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Hericium erinaceus

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https://www.readbyqxmd.com/read/28742114/a-unique-polysaccharide-purified-from-hericium-erinaceus-mycelium-prevents-oxidative-stress-induced-by-h2o2-in-human-gastric-mucosa-epithelium-cell
#1
Mingxing Wang, Nakajima Kanako, Yanqiu Zhang, Xulang Xiao, Qipin Gao, Konishi Tetsuya
Hericium erinaceus (HE) has been used both as a traditional Chinese medicine and home remedy for treatment of gastric and duodenal ulcers and gastritis. EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity. Because oxidative stress has been implicated as a pathogenic cause of gastritis and gastric ulcers, EP-1 antioxidant properties were systematically examined in vitro using the human gastric mucosal epithelial cell line, GES-1...
2017: PloS One
https://www.readbyqxmd.com/read/28729219/immunomodulatory-effects-of-hydroxyethylated-hericium-erinaceus-polysaccharide-on-macrophages-raw264-7
#2
Zhe Ren, Tao Qin, Fuan Qiu, Yulong Song, Dandan Lin, Yufang Ma, Jian Li, Yifan Huang
Hericium erinaceus polysaccharide (HEP) has been shown to possess a variety of biological activities. In present study, HEP was successfully modified to obtain its hydroxyethylated derivative hHEP. Its potential immunomodulatory activities on RAW264.7 macrophages were investigated. Results showed that the hHEP were significantly stronger than that of the corresponding unmodified polysaccharide, HEP. Meanwhile, the NO, IL-6 and TNF-α production activities of macrophages were enhanced in the RAW264.7 macrophages by stimulation of hHEP...
July 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28713364/immunomodulatory-activities-of-a-fungal-protein-extracted-from-hericium-erinaceus-through-regulating-the-gut-microbiota
#3
Chen Diling, Zheng Chaoqun, Yang Jian, Li Jian, Su Jiyan, Xie Yizhen, Lai Guoxiao
A single-band protein (HEP3) was isolated from Hericium erinaceus using a chemical separation combined with pharmacodynamic evaluation methods. This protein exhibited immunomodulatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by decreasing the overproduction of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and downregulating the expression of inducible nitric oxide synthase and nuclear factor-κB p65. Further researches revealed that HEP3 could improve the immune system via regulating the composition and metabolism of gut microbiota to activate the proliferation and differentiation of T cells, stimulate the intestinal antigen-presenting cells in high-dose cyclophosphamide-induced immunotoxicity in mice, and play a prebiotic role in the case of excessive antibiotics in inflammatory bowel disease model mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28553224/docking-studies-and-biological-evaluation-of-a-potential-%C3%AE-secretase-inhibitor-of-3-hydroxyhericenone-f-from-hericium-erinaceus
#4
Chen Diling, Yong Tianqiao, Yang Jian, Zheng Chaoqun, Shuai Ou, Xie Yizhen
Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting approximately more than 5% of the population worldwide over the age 65, annually. The incidence of AD is expected to be higher in the next 10 years. AD patients experience poor prognosis and as a consequence new drugs and therapeutic strategies are required in order to improve the clinical responses and outcomes of AD. The purpose of the present study was to screen a certain number of potential compounds from herbal sources and investigate their corresponding mode of action...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28443294/dataset-on-records-of-hericium-erinaceus-in-slovakia
#5
Vladimír Kunca, Marek Čiliak
The data presented in this article are related to the research article entitled "Habitat preferences of Hericium erinaceus in Slovakia" (Kunca and Čiliak, 2016) [FUNECO607] [2]. The dataset include all available and unpublished data from Slovakia, besides the records from the same tree or stem. We compiled a database of records of collections by processing data from herbaria, personal records and communication with mycological activists. Data on altitude, tree species, host tree vital status, host tree position and intensity of management of forest stands were evaluated in this study...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28351165/two-new-isobenzofuranone-derivatives-from-the-fruiting-bodies-of-hericium-erinaceus
#6
Jing Li, Xu-Li Wang, Guang Li, Ping-Sheng Xu, Kang-Ping Xu, Gui-Shan Tan
Two new isobenzofuranone derivatives erinaceolactones G and H (1 and 2) were isolated from the ethanolic extract of fruiting bodies of Hericium erinaceus. Their structures were characterized on the basis of spectroscopic evidences. Compound 2 was suggested to be racemic by specific rotation, which was resolved by chiral HPLC into enantiomers.
March 29, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28266682/immunomodulatory-effects-of-hericium-erinaceus-derived-polysaccharides-are-mediated-by-intestinal-immunology
#7
Xiaotong Sheng, Jingmin Yan, Yue Meng, Yuying Kang, Zhen Han, Guihua Tai, Yifa Zhou, Hairong Cheng
This study was aimed at investigating the immunomodulating activity of Hericium erinaceus polysaccharide (HEP) in mice, by assessing splenic lymphocyte proliferation (cell-mediated immunity), serum hemolysin levels (humoral immunity), phagocytic capacity of peritoneal cavity phagocytes (macrophage phagocytosis), and NK cell activity. ELISA of immunoglobulin A (SIgA) in the lamina propria, and western blotting of small intestinal proteins were also performed to gain insight into the mechanism by which HEP affects the intestinal immune system...
March 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28181079/anti-obesity-activity-of-yamabushitake-hericium-erinaceus-powder-in-ovariectomized-mice-and-its-potentially-active-compounds
#8
Eri Hiraki, Shoko Furuta, Rika Kuwahara, Naomichi Takemoto, Toshiro Nagata, Taiki Akasaka, Bungo Shirouchi, Masao Sato, Koichiro Ohnuki, Kuniyoshi Shimizu
Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract...
July 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28115973/dietary-supplementation-of-hericium-erinaceus-increases-mossy-fiber-ca3-hippocampal-neurotransmission-and-recognition-memory-in-wild-type-mice
#9
Federico Brandalise, Valentina Cesaroni, Andrej Gregori, Margherita Repetti, Chiara Romano, Germano Orrù, Laura Botta, Carolina Girometta, Maria Lidia Guglielminetti, Elena Savino, Paola Rossi
Hericium erinaceus (Bull.) Pers. is a medicinal mushroom capable of inducing a large number of modulatory effects on human physiology ranging from the strengthening of the immune system to the improvement of cognitive functions. In mice, dietary supplementation with H. erinaceus prevents the impairment of spatial short-term and visual recognition memory in an Alzheimer model. Intriguingly other neurobiological effects have recently been reported like the effect on neurite outgrowth and differentiation in PC12 cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28089932/selenizing-hericium-erinaceus-polysaccharides-induces-dendritic-cells-maturation-through-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#10
Tao Qin, Zhe Ren, Yifan Huang, Yulong Song, Dandan Lin, Jian Li, Yufang Ma, Xiuqin Wu, Fuan Qiu, Qi Xiao
In this study, polysaccharides extracted from Hericium erinaceus were modified to obtain its nine selenium derivatives, sHEP1-sHEP9. Their structures were identified, yields and selenium contents were determined, the phenotypic and functional maturation of murine bone marrow-derived dendritic cells (DCs) and relevant mechanisms were compared taking unmodified HEP as control. The results revealed that the selenylation were successful. sHEP1, sHEP2 and sHEP8 treatment of DCs increased their surface expression of MHC-II and CD86 and indicated that sHEP1, sHEP2 and sHEP8 induced DC maturation...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28087447/structures-biological-activities-and-industrial-applications-of-the-polysaccharides-from-hericium-erinaceus-lion-s-mane-mushroom-a-review
#11
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huang, Xiaoqiang Huang, Zefeng Zhao
Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27816657/haematological-biochemical-and-histopathological-aspects-of-hericium-erinaceus-ingestion-in-a-rodent-model-a-sub-chronic-toxicological-assessment
#12
Hariprasath Lakshmanan, Jegadeesh Raman, Pamela David, Kah-Hui Wong, Murali Naidu, Vikineswary Sabaratnam
ETHNOPHARMACOLOGICAL RELEVANCE: Hericium erinaceus is a culinary-medicinal mushroom and has a long history of usage in traditional Chinese medicine as a tonic for stomach disorders, ulcers and gastrointestinal ailments. AIM OF THE STUDY: The present investigation was aimed to evaluate the potential toxic effects of the aqueous extract from the fruiting bodies of H. erinaceus in rats by a sub-chronic oral toxicity study. MATERIALS AND METHODS: In this sub-chronic toxicity study, rats were orally administered with the aqueous extract of H...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27809277/the-neuroprotective-properties-of-hericium-erinaceus-in-glutamate-damaged-differentiated-pc12-cells-and-an-alzheimer-s-disease-mouse-model
#13
Junrong Zhang, Shengshu An, Wenji Hu, Meiyu Teng, Xue Wang, Yidi Qu, Yang Liu, Ye Yuan, Di Wang
Hericium erinaceus, an edible and medicinal mushroom, displays various pharmacological activities in the prevention of dementia in conditions such as Parkinson's and Alzheimer's disease. The present study explored the neuroprotective effects of H. erinaceus mycelium polysaccharide-enriched aqueous extract (HE) on an l-glutamic acid (l-Glu)-induced differentiated PC12 (DPC12) cellular apoptosis model and an AlCl₃ combined with d-galactose-induced Alzheimer's disease mouse model. The data revealed that HE successfully induced PC12 cell differentiation...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27716564/efficient-conversion-of-pretreated-brewer-s-spent-grain-and-wheat-bran-by-submerged-cultivation-of-hericium-erinaceus
#14
Niklas Wolters, Christoph Schabronath, Gerhard Schembecker, Juliane Merz
Brewer's spent grain (BSG) and wheat bran (WB) are industrial byproducts that accumulate in millions of tons per year and are typically applied as animal feed. Since both byproducts show a great potential as substrates for fermentation, the approach developed in this study consists of utilizing these lignocellulosic byproducts for biomass production of the medicinal fungus Hericium erinaceus through submerged cultivation. To increase the biological efficiency of the bioconversion, acidic pretreatment was applied yielding a bioconversion of 38...
December 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27709782/a-proteomics-approach-to-identifying-novel-protein-targets-involved-in-erinacine-a-mediated-inhibition-of-colorectal-cancer-cells-aggressiveness
#15
Ko-Chao Lee, Hsing-Chun Kuo, Chien-Heng Shen, Chien-Chang Lu, Wen-Shih Huang, Meng-Chiao Hsieh, Cheng-Yi Huang, Yi-Hung Kuo, Yung-Yu Hsieh, Chih-Chuan Teng, Li-Ya Lee, Shui-Yi Tung
Erinacine A, a major active component of a diterpenoid derivative isolated from Hericium erinaceus mycelium, has been demonstrated to exert anticancer effects. Herein, we present an investigation of the molecular mechanism of erinacine A induction associated with cancer cells' aggressive status and death. A proteomic approach was used to purify and identify the differentially expressed proteins following erinacine A treatment and the mechanism of its action in apoptotic and the targets of erinacine A. Our results demonstrate that erinacine A treatment of HCT-116 and DLD-1 cells increased cell cytotoxicity and reactive oxygen species (ROS) production as well as decreased cell proliferation and invasiveness...
March 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27696140/use-of-swine-wastewater-as-alternative-substrate-for-mycelial-bioconversion-of-white-rot-fungi
#16
Jangwoo Lee, Seung Gu Shin, Jinmo Ahn, Gyuseong Han, Kwanghyun Hwang, Woong Kim, Seokhwan Hwang
Seven white rot fungal species were tested for growth as mycelia using swine wastewater (SW), an agro-waste with tremendous environmental footprint, as the sole nutrient source. The SW contained high concentrations of carbon and nitrogen components, which could support nutritional requirements for mycelial growth. Out of the seven species, Pleurotus ostreatus and Hericium erinaceus were successfully cultivated on the SW medium using solid-state fermentation. Response surface methodology was employed to determine the combination of pH, temperature (T), and substrate concentration (C) that maximizes mycelial growth rate (Kr) for the two species...
February 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27544998/hericium-erinaceus-extracts-alter-behavioral-rhythm-in-mice
#17
Shoko Furuta, Rika Kuwahara, Eri Hiraki, Koichiro Ohnuki, Shinobu Yasuo, Kuniyoshi Shimizu
Hericium erinaceus (HE), an edible mushroom, has been used as a herbal medicine in several Asian countries since ancient times. HE has potential as a medicine for the treatment and prevention of dementia, a disorder closely linked with circadian rhythm. This study investigated the effects of the intake of HE extracts on behavioral rhythm, photosensitivity of the circadian clock, and clock gene mRNA expression in the suprachiasmatic nucleus (SCN), a central clock, in mice. Although the HE ethanol extract only affected the offset time of activity, the HE water extract advanced the sleep-wake cycle without affecting the free-running period, photosensitivity, or the clock gene mRNA expression in SCN...
2016: Biomedical Research
https://www.readbyqxmd.com/read/27398086/redox-modulation-of-cellular-stress-response-and-lipoxin-a4-expression-by-hericium-erinaceus-in-rat-brain-relevance-to-alzheimer-s-disease-pathogenesis
#18
A Trovato, R Siracusa, R Di Paola, M Scuto, M L Ontario, Ornella Bua, Paola Di Mauro, M A Toscano, C C T Petralia, L Maiolino, A Serra, S Cuzzocrea, Vittorio Calabrese
BACKGROUND: There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have long been used in traditional medicine for thousands of years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial and hepatoprotective agent also capable to stimulate host immune responses. RESULTS: Here we provide evidence of neuroprotective action of Hericium Herinaceus when administered orally to rat...
2016: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/27350344/erinacine-a-enriched-hericium-erinaceus-mycelium-ameliorates-alzheimer-s-disease-related-pathologies-in-appswe-ps1de9-transgenic-mice
#19
Tzeng Tsai-Teng, Chen Chin-Chu, Lee Li-Ya, Chen Wan-Ping, Lu Chung-Kuang, Shen Chien-Chang, Huang F Chi-Ying, Chen Chien-Chih, Young-Ji Shiao
BACKGROUND: The fruiting body of Hericium erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer's disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium erinaceus mycelia on Alzheimer's disease remains unclear. In this study, the effects of erinacine A-enriched Hericium erinaceus mycelia (HE-My) on the pathological changes in APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease are studied. RESULTS: After a 30 day oral administration to 5 month-old female APPswe/PS1dE9 transgenic mice, we found that HE-My and its ethanol extracts (HE-Et) attenuated cerebral Aβ plaque burden...
June 27, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27347087/comparative-studies-on-extracts-from-hericium-erinaceus-by-different-polarity-reagents-to-gain-higher-antioxidant-activities
#20
Shengjuan Jiang, Yuliang Wang, Xiaolong Zhang
Hericium erinaceus (H. erinaceus) is a source of exogenous antioxidants that has been traditionally used in China for the prevention and treatment of oxidative stress-associated disease. In the present study, the bioactive compounds of H. erinaceus were extracted with the following eight representative reagents: n-Hexane, xylene, chloroform, anhydrous ether, ethyl acetate, acetone, anhydrous ethanol and distilled water. The in vitro antioxidant activities were also evaluated. All of the extracted compounds exhibited reducing power and scavenging activity against 1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion free radicals...
July 2016: Experimental and Therapeutic Medicine
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