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Hericium erinaceus

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https://www.readbyqxmd.com/read/29780164/three-new-cyathane-diterpenes-with-neurotrophic-activity-from-the-liquid-cultures-of-hericium-erinaceus
#1
Yuting Zhang, Li Liu, Li Bao, Yanlong Yang, Ke Ma, Hongwei Liu
Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73...
May 21, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29773393/comparative-study-of-physicochemical-properties-and-bioactivity-of-hericium-erinaceus-polysaccharides-at-different-solvent-extractions
#2
Jing-Kun Yan, Zhi-Chao Ding, Xianli Gao, Yao-Yao Wang, Yan Yang, Di Wu, He-Nan Zhang
In this study, hot water, 0.9% NaCl, citric acid, and 1.25 M NaOH/0.05% NaBH4 were separately used for the extraction of water-soluble H. erinaceus polysaccharides (HEPs; HEP-W, HEP-S, HEP-C, and HEP-A) from the fruit body of Hericium erinaceus. The physicochemical properties and biological activities were then investigated and compared. Results showed that the extraction solvents exhibited significant effects on the extraction yields, molecular weights, monosaccharide compositions, preliminary structural characteristics, microstructures of HEPs and on their contents, such as neutral sugar, uronic acid, protein, and β-(1 → 3)-glucan...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29738838/proteome-analysis-provides-insight-into-the-regulation-of-bioactive-metabolites-in-hericium-erinaceus
#3
Xu Zeng, Hong Ling, Jianwen Yang, Juan Chen, Shunxing Guo
BACKGROUND: Hericium erinaceus, a famous edible mushroom, is also a well-known traditional medicinal fungus. To date, a large number of bioactive metabolites with antitumor, antibacterial, and immune-boosting effects were isolated from the free-living mycelium and fruiting body of H. erinaceus. OBJECTIVE: Here we used the proteomic approach to explore proteins involved in the regulation of bioactive metabolites, including terpenoid, polyketide, sterol and etc. RESULTS: Using mass spectrometry, a total of 2543 unique proteins were identified using H...
May 5, 2018: Gene
https://www.readbyqxmd.com/read/29717671/improvement-of-nutritional-and-bioactive-compound-production-by-lion-s-mane-medicinal-mushroom-hericium-erinaceus-agaricomycetes-by-spraying-growth-regulators
#4
Minhthuan Vi, Xueqin Yang, Xianlu Zeng, Rui'an Chen, Liqiong Guo, Junfang Lin, Qianyun He, Qianwang Zheng, Tao Wei
Hericium erinaceus is a popular culinary and medicinal mushroom in China because of its broad beneficial effects. In this study we evaluated the effects of stimulation with 7 growth regulators at 5 different concentrations on improving the production of nutritional and bioactive compounds by H. erinaceus. Results showed that among all the tested regulators, gibberellic acid (GA) increased protein content (165%), free amino acids (100%), polysaccharides (108%), and polyphenols (26%). Spraying nephthyl acetic acid increased polysaccharides and triterpenoids to 4...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29677563/polysaccharide-of-hericium-erinaceus-attenuates-colitis-in-c57bl-6-mice-via-regulation-of-oxidative-stress-inflammation-related-signaling-pathways-and-modulating-the-composition-of-the-gut-microbiota
#5
Yilin Ren, Yan Geng, Yan Du, Wang Li, Zhen-Ming Lu, Hong-Yu Xu, Guo-Hua Xu, Jin-Song Shi, Zheng-Hong Xu
Inflammatory bowel disease (IBD) is a disease caused by a dysregulated immune with unknown etiology. Hericium erinaceus (H. erinaceus) is a Chinese medicinal fungus, with the effect of prevention and treatment of gastrointestinal disorders. In this study, we have tested the anti-inflammatory effect of polysaccharide of H. erinaceus (HECP, Mw: 86.67 kDa) in the model of dextran sulfate sodium (DSS)-induced colitis in C57BL/6 mice. Our data indicated that HECP could improve clinical symptoms and down-regulate key markers of oxidative stresses, including nitric oxide (NO), malondialdehyde (MDA), total superoxide dismutase (T-SOD), and myeloperoxidase (MPO)...
March 16, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29619846/lactobacillus-fermentum-hp3-mediated-fermented-hericium-erinaceus-juice-as-a-health-promoting-food-supplement-to-manage-diabetes-mellitus
#6
Chaiyavat Chaiyasut, Sasimar Woraharn, Bhagavathi Sundaram Sivamaruthi, Narissara Lailerd, Periyanaina Kesika, Sartjin Peerajan
The current study investigated the antidiabetic property of Lactobacillus fermentum HP3-mediated fermented Hericium erinaceus juice (FHJ) using male Wistar rats with streptozotocin-induced diabetes mellitus (DM). FHJ was prepared using boiled mushroom juice and L. fermentum HP3. Amino acid and γ-aminobutyric acid (GABA) content of FHJ was analyzed. Streptozotocin-induced DM rats were supplemented with FHJ in a pre- and posttreatment method. The changes in plasma insulin, plasma glucose level, glycated hemoglobin (HbA1c), representative cytokines, and the antioxidant system were assessed in experimental rats using spectrophotometric methods and enzyme-linked immunosorbent assay...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29580208/screening-for-inhibitors-of-mutacin-synthesis-in-streptococcus-mutans-using-fluorescent-reporter-strains
#7
Priyanka Premnath, Michael Reck, Kathrin Wittstein, Marc Stadler, Irene Wagner-Döbler
BACKGROUND: Within the polymicrobial dental plaque biofilm, bacteria kill competitors by excreting mixtures of bacteriocins, resulting in improved fitness and survival. Inhibiting their bacteriocin synthesis might therefore be a useful strategy to eliminate specific pathogens. We used Streptococcus mutans, a highly acidogenic inhabitant of dental plaque, as a model and searched for natural products that reduced mutacin synthesis. To this end we fused the promoter of mutacin VI to the GFP+ gene and integrated the construct into the genome of S...
March 27, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29543781/chondroprotective-effects-of-a-standardized-extract-kbh-jp-040-from-kalopanax-pictus-hericium-erinaceus-and-astragalus-membranaceus-in-experimentally-induced-in-vitro-and-in-vivo-osteoarthritis-models
#8
Md Mahbubur Rahman, Hyun-Kyu Kim, Seong-Eun Kim, Myung-Jin Kim, Do-Hyung Kim, Hak Sung Lee
The aim of this study was to investigate the chondroprotective effect of a standardized extract (KBH-JP-040) of the Korean traditional herbs Kalopanax pictus Castor-Aralia, Hericium erinaceus (Bull.) Persoon, and Astragalus membranaceus Schischkin on in vivo and in vitro osteoarthritis (OA) models. Cultured rat chondrocytes were pre-treated with KBH-JP-040 (50, 100 and 200 μg/mL) for 1 h, then recombinant human IL-1α (rhIL-1α) for 24 h. For the in vivo model, rabbits ( n = 60) were equally divided into experimental groups: normal control (NC), a collagenase-induced OA group, and OA groups treated with KBH-JP-040 (75, 100, and 150 mg/kg body weight) and celecoxib (Cx, 100 mg/kg) orally for 28 days...
March 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29509661/two-new-cyathane-diterpenoids-from-mycelial-cultures-of-the-medicinal-mushroom-hericium-erinaceus-and-the-rare-species-hericium-flagellum
#9
Zeljka Rupcic, Monique Rascher, Sae Kanaki, Reinhard W Köster, Marc Stadler, Kathrin Wittstein
Basidiomycetes of the genus Hericium are among the most praised medicinal and edible mushrooms, which are known to produce secondary metabolites with the potential to treat neurodegenerative diseases. This activity has been attributed to the discovery of various terpenoids that can stimulate the production of nerve growth factor ( NGF ) or (as established more recently) brain-derived neurotrophic factor ( BDNF ) in cell-based bioassays. The present study reports on the metabolite profiles of a Lion's Mane mushroom ( Hericium erinaceus ) strain and a strain of the rare species, Hericium flagellum (synonym H...
March 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29463001/the-cyanthin-diterpenoid-and-sesterterpene-constituents-of-hericium-erinaceus-mycelium-ameliorate-alzheimer-s-disease-related-pathologies-in-app-ps1-transgenic-mice
#10
Tsai-Teng Tzeng, Chien-Chih Chen, Chin-Chu Chen, Huey-Jen Tsay, Li-Ya Lee, Wan-Ping Chen, Chien-Chang Shen, Young-Ji Shiao
Hericium erinaceus was used in traditional Chinese medicine for physiologically beneficial medicines. Recently, it has become a candidate in causing positive brain health-related activities. We previously reported that Hericium erinaceus mycelium ameliorates Alzheimer's disease (AD)-related pathologies. To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated...
February 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29455967/gastroprotective-activity-of-polysaccharide-from-hericium-erinaceus-against-ethanol-induced-gastric-mucosal-lesion-and-pylorus-ligation-induced-gastric-ulcer-and-its-antioxidant-activities
#11
Xiao-Yin Wang, Jun-Yi Yin, Ming-Ming Zhao, Shi-Yu Liu, Shao-Ping Nie, Ming-Yong Xie
The gastroprotective activity of Hericium erinaceus polysaccharide was investigated in rats. The antioxidant activities were also evaluated. Pre-treatment of polysaccharide could reduce ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer. The polysaccharide exhibited scavenging activities of 1, 1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and ferrous ion-chelating ability. In the pylorus ligation-induced model, gastric secretions (volume of gastric juice, gastric acid, pepsin and mucus) of ulcer rats administrated with polysaccharide were regulated...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29364170/erinacine-a-enriched-hericium-erinaceus-mycelium-produces-antidepressant-like-effects-through-modulating-bdnf-pi3k-akt-gsk-3%C3%AE-signaling-in-mice
#12
Chun-Hung Chiu, Charng-Cherng Chyau, Chin-Chu Chen, Li-Ya Lee, Wan-Ping Chen, Jia-Ling Liu, Wen-Hsin Lin, Mei-Chin Mong
Antidepressant-like effects of ethanolic extract of Hericium erinaceus (HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice except the control group went through with 14 days of RS protocol. Stressed mice exhibited various behavioral alterations, such as extending immobility time in the tail suspension test (TST) and forced swimming test (FST), and increasing the number of entries in open arm (POAE) and the time spent in the open arm (PTOA)...
January 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29359595/acute-and-developmental-toxicity-assessment-of-erincine-a-enriched-hericium-erinaceus-mycelia-in-sprague-dawley-rats
#13
I-Chen Li, Wan-Ping Chen, Yen-Po Chen, Li-Ya Lee, Yueh-Ting Tsai, Chin-Chu Chen
This study aimed to establish an in vitro model to confirm the efficacy of erinacine A-enriched Hericium erinaceus (EAHE) mycelia and investigate its potential adverse effects in a preclinical experimental setting, including an assessment on the oral administration of EAHE mycelia in acute and prenatal developmental toxicity tests. At a single dose of 5000 mg/kg body weight, EAHE mycelia elicited no death or treatment-related signs of toxicity in ten Sprague-Dawley rats of both sexes during the 14 days of the experimental period...
January 23, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29238712/cytotoxic-effect-on-human-myeloma-cells-and-leukemic-cells-by-the-agaricus-blazei-murill-based-mushroom-extract-andosan%C3%A2
#14
Jon-Magnus Tangen, Toril Holien, Mohammad Reza Mirlashari, Kristine Misund, Geir Hetland
Agaricus blazei Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4% Agaricus blazei Murill, together with medicinal mushrooms Hericium erinaceus (14.7%) and Grifola frondosa (2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell lines in vitro...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29199560/lion-s-mane-medicinal-mushroom-hericium-erinaceus-agaricomycetes-modulates-purinoceptor-coupled-calcium-signaling-and-murine-nociceptive-behavior
#15
Pei-Shan Liu, Sheau-Huei Chueh, Chin-Chu Chen, Li-Ya Lee, Li-Yen Shiu
Hericium erinaceus is well known for the neurotrophic effect it confers by promoting nerve growth factor biosynthesis. We discovered a novel bioactivity of H. erinaceus in its ability to suppress adenosine triphosphate (ATP)-induced calcium signaling in neuronal PC12 cells. ATP, known primarily as a neurotransmitter, also acts on purinoceptors (P2 purinergic receptor [P2R]) to generate the cellular calcium signaling and secretion that mediate P2R physiological manifestations, including pain. Chronic pain reduces quality of life...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29168863/structure-characterization-of-a-novel-polysaccharide-from-hericium-erinaceus-fruiting-bodies-and-its-immunomodulatory-activities
#16
Fangfang Wu, Chunhui Zhou, Dandan Zhou, Shiyi Ou, Xiaoai Zhang, Huihua Huang
A novel polysaccharide fraction (HEP-S) was extracted and isolated from the fruiting bodies of Hericium erinaceus. Structural characterization revealed that HEP-S had an average molecular weight of 1.83 × 104 Da and consisted of rhamnose, fucose, mannose, glucose and galactose at a molar ratio of 1.47 : 0.93 : 1.36 : 8.68 : 4.08. Periodate oxidation-Smith degradation and NMR analysis showed that the main linkage types of HEP-S were composed of (1→)-α-d-Glc, (1→3,4)-α-d-Glc, (1→6)-α-d-Gal, (1→3,4)-β-d-Man, (1→3,6)-α-Rha and (1→2)-β-l-Fuc...
January 24, 2018: Food & Function
https://www.readbyqxmd.com/read/29156761/extracts-from-hericium-erinaceus-relieve-inflammatory-bowel-disease-by-regulating-immunity-and-gut-microbiota
#17
Chen Diling, Yang Xin, Zheng Chaoqun, Yang Jian, Tang Xiaocui, Chen Jun, Shuai Ou, Xie Yizhen
Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using solvent extraction methods) were administrated for 2 weeks in rats with IBD induced by trinitro-benzene-sulfonic acid (TNBS) enema (150 mg/kg). Significant clinical and histological changes in IBD rats were identified, including damage activity, common morphous and tissue damage index scores in colonic mucosa and myeloperoxidase (MPO) activity...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29091526/hericium-erinaceus-extract-reduces-anxiety-and-depressive-behaviors-by-promoting-hippocampal-neurogenesis-in-the-adult-mouse-brain
#18
Sun Ryu, Hyoun Geun Kim, Joo Youn Kim, Seong Yun Kim, Kyung-Ok Cho
Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain diseases. However, roles of HE in major psychiatric disorders such as depression and anxiety remain to be investigated. Therefore, we evaluated whether HE could reduce anxiety and depressive behaviors in the adult mouse and its underlying mechanisms. Male C57BL/6 mice were administered HE (20 or 60 mg/kg, p.o.) or saline once a day for 4 weeks. Open field and tail suspension tests were performed 30 min after the last administration of HE, followed by forced swim test 2 days later...
February 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28988842/a-novel-core-1-o-linked-glycan-specific-binding-lectin-from-the-fruiting-body-of-hericium-erinaceus
#19
Seonghun Kim
Mucin-type O-glycans are involved in biological functions on the cell surface as well as the glycoproteins and can also be used as specific carbohydrate biomarkers of many diseases. In this study, I purified a novel core 1 O-linked glycan specific lectin, Hericium erinaceus lecin (HeL), from the fruiting body of the mushroom Hericium erinaceus, which is known as the natural source for a sialic acid-binding lectin. Upon optimization of the purification conditions, a sequence of ion exchange, affinity, ion exchange, and size-exclusion chromatography resulted in the highest yield and best quality of lectin without protease activity...
February 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28965966/isolation-purification-and-physicochemical-properties-of-polysaccharide-from-fruiting-body-of-hericium-erinaceus-and-its-effect-on-colonic-health-of-mice
#20
Xiao-Yin Wang, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
Hericium erinaceus was extracted with boiling water to obtain the crude polysaccharide (HECP) and refined polysaccharide (HERP). HERP was further purified using gradual ethanol precipitation to obtain five sub-fractions. Their physicochemical properties were evaluated, including chemical components, monosaccharide composition and molecular weight. Meanwhile, the effect of HERP on colonic health of mice was investigated by oral administration at dosages of 100, 200 and 400mg/kg of body weight (mg/kgbw), comparing with that of HECP...
February 2018: International Journal of Biological Macromolecules
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