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Iodine-131

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https://www.readbyqxmd.com/read/29899030/possible-delayed-diagnosis-and-treatment-of-metastatic-differentiated-thyroid-cancer-by-adopting-the-2015-ata-guidelines
#1
Domenico Albano, Francesco Bertagna, Mattia Bonacina, Rexhep Durmo, Elisabetta Cerudelli, Maria Gazzilli, Maria Beatrice Panarotto, Anna Maria Formenti, Gherando Mazziotti, Andrea Giustina, Raffaele Giubbini
OBJECTIVE: According to the 2015 ATA guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim of our study was to retrospectively analyze the prevalence of metastatic disease before and after I-131 and to evaluate the influence of the new ATA guidelines in the management of DTC. METHODS: We retrospectively analyzed 140 patients showing distant metastases...
June 13, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29867775/teriparatide-replacement-therapy-for-hypoparathyroidism-during-treatment-with-lenvatinib-for-advanced-thyroid-cancer-a-case-report
#2
Tommaso Porcelli, Francesca Sessa, Angela Caputo, Christian Catalini, Domenico Salvatore
Thyroid cancer metastasizes in 4% of cases. Approximately two-thirds of these patients are refractory to radioactive iodine-131 (RAI) therapy and have a poor 10-year survival prognosis. Treatment with tyrosine kinase inhibitors (TKIs) may be administered in selected RAI-refractory patients. However, these agents are often associated with adverse events, including vomiting. We report the case of a patient affected by RAI-refractory thyroid cancer with lung and intracranial metastases undergoing treatment with the antiangiogenic TKI lenvatinib, and with teriparatide replacement therapy for postsurgical hypoparathyroidism...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29807824/outcome-after-ablation-in-patients-with-low-risk-thyroid-cancer-estimabl1-5-year-follow-up-results-of-a-randomised-phase-3-equivalence-trial
#3
Martin Schlumberger, Sophie Leboulleux, Bogdan Catargi, Desiree Deandreis, Slimane Zerdoud, Stephane Bardet, Daniela Rusu, Yann Godbert, Camille Buffet, Claire Schvartz, Pierre Vera, Olivier Morel, Danielle Benisvy, Claire Bournaud, Marie-Elisabeth Toubert, Antony Kelly, Ellen Benhamou, Isabelle Borget
BACKGROUND: In ESTIMABL1, a randomised phase 3 trial of radioactive iodine (131 I) administration after complete surgical resection in patients with low-risk thyroid cancer, 92% of patients had complete thyroid ablation at 6-10 months, defined as a recombinant human thyroid-stimulating hormone (rhTSH)-stimulated serum thyroglobulin concentration of 1 ng/mL or less and normal findings on neck ultrasonography. Equivalence was shown between low-activity (1·1 GBq) and high-activity (3·7 GBq) radioactive iodine and also between the use of rhTSH injections and thyroid hormone withdrawal...
May 25, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29756327/use-of-radioiodine-131-scan-to-measure-influence-of-surgical-discipline-practice-and-volume-on-residual-thyroid-tissue-after-total-thyroidectomy-for-differentiated-thyroid-carcinoma
#4
Jin Soo A Song, Nico Moolman, Steven Burrell, Murali Rajaraman, Martin Joseph Bullock, Jonathan Trites, S Mark Taylor, Matthew H Rigby, Robert D Hart
BACKGROUND: Our study's purpose is to determine the influence of surgical discipline, surgeon site, and volume on remnant thyroid tissue visualized on radioactive iodine-131 (I-131) scans after total thyroidectomy and I-131 ablation in patients with well-differentiated thyroid carcinomas. METHODS: We retrospectively reviewed all cases of patients who received I-131 therapeutic ablation and postablation radioactive I-131 scans at our center after thyroidectomy to calculate the fraction of administered dose multiplied by 1000 (UDR1000)...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29737084/-preparation-of-131-i-labeled-collagen-chitosan-microspheres-and-it-s-antitumor-effect-on-human-liver-cancer
#5
Fu-Wen Pang, Hua-Wei Cai, Yu-Hao Li, Wen-Jie Zhang, Lin Li
OBJECTIVE: To prepare iodine-131(131 I) labeled biodegradable microspheres with chitosan and collagen for treating liver cancer. METHODS: Collagen-chitosan microspheres (CCMSs) were prepared with type-Ⅰ collagen and chitosan using emulsification-chemical cross-linking method. The size of the CCMSs were determined by electron microscope. 131 I-CCMSs were achieved using Chloramine-T. The labelling rate of 131 I was recorded. The stability of 131 I-CCMSs in vitro were evaluated in PBS or human blood serum through 192 h incubation...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#6
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
June 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29628632/expression-of-bax-and-bcl2-genes-in-peripheral-blood-lymphocytes-of-patients-with-differentiated-thyroid-cancer
#7
Zari Hamivand, Gholamhassan Haddadi, Reza Fardid
Context: Thyroid cancer is the most common endocrine malignancy worldwide. Iodine-131 is used in the treatment of thyroid cancer with dosage of 100 mCi. In the medical applications of ionizing radiation besides the advantages such as diagnosis and treatment of diseases, the risks arising from exposure should be considered as well. Aims: The present study aimed to evaluate the changes in expression levels of apoptotic Bax and Bcl-2 and the ratio of Bax/Bcl-2, in the peripheral blood lymphocytes (PBLs) of patients with differentiated thyroid cancer (DTC)...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29584908/methodology-at-ciemat-whole-body-counter-for-in-vivo-monitoring-of-radioiodine-in-the-thyroid-of-exposed-population-in-case-of-nuclear-emergency
#8
B Pérez López, J F Navarro, M A López
Iodine-131 is one of the main concerns from the point of view of radiological protection in a short term after a nuclear accident. The WBC Laboratory of CIEMAT has developed a methodology for in vivo monitoring of radioiodine in the thyroid of exposed individuals in case of emergency. Thyroid-neck phantoms of different sizes are required for calibrating the detection systems in appropriate counting geometries for the measurement of exposed population. A Low-Energy Germanium (LEGe) detector and a Fastscan Counter were calibrated using a set of thyroid phantoms fabricated by CIEMAT...
March 23, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29562827/location-and-causation-of-residual-lymph-node-metastasis-after-surgical-treatment-of-regionally-advanced-differentiated-thyroid-cancer
#9
Jessa E Miller, Neal C Al-Attar, Owen H Brown, Gabrielle G Shaughness, Natalja P Rosculet, Anca M Avram, David T Hughes
BACKGROUND: After initial surgical treatment of differentiated thyroid cancer (DTC) residual lymph node metastases are often found at the time of radioactive iodine (131 I) therapy. Recurrence of DTC is due to persistent disease not removed at initial surgery which also did not respond to 131 I treatment. This study aimed at determining locations of, and reasons for, residual nodal metastases detected by 131 I scans with single-photon emission computed tomography (SPECT/CT) obtained prior to radioiodine therapy following surgical treatment of DTC...
May 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29522502/use-of-iodine-131-to-tellurium-132-ratios-for-assessing-the-relationships-between-human-inhaled-radioactivity-and-environmental-monitoring-after-the-accident-in-fukushima
#10
Koji Uchiyama, Masami Miyashita, Yoshinobu Tanishima, Shigenobu Maeda, Hitoshi Sato, Jun Yoshikawa, Shuji Watanabe, Masamichi Shibata, Shuji Ohhira, Gen Kobashi
Significant differences in findings were seen between the intake amounts of iodine-131 that were derived from direct measurements and the estimated intake from environmental monitoring data at the Fukushima accident. To clarify these discrepancies, we have investigated the iodine-131 and tellurium-132 body burdens of five human subjects, who after being exposed to a radioactive plume, underwent 21.5 h whole body counter measurements at Fukui Prefectural Hospital, so clear intake scenario and thyroid counter measurement data were available...
March 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29498418/papillary-thyroid-carcinoma-recurrence-low-yield-of-neck-ultrasound-with-an-undetectable-serum-thyroglobulin-level
#11
Samantha Epstein, Rachel McEachern, Rachita Khot, Shetal Padia, James T Patrie, Jason N Itri
OBJECTIVES: To assess the yield of neck ultrasound (US) when serum thyroglobulin (Tg) is undetectable (<0.1 ng/mL) compared to elevated serum Tg in patients with differentiated papillary thyroid carcinoma (PTC) treated with thyroidectomy and radioactive iodine 131 (RAI) ablation. METHODS: A retrospective chart review was conducted from 2010 through 2015 at an academic institution evaluating US results in patients with serum Tg levels obtained within 6 months of a neck US examination after thyroidectomy and RAI...
March 2, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29480611/radioactive-iodine-an-unappreciated-threat-to-salivary-gland-function
#12
G Sunavala-Dossabhoy
Thyroid cancer is an endocrine malignancy whose prevalence is increasing in the United States. Nearly 57,000 new cases of thyroid cancer are estimated to be diagnosed in 2017. The standard of care for differentiated thyroid cancer is thyroidectomy followed by ablation of thyroid remnants with high-dose radioactive iodine (131 I). Apart from thyroid glands, 131 I accumulates in cells of salivary glands and compromises its function. Xerostomia is, therefore, a frequent and often persistent complaint of patients...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29475590/validation-of-iodine-131-meta-iodobenzylguanidine-cardiac-scintigraphy-in-parkinsonism-a-preliminary-study
#13
Dan Xu, Wenjia Zhu, Li Huo, Shikun Zhu, Fang Li, Han Wang
INTRODUCTION: 123 I-MIBG is the most commonly used radiopharmaceutical to depict cardiac sympathetic innervation. The purpose of this study was to validate the feasibility of 131 I-MIBG as an alternative myocardial sympathetic imaging probe in differential diagnosis of Parkinsonism. METHODS: We recruited 17 patients with PD, 21 patients with other parkinsonism (17 with MSA and 4 with PSP), and 6 normal controls. All participants underwent 131 I-MIBG scintigraphy for both early and delayed imaging...
May 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29467858/effects-of-iodine-131-radiotherapy-on-th17-tc17-and-treg-th17-cells-of-patients-with-differentiated-thyroid-carcinoma
#14
Lixia Zhang, Jinyan Chen, Caiyun Xu, Lili Qi, Yan Ren
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells serve important roles in a number of inflammatory and autoimmune diseases. The aim of the present study was to examine the distribution of Th17, Tc17 and Treg cells in patients with differentiated thyroid cancer (DTC) prior to as well as 7, 30 and 90 days following radioactive iodine-131 (131 I) therapy, and to elucidate the probable effects of 131 I therapy on Th17/Tc17 and Treg/Th17 cells in patients with DTC. A total of 40 patients with DTC (26 female; 14 male) between the ages of 24 and 72 years, as well as 13 age- and sex-matched healthy subjects were included in this study...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29465605/a-false-positive-i-131-finding-of-duodenum-diverticulum-in-thyroid-cancer-evaluation-by-spect-ct-a-case-report
#15
Rang Wang, Ke Zhou, Qiuping Fan, Haotian Chen, Chengzhong Fan
RATIONALE: Iodine-131 (I-131) is a sensitive marker for the detection of differentiated thyroid cancer (DTC). I-131 whole-body scintigraphy (WBS) has been used widely in evaluation of DTC patient. However, I-131 WBS exists many false-positive uptake of I-131 because radioiodine uptake can also be seen in healthy tissue or in a variety of benign and malignant non-thyroidal tumors. PATIENT CONCERNS: A 44-year-old woman with a papillary thyroid carcinoma for the purpose of ablation therapy after a total thyroidectomy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29459090/-thyroid-carcinoma-on-struma-ovarii-diagnosis-and-treatment
#16
REVIEW
Coriolan Lebreton, Abir Al Ghuzlan, Anne Floquet, Michèle Kind, Sophie Leboulleux, Yann Godbert
Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Because of its rarity, the treatment of TCSO is not consensual and should be validated in multidisciplinary team involved in rare ovarian carcinoma. The first treatment is a surgical removal, with a laparoscopic approach...
March 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29442477/role-of-thyroid-ultrasound-combined-with-thyroglobulin-in-the-diagnosis-of-postoperative-recurrence-of-thyroid-cancer
#17
Li Zhang, Guilan Zou
BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice. METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29430110/vitamins-e-and-c-prevent-dna-double-strand-breaks-in-peripheral-lymphocytes-exposed-to-radiations-from-iodine-131
#18
Mehdi Safaei, Seyed Masoud Jafarpour, Mehran Mohseni, Morteza Salimian, Hossein Akbari, Fateme Karami, Akbar Aliasgharzadeh, Bagher Farhood
Purpose: Iodine-131 is used as a radiopharmaceutical to treat thyroid cancer. The current study aimed to evaluate the effects of vitamins E and C on the level of DNA double-strand breaks (DSBs) caused by Radioiodine-131 (I-131) in human lymphocytes. Materials and Methods: Whole blood samples from human volunteers were incubated with a certain concentration of vitamins. After 1-h incubation, the samples were incubated with 20 μCi I-131/2 mL (blood + NaCl) for 1 h...
January 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29393056/inguinal-endometriosis-visualized-on-i-131-whole-body-scan
#19
Derya Çayır, Mine Araz, Mahmut Apaydın, Erman Çakal
We present a rare case with inguinal iodine-131 (I-131) uptake on whole body scan. The patient was suffering from a painful right inguinal mass during menstrual period, which was later sonographically and histopathologically confirmed to be an inguinal focus of endometriosis. Endometriosis is a previously reported site of radioiodine uptake and detection of radioiodine uptake in the inguinal region has also been described. Nevertheless, to the best of our knowledge, this is the first case report of I-131 uptake in an inguinal endometriosis focus...
February 1, 2018: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/29390537/anca-positive-relapsing-polychondritis-graves-disease-and-suspected-moyamoya-disease-a-case-report
#20
Yi-Yi Xuan, Tian-Fang Li, Lei Zhang, Sheng-Yun Liu
RATIOINALE: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Central involvement of RP is very rare, and there is almost no report of cerebral vasculopathy manifested as moyamoya...
December 2017: Medicine (Baltimore)
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