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Iodine-131

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https://www.readbyqxmd.com/read/28966960/seeking-optimal-management-for-radioactive-iodine-therapy-induced-adverse-effects
#1
REVIEW
Andreas Charalambous
Radioactive iodine therapy (RAIT) is one of the important treatment modalities in the management of differentiated thyroid cancer (DTC). RAIT with iodine-131 has long been used in the management of DTC for the ablation of residual thyroid or treatment of its metastases. Despite being reasonably safe, radioiodine therapy is not always without side effects. Even relatively low administered activities of RAIT used for remnant ablation have been associated with the more clinically significant side effects of sialadenitis, xerostomia, salivary gland pain and swelling, dry eyes, excessive tearing, or alterations in taste in as many as 25% of patients...
October 2017: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28883260/a-case-of-metastatic-follicular-thyroid-carcinoma-complicated-with-graves-disease-after-total-thyroidectomy
#2
Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa, Akira Tangoku
Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28867113/precision-medicine-and-pet-computed-tomography-in-pediatric-malignancies
#3
REVIEW
Yasemin Sanli, Ebru Yilmaz, Rathan M Subramaniam
Fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET-computed tomography (CT) plays a significant role in diagnosis, staging, therapy selection, and therapy assessment of multiple pediatric malignancies and facilitating precision medicine delivery in pediatric patients. In patients with Hodgkin lymphoma, interim fludeoxyglucose (18)F-FDG PET/CT is highly sensitive and specific for predicting survival and multiple trials with FDG PET/CT-based adaptive therapies are currently ongoing. It is superior to iodine-131 metaiodobenzylguanidine ((131)I-MIBG) scintigraphy and bone scintigraphy for detecting metastases in neuroblastoma patients and sarcoma patients...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28856527/neonatal-outcomes-following-exposure-in-utero-to-fallout-from-chernobyl
#4
Maureen Hatch, Mark P Little, Alina V Brenner, Elizabeth K Cahoon, Valery Tereshchenko, Ludmyla Chaikovska, Igor Pasteur, Ilya Likhtarov, Andre Bouville, Victor Shpak, Olena Bolshova, Galyna Zamotayeva, Katherine Grantz, Liping Sun, Kiyohiko Mabuchi, Paul Albert, Mykola Tronko
Iodine 131 (I-131), the principal component of nuclear fallout from the Chernobyl accident, concentrates in the thyroid gland and may pose risks to fetal development. To evaluate this, neonatal outcomes following the accident in April of 1986 were investigated in a cohort of 2582 in utero-exposed individuals from northern Ukraine for whom estimates of fetal thyroid I-131 dose were available. We carried out a retrospective review of cohort members' prenatal, delivery and newborn records. The relationships of dose with neonatal anthropometrics and gestational length were modeled via linear regression with adjustment for potentially confounding variables...
August 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28834790/comparison-of-treatment-efficacy-1-and-2-years-after-thyroid-remnant-ablation-with-1110-versus-5550%C3%A2-mbq-of-iodine-131-in-patients-with-intermediate-risk-differentiated-thyroid-cancer
#5
Atena Aghaei, Narjess Ayati, Susan Shafiei, Bita Abbasi, S Rasoul Zakavi
BACKGROUND: Radioiodine ablation may be associated with improved survival in patients with intermediate-risk follicular cell differentiated thyroid cancer (FCDTC). The aim of this study was to compare ablation efficacy of 1110 versus 5500 MBq of iodine-131 (I) in FCDTC patients with intermediate risk. METHODS: Thirty-nine patients with intermediate-risk FCDTC (T3N0, T1-2N1b and T1-3N1a) were treated with 1110 MBq of I and compared with 43 age-matched and sex-matched patients who received 5550 MBq of I...
November 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28811561/analysis-of-risk-factors-of-rapid-thyroidal-radioiodine-131-turnover-in-graves-disease-patients
#6
Ruiguo Zhang, Jian Tan, Renfei Wang, Guizhi Zhang, Qiang Jia, Zhaowei Meng, Yueqian Zhang
Rapid iodine-131((131)I) turnover in the thyroid gland is an important feature of Graves' disease (GD) and also a strong predictor of radioiodine therapy failure. The aim of this study was to explore the predictors of rapid (131)I turnover. The clinical data on 2543 patients were retrospectively reviewed. Patients were divided into 2 groups depending on present or absent with rapid (131)I turnover defined as a 4-hour to 24-hour (131)I uptake ratio of ≥1. Overall, 590 cases (23.2%) had a rapid (131)I turnover...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800880/radioactive-iodine-131-i-uptake-in-an-ovarian-teratoma
#7
M Oporto, N Orta, F Cepa, M Pons, M Cabrer, C Peña
No abstract text is available yet for this article.
August 8, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28760238/selected-controversies-of-radioiodine-imaging-and-therapy-in-differentiated-thyroid-cancer
#8
REVIEW
Douglas Van Nostrand
This article discusses the more controversial areas of the management of differentiated thyroid cancer, namely, the utility of pretherapy staging radioiodine scans; the prescribed activity for iodine-131 remnant ablation, adjuvant treatment, and distant metastases; preparation with thyroid hormone withdrawal versus recombinant human thyroid-stimulating hormone; and the classification of radioiodine refractory differentiated thyroid cancer. The author reviews various aspects of the controversies, such as the recommendations of the 2015 guidelines of the American Thyroid Association, arguments for and against the various controversies, and selected references...
September 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28734182/using-medically-derived-iodine-131-to-track-sewage-effluent-in-the-laurentian-great-lakes
#9
Michael P Montenero, Elizabeth K Dilbone, James T Waples
Tracking sewage wastewater in a large lake is difficult. Concentrations of pharmaceuticals that can be used as indicator compounds are quickly diluted and not easy to measure. In this study, we examined the potential of using medically-derived iodine-131 ((131)I, t½ = 8.02 d) as a tracer for Milwaukee sewage effluent in Lake Michigan. (131)I activities in sewage effluent from two Milwaukee wastewater treatment plants (WWTPs) were measured in conjunction with (131)I activities in water, sediment and biota in the Milwaukee Outer Harbor and Lake Michigan...
October 15, 2017: Water Research
https://www.readbyqxmd.com/read/28727659/patient-release-criteria-following-radioactive-iodine-131-treatment-in-the-light-of-international-practice-where-does-south-africa-fit-in
#10
Modisenyane S Mongane, William I D Rae
The release from hospital of patients treated with radioactive iodine-131 (I) remains a controversial issue as a result of the range of guidelines implemented by national regulatory bodies responsible for radiation protection in various countries worldwide. The aim of this study was to review and analyse the literature on patient release criteria (PRC) applied internationally in an attempt to achieve a justifiable approach to setting equivalent criteria in South Africa. In 2016, the South African Department of Health, Directorate: Radiation Control added conditions (numbers 50 and 90), to licences to use radioactive nuclides...
October 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28714021/iodine-131-induces-apoptosis-in-human-cardiac-muscle-cells-through-the-p53-bax-caspase-3-and-pidd-caspase-2-t%C3%A2-bid-cytochrome%C3%A2-c-caspase-3-signaling-pathway
#11
Yansheng Wang, Changqing Liu, Jianchun Wang, Yang Zhang, Linlin Chen
The aim of this study was to elucidate the effects of iodine-131 on the induction of apoptosis in human cardiac muscle cells and the underlying molecular mechanisms. We found that iodine-131 reduced cell proliferation, induced apoptosis, induced p53, PIDD, t-BID (mitochondria) protein expression, suppressed cytochrome c (mitochondria) protein expression, and increased Bax protein expression, and promoted caspase-2, -3 and -9 expression levels in human cardiac muscle cells. Meanwhile, si-p53 inhibited the effects of iodine-131 on the reduction in cell proliferation and induction of apoptosis in human cardiac muscle cells through regulation of Bax/cytochrome c/caspase-3 and PIDD/caspase‑2/t-BID/cytochrome c/caspase-3 signaling pathway...
July 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28699814/survival-times-for-cats-with-hyperthyroidism-treated-with-a-3-35-mci-iodine-131-dose-a-retrospective-study-of-96-cases
#12
Marie Vagney, Loic Desquilbet, Edouard Reyes-Gomez, Françoise Delisle, Patrick Devauchelle, Maria Isabel Rodriguez-Piñeiro, Dan Rosenberg, Pauline de Fornel-Thibaud
Objectives Radioiodine ((131)I) dose determination using radiotracer kinetic studies or scoring systems, and fixed relatively high (131)I dose (ie, 4 or 5 mCi) administration, are effective and associated with prolonged survival times for hyperthyroid cats. The latter method is less complicated but could expose patients and veterinary personnel to unnecessary levels of radiation. The aim of this study was to retrospectively evaluate the efficacy of a fixed 3.35 mCi (131)I dose for the treatment of 96 hyperthyroid cats with no length estimation for any palpated goitre ⩾20 mm, assess outcome and identify factors associated with survival...
July 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28660918/iodine-131-labeled-transferrin-capped-polypyrrole-nanoparticles-for-tumor-targeted-synergistic-photothermal-radioisotope-therapy
#13
Xuejiao Song, Chao Liang, Liangzhu Feng, Kai Yang, Zhuang Liu
Combining different therapeutic functions within single tumor-targeted nanoscale delivery systems is promising to overcome the limitations of conventional cancer therapies. Herein, transferrin that recognizes transferrin receptors up-regulated on tumor cells is pre-labeled with iodine-131 ((131)I) and then utilized as the stabilizer in the fabrication of polypyrrole (PPy) nanoparticles. The obtained transferrin-capped PPy@Tf-(131)I nanoparticles could be used for tumor-targeted radioisotope therapy (RIT) and photothermal therapy (PTT), by employing beta-emission from (131)I and the intrinsic high near-infrared (NIR) absorbance of PPy, respectively...
August 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28651065/the-removal-of-particle-reactive-radionuclides-in-shallow-water-bottom-scavenging-versus-particle-settling-of-iodine-131-and-beryllium-7
#14
Michael P Montenero, Elizabeth K Dilbone, James T Waples
In pelagic waters, the removal of particle-reactive radionuclides is controlled by nuclide sorption to particles and subsequent settling by gravity. However, in shallow nearshore waters, the dominant mechanism of nuclide scavenging is not so clear. Understanding how particle-reactive radionuclides are scavenged from the water column is critical if these tracers are to be used as proxies of particle flux in shallow aquatic systems. In this study, we present evidence that the removal of particle-reactive radionuclides in nearshore and turbulent waters is primarily controlled by bottom scavenging...
October 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28622037/inhibition-of-the-akt-mtor-pathway-augments-the-anticancer-effects-of-sorafenib-in-thyroid-cancer
#15
Heqing Yi, Xuemei Ye, Bin Long, Ting Ye, Lijun Zhang, Fengqin Yan, Yang Yang, Linfa Li
BACKGROUND: Sorafenib is a multikinase inhibitor that has been approved for the treatment of patients with advanced (131)iodine ((131)I) refractory differentiated thyroid cancer (DTC). However, the progression-free survival of patients with advanced (131)I refractory DTC is short, and most DTC patients eventually acquire resistance to sorafenib. Therefore, new therapeutic strategies need to be developed. MATERIALS AND METHODS: The thyroid cancer cell lines 8505C and FTC133 were treated with sorafenib in the presence or absence of BEZ235 or small interfering RNA (siRNA) directed against AKT...
June 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28620714/the-outcome-of-i-131-ablation-therapy-for-intermediate-and-high-risk-differentiated-thyroid-cancer-using-a-strict-definition-of-successful-ablation
#16
Ken Watanabe, Mayuki Uchiyama, Kunihiko Fukuda
PURPOSE: This article examines the outcome of radioactive iodine ablation therapy for thyroid cancer in high-risk patients and investigates background factors influencing ablation failure. MATERIALS AND METHODS: We included 91 patients in this retrospective analysis and evaluated the ablation success rate. Successful ablation was defined as the absence of visible iodine-131 (I-131) accumulation in the thyroid bed after whole-body scans and thyroglobulin levels <2 ng/ml in a TSH-stimulated state after ablation...
June 15, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28572231/thyrotoxicosis-investigation-and-management%C3%A2
#17
REVIEW
Jackie Gilbert
Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism...
June 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28542643/correction-numerical-simulations-of-atmospheric-dispersion-of-iodine-131-by-different-models
#18
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0172312.].
2017: PloS One
https://www.readbyqxmd.com/read/28516979/interventional-sialendoscopy-for-radioiodine-induced-sialadenitis-quo-vadis
#19
P Canzi, S Cacciola, P Capaccio, F Pagella, A Occhini, L Pignataro, M Benazzo
Salivary gland toxicity is a common adverse effect of radioactive iodine ((131)I) for the treatment of thyroid cancers with a prevalence ranging from 2% to 67% of the (131)I exposed population. Recently, sialendoscopy has been introduced as an attractive diagnostic and therapeutic tool for management of patients with radioiodine-induced sialadenitis that is unresponsive to standard medical treatments. The objective of the current review was to assess the impact of this procedure on outcomes in patients suffering from radioiodine sialadenitis...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28505591/factors-associated-with-serum-thyroglobulin-in-a-ukrainian-cohort-exposed-to-iodine-131-from-the-accident-at-the-chernobyl-nuclear-plant
#20
Kamau O Peters, Mykola Tronko, Maureen Hatch, Valeriy Oliynyk, Galyna Terekhova, Ruth M Pfeiffer, Victor M Shpak, Robert J McConnell, Vladimir Drozdovitch, Mark P Little, Lydia B Zablotska, Kiyohiko Mabuchi, Alina V Brenner, Elizabeth K Cahoon
BACKGROUND: Serum thyroglobulin (Tg) is associated with the presence of thyroid disease and has been proposed as a biomarker of iodine status. Few studies have examined factors related to serum Tg in populations environmentally exposed to ionizing radiation and living in regions with endemic mild-to-moderate iodine deficiency. METHODS: We screened 10,430 individuals who were living in Ukraine and under 18 years of age at the time of the 1986 Chernobyl Nuclear Power Plant accident for thyroid disease from 2001 to 2003...
July 2017: Environmental Research
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