVB) injection on macular edema (ME) secondary to Behcet's disease. METHODS: This prospective case series included 15 patients with bilateral ME due to Behcet's disease. Intravitreal bevacizumab was injected into the more severely involved eye; the contralateral eye was evaluated as the control. Patients were followed up with comprehensive ocular examination, optical coherence tomography, and fluorescein angiography (FA) for a minimum of 6 months by a single ophthalmologist...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28289419/cytokine-signatures-in-mucocutaneous-and-ocular-beh%C3%A3-et-s-disease
#5
Giuseppe Lopalco, Orso Maria Lucherini, Antonio Lopalco, Vincenzo Venerito, Claudia Fabiani, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Luca Cantarini, Florenzo Iannone
Behçet's disease (BD) is a multi-systemic inflammatory disorder consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis; however, many other organs may be affected. Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. On this basis, the primary aim of our study was to compare a core set of pro-inflammatory cytokines between patients with BD and healthy control (HC)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28285799/investigating-the-link-between-ischemic-heart-disease-and-behcet-s-disease-a-cross-sectional-analysis
#6
Yarden Yavne, Shmuel Tiosano, Abdulla Watad, Doron Comaneshter, Arnon D Cohen, Howard Amital
BACKGROUND: Behcet's disease (BD) is a multi-systemic chronic inflammatory disorder which involves the vasculature tree of all sizes. The current study's aim was to examine the association between BD and the development of ischemic heart disease (IHD) and its potential impact as a cardiovascular risk factor. METHODS: This study was conducted as a case-control study utilizing the database of Clalit Health Services. The proportion of IHD was compared between patients diagnosed with BD and age- and gender-matched controls...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28284201/the-utility-of-apoptosis-inhibitor-of-macrophages-as-a-possible-diagnostic-marker-in-patients-with-crohn-s-disease
#7
Yohei Ono, Shuji Kanmura, Yuko Morinaga, Kohei Oda, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Hiroki Taguchi, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido
BACKGROUND: Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages may contribute to the pathogenesis of inflammatory bowel diseases (IBDs). However, there have been no reports on the kinetics of AIM in IBD and the impact of AIM on the pathogenesis of IBD. In this study, we aimed to investigate the diagnostic utility of levels of AIM and their correlation with the activity of Crohn's disease (CD) and IBD...
March 11, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28283819/neurological-complications-of-beh%C3%A3-et-s-syndrome
#8
D P Kidd
In this review of the neurological complications of Behçet's syndrome, the clinical features and epidemiology of the systemic disease are summarised before a discussion of the neurological syndromes which may develop is made. Neurological involvement occurs in 9% of cases, and is equally prevalent in each geographical area. Vascular complications occur in 14%, in whom thrombosis of the venous sinuses or cerebral veins occurs, and intracranial hypertension, venous infarction and parenchymal haemorrhage may develop...
March 10, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28283043/birmingham-beh%C3%A3-et-s-service-classification-of-disease-and-application-of-the-2014-international-criteria-for-beh%C3%A3-et-s-disease-icbd-to-a-uk-cohort
#9
Tim Blake, Luke Pickup, David Carruthers, Erika Marie Damato, Alastair Denniston, John Hamburger, Claire Maxton, Debbie Mitton, Philip I Murray, Peter Nightingale, Ana Poveda-Gallego, Andrea Richards, Andrew Whallett, Deva Situnayake
BACKGROUND: This study reports on the analysis of the application and diagnostic predictability of the revised 2014 ICBD criteria in an unselected cohort of UK patients, and the ensuing organ associations and patterns of disease. METHODS: A retrospective cohort study was conducted using a database of electronic medical records. Three categories were recognised: clinically defined BD, incomplete BD and rejected diagnoses of BD. We applied the ISG 1990 and ICBD 2014 classification criteria to these subgroups to validate diagnostic accuracy against the multidisciplinary assessment...
March 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28278670/bioactivity-guided-isolation-of-flavonoids-from-cynanchum-acutum-l-subsp-sibiricum-willd-rech-f-and-investigation-of-their-antiproliferative-activity
#10
Ilyas Yildiz, Ozkan Sen, Ramazan Erenler, Ibrahim Demirtas, Lutfi Behcet
Cynanchum acutum L. subsp. sibiricum (Willd.) Rech. f. was extracted with hexane, acetone, methanol and water individually. A sample was heated in water then extracted with ethyl acetate. Among the extracts, the ethyl acetate extract exhibited the most antiproliferative activity, so isolation of bioactive compounds was carried out from this extract. A new compound, kaempferol-3-O-β-xylopyranosyl-(1-2)-β-rhamnopyranoside (1) along with five known compounds, quercetin-3-O-β-xyloside (2), kaempferol-3-O-β-glucoside (3), quercetin-3-O-β-glucoside (4), kaempferol-3-O-β-rhamnopyranoside (5), and kaempferol-3-O-β-d-neohesperidoside (6) were isolated from ethyl acetate extract...
February 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28276957/evaluation-of-the-relationship-between-salivary-concentration-of-anti-heat-shock-protein-immunoglobulin-and-clinical-manifestations-of-beh%C3%A3-et-s-disease
#11
M Doino, M Yokoyama, Y Sasaki, K Kondo, Y Yasuda, S Arakawa
OBJECTIVE: This study investigated the relationship between the concentration of anti-heat shock protein (HSP) 60 antibody in resting saliva and the severity of Behçet's disease (BD). METHOD: Sixty-five patients diagnosed with BD at Tokyo Medical and Dental University Hospital were enrolled in this study. Based on clinical severity scores, patients were categorized as having mild, moderate, or severe BD. Periodontal status was evaluated with the Community Periodontal Index (CPI), and anti-HSP60 antibody concentrations in resting saliva were measured with an enzyme-linked immunosorbent assay...
February 14, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28272284/quantitative-analysis-of-structural-alterations-in-the-choroid-of-patients-with-active-beh%C3%A3-et-uveitis
#12
Sumru Onal, Gunay Uludag, Merih Oray, Emre Mengi, Carl P Herbort, Mehmet Akman, Mustafa M Metin, Aylin Koc Akbay, Ilknur Tugal-Tutkun
PURPOSE: To quantitatively analyze in vivo morphology of subfoveal choroid during an acute attack of Behçet uveitis. METHODS: In this prospective study, 28 patients with Behçet uveitis of ≤4-year duration, and 28 control subjects underwent enhanced depth imaging optical coherence tomography. A novel custom software was used to calculate choroidal stroma-to-choroidal vessel lumen ratio. Subfoveal choroidal thickness was measured at fovea and 750 μm nasal, temporal, superior, and inferior to fovea...
March 7, 2017: Retina
https://www.readbyqxmd.com/read/28261027/the-effect-of-vitamin-d-on-clinical-manifestations-and-activity-of-beh%C3%A3-et-s-disease
#13
Nurşad Aslan, Kamile Demirci, Tuba Güler, Fulya Dörtbaş, Ebru Kale
INTRODUCTION: Immune mechanisms have been implemented to have a role in the pathogenesis of Behçet's disease (BD) and vitamin D has been shown to have a regulatory role in the immune system function. AIM: To evaluate the vitamin D levels of BD patients and its relationship between clinical findings and disease activity of BD. MATERIAL AND METHODS: Sixty-eight patients with BD and 70 age- and sex-matched controls were examined retrospectively...
February 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28255922/the-clinical-and-pathological-characteristics-of-nephropathies-in-connective-tissue-diseases-in-the-japan-renal-biopsy-registry-j-rbr
#14
Kazunobu Ichikawa, Tsuneo Konta, Hiroshi Sato, Yoshihiko Ueda, Hitoshi Yokoyama
BACKGROUND: In connective tissue diseases, a wide variety of glomerular, tubulointerstitial, and vascular lesions of the kidney are observed. Nonetheless, recent information is limited regarding renal lesions in connective tissue diseases, except in systemic lupus erythematosus (SLE). METHODS: In this study, we used a nationwide database of biopsy-confirmed renal diseases in Japan (J-RBR) (UMIN000000618). In total, 20,523 registered patients underwent biopsy between 2007 and 2013; from 110 patients with connective tissue diseases except SLE, we extracted data regarding the clinico-pathological characteristics of the renal biopsy...
March 2, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28250463/vasculitis-syndromes-shared-genetic-risk-for-beh%C3%A3-et-disease-and-crohn-s-disease
#15
Jessica McHugh
No abstract text is available yet for this article.
April 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28244285/increased-serum-antibody-titer-against-hpv-16-antigen-in-patients-with-beh%C3%A3-et-s-disease
#16
Kyu Yeun Kim, Do Young Kim, Jimyung Seo, Yuri Ahn, Dong Soo Kim
Quadrivalent human papillomavirus (HPV) vaccine has been reported to be significantly associated with Behçet's disease (BD). However, no reports have described HPV infection as a possible cause for the development of BD. The objective of this study was to evaluate whether anti-HPV immunoglobulin G (IgG) antibody titer is increased in BD. Serum samples from 93 Korean BD patients, who fulfilled the diagnostic criteria of the International Study Group for BD, were used in an enzyme-linked immunosorbent assay (ELISA)...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28237149/enhanced-depth-imaging-optical-coherence-tomography-in-patients-with-different-phases-of-behcet-s-panuveitis
#17
Nilufer Yesilirmak, Wen-Hsiang Lee, Sirel Gur Gungor, Eylem Yaman Pinarci, Imren Akkoyun, Gursel Yilmaz
OBJECTIVE: To evaluate the changes in choroidal thickness (CT) at 13 different points between "active," "remission," and "end-stage" phase of Behcet's panuveitis and compare this with the age, sex, and spherical equivalent matched healthy controls using enhanced depth imaging optical coherence tomography. DESIGN: Prospective study. PARTICIPANTS: Eighty-five eyes of 45 patients with Behcet's panuveitis (19 eyes with active phase, 48 eyes with remission phase, and 18 eyes with end-stage phase) and 84 eyes of 42 controls were enrolled in this study...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28224327/effects-of-in-vivo-and-in-vitro-administration-of-neuro-behcet-s-disease-igg
#18
Ece Erdağ, Ceren Şahin, Cem İsmail Küçükali, Sinem Bireller, Melike Küçükerden, Murat Kürtüncü, Recai Türkoğlu, Bedia Cakmakoglu, Erdem Tüzün, Feyza Arıcıoğlu
Antibodies directed against membrane antigens of neuronal axonal processes (neuropil) have been recently identified in neuro-Behcet's disease (NBD) patients. To delineate the potential pathogenic action of these antibodies, pooled sera from seven NBD patients with neuropil antibodies and seven healthy controls were divided into purified IgG and IgG-depleted serum (IgG-DS) fractions and each fraction was administered into lateral ventricles of rats. NBD IgG-injected rats showed reduced locomotor activity in the open field test as compared to NBD IgG-DS, healthy control IgG, healthy control IgG-DS and PBS injected rats (n = 10 for each group)...
February 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28223848/severe-panuveitis-in-neuro-beh%C3%A3-et-s-disease-in-malaysia-a-case-series
#19
Khairuddin Othman, Ahmad Tajudin Liza-Sharmini, Mohtar Ibrahim, John Tharakan, Ryoji Yanai, Embong Zunaina
Behçet's disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet's. Neuro-Behçet's is one of the most serious causes of long-term morbidity and mortality. We report two cases of neuro-Behçet's associated with uveitis (ocular BD) highlighting the clinical presentation, diagnostic measurement, and therapeutic management of these cases.
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28219578/valved-conduit-attached-to-left-ventricular-outflow-tract-for-valve-detachment-in-beh%C3%A3-et-s-disease
#20
Liang-Wan Chen, Xi-Jie Wu, Hua Cao, Xiao-Fu Dai
Standard aortic valve replacement for aortic regurgitation caused by Behçet's disease is frequently complicated by postoperative recurrent prosthetic valve detachment. To prevent this, we have developed a modified Bentall procedure, in which the valved conduit is proximally attached to the left ventricular outflow tract instead of to the fragile annulus, based on the fact that the left ventricular outflow tract myocardium is rarely involved in Behçet's disease. This modified Bentall procedure was performed in 5 Behçet's disease patients with prosthetic valve detachment after primary aortic valve replacement, and satisfactory results were achieved...
March 2017: Annals of Thoracic Surgery
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