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Murray grossman

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https://www.readbyqxmd.com/read/28025395/message-from-the-editors-to-our-reviewers
#1
Robert A Gross, Bradford B Worrall, Anthony A Amato, Gregory D Cascino, Olga Ciccarelli, John R Corboy, Josep O Dalmau, Rebecca F Gottesman, Murray Grossman, John J Millichap, Jonathan W Mink, Stefan M Pulst, Ryan J Uitti
No abstract text is available yet for this article.
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/28019685/tauopathy-with-hippocampal-4-repeat-tau-immunoreactive-spherical-inclusions-a-report-of-three-cases
#2
Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowski
Tauopathies are a major group of neurodegenerative proteinopathies characterized by the accumulation of abnormal and hyperphosphorylated tau proteins in the brain. Tau pathology is characterized as 3R (repeat) or 4R predominant or mixed 3R and 4R type. Here we report three cases lacking mutations in the microtubule associated protein tau (MAPT) gene with unusual tau pathology. The age at onset and duration of illness, respectively, were 63 and 20 years (male), 67 and 5 years (female) and 72 and 20 years (female)...
December 26, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27984347/hepatic-issues-and-complications-associated-with-inflammatory-bowel-disease-a-clinical-report-from-the-naspghan-inflammatory-bowel-disease-and-hepatology-committees
#3
Lawrence J Saubermann, Mark Deneau, Richard A Falcone, Karen F Murray, Sabina Ali, Rohit Kohli, Udeme D Ekong, Pamela L Valentino, Andrew B Grossman, Elizabeth B Rand, Maureen M Jonas, Shehzad A Saeed, Binita M Kamath
Hepatobiliary disorders are very common in inflammatory bowel disease (IBD) patients, and persistent abnormal liver function tests are found in approximately 20-30% of individuals with IBD. In most cases, the cause of these elevations will fall into one of three main categories. They can be as a result of extraintestinal manifestations of the disease process, related to medication toxicity, or the result of an underlying primary hepatic disorder unrelated to IBD. This latter possibility is beyond the scope of this review article, but does need to be considered in anyone with elevated liver function tests...
December 15, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27979356/neuropathological-and-genetic-correlates-of-survival-and-dementia-onset-in-synucleinopathies-a-retrospective-analysis
#4
David J Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, John E Duda, Sharon X Xie, Edward B Lee, Vivianna M Van Deerlin, Oscar L Lopez, Julia K Kofler, Peter T Nelson, Gregory A Jicha, Randy Woltjer, Joseph F Quinn, Jeffery Kaye, James B Leverenz, Debby Tsuang, Katelan Longfellow, Dora Yearout, Walter Kukull, C Dirk Keene, Thomas J Montine, Cyrus P Zabetian, John Q Trojanowski
BACKGROUND: Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies. METHODS: In this retrospective study, we examined symptom onset, and genetic and neuropathological data from a cohort of patients with Lewy body disorders with autopsy-confirmed α synucleinopathy (as of Oct 1, 2015) who were previously included in other studies from five academic institutions in five cities in the USA...
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27912073/dissociable-substrates-underlie-the-production-of-abstract-and-concrete-nouns
#5
Katheryn A Q Cousins, Sharon Ash, David J Irwin, Murray Grossman
No abstract text is available yet for this article.
February 2017: Brain and Language
https://www.readbyqxmd.com/read/27716988/progression-of-alpha-synuclein-pathology-in-multiple-system-atrophy-of-the-cerebellar-type
#6
Johannes Brettschneider, David J Irwin, Susana Boluda, Matthew D Byrne, Lubin Fang, Edward B Lee, John L Robinson, EunRan Suh, Vivianna M Van Deerlin, Jon B Toledo, Murray Grossman, Howard Hurtig, Reinhard Dengler, Susanne Petri, Virginia M-Y Lee, John Q Trojanowski
AIMS: To identify early foci of α-synuclein (α-syn pathology) accumulation, subsequent progression and neurodegeneration in multiple system atrophy of the cerebellar type (MSA-C). METHODS: We analyzed 70 μm thick sections of 10 cases with MSA-C and 24 normal controls. RESULTS: MSA-C cases with the lowest burden of pathology showed α-syn glial cytoplasmic inclusions (GCIs) in the cerebellum as well as in medullary and pontine cerebellar projections...
September 22, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27686111/using-precise-word-timing-information-improves-decoding-accuracy-in-a-multiband-accelerated-multimodal-reading-experiment
#7
An T Vu, Jeffrey S Phillips, Kendrick Kay, Matthew E Phillips, Matthew R Johnson, Svetlana V Shinkareva, Shannon Tubridy, Rachel Millin, Murray Grossman, Todd Gureckis, Rajan Bhattacharyya, Essa Yacoub
The blood-oxygen-level-dependent (BOLD) signal measured in functional magnetic resonance imaging (fMRI) experiments is generally regarded as sluggish and poorly suited for probing neural function at the rapid timescales involved in sentence comprehension. However, recent studies have shown the value of acquiring data with very short repetition times (TRs), not merely in terms of improvements in contrast to noise ratio (CNR) through averaging, but also in terms of additional fine-grained temporal information...
May 2016: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/27683847/cognitive-reserve-in-frontotemporal-degeneration-neuroanatomic-and-neuropsychological-evidence
#8
Katerina Placek, Lauren Massimo, Christopher Olm, Kylie Ternes, Kim Firn, Vivianna Van Deerlin, Edward B Lee, John Q Trojanowski, Virginia M-Y Lee, David Irwin, Murray Grossman, Corey T McMillan
OBJECTIVE: To evaluate if cognitive reserve (CR) contributes to interindividual differences in frontal gray matter density (GMD) and executive impairment that underlie heterogeneity in the disease course of confirmed frontotemporal lobar degeneration (FTLD) pathology. METHODS: Fifty-five patients with autopsy confirmation or a pathogenic mutation consistent with underlying tau (FTLD-tau) or TDP-43 (FTLD-TDP) pathology and 90 demographically comparable healthy controls were assessed with T1 MRI and neuropsychological measures (Mini-Mental State Examination, letter fluency, forward digit span, Rey complex figure, and Boston Naming Test)...
October 25, 2016: Neurology
https://www.readbyqxmd.com/read/27543644/multimodal-imaging-evidence-of-pathology-mediated-disease-distribution-in-corticobasal-syndrome
#9
Corey T McMillan, Clara Boyd, Rachel G Gross, Jessica Weinstein, Kim Firn, Jon B Toledo, Katya Rascovsky, Leslie Shaw, David A Wolk, David J Irwin, Edward B Lee, John Q Trojanowski, Murray Grossman
OBJECTIVE: To use multimodal neuroimaging to evaluate the influence of heterogeneous underlying pathology in corticobasal syndrome (CBS) on the neuroanatomical distribution of disease. METHODS: We performed a retrospective evaluation of 35 patients with CBS with T1-weighted MRI, diffusion tensor imaging, and neuropathologic, genetic, or CSF evidence of underlying pathology. Patients were assigned to 2 groups: those with evidence of Alzheimer pathology (CBS-AD) and those without Alzheimer pathology (CBS-non-AD)...
September 20, 2016: Neurology
https://www.readbyqxmd.com/read/27522537/transcranial-direct-current-stimulation-for-the-treatment-of-primary-progressive-aphasia-an-open-label-pilot-study
#10
Felix Gervits, Sharon Ash, H Branch Coslett, Katya Rascovsky, Murray Grossman, Roy Hamilton
Primary progressive aphasia (PPA) is a neurodegenerative condition characterized by gradual deterioration of language function. We investigated whether two weeks of daily transcranial direct current stimulation (tDCS) treatment would improve language abilities in six people with a non-fluent form of PPA. tDCS was applied in an unblinded trial at an intensity of 1.5mA for 20min/day over 10days. At the time of stimulation, patients were engaged in narrating one of several children's wordless picture stories. A battery of neuropsychological assessments was administered four times: at baseline, immediately following the 2-week stimulation period, and then 6-weeks and 12-weeks following the end of stimulation...
November 2016: Brain and Language
https://www.readbyqxmd.com/read/27394151/category-learning-in-alzheimer-s-disease-and-normal-cognitive-aging-depends-on-initial-experience-of-feature-variability
#11
Jeffrey S Phillips, Corey T McMillan, Edward E Smith, Murray Grossman
Semantic category learning is dependent upon several factors, including the nature of the learning task, as well as individual differences in the quality and heterogeneity of exemplars that an individual encounters during learning. We trained healthy older adults (n=39) and individuals with a diagnosis of Alzheimer's disease or Mild Cognitive Impairment (n=44) to recognize instances of a fictitious animal, a "crutter". Each stimulus item contained 10 visual features (e.g., color, tail shape) which took one of two values for each feature (e...
July 6, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27379517/arterial-spin-labeling-perfusion-predicts-longitudinal-decline-in-semantic-variant-primary-progressive-aphasia
#12
Christopher A Olm, Benjamin M Kandel, Brian B Avants, John A Detre, James C Gee, Murray Grossman, Corey T McMillan
The objective of the study was to evaluate the prognostic value of regional cerebral blood flow (CBF) measured by arterial spin labeled (ASL) perfusion MRI in patients with semantic variant primary progressive aphasia (svPPA). We acquired pseudo-continuous ASL (pCASL) MRI and whole-brain T1-weighted structural MRI in svPPA patients (N = 13) with cerebrospinal fluid biomarkers consistent with frontotemporal lobar degeneration pathology. Follow-up T1-weighted MRI was available in a subset of patients (N = 8)...
October 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27371492/a-race-effect-on-amyloid-deposition
#13
EDITORIAL
Gaël Chételat, Murray Grossman
No abstract text is available yet for this article.
August 2, 2016: Neurology
https://www.readbyqxmd.com/read/27301638/dissociation-of-quantifiers-and-object-nouns-in-speech-in-focal-neurodegenerative-disease
#14
Sharon Ash, Kylie Ternes, Teagan Bisbing, Nam Eun Min, Eileen Moran, Collin York, Corey T McMillan, David J Irwin, Murray Grossman
Quantifiers such as many and some are thought to depend in part on the conceptual representation of number knowledge, while object nouns such as cookie and boy appear to depend in part on visual feature knowledge associated with object concepts. Further, number knowledge is associated with a frontal-parietal network while object knowledge is related in part to anterior and ventral portions of the temporal lobe. We examined the cognitive and anatomic basis for the spontaneous speech production of quantifiers and object nouns in non-aphasic patients with focal neurodegenerative disease associated with corticobasal syndrome (CBS, n=33), behavioral variant frontotemporal degeneration (bvFTD, n=54), and semantic variant primary progressive aphasia (svPPA, n=19)...
August 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27270271/computerized-assessment-of-goal-directed-behavior-in-parkinson-s-disease
#15
Whitney Fitts, Lauren Massimo, Nicholas Lim, Murray Grossman, Nabila Dahodwala
INTRODUCTION: Apathy is a syndrome characterized by a reduction in goal-directed behavior. Neurodegenerative diseases frequently exhibit apathy. However, we lack an objective measure of apathy. The Philadelphia Apathy Computerized Task (PACT) measures impairments in goal-directed behavior that contribute to apathy, including initiation, planning, and motivation. We sought to examine these mechanisms in Parkinson's disease (PD) patients. METHOD: PD patients and healthy controls with a caregiver were recruited for the study...
November 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27172829/predicting-disease-progression-in-progressive-supranuclear-palsy-in-multicenter-clinical-trials
#16
Jee Bang, Iryna V Lobach, Anthony E Lang, Murray Grossman, David S Knopman, Bruce L Miller, Lon S Schneider, Rachelle S Doody, Andrew Lees, Michael Gold, Bruce H Morimoto, Adam L Boxer
INTRODUCTION: Clinical and MRI measurements can track disease progression in PSP, but many have not been extensively evaluated in multicenter clinical trials. We identified optimal measures to capture clinical decline and predict disease progression in multicenter PSP trials. METHODS: Longitudinal clinical rating scales, neuropsychological test scores, and volumetric MRI data from an international, phase 2/3 clinical trial of davunetide for PSP (intent to treat population, n = 303) were used to identify measurements with largest effect size, strongest correlation with clinical change, and best ability to predict dropout or clinical decline over one year as measured by PSP Rating Scale (PSPRS)...
July 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27042900/the-mental-status-examination-in-patients-with-suspected-dementia
#17
REVIEW
Murray Grossman, David J Irwin
PURPOSE OF REVIEW: This article describes a comprehensive approach to the mental status examination and diagnostic workup of patients suspected of having an emerging neurodegenerative dementia. Key strategies for obtaining a history and bedside examination techniques are highlighted. RECENT FINDINGS: Classic descriptions of behavioral neurology syndromes were largely based on clinicopathologic correlations of strategic lesions in stroke patients. While still very important, advances in neuroimaging have expanded our armamentarium of cognitive evaluations to include assessments of findings in nonstroke anatomic distributions of disease...
April 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27030767/causal-evidence-for-a-mechanism-of-semantic-integration-in-the-angular-gyrus-as-revealed-by-high-definition-transcranial-direct-current-stimulation
#18
Amy Rose Price, Jonathan E Peelle, Michael F Bonner, Murray Grossman, Roy H Hamilton
UNLABELLED: A defining aspect of human cognition is the ability to integrate conceptual information into complex semantic combinations. For example, we can comprehend "plaid" and "jacket" as individual concepts, but we can also effortlessly combine these concepts to form the semantic representation of "plaid jacket." Many neuroanatomic models of semantic memory propose that heteromodal cortical hubs integrate distributed semantic features into coherent representations. However, little work has specifically examined these proposed integrative mechanisms and the causal role of these regions in semantic integration...
March 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26973557/the-two-sides-of-sensory-cognitive-interactions-effects-of-age-hearing-acuity-and-working-memory-span-on-sentence-comprehension
#19
Renee DeCaro, Jonathan E Peelle, Murray Grossman, Arthur Wingfield
Reduced hearing acuity is among the most prevalent of chronic medical conditions among older adults. An experiment is reported in which comprehension of spoken sentences was tested for older adults with good hearing acuity or with a mild-to-moderate hearing loss, and young adults with age-normal hearing. Comprehension was measured by participants' ability to determine the agent of an action in sentences that expressed this relation with a syntactically less complex subject-relative construction or a syntactically more complex object-relative construction...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/26944874/cognitive-and-anatomic-double-dissociation-in-the-representation-of-concrete-and-abstract-words-in-semantic-variant-and-behavioral-variant-frontotemporal-degeneration
#20
Katheryn A Q Cousins, Collin York, Laura Bauer, Murray Grossman
We examine the anatomic basis for abstract and concrete lexical representations in semantic memory by assessing patients with focal neurodegenerative disease. Prior evidence from healthy adult studies suggests that there may be an anatomical dissociation between abstract and concrete representations: abstract words more strongly activate the left inferior frontal gyrus relative to concrete words, while concrete words more strongly activate left anterior-inferior temporal regions. However, this double dissociation has not been directly examined...
April 2016: Neuropsychologia
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