Jaber Alizadehgoradel, Behnam Molaei, Khandan Barzegar Jalali, Asghar Pouresmali, Kiomars Sharifi, Amir-Homayun Hallajian, Vahid Nejati, Benedikt Glinski, Carmelo M Vicario, Michael A Nitsche, Mohammad Ali Salehinejad
Obsessive-compulsive disorder (OCD) is associated with a high disease burden, and treatment options are limited. We used intensified electrical stimulation in two dosages to target a main circuitry associated with the pathophysiology of OCD, left dorsolateral prefrontal cortex (l-DLPFC), and pre-supplementary motor area (pre-SMA) and assessed clinical outcomes, neuropsychological performance, and brain physiology. In a double-blind, randomized controlled trial, thirty-nine patients with OCD were randomly assigned to three groups of sham, 2-mA, or 1-mA transcranial direct current stimulation (tDCS) targeting the l-DLPFC (F3) and pre-SMA (FC2) with anodal and cathodal stimulation respectively...
February 5, 2024: Translational Psychiatry