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Iodine-131

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https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#1
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29628632/expression-of-bax-and-bcl2-genes-in-peripheral-blood-lymphocytes-of-patients-with-differentiated-thyroid-cancer
#2
Zari Hamivand, Gholamhassan Haddadi, Reza Fardid
Context: Thyroid cancer is the most common endocrine malignancy worldwide. Iodine-131 is used in the treatment of thyroid cancer with dosage of 100 mCi. In the medical applications of ionizing radiation besides the advantages such as diagnosis and treatment of diseases, the risks arising from exposure should be considered as well. Aims: The present study aimed to evaluate the changes in expression levels of apoptotic Bax and Bcl-2 and the ratio of Bax/Bcl-2, in the peripheral blood lymphocytes (PBLs) of patients with differentiated thyroid cancer (DTC)...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29584908/methodology-at-ciemat-whole-body-counter-for-in-vivo-monitoring-of-radioiodine-in-the-thyroid-of-exposed-population-in-case-of-nuclear-emergency
#3
B Pérez López, J F Navarro, M A López
Iodine-131 is one of the main concerns from the point of view of radiological protection in a short term after a nuclear accident. The WBC Laboratory of CIEMAT has developed a methodology for in vivo monitoring of radioiodine in the thyroid of exposed individuals in case of emergency. Thyroid-neck phantoms of different sizes are required for calibrating the detection systems in appropriate counting geometries for the measurement of exposed population. A Low-Energy Germanium (LEGe) detector and a Fastscan Counter were calibrated using a set of thyroid phantoms fabricated by CIEMAT...
March 23, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29562827/location-and-causation-of-residual-lymph-node-metastasis-after-surgical-treatment-of-regionally-advanced-differentiated-thyroid-cancer
#4
Jessa E Miller, Neal C Al-Attar, Owen H Brown, Gabrielle G Shaughness, Natalja P Rosculet, Anca Avram, David T Hughes
BACKGROUND: After initial surgical treatment of differentiated thyroid cancer (DTC) residual lymph node metastases are often found at the time of radioactive iodine (131-I) therapy. Recurrence of DTC is due to persistent disease not removed at initial surgery and that did not respond to 131-I treatment. This study aims to determine locations of, and reasons for, residual nodal metastases detected by 131-I scans with SPECT/CT obtained prior to radioiodine therapy following surgical treatment of DTC...
March 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29522502/use-of-iodine-131-to-tellurium-132-ratios-for-assessing-the-relationships-between-human-inhaled-radioactivity-and-environmental-monitoring-after-the-accident-in-fukushima
#5
Koji Uchiyama, Masami Miyashita, Yoshinobu Tanishima, Shigenobu Maeda, Hitoshi Sato, Jun Yoshikawa, Shuji Watanabe, Masamichi Shibata, Shuji Ohhira, Gen Kobashi
Significant differences in findings were seen between the intake amounts of iodine-131 that were derived from direct measurements and the estimated intake from environmental monitoring data at the Fukushima accident. To clarify these discrepancies, we have investigated the iodine-131 and tellurium-132 body burdens of five human subjects, who after being exposed to a radioactive plume, underwent 21.5 h whole body counter measurements at Fukui Prefectural Hospital, so clear intake scenario and thyroid counter measurement data were available...
March 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29498418/papillary-thyroid-carcinoma-recurrence-low-yield-of-neck-ultrasound-with-an-undetectable-serum-thyroglobulin-level
#6
Samantha Epstein, Rachel McEachern, Rachita Khot, Shetal Padia, James T Patrie, Jason N Itri
OBJECTIVES: To assess the yield of neck ultrasound (US) when serum thyroglobulin (Tg) is undetectable (<0.1 ng/mL) compared to elevated serum Tg in patients with differentiated papillary thyroid carcinoma (PTC) treated with thyroidectomy and radioactive iodine 131 (RAI) ablation. METHODS: A retrospective chart review was conducted from 2010 through 2015 at an academic institution evaluating US results in patients with serum Tg levels obtained within 6 months of a neck US examination after thyroidectomy and RAI...
March 2, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29480611/radioactive-iodine-an-unappreciated-threat-to-salivary-gland-function
#7
G Sunavala-Dossabhoy
Thyroid cancer is an endocrine malignancy whose prevalence is increasing in the United States. Nearly 57,000 new cases of thyroid cancer are estimated to be diagnosed in 2017. The standard of care for differentiated thyroid cancer is thyroidectomy followed by ablation of thyroid remnants with high-dose radioactive iodine (131 I). Apart from thyroid glands,131 I accumulates in cells of salivary glands and compromises its function. Xerostomia is, therefore, a frequent and often persistent complaint of patients...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29475590/validation-of-iodine-131-meta-iodobenzylguanidine-cardiac-scintigraphy-in-parkinsonism-a-preliminary-study
#8
Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
INTRODUCTION: 123 I-MIBG is the most commonly used radiopharmaceutical to depict cardiac sympathetic innervation. The purpose of this study was to validate the feasibility of131 I-MIBG as an alternative myocardial sympathetic imaging probe in differential diagnosis of Parkinsonism. METHODS: We recruited 17 patients with PD, 21 patients with other parkinsonism (17 with MSA and 4 with PSP), and 6 normal controls. All participants underwent131 I-MIBG scintigraphy for both early and delayed imaging...
February 14, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29467858/effects-of-iodine-131-radiotherapy-on-th17-tc17-and-treg-th17-cells-of-patients-with-differentiated-thyroid-carcinoma
#9
Lixia Zhang, Jinyan Chen, Caiyun Xu, Lili Qi, Yan Ren
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (131 I) therapy, and to elucidate the probable effects of131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29465605/a-false-positive-i-131-finding-of-duodenum-diverticulum-in-thyroid-cancer-evaluation-by-spect-ct-a-case-report
#10
Rang Wang, Ke Zhou, Qiuping Fan, Haotian Chen, Chengzhong Fan
RATIONALE: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCERNS: A 44-year-old woman with a papillary thyroid carcinoma for the purpose of ablation therapy after a total thyroidectomy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29459090/-thyroid-carcinoma-on-struma-ovarii-diagnosis-and-treatment
#11
REVIEW
Coriolan Lebreton, Abir Al Ghuzlan, Anne Floquet, Michèle Kind, Sophie Leboulleux, Yann Godbert
Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, the treatment of TCSO is not consensual and should be validated in multidisciplinary team involved in rare ovarian carcinoma. The first treatment is a surgical removal, with a laparoscopic approach...
February 16, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29442477/role-of-thyroid-ultrasound-combined-with-thyroglobulin-in-the-diagnosis-of-postoperative-recurrence-of-thyroid-cancer
#12
Li Zhang, Guilan Zou
BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice. METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29430110/vitamins-e-and-c-prevent-dna-double-strand-breaks-in-peripheral-lymphocytes-exposed-to-radiations-from-iodine-131
#13
Mehdi Safaei, Seyed Masoud Jafarpour, Mehran Mohseni, Morteza Salimian, Hossein Akbari, Fateme Karami, Akbar Aliasgharzadeh, Bagher Farhood
Purpose: Iodine-131 is used as a radiopharmaceutical to treat thyroid cancer. The current study aimed to evaluate the effects of vitamins E and C on the level of DNA double-strand breaks (DSBs) caused by Radioiodine-131 (I-131) in human lymphocytes. Materials and Methods: Whole blood samples from human volunteers were incubated with a certain concentration of vitamins. After 1-h incubation, the samples were incubated with 20 μCi I-131/2 mL (blood + NaCl) for 1 h...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29393056/inguinal-endometriosis-visualized-on-i-131-whole-body-scan
#14
Derya Çayır, Mine Araz, Mahmut Apaydın, Erman Çakal
We present a rare case with inguinal iodine-131 (I-131) uptake on whole body scan. The patient was suffering from a painful right inguinal mass during menstrual period, which was later sonographically and histopathologically confirmed to be an inguinal focus of endometriosis. Endometriosis is a previously reported site of radioiodine uptake and detection of radioiodine uptake in the inguinal region has also been described. Nevertheless, to the best of our knowledge, this is the first case report of I-131 uptake in an inguinal endometriosis focus...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29390537/anca-positive-relapsing-polychondritis-graves-disease-and-suspected-moyamoya-disease-a-case-report
#15
Yi-Yi Xuan, Tian-Fang Li, Lei Zhang, Sheng-Yun Liu
RATIOINALE: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Central involvement of RP is very rare, and there is almost no report of cerebral vasculopathy manifested as moyamoya...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387983/factors-involved-in-early-lenvatinib-dose-reduction-a-retrospective-analysis
#16
Koichi Suyama, Mai Tomiguchi, Takashi Takeshita, Aiko Sueta, Mutsuko Yamamoto-Ibusuki, Mototsugu Shimokawa, Yutaka Yamamoto, Hirotaka Iwase
Lenvatinib, a multi-tyrosine kinase inhibitor, has been proven to be an effective treatment option for patients with iodine-131-refractory thyroid cancer. Many adverse effects of lenvatinib have been reported; thus, dose reduction is common. However, a few studies have analyzed the causes of lenvatinib dose reduction in daily clinical practice. Here, we investigate the factors involved in early lenvatinib dose reduction to analyze lenvatinib dose modification. We analyzed 20 thyroid cancer patients who began receiving lenvatinib at the Kumamoto University Hospital Cancer Center from July 2015 to November 2016...
January 31, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29315139/-dtpa-pabn-leu5-des-acyl-ghrelin-1-5-as-a-new-carrier-of-radionuclides-and-potential-precursor-of-radiopharmaceuticals
#17
Grzegorz Wójciuk, Marcin Kruszewski
BACKGROUND: Ghrelin is a peptide consisting of 28 aminoacids and an octadecyl side chain (acyl group) binding to the growth hormone secretagogue receptor type 1a (GHS-R1a). Its des-acylated form, des-acyl ghrelin (DAG) binds to the corticotropin releasing factor receptor type 2a (CRF2a) located on endocrine cancer cells such as the prostate carcinoma cell line DU 145. AIM: The aim of this study is to develop a new DAG-based carrier of radionuclides with potential application in therapy...
February 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29314561/biodistribution-and-tolerance-of-intravenous-iodine-131-labelled-hypericin-in-healthy-dogs
#18
E Abma, K Peremans, F De Vos, T Bosmans, A M Kitshoff, S Daminet, Y Ni, R Dockx, H de Rooster
Hypericin (Hyp) is a necrosis-avid compound that can be efficiently labelled with radioiodine for both diagnostic and therapeutic purposes. Before 131 I-Hyp can be considered as a clinically useful drug in a combination therapy for canine cancer patients, evaluation of its toxicity is necessary. The aim of this study was to investigate the biodistribution and tolerance of a single dose administration of 131 I-Hyp. Three healthy dogs were included. 131 I-Hyp at a dose of 0.2 mg/kg and an activity of 185 MBq was intravenously injected...
January 4, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29305726/evaluation-of-necrosis-avidity-and-potential-for-rapid-imaging-of-necrotic-myocardium-of-radioiodinated-hypocrellins
#19
Qiaomei Jin, Juanzhi Zhao, Meng Gao, Yuanbo Feng, Wei Liu, Zhiqi Yin, Tiannv Li, Shaoli Song, Yicheng Ni, Jian Zhang, Dejian Huang, Dongjian Zhang
PURPOSE: Rapid noninvasive delineation of necrotic myocardium in ischemic regions is very critical for risk stratification and clinical decision-making but still challenging. This study aimed to evaluate the necrosis avidity of radioiodinated hypocrellins and its potential for rapidly imaging necrotic myocardium. PROCEDURES: The aggregation constants of four natural hypocrellins were analyzed by UV/vis spectroscopy. Then, they were radiolabeled with iodine-131 by iodogen oxidation method...
January 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29286504/features-of-morfological-changes-in-primary-thyroid-gland-ctll-cultures-of-rats-descendants-prenatally-exposed-by-radioisotopes-of-iodine-131
#20
O A Boiko, H Yo Lavrenchuk, A I Lypska, V V Talko, V S Asmolkov
OBJECTIVE: to investigate morphological changes in the primary thyroid cell culture of rat infants whose parents were prenatally exposed by radioisotope iodine 131. MATERIALS AND METHODS: obtaining and culturing of thyroid tissue primary cell cultures of newborn rats, cytological (receipt and analysis of cell cultures agents for optical microscopy), biophysical (flow cytometry), statistics. RESULTS: It was shown that cells in thyroid primary culture of offspring rats prenatally exposed by radioisotopes of iodine 131 signs of destructive degenerative changes were observed mostly when animals of both sexes were irra diated...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
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