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Iodine-131

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https://www.readbyqxmd.com/read/28225997/intrathoracic-stomach-mimicking-bone-metastasis-from-thyroid-cancer-in-whole-body-iodine-131-scan-diagnosed-by-spect-ct
#1
Francisco Javier García-Gómez, Pablo Antonio de la Riva-Pérez, Cinta Calvo-Morón, Cristina Buján-Lloret, Teresa Cambil-Molina, Juan Castro-Montaño
The whole-body iodine-131 scintigraphy is an imaging technique in monitoring patients with a history of thyroid cancer. Although the rate of false positives is negligible, it is not nonexistent. We report the case of an intervened and treated patient for thyroid cancer with good clinical and biochemical response. Scintigraphic findings were consistent with unsuspected bone metastasis. Fused SPECT/CT data allowed accurate diagnosis of giant diaphragmatic hernia associated with intrathoracic stomach, a very rare pathology that can lead to false positive results...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28224279/np-59-test-for-preoperative-localization-of-primary-hyperaldosteronism
#2
Marcello Di Martino, Iñigo García Sanz, Jose Luis Muñoz de Nova, Cristina Marín Campos, Miguel Martínez Martín, Luis Domínguez Gadea
PURPOSE: Adrenal venous sampling is generally considered the gold standard to identify unilateral hormone production in cases of primary hyperaldosteronism. The aim of this study is to evaluate whether the iodine-131-6-β-iodomethyl-19-norcholesterol (NP-59) test may represent an alternative in selected cases. METHODS: Patients submitted to laparoscopic adrenalectomy for suspected primary hyperaldosteronism (n = 27) were retrospectively reviewed. When nuclear medicine tests were preoperatively performed, their results were compared with the histopathologic findings and clinical improvement...
February 21, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28217013/contributions-to-the-study-of-blood-brain-flux-using-radioactive-tracers
#3
Ioan Mureşan, Ioan Cosma
In this paper, we present an original radiocirculographic method for investigates of cerebral blood flow, which has proven to be very useful, simple, and efficient for studies of brain hemodynamics. Physical considerations on injected radioactive tracer in cardiovascular system, allowed us to state a relationship for the blood flux, F, valued as the amount of fluid-blood that traverses a vascular segment in unit time. All these theoretical facts, along with a host of remarkable clinical results, are presented in a doctoral thesis entitled "The cerebral Hemodynamics in Essential Hypertension and Arteriosclerosis" of the eminent doctor Ioan Mures,an, who died in 1984, at only 50 years old...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28213878/cotransfecting-norepinephrine-transporter-and-vesicular-monoamine-transporter-2-genes-for-increased-retention-of-metaiodobenzylguanidine-labeled-with-iodine-131-in-malignant-hepatocarcinoma-cells
#4
Yanlin Zhao, Xiao Zhong, Xiaohong Ou, Huawei Cai, Xiaoai Wu, Rui Huang
Norepinephrine transporter (NET) transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine ((131)I-MIBG) in non-neuroendocrine tumors. However, the use of (131)I-MIBG is limited by its short retention time in target cells. To prolong the retention of (131)I-MIBG in target cells, we infected hepatocarcinoma (HepG2) cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 (VMAT2) genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines...
February 17, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28207853/numerical-simulations-of-atmospheric-dispersion-of-iodine-131-by-different-models
#5
Ádám Leelőssy, Róbert Mészáros, Attila Kovács, István Lagzi, Tibor Kovács
Nowadays, several dispersion models are available to simulate the transport processes of air pollutants and toxic substances including radionuclides in the atmosphere. Reliability of atmospheric transport models has been demonstrated in several recent cases from local to global scale; however, very few actual emission data are available to evaluate model results in real-life cases. In this study, the atmospheric dispersion of 131I emitted to the atmosphere during an industrial process was simulated with different models, namely the WRF-Chem Eulerian online coupled model and the HYSPLIT and the RAPTOR Lagrangian models...
2017: PloS One
https://www.readbyqxmd.com/read/28182580/internal-dosimetry-with-the-monte-carlo-code-gate-validation-using-the-icrp-icru-female-reference-computational-model
#6
Daphnée Villoing, Sara Marcatili, Marie-Paule Garcia, Manuel Bardiès
The purpose of this work was to validate GATE-based clinical scale absorbed dose calculations in nuclear medicine dosimetry. GATE (version 6.2) and MCNPX (version 2.7.a) were used to derive dosimetric parameters (absorbed fractions, specific absorbed fractions and S-values) for the reference female computational model proposed by the International Commission on Radiological Protection in ICRP report 110. Monoenergetic photons and electrons (from 50 keV to 2 MeV) and four isotopes currently used in nuclear medicine (fluorine-18, lutetium-177, iodine-131 and yttrium-90) were investigated...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28169221/gaussian-plume-atmospheric-modelling-and-radiation-exposure-calculations-following-the-cremation-of-a-deceased-thyroid-cancer-patient-treated-with-iodine-131
#7
Phillipe J Calais
Shortly after treatment with 7200 MBq of (131)I, a thyroid cancer patient died and was subsequently cremated. Calculations of the atmospheric emissions of (131)I from the crematorium flue were performed using a standard atmospheric pollution Gaussian Plume Dispersal model. Estimates of whole-body and thyroid dose of those potentially exposed were made using OLINDA/EXM dosimetry software. Under the meteorological conditions prevalent at the time of the cremation, and depending on the actual release rate of the (131)I, the Western Australian legal limit of 3...
February 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28151911/risk-factors-of-hepatic-dysfunction-in-patients-with-graves-hyperthyroidism-and-the-efficacy-of-131iodine-treatment
#8
Renfei Wang, Jian Tan, Guizhi Zhang, Wei Zheng, Chengxia Li
Hepatic dysfunction is often observed in patients with Graves' hyperthyroidism. The aims of this study were to investigate the risk factors for hepatic dysfunction and to analyze the efficacy of I (radioactive iodine-131) treatment. In total, 2385 patients with Graves' hyperthyroidism (478 males, 1907 females; age 42.8 ± 13.5 years) were involved in our study. Of these, 1552 cases with hepatic dysfunction received I treatment. All clinical data were retrospectively reviewed to explore the risk factors associated with hepatic dysfunction using logistic regression analysis...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28127555/preparation-and-characterization-of-hyaluronic-acid-polycaprolactone-copolymer-micelles-for-the-drug-delivery-of-radioactive-iodine-131-labeled-lipiodol
#9
Shih-Cheng Chen, Ming-Hui Yang, Tze-Wen Chung, Ting-Syuan Jhuang, Jean-Dean Yang, Ko-Chin Chen, Wan-Jou Chen, Ying-Fong Huang, Shiang-Bin Jong, Wan-Chi Tsai, Po-Chiao Lin, Yu-Chang Tyan
Micelles, with the structure of amphiphilic molecules including a hydrophilic head and a hydrophobic tail, are recently developed as nanocarriers for the delivery of drugs with poor solubility. In addition, micelles have shown many advantages, such as enhanced permeation and retention (EPR) effects, prolonged circulation times, and increased endocytosis through surface modification. In this study, we measured the critical micelle concentrations, diameters, stability, and cytotoxicity and the cell uptake of micelles against hepatic cells with two kinds of hydrophilic materials: PEG-PCL and HA-g-PCL...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28099584/iodine-131-treatment-of-thyroid-cancer-cells-leads-to-suppression-of-cell-proliferation-followed-by-induction-of-cell-apoptosis-and-cell-cycle-arrest-by-regulation-of-b-cell-translocation-gene-2-mediated-jnk-nf-%C3%AE%C2%BAb-pathways
#10
L M Zhao, A X Pang
Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters...
January 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28054519/radioiodine-as-an-adjuvant-therapy-and-its-role-in-follow-up-of-differentiated-thyroid-cancer
#11
REVIEW
S Padma, P Shanmuga Sundaram
Papillary and follicular cancers of thyroid are the most common varieties of differentiated thyroid cancers exhibiting excellent long-term prognosis when carefully managed. Being a slow-growing malignancy, guidelines exist on the staging, preoperative risk stratification, and management of these cancers to increase the overall survival of these patients. Radioactive iodine has a central role in differentiated thyroid malignancies. It has the same physical properties as stable iodine, thus both normal and malignant thyrocytes cannot differentiate radioactive from stable iodine...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28002173/higher-preablative-serum-thyroid-stimulating-hormone-level-predicts-radioiodine-ablation-effectiveness-in-patients-with-differentiated-thyroid-carcinoma
#12
Ismaheel O Lawal, Nozipho E Nyakale, Lerwine M Harry, Thabo Lengana, Neo P Mokgoro, Mariza Vorster, Mike M Sathekge
INTRODUCTION: Radioiodine ablation of remnant thyroid tissue is an important adjuvant therapy of differentiated thyroid carcinoma (DTC) after thyroidectomy. Elevated serum thyroid-stimulating hormone (TSH) level is necessary for successful ablation. The optimum level of serum TSH level necessary for successful radioiodine ablation of well-DTC is, however, yet to be defined. We aimed to determine whether higher serum TSH level will result in a better rate of complete ablation of well-DTC using iodine-131 (I) following initial thyroidectomy...
March 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28000859/131i-labeled-monoclonal-antibody-targeting-neuropilin-receptor-type-2-for-tumor-spect-imaging
#13
Lichun Chen, Liangliang Wang, Jianghua Yan, Chao Ma, Jing Lu, Guoqiang Chen, Shengyou Chen, Fu Su, Weixing Wang, Xinhui Su
As a co-receptor for vascular endothelial growth factor‑3 (VEGF‑3), neuropilin receptor type‑2 (NRP‑2) plays a central role in lymphangiogenesis and angiogenesis. Recently, mounting data of evidence show that NRP‑2 is overexpressed in several human cancers, and its overexpression is often associated with poor prognosis. Therefore, it is necessary for us to develop an affinity reagent for noninvasive imaging of NRP‑2 expression because it may be possible to provide early cancer diagnosis, more accurate prognosis, and better treatment planning...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27987437/theranostic-approach-for-metastatic-pigmented-melanoma-using-icf15002-a-multimodal-radiotracer-for-both-pet-imaging-and-targeted-radionuclide-therapy
#14
Latifa Rbah-Vidal, Aurélien Vidal, Emilie M F Billaud, Sophie Besse, Isabelle Ranchon-Cole, Florence Mishellany, Yann Perrot, Lydia Maigne, Nicole Moins, Jean-Luc Guerquin-Kern, Françoise Degoul, Jean-Michel Chezal, Philippe Auzeloux, Elisabeth Miot-Noirault
PURPOSE: This work reports, in melanoma models, the theranostic potential of ICF15002 as a single fluorinated and iodinated melanin-targeting compound. METHODS: Studies were conducted in the murine syngeneic B16BL6 model and in the A375 and SK-MEL-3 human xenografts. ICF15002 was radiolabeled with fluorine-18 for positron emission tomography (PET) imaging and biodistribution, with iodine-125 for metabolism study, and iodine-131 for targeted radionuclide therapy (TRT)...
December 14, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27974741/iodine-131-an-effective-method-for-treating-lymph-node-metastases-of-differentiated-thyroid-cancer
#15
Ying He, Ming-Zhi Pan, Jian-Min Huang, Peng Xie, Fang Zhang, Ling-Ge Wei
BACKGROUND The aim of this study was to assess the efficacy of radioactive iodine-131 (¹³¹I) therapy for lymph node metastasis of differentiated thyroid cancer (DTC) and to identify influential factors using univariate and multivariate analyses to determine if identified factors influence the efficacy of treatment. MATERIAL AND METHODS This study included a retrospective review of 218 patients with histologically proven DTC in the post-operation stage. After thyroid tissue remnants were eliminated with ¹³¹I therapy, patients' lymph node status was confirmed by ultrasound and by ¹³¹I whole body scan regarding lymph node metastasis, and then patients were treated with ¹³¹I as appropriate...
December 15, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27960236/radiation-associated-neoplasia-clinical-pathological-and-genomic-correlates
#16
REVIEW
Lynette M Sholl, Justine A Barletta, Jason L Hornick
Ionizing radiation is an established risk factor for the development of benign and malignant tumours. The epidemiology of radiation-associated neoplasia has been studied over the decades in diverse populations, including Japanese atomic bomb survivors, exposed communities following the Chernobyl nuclear power plant disaster, and paediatric and adult populations receiving therapeutic irradiation. Radiation has been associated with an increased risk of neoplasia throughout the human body, with some sites showing a markedly increased relative risk of developing tumours (thyroid; soft tissues), depending on patient age and the context of exposure...
January 2017: Histopathology
https://www.readbyqxmd.com/read/27918920/highly-efficient-method-for-production-of-radioactive-silver-seed-cores-for-brachytherapy
#17
Roberta Mansini Cardoso, Carla Daruich de Souza, Maria Elisa Chuery Martins Rostelato, Koiti Araki
A simple and highly efficient (shorter reaction time and almost no rework) method for production of iodine based radioactive silver seed cores for brachytherapy is described. The method allows almost quantitative deposition of iodine-131 on dozens of silver substrates at once, with even distribution of activity per core and insignificant amounts of liquid and solid radioactive wastes, allowing the fabrication of cheaper radioactive iodine seeds for brachytherapy.
February 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27893453/a-geographical-study-of-thyroid-cancer-incidence-in-north-west-england-following-the-windscale-nuclear-reactor-fire-of-1957
#18
Richard J Q McNally, Richard Wakeford, Peter W James, Nermine O Basta, Robert D Alston, Mark S Pearce, Alex T Elliott
The Windscale nuclear reactor fire at Sellafield, United Kingdom, in October 1957 led to an uncontrolled release of iodine-131 (radioactive half-life, 8 d) into the atmosphere. Contamination from the accident was most pronounced in the counties of Cumbria and Lancashire, north-west England. Radioiodine concentrates in the thyroid gland producing an excess risk of thyroid cancer, notably among those exposed as children, which persists into later life. For an initial investigation of thyroid cancer incidence in north-west England, data were obtained on cases of thyroid cancer among people born during 1929-1973 and diagnosed during 1974-2012 while resident in England, together with corresponding populations...
December 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27856921/lenvatinib-a-multikinase-inhibitor-for-radioiodine-refractory-differentiated-thyroid-cancer
#19
REVIEW
Yvonne Hewett, Subash Ghimire, Bilal Farooqi, Binay K Shah
Lenvatinib, an oral multikinase inhibitor, was approved by the US Food and Drug Administration in February 2015. In a pivotal phase III study of 392 patients with progressive radioiodine-refractory thyroid cancer, the overall response rate of patients receiving lenvatinib was 64.8%, with complete response in four patients. The median progression-free survival was 18.3 months in the lenvatinib arm versus 3.6 months in patients receiving placebo. Median overall survival was not reached in either arm. Lenvatinib is a promising new treatment for patients with radioiodine (iodine-131)-refractory differentiated thyroid cancer...
November 17, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27853073/feminizing-adrenocortical-carcinoma-with-distinct-histopathological-findings
#20
Masako Hatano, Yasuhiro Takenaka, Ikuo Inoue, Keiko Homma, Tomonobu Hasegawa, Hisanobu Sasano, Takuya Awata, Shigehiro Katayama
We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma...
2016: Internal Medicine
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