keyword
MENU ▼
Read by QxMD icon Read
search

Nir eyal

keyword
https://www.readbyqxmd.com/read/28706038/improving-vaccine-trials-in-infectious-disease-emergencies
#1
REVIEW
Marc Lipsitch, Nir Eyal
Unprecedented global effort is under way to facilitate the testing of countermeasures in infectious disease emergencies. Better understanding of the various options for trial design is needed in advance of outbreaks, as is preliminary global agreement on the most suitable designs for the various scenarios. What would enhance the speed, validity, and ethics of clinical studies of such countermeasures? Focusing on studies of vaccine efficacy and effectiveness in emergencies, we highlight three needs: for formal randomized trials-even in most emergencies; for individually randomized trials-even in many emergencies; and for six areas of innovation in trial methodology...
July 14, 2017: Science
https://www.readbyqxmd.com/read/28626601/long-term-efficacy-of-gmp-grade-xeno-free-hesc-derived-rpe-cells-following-transplantation
#2
Trevor J McGill, Osnat Bohana-Kashtan, Jonathan W Stoddard, Michael D Andrews, Neelay Pandit, Lior R Rosenberg-Belmaker, Ofer Wiser, Limor Matzrafi, Eyal Banin, Benjamin Reubinoff, Nir Netzer, Charles Irving
PURPOSE: Retinal pigment epithelium (RPE) dysfunction underlies the retinal degenerative process in age-related macular degeneration (AMD), and thus RPE cell replacement provides an optimal treatment target. We characterized longitudinally the efficacy of RPE cells derived under xeno-free conditions from clinical and xeno-free grade human embryonic stem cells (OpRegen) following transplantation into the subretinal space of Royal College of Surgeons (RCS) rats. METHODS: Postnatal (P) day 20 to 25 RCS rats (n = 242) received a single subretinal injection of 25,000 (low)-, 100,000 (mid)-, or 200,000 (high)-dose xeno-free RPE cells...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28601279/escitalopram-or-novel-herbal-treatments-differentially-alter-cytokine-and-behavioral-responses-to-immune-challenge
#3
Ronit Avitsur, Shalva Paley, Motty Franko, Nizan Wolff, Nir Eyal, Ravid Doron
Studies suggest that inflammation is involved in the pathophysiology of depression. The present study examined the effects of the commonly used antidepressant escitalopram, in comparison with a novel herbal treatment (NHT) consisted of Crataegus pinnatifida, Triticum aestivum, Lilium brownii and Fructus Ziziphus jujuba, on cytokine and behavioral responses to an immune challenge. Escitalopram augmented lipopolysaccharide-induced tumor necrosis factor (TNF)-α peripheral secretion and induced a faster kinetics of interleukin-1β secretion, while marginally reducing sickness behavior...
August 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28559673/three-case-studies-in-making-fair-choices-on-the-path-to-universal-health-coverage
#4
Alex Voorhoeve, Tessa T T Edejer, Lydia Kapiriri, Ole F Norheim, James Snowden, Olivier Basenya, Dorjsuren Bayarsaikhan, Ikram Chentaf, Nir Eyal, Amanda Folsom, Rozita Halina Tun Hussein, Cristian Morales, Florian Ostmann, Trygve Ottersen, Phusit Prakongsai, Carla Saenz, Karima Saleh, Angkana Sommanustweechai, Daniel Wikler, Afisah Zakariah
The goal of achieving Universal Health Coverage (UHC) can generally be realized only in stages. Moreover, resource, capacity, and political constraints mean governments often face difficult trade-offs on the path to UHC. In a 2014 report, Making fair choices on the path to UHC, the WHO Consultative Group on Equity and Universal Health Coverage articulated principles for making such trade-offs in an equitable manner. We present three case studies which illustrate how these principles can guide practical decision-making...
December 2016: Health and Human Rights
https://www.readbyqxmd.com/read/28440944/the-regulatory-significance-of-tag-recycling-in-the-mycobacterial-pup-proteasome-system
#5
Yifat Elharar, Shai Schlussel, Nir Hecht, Michael M Meijler, Eyal Gur
Pup, a ubiquitin analog, tags proteins for degradation by the bacterial proteasome. As an intracellular proteolytic system, the Pup-proteasome system (PPS) must be carefully regulated to prevent excessive protein degradation. Currently, those factors underlying PPS regulation remain poorly understood. Here, experimental analysis combined with theoretical modeling of in vivo protein pupylation revealed how the basic PPS design allows stable and controlled protein pupylation. Specifically, the recycling of Pup when targets are degraded allows the PPS to maintain steady-state levels of protein pupylation and degradation at a rate limited by proteasome function, and at a pupylome level limited by Pup concentrations...
April 25, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28422434/rat-hindlimb-cryopreservation-and-transplantation-a-step-toward-organ-banking
#6
A Arav, O Friedman, Y Natan, E Gur, N Shani
In 2016, over 5 million reconstructive procedures were performed in the United States. The recent successes of clinical vascularized composite allotransplantations, hand and face transplantations included, established the tremendous potential of these life-enhancing reconstructions. Nevertheless, due to limited availability and lifelong immunosuppression, application is limited. Long-term banking of composite transplants may increase the availability of esthetically compatible parts with partial or complete HLA matching, reducing the risk of rejection and the immunosuppressive burden...
April 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28402651/dna-bipedal-motor-achieves-a-large-number-of-steps-due-to-operation-using-microfluidics-based-interface
#7
Toma E Tomov, Roman Tsukanov, Yair Glick, Yaron Berger, Miran Liber, Dorit Avrahami, Doron Gerber, Eyal Nir
Realization of bioinspired molecular machines that can perform many and diverse operations in response to external chemical commands is a major goal in nanotechnology, but current molecular machines respond to only a few sequential commands. Lack of effective methods for introduction and removal of command compounds and low efficiencies of the reactions involved are major reasons for the limited performance. We introduce here a user interface based on a microfluidics device and single-molecule fluorescence spectroscopy that allows efficient introduction and removal of chemical commands and enables detailed study of the reaction mechanisms involved in the operation of synthetic molecular machines...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28396558/vaccine-testing-for-emerging-infections-the-case-for-individual-randomisation
#8
Nir Eyal, Marc Lipsitch
During the 2014-2015 Ebola outbreak in Guinea, Liberia and Sierra Leone, many opposed the use of individually randomised controlled trials to test candidate Ebola vaccines. For a raging fatal disease, they explained, it is unethical to relegate some study participants to control arms. In Zika and future emerging infections, similar opposition may hinder urgent vaccine research, so it is best to address these questions now. This article lays out the ethical case for individually randomised control in testing vaccines against many emerging infections, including lethal infections in low-income countries, even when at no point in the trial do the controls receive the countermeasures being tested...
April 10, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28330904/autonomous-tnf-is-critical-for-in-vivo-monocyte-survival-in-steady-state-and-inflammation
#9
Yochai Wolf, Anat Shemer, Michal Polonsky, Mor Gross, Alexander Mildner, Simon Yona, Eyal David, Ki-Wook Kim, Tobias Goldmann, Ido Amit, Mathias Heikenwalder, Sergei Nedospasov, Marco Prinz, Nir Friedman, Steffen Jung
Monocytes are circulating mononuclear phagocytes, poised to extravasate to sites of inflammation and differentiate into monocyte-derived macrophages and dendritic cells. Tumor necrosis factor (TNF) and its receptors are up-regulated during monopoiesis and expressed by circulating monocytes, as well as effector monocytes infiltrating certain sites of inflammation, such as the spinal cord, during experimental autoimmune encephalomyelitis (EAE). In this study, using competitive in vitro and in vivo assays, we show that monocytes deficient for TNF or TNF receptors are outcompeted by their wild-type counterpart...
April 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28220549/somatic-psychological-and-sexual-triggers-for-overactive-bladder-syndrome-in-women
#10
Ariel Zilberlicht, Nir Haya, Ido Feferkorn, Eyal Goldschmidt, Anis Kaldawy, Yoram Abramov
AIMS: Patients with overactive bladder (OAB) often describe somatic, psychological, and sexual triggers for their symptoms. The aim of this study was to characterize these triggers and assess their impact on patients' symptoms and quality of life (QoL). METHODS: Patients who visited our urogynecologic clinic between August 2015 and March 2016 and diagnosed with OAB syndrome were asked to fill a questionnaire comprising 34 statements regarding SOmatic, Psychological, and Sexual Triggers for OAB (SOPSETO)...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28152672/intraoperative-localization-of-rectal-tumors-using-liposomal-indocyanine-green
#11
Shlomo Magdassi, Shoshi Bar-David, Yael Friedman-Levi, Ehud Zigmond, Chen Varol, Guy Lahat, Joseph Klausner, Sara Eyal, Eran Nizri
BACKGROUND: Tumor localization may pose a significant challenge during minimally invasive rectal resection. Near-infrared (NIR) imaging can penetrate biological tissue and afford tumor localization from the external surface of the rectum. Our aim was to develop an NIR-based tool for rectal tumor imaging that can be administered intravenously. METHODS: We prepared indocyanine-green (ICG)-loaded liposomes by sonication. Liposomes were evaluated for their size and morphology...
February 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/27977207/photon-by-photon-hidden-markov-model-analysis-for-microsecond-single-molecule-fret-kinetics
#12
Menahem Pirchi, Roman Tsukanov, Rashid Khamis, Toma E Tomov, Yaron Berger, Dinesh C Khara, Hadas Volkov, Gilad Haran, Eyal Nir
The function of biological macromolecules involves large-scale conformational dynamics spanning multiple time scales, from microseconds to seconds. Such conformational motions, which may involve whole domains or subunits of a protein, play a key role in allosteric regulation. There is an urgent need for experimental methods to probe the fastest of these motions. Single-molecule fluorescence experiments can in principle be used for observing such dynamics, but there is a lack of analysis methods that can extract the maximum amount of information from the data, down to the microsecond time scale...
December 29, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27895581/evaluation-of-near-infrared-dyes-as-markers-of-p-glycoprotein-activity-in-tumors
#13
Inessa Semenenko, Emma Portnoy, Mohammed Aboukaoud, Serge Guzy, Miriam Shmuel, Gal Itzhak, Sara Eyal
Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and with poor patient prognosis. This study evaluated the feasibility of non-invasive, non-radioactive near infrared (NIR) imaging methodology for detection of MDR1 functional activity in tumors. Methods: Initial accumulation assays were conducted in MDR1-overexpressing MDCK cells (MDCK-MDR1) and control MDCK cells (MDCK-CT) using the NIR dyes indocyanine green (ICG), IR-783, IR-775, rhodamine 800, XenoLight DiR, and Genhance 750, at 0...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27645199/paying-for-antiretroviral-adherence-is-it-unethical-when-the-patient-is-an-adolescent
#14
Justin Healy, Rebecca Hope, Jacqueline Bhabha, Nir Eyal
With the expansion of antiretroviral treatment programmes, many children and adolescents with HIV in sub-Saharan Africa could expect to live healthy lives. Yet adolescents have the highest levels of poor antiretroviral adherence and of loss to follow-up compared with other age groups. This can lead to increased morbidity and mortality, to the development of drug-resistant strains, and to high societal costs. While financial incentives have been extensively used to promote medication adherence among adults, their use among adolescents remains rare...
September 19, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27630193/distinct-biological-events-generated-by-ecm-proteolysis-by-two-homologous-collagenases
#15
Inna Solomonov, Eldar Zehorai, Dalit Talmi-Frank, Sharon G Wolf, Alla Shainskaya, Alina Zhuravlev, Elena Kartvelishvily, Robert Visse, Yishai Levin, Nir Kampf, Diego Adhemar Jaitin, Eyal David, Ido Amit, Hideaki Nagase, Irit Sagi
It is well established that the expression profiles of multiple and possibly redundant matrix-remodeling proteases (e.g., collagenases) differ strongly in health, disease, and development. Although enzymatic redundancy might be inferred from their close similarity in structure, their in vivo activity can lead to extremely diverse tissue-remodeling outcomes. We observed that proteolysis of collagen-rich natural extracellular matrix (ECM), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM morphology, viscoelastic properties, and molecular composition...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27533351/can-unenhanced-ct-findings-predict-interventional-versus-conservative-treatment-in-acute-renal-colic
#16
COMPARATIVE STUDY
Eyal Lotan, Omer Weissman, Larisa Guranda, Nir Kleinmann, Rachel Schor, Harry Winkler, Orith Portnoy
OBJECTIVE: The purpose of this study was to determine the value of clinical parameters and radiologic findings on unenhanced CT to the choice between interventional and conservative management for patients with acute renal colic. MATERIALS AND METHODS: Unenhanced CT records of 183 consecutive patients with acute renal colic were retrospectively reviewed. Urolithiasis was confirmed at both unenhanced CT and clinical follow-up findings of 80 patients (study group)...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27497689/an-extended-loop-of-the-pup-ligase-pafa-mediates-interaction-with-protein-targets
#17
Ofir Regev, Maayan Korman, Nir Hecht, Ziv Roth, Nadav Forer, Raz Zarivach, Eyal Gur
Pupylation, the bacterial equivalent of ubiquitylation, involves the conjugation of a prokaryotic ubiquitin-like protein (Pup) to protein targets. In contrast to the ubiquitin system, where many ubiquitin ligases exist, a single bacterial ligase, PafA, catalyzes the conjugation of Pup to a wide array of protein targets. As mediators of target recognition by PafA have not been identified, it would appear that PafA alone determines pupylation target selection. Previous studies indicated that broad specificity and promiscuity are indeed inherent PafA characteristics that probably dictate which proteins are selected for degradation by the Pup-proteasome system...
October 9, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27400264/international-aids-society-global-scientific-strategy-towards-an-hiv-cure-2016
#18
Steven G Deeks, Sharon R Lewin, Anna Laura Ross, Jintanat Ananworanich, Monsef Benkirane, Paula Cannon, Nicolas Chomont, Daniel Douek, Jeffrey D Lifson, Ying-Ru Lo, Daniel Kuritzkes, David Margolis, John Mellors, Deborah Persaud, Joseph D Tucker, Françoise Barre-Sinoussi, Galit Alter, Judith Auerbach, Brigitte Autran, Dan H Barouch, Georg Behrens, Marina Cavazzana, Zhiwei Chen, Éric A Cohen, Giulio Maria Corbelli, Serge Eholié, Nir Eyal, Sarah Fidler, Laurindo Garcia, Cynthia Grossman, Gail Henderson, Timothy J Henrich, Richard Jefferys, Hans-Peter Kiem, Joseph McCune, Keymanthri Moodley, Peter A Newman, Monique Nijhuis, Moses Supercharger Nsubuga, Melanie Ott, Sarah Palmer, Douglas Richman, Asier Saez-Cirion, Matthew Sharp, Janet Siliciano, Guido Silvestri, Jerome Singh, Bruno Spire, Jeffrey Taylor, Martin Tolstrup, Susana Valente, Jan van Lunzen, Rochelle Walensky, Ira Wilson, Jerome Zack
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a global population of more than 35 million people living with HIV, there is intense interest in developing a cure for HIV infection. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. This Perspective summarizes the group's strategy.
August 2016: Nature Medicine
https://www.readbyqxmd.com/read/27354247/afterword-returning-to-philosophical-foundations-in-research-ethics
#19
Nir Eyal
This is an afterword to the JME symposium on the benefit/risk ratio challenge in clinical research, and the case of HIV cure. It notes implications of the symposium for research ethics in general.
February 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27215763/the-benefit-risk-ratio-challenge-in-clinical-research-and-the-case-of-hiv-cure-an-introduction
#20
Nir Eyal
This piece introduces the JME symposium 'The benefit/risk ratio challenge in clinical research, and the case of HIV cure.'
February 2017: Journal of Medical Ethics
keyword
keyword
67739
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"