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Hericium erinaceus

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https://www.readbyqxmd.com/read/29156761/extracts-from-hericium-erinaceus-relieve-inflammatory-bowel-disease-by-regulating-immunity-and-gut-microbiota
#1
Chen Diling, Yang Xin, Zheng Chaoqun, Yang Jian, Tang Xiaocui, Chen Jun, Shuai Ou, Xie Yizhen
Hericium erinaceus (HE), a traditional edible mushroom, is known as a medicine food homology to ameliorate gastrointestinal diseases. To investigate whether HE is clinically effective in alleviating inflammatory bowel disease (IBD), HE extracts (polysaccharide, alcoholic extracts and whole extracts were prepared using solvent extraction methods) were administrated for 2 weeks in rats with IBD induced by trinitro-benzene-sulfonic acid (TNBS) enema (150 mg/kg). Significant clinical and histological changes in IBD rats were identified, including damage activity, common morphous and tissue damage index scores in colonic mucosa and myeloperoxidase (MPO) activity...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29091526/hericium-erinaceus-extract-reduces-anxiety-and-depressive-behaviors-by-promoting-hippocampal-neurogenesis-in-the-adult-mouse-brain
#2
Sun Ryu, Hyoun Geun Kim, Joo Youn Kim, Seong Yun Kim, Kyung-Ok Cho
Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain diseases. However, roles of HE in major psychiatric disorders such as depression and anxiety remain to be investigated. Therefore, we evaluated whether HE could reduce anxiety and depressive behaviors in the adult mouse and its underlying mechanisms. Male C57BL/6 mice were administered HE (20 or 60 mg/kg, p.o.) or saline once a day for 4 weeks. Open field and tail suspension tests were performed 30 min after the last administration of HE, followed by forced swim test 2 days later...
November 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28988842/a-novel-core-1-o-linked-glycan-specific-binding-lectin-from-the-fruiting-body-of-hericium-erinaceus
#3
Seonghun Kim
Mucin-type O-glycans are involved in biological functions on the cell surface as well as the glycoproteins and can also be used as specific carbohydrate biomarkers of many diseases. In this study, we purified a novel core 1 O-linked glycan specific lectin, Hericium erinaceus lecin (HeL), from the fruiting body of the mushroom Hericium erinaceus, which is known as the natural source for a sialic acid-binding lectin. Upon optimization of the purification conditions, a sequence of ion exchange, affinity, ion exchange, and size-exclusion chromatography resulted in the highest yield and best quality of lectin without protease activity...
October 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28965966/isolation-purification-and-physicochemical-properties-of-polysaccharide-from-fruiting-body-of-hericium-erinaceus-and-its-effect-on-colonic-health-of-mice
#4
Xiao-Yin Wang, Jun-Yi Yin, Shao-Ping Nie, Ming-Yong Xie
Hericium erinaceus was extracted with boiling water to obtain the crude polysaccharide (HECP) and refined polysaccharide (HERP). HERP was further purified using gradual ethanol precipitation to obtain five sub-fractions. Their physicochemical properties were evaluated, including chemical components, monosaccharide composition and molecular weight. Meanwhile, the effect of HERP on colonic health of mice was investigated by oral administration at dosages of 100, 200 and 400mg/kg of body weight (mg/kgbw), comparing with that of HECP...
September 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28951299/hericium-erinaceus-polysaccharide-facilitates-restoration-of-injured-intestinal-mucosal-immunity-in-muscovy-duck-reovirus-infected-muscovy-ducklings
#5
Yijian Wu, Huihui Jiang, Erpeng Zhu, Jian Li, Quanxi Wang, Wuduo Zhou, Tao Qin, Xiaoping Wu, Baocheng Wu, Yifan Huang
To elucidate the effect of Hericium erinaceus polysaccharide (HEP) on the intestinal mucosal immunity in normal and Muscovy duck reovirus (MDRV)-infected Muscovy ducklings, 1-day-old healthy Muscovy ducklings were pretreated with 0.2g/L HEP and/or following by MDRV infection in this study, duodenal samples were respectively collected at 1, 3, 6, 10, 15 and 21day post-infection, tissue sections were prepared for observation of morphological structure and determination of intestinal parameters (villus height/crypt depth ratio, villus surface area) as well as counts of intraepithelial lymphocytes (IELs), goblet cells, mast cells...
September 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28883631/antihyperglycaemic-and-organic-protective-effects-on-pancreas-liver-and-kidney-by-polysaccharides-from-hericium-erinaceus-sg-02-in-streptozotocin-induced-diabetic-mice
#6
Chen Zhang, Juan Li, Chunlong Hu, Jing Wang, Jianjun Zhang, Zhenzhen Ren, Xinling Song, Le Jia
The present work was designed to investigate the antihyperglycaemic and protective effects of two Hericium erinaceus intracellular polysaccharide (HIPS) purified fractions (HIPS1 and HIPS2) from mycelia of H. erinaceus SG-02 on pancreas, liver and kidney in streptozotocin (STZ)-induced diabetic mice. The supplementation of HIPS1 and HIPS2 significantly decreased the blood glucose (GLU) levels; suppressed the abnormal elevations of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea nitrogen (BUN) and creatinine (CRE) levels in serum; improved the antioxidant enzymatic (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)) activities; and attenuated the pathological damage to these organs...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860534/genomic-and-transcriptomic-analyses-reveal-differential-regulation-of-diverse-terpenoid-and-polyketides-secondary-metabolites-in-hericium-erinaceus
#7
Juan Chen, Xu Zeng, Yan Long Yang, Yong Mei Xing, Qi Zhang, Jia Mei Li, Ke Ma, Hong Wei Liu, Shun Xing Guo
The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus credited with anti-dementia activity and a producer of cyathane diterpenoid natural products (erinacines) useful against nervous system diseases. To date, few studies have explored the biosynthesis of these compounds, although their chemical synthesis is known. Here, we report the first genome and tanscriptome sequence of the medicinal fungus H. erinaceus. The size of the genome is 39.35 Mb, containing 9895 gene models. The genome of H...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859931/isoindolinone-containing-meroterpenoids-with-%C3%AE-glucosidase-inhibitory-activity-from-mushroom-hericium-caput-medusae
#8
Lin Chen, Zheng-Hui Li, Jian-Neng Yao, Yue-Ling Peng, Rong Huang, Tao Feng, Ji-Kai Liu
Hericium caput-medusae is an edible and medicinal mushroom closely relative to H. erinaceus. According to our detailed chemical investigation, two novel isoindolinone-containing meroterpene dimers, caputmedusins A (1) and B (2), as well as nine analogues, caputmedusins C-K (3-11), were isolated from the fermentation broth of H. caput-medusae. Their structures were elucidated by analyses of 1D and 2D NMR spectroscopic methods. The absolute configurations of 1-4 were speculated based on the specific optical rotation and biogenetic consideration...
October 2017: Fitoterapia
https://www.readbyqxmd.com/read/28854418/a-comparative-proteomic-analysis-of-erinacine-a-s-inhibition-of-gastric-cancer-cell-viability-and-invasiveness
#9
Hsing-Chun Kuo, Yur-Ren Kuo, Kam-Fai Lee, Meng-Chiao Hsieh, Cheng-Yi Huang, Yung-Yu Hsieh, Ko-Chao Lee, Hsiang-Lan Kuo, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Shui-Yi Tung
Background / Aims: Erinacine A, isolated from the ethanol extract of the Hericium erinaceus mycelium, has been demonstrated as a new alternative anticancer medicine. Drawing upon current research, this study presents an investigation of the molecular mechanism of erinacine A inhibition associated with gastric cancer cell growth. METHODS: Cell viability was determined by Annexin V-FITC/propidium iodide staining and migration using a Boyden chamber assay to determine the effects of erinacine A treatment on the proliferation capacity and invasiveness of gastric cancer cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28845772/volatile-composition-of-some-cultivated-and-wild-culinary-medicinal-mushrooms-from-hungary
#10
Mariann Csóka, Andras Geosel, Maria Amtmann, Kornel Korany
The volatile constituents of the fruiting bodies of 4 culinary-medicinal mushroom species (Agaricus bisporus, Boletus edulis, Cantharellus cibarius, and Hericium erinaceus) from Hungary were examined to review their aroma composition. Simultaneous distillation/extraction was applied to extract volatile compounds from fungi, and the values were measured with gas chromatography--mass spectrometry. Although the fragrances of fungi are not as characteristic as those of spices, several groups of volatile compounds have been found in mushrooms...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28758954/chemical-constituents-from-hericium-erinaceus-promote-neuronal-survival-and-potentiate-neurite-outgrowth-via-the-trka-erk1-2-pathway
#11
Cheng-Chen Zhang, Chen-Yu Cao, Miwa Kubo, Kenichi Harada, Xi-Tao Yan, Yoshiyasu Fukuyama, Jin-Ming Gao
Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of the secondary metabolites isolated from the MeOH extract of cultured mycelium of H. erinaceus and the primary mechanisms involved. One new dihydropyridine compound (6) and one new natural product (2) together with five known compounds (1,3-5,7) were obtained and their structures were elucidated by spectroscopic analysis, including 2D NMR and HRMS...
July 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28742114/a-unique-polysaccharide-purified-from-hericium-erinaceus-mycelium-prevents-oxidative-stress-induced-by-h2o2-in-human-gastric-mucosa-epithelium-cell
#12
Mingxing Wang, Nakajima Kanako, Yanqiu Zhang, Xulang Xiao, Qipin Gao, Konishi Tetsuya
Hericium erinaceus (HE) has been used both as a traditional Chinese medicine and home remedy for treatment of gastric and duodenal ulcers and gastritis. EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity. Because oxidative stress has been implicated as a pathogenic cause of gastritis and gastric ulcers, EP-1 antioxidant properties were systematically examined in vitro using the human gastric mucosal epithelial cell line, GES-1...
2017: PloS One
https://www.readbyqxmd.com/read/28740296/lithium-biofortification-of-medicinal-mushrooms-agrocybe-cylindracea-and-hericium-erinaceus
#13
Piotr Rzymski, Przemysław Niedzielski, Marek Siwulski, Mirosław Mleczek, Sylwia Budzyńska, Monika Gąsecka, Barbara Poniedziałek
Although an increase in dietary lithium (Li) has been suggested as a possible method for mood stabilization and for decreasing violence and suicidal rates, no Li-enriched food has entered the market. Here we continue to explore the feasibility of mushrooms in this respect and have investigated the growth, accumulation and mineral content (Ca, K, Mg and Na) of Agrocybe cylidracea and Hericium erinaceus cultivated on substrates supplemented with 0.25-1.0 mM of Li as acetate or chloride. As demonstrated, supplementation with LiCl yielded more satisfactory results, did not alter mushroom biomass, appearance, shape or size regardless of Li concentration...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28729219/immunomodulatory-effects-of-hydroxyethylated-hericium-erinaceus-polysaccharide-on-macrophages-raw264-7
#14
Zhe Ren, Tao Qin, Fuan Qiu, Yulong Song, Dandan Lin, Yufang Ma, Jian Li, Yifan Huang
Hericium erinaceus polysaccharide (HEP) has been shown to possess a variety of biological activities. In present study, HEP was successfully modified to obtain its hydroxyethylated derivative hHEP. Its potential immunomodulatory activities on RAW264.7 macrophages were investigated. Results showed that the hHEP were significantly stronger than that of the corresponding unmodified polysaccharide, HEP. Meanwhile, the NO, IL-6 and TNF-α production activities of macrophages were enhanced in the RAW264.7 macrophages by stimulation of hHEP...
December 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28713364/immunomodulatory-activities-of-a-fungal-protein-extracted-from-hericium-erinaceus-through-regulating-the-gut-microbiota
#15
Chen Diling, Zheng Chaoqun, Yang Jian, Li Jian, Su Jiyan, Xie Yizhen, Lai Guoxiao
A single-band protein (HEP3) was isolated from Hericium erinaceus using a chemical separation combined with pharmacodynamic evaluation methods. This protein exhibited immunomodulatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by decreasing the overproduction of tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and downregulating the expression of inducible nitric oxide synthase and nuclear factor-κB p65. Further researches revealed that HEP3 could improve the immune system via regulating the composition and metabolism of gut microbiota to activate the proliferation and differentiation of T cells, stimulate the intestinal antigen-presenting cells in high-dose cyclophosphamide-induced immunotoxicity in mice, and play a prebiotic role in the case of excessive antibiotics in inflammatory bowel disease model mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28553224/docking-studies-and-biological-evaluation-of-a-potential-%C3%AE-secretase-inhibitor-of-3-hydroxyhericenone-f-from-hericium-erinaceus
#16
Chen Diling, Yong Tianqiao, Yang Jian, Zheng Chaoqun, Shuai Ou, Xie Yizhen
Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting approximately more than 5% of the population worldwide over the age 65, annually. The incidence of AD is expected to be higher in the next 10 years. AD patients experience poor prognosis and as a consequence new drugs and therapeutic strategies are required in order to improve the clinical responses and outcomes of AD. The purpose of the present study was to screen a certain number of potential compounds from herbal sources and investigate their corresponding mode of action...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28443294/dataset-on-records-of-hericium-erinaceus-in-slovakia
#17
Vladimír Kunca, Marek Čiliak
The data presented in this article are related to the research article entitled "Habitat preferences of Hericium erinaceus in Slovakia" (Kunca and Čiliak, 2016) [FUNECO607] [2]. The dataset include all available and unpublished data from Slovakia, besides the records from the same tree or stem. We compiled a database of records of collections by processing data from herbaria, personal records and communication with mycological activists. Data on altitude, tree species, host tree vital status, host tree position and intensity of management of forest stands were evaluated in this study...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28351165/two-new-isobenzofuranone-derivatives-from-the-fruiting-bodies-of-hericium-erinaceus
#18
Jing Li, Xu-Li Wang, Guang Li, Ping-Sheng Xu, Kang-Ping Xu, Gui-Shan Tan
Two new isobenzofuranone derivatives erinaceolactones G and H (1 and 2) were isolated from the ethanolic extract of fruiting bodies of Hericium erinaceus. Their structures were characterized on the basis of spectroscopic evidences. Compound 2 was suggested to be racemic by specific rotation, which was resolved by chiral HPLC into enantiomers.
March 29, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28266682/immunomodulatory-effects-of-hericium-erinaceus-derived-polysaccharides-are-mediated-by-intestinal-immunology
#19
Xiaotong Sheng, Jingmin Yan, Yue Meng, Yuying Kang, Zhen Han, Guihua Tai, Yifa Zhou, Hairong Cheng
This study was aimed at investigating the immunomodulating activity of Hericium erinaceus polysaccharide (HEP) in mice, by assessing splenic lymphocyte proliferation (cell-mediated immunity), serum hemolysin levels (humoral immunity), phagocytic capacity of peritoneal cavity phagocytes (macrophage phagocytosis), and NK cell activity. ELISA of immunoglobulin A (SIgA) in the lamina propria, and western blotting of small intestinal proteins were also performed to gain insight into the mechanism by which HEP affects the intestinal immune system...
March 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28181079/anti-obesity-activity-of-yamabushitake-hericium-erinaceus-powder-in-ovariectomized-mice-and-its-potentially-active-compounds
#20
Eri Hiraki, Shoko Furuta, Rika Kuwahara, Naomichi Takemoto, Toshiro Nagata, Taiki Akasaka, Bungo Shirouchi, Masao Sato, Koichiro Ohnuki, Kuniyoshi Shimizu
Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract...
July 2017: Journal of Natural Medicines
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