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https://www.readbyqxmd.com/read/27911431/-o%C3%B1-umethyl-in-the-treatment-of-allergic-diseases-of-eyelids-and-conjunctiva
#1
N R Marchenko
Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27910802/near-infrared-spectroscopy-evaluated-cerebral-oxygenation-during-anesthesia
#2
Henrik Sørensen
Likely, maintained organ and notably cerebral perfusion, secures rapid recovery following anesthesia. To secure cerebral blood flow (CBF) at least mean arterial pressure (MAP) and the arterial carbon dioxide tension (PaCO2) need to be considered. CBF is "autoregulated", i.e. stays more or less stable within a MAP of 50-150 mmHg, but the lower limit appears to depend on the central blood volume and/or cardiac output, illustrated by a decrease in CBF at a MAP of 80 mmHg with a compromised central blood volume, while CBF remains constant with a MAP < 40 mmHg, if the central blood volume is maintained...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27890755/predictors-of-shunt-insertion-in-aneurysmal-subarachnoid-hemorrhage
#3
Rouzbeh Motiei-Langroudi, Nimer Adeeb, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, Shane R Tubbs, Mohammadali M Shoja, Justin M Moore, Raghav Gupta, Christopher S Ogilvy, Ajith T Thomas, Christoph J Griessenauer
OBJECTS: Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) requiring permanent cerebrospinal fluid (CSF) diversion in up to two thirds of patients. Factors that predict permanent CSF diversion are not well established. METHODS: An exploratory analysis of 149 patients enrolled in the Cerebral Aneurysm Renin Angiotensin System (CARAS) study was performed in an effort to identify factors predictive of permanent CSF diversion following aSAH; only the 135 patients surviving the initial hospitalization were included in the present study...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27884871/simultaneous-liquid-chromatographic-determination-of-ebastine-with-two-sympathomimetic-drugs-using-a-monolithic-column
#4
F Ibrahim, M E K Wahba
Ebastine (EBS) has been assayed in its laboratory-prepared co-formulated tablets with either pseudoephedrine hydrochloride (PSU) or phenylephrine hydrochloride (PHR) using isocratic reversed-phase chromatography. Separation was conducted using a 50 mm × 4.6 mm i.d., Chromolith(®) SpeedROD RP-18 end-capped column at ambient temperature. A mobile phase composed of water:acetonitrile in a ratio of 25:75 having a pH of 3.2, has been utilized at 1 mL/min with UV detection at 254 nm for both EBS and PSU and 274 nm for PHR which in turn increased the sensitivity of the proposed method significantly...
November 24, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27881583/acute-oesophageal-necrosis-in-a-young-man-with-cocaine-and-alcohol-abuse
#5
Caleb Evans Pineo, Thomas Zeitler Pineo
We report a case of acute oesophageal necrosis (AEN) and non-occlusive mesenteric ischaemia in an otherwise healthy 30-year-old man with cocaine and alcohol abuse. Although cocaine might be expected more frequently to cause oesophageal necrosis through sympathomimetic vasoconstriction, this is only the second known case report of AEN in a patient with cocaine abuse. His symptoms at presentation included epigastric abdominal pain, haematemesis and generalised weakness. He developed moderate neutropenia and severe lactic acidosis...
November 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27861299/impact-of-concomitant-medication-use-on-myocardial-123i-mibg-imaging-results-in-patients-with-heart-failure
#6
Arnold F Jacobson, Susan White, Mark I Travin, Carol Tseng
INTRODUCTION: Medications that interfere with sympathetic neuronal norepinephrine uptake and storage, such as neuropsychiatrics (NP) and sympathomimetic amines, are most likely to affect cardiac uptake of iodine-123 metaiodobenzylguanidine (I-mIBG). The present study examined these and other medications reported to affect I-mIBG uptake using measurements of cardiac I-mIBG uptake on the heart failure (HF) patients in the ADMIRE-HF extension (X) study. METHODS: Baseline concomitant medications taken by the 961 HF patients were categorized into five groups: calcium channel blockers, NP medications, β agonists and sympathomimetics, α antagonists, and other antihypertensives...
November 16, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27798760/rad-deletion-phenocopies-tonic-sympathetic-stimulation-of-the-heart
#7
Bryana M Levitan, Janet R Manning, Catherine N Withers, Jeffrey D Smith, Robin M Shaw, Douglas A Andres, Vincent L Sorrell, Jonathan Satin
Sympathetic stimulation modulates L-type calcium channel (LTCC) gating to contribute to increased systolic heart function. Rad is a monomeric G-protein that interacts with LTCC. Genetic deletion of Rad (Rad(-/-)) renders LTCC in a sympathomimetic state. The study goal was to use a clinically inspired pharmacological stress echocardiography test, including analysis of global strain, to determine whether Rad(-/-) confers tonic positive inotropic heart function. Sarcomere dynamics and strain showed partial parallel isoproterenol (ISO) responsiveness for wild-type (WT) and for Rad(-/-)...
December 2016: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/27756839/necroptosis-like-neuronal-cell-death-caused-by-cellular-cholesterol-accumulation
#8
Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura
Aberrant cellular accumulation of cholesterol is associated with neuronal lysosomal storage disorders such as Niemann-Pick disease Type C (NPC). We have shown previously that l-norephedrine (l-Nor), a sympathomimetic amine, induces necrotic cell death associated with massive cytoplasmic vacuolation in SH-SY5Y human neuroblastoma cells. To reveal the molecular mechanism underling necrotic neuronal cell death caused by l-Nor, we examined alterations in the gene expression profile of cells during l-Nor exposure...
November 25, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27753838/sy-06-1-obesity-diabetes-and-hypertension-are-adipokines-responsible
#9
Anthony Heagerty
There is now a considerable body of evidence to suggest that the fat cells that surround blood vessels (perivascular adipose tissue, PVAT) can influence profoundly arterial tone by releasing vasodilator adipokines which can act locally in a paracrine fashion. In healthy lean individuals the primary vasodilator released appears to be adiponectin and there is a complex interation between autonomic nerve firing in PVAT and the release of nitric oxide from adipocytes and an increased bioavailability of adiponectin...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27725296/dural-traction-a-possible-cause-of-hemodynamic-changes-during-single-level-transforaminal-lumbar-interbody-fusion
#10
Jonathan M Weimer, Martin Marinov, Rafi Avitsian
A 58-year old male with grade II L4-L5 spondylolisthesis and degenerative changes presented for single level transforaminal lumbar interbody fusion. During decompression of the L4 foramina, distraction of the disc space, and placement of the interbody cage and pedicle screws, episodes of extreme bradycardia with up to 5 seconds of asystole were detected on both EKG and invasive hemodynamic monitoring. The events correlated with and could possibly be a result of traction on the dura. Lumbar spinal surgery may be associated with electrophysiological and hemodynamic abnormalities, and anesthesia providers should be aware of such possibilities and the need to respond appropriately with sympathomimetic or vagolytic interventions...
October 7, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27718465/analysis-of-beta-agonist-residues-in-bovine-hair-development-of-a-uplc-ms-ms-method-and-stability-study
#11
Luigi Giannetti, Giovanni Ferretti, Valentina Gallo, Francesco Necci, Andrea Giorgi, Francesca Marini, Elisa Gennuso, Bruno Neri
Beta-sympathomimetic compounds are widely used in therapy because of the bronchodilator, smooth muscle-relaxant and tocolytic properties. However, their growth promoting and performance enhancing effects are often subject to illegal use. The present work describes the development of a fast and reliable analytical multiresidue method for the confirmation 20 β-agonist compounds in animal hair. The procedure is based on alkaline digestion, LLE with organic solvents, SPE clean up and liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis, and is suitable for the public Official control of β-agonist residues in hair sample...
September 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27695298/patient-considerations-in-cataract-surgery-the-role-of-combined-therapy-using-phenylephrine-and-ketorolac
#12
Roberto Gonzalez-Salinas, Adriano Guarnieri, María Concepción Guirao Navarro, Manuel Saenz-de-Viteri
Cataract, a degradation of the optical quality of the crystalline lens, progressive and age-related, is the leading cause of treatable blindness worldwide. Cataract surgery is the most common surgical procedure performed by ophthalmologists and is the only effective treatment for cataracts. Advances in the surgical techniques and better postoperative visual outcomes have progressively changed the primary concern of cataract surgery to become a procedure refined to yield the best possible refractive results...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27692841/use-of-high-dose-phenylephrine-in-the-treatment-of-ischemic-priapism-five-year-experience-at-a-single-institution
#13
Douglas G Ridyard, Elizabeth A Phillips, William Vincent, Ricardo Munarriz
INTRODUCTION: Ischemic priapism is an uncommon urologic emergency characterized by a compartment syndrome-like ischemic insult to the corpora cavernosa of the penis. The goal of treatment in ischemic priapism is rapid detumescence to prevent long-term erectile dysfunction. Non-surgical treatment options include aspiration, irrigation, and intracavernous injections of sympathomimetic agents. At our institution, phenylephrine is used in the treatment of ischemic priapism at concentrations and doses that are higher than those recommended in established guidelines...
November 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27687736/the-case-report-of-priapus-and-a-modern-approach-to-an-ancient-affliction
#14
Ömer Barış Yücel, Emre Salabaş, Bahadır Ermeç, Ateş Kadıoğlu
INTRODUCTION: Priapism, taking its name from God Priapus, is total or partial erection lasting longer than 4 hours independent of sexual stimulus and can result in erectile dysfunction. There are three subtypes of priapism. AIM: To review the three subtypes of priapism, their pathophysiology, current treatment options, and complications. METHODS: The literature including priapism guidelines, review articles, and current trial studies was reviewed and the priapism type of God Priapus was investigated according to the mythology...
September 26, 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27647490/the-complementary-and-divergent-roles-of-uncoupling-proteins-1-and-3-in-thermoregulation
#15
Christopher L Riley, Christine Dao, M Alexander Kenaston, Luigina Muto, Shohei Kohno, Sara M Nowinski, Ashley D Solmonson, Matthew Pfeiffer, Michael N Sack, Zhongping Lu, Giuseppe Fiermonte, Jon E Sprague, Edward M Mills
KEY POINTS: Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively. Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1. Acute noradrenaline-induced hyperthermia requires UCP1 but not UCP3. Loss of both UCP1 and UCP3 accelerate the loss of body temperature compared to UCP1KO alone during acute cold exposure. ABSTRACT: Uncoupling protein 1 (UCP1) is the established mediator of brown adipose tissue-dependent thermogenesis...
September 20, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27642933/sy-06-1-obesity-diabetes-and-hypertension-are-adipokines-responsible
#16
Anthony Heagerty
There is now a considerable body of evidence to suggest that the fat cells that surround blood vessels (perivascular adipose tissue, PVAT) can influence profoundly arterial tone by releasing vasodilator adipokines which can act locally in a paracrine fashion. In healthy lean individuals the primary vasodilator released appears to be adiponectin and there is a complex interation between autonomic nerve firing in PVAT and the release of nitric oxide from adipocytes and an increased bioavailability of adiponectin...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27640730/intubation-of-profoundly-agitated-patients-treated-with-prehospital-ketamine
#17
Travis D Olives, Paul C Nystrom, Jon B Cole, Kenneth W Dodd, Jeffrey D Ho
BACKGROUND: Profound agitation in the prehospital setting confers substantial risk to patients and providers. Optimal chemical sedation in this setting remains unclear. OBJECTIVE: The goal of this study was to describe intubation rates among profoundly agitated patients treated with prehospital ketamine and to characterize clinically significant outcomes of a prehospital ketamine protocol. METHODS: This was a retrospective cohort study of all patients who received prehospital ketamine, per a predefined protocol, for control of profound agitation and who subsequently were transported to an urban Level 1 trauma center from May 1, 2010 through August 31, 2013...
December 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27636114/-physical-training-in-chronic-heart-failure-pathophysiology-and-clinical-evolution
#18
Eduardo Rivas Estany, Susana Hernández García
Chronic heart failure has become one of the main global health problems; 23 million people suffer from this disease worldwide and age of onset has varied considerably over the past five decades, coinciding with other co-morbidities as longevity in the population increases. Treatment of heart failure has also shown striking variations in recent years. Such is the case of the substitution of sympathomimetic drugs by beta-blocking agents, which primarily means a conceptual change in the pathophysiological interpretation of this syndrome...
2016: Medwave
https://www.readbyqxmd.com/read/27633326/the-chromogranin-a-derived-sympathomimetic-serpinin-depresses-myocardial-performance-in-teleost-and-amphibian-hearts
#19
S Imbrogno, R Mazza, C Pugliese, M Filice, T Angelone, Y P Loh, B Tota, M C Cerra
Chromogranin A (CgA) is an acidic protein co-stored with catecholamines, hormones and neuropeptides in the secretory granules of endocrine, neuronal and other cell types (including cardiomyocytes). Proteolytic cleavage in the C terminus of CgA generates a 2.9kDa peptide named serpinin (Serp; Ala26Leu) that can be modified at its N terminus to form a pyroglutamate residue (pGlu-Serp). In the rat heart, both peptides increase contractility and relaxation through a β-adrenergic-like action mechanism. Accordingly, Serp and pGlu-Serp were proposed as novel myocardial sympatho-adrenergic modulators in mammals...
January 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27568894/nasal-resistance-is-elevated-in-people-with-tetraplegia-and-is-reduced-by-topical-sympathomimetic-administration
#20
Laura Gainche, David J Berlowitz, Mariannick LeGuen, Warren R Ruehland, Fergal J O'Donoghue, John Trinder, Marnie Graco, Rachel Schembri, Danny J Eckert, Peter D Rochford, Amy S Jordan
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in individuals with tetraplegia and associated with adverse health outcomes. The causes of the high prevalence of OSA in this population are unknown, but it is important to understand as standard treatments are poorly tolerated in tetraplegia. Nasal congestion is common in tetraplegia, possibly because of unopposed parasympathetic activity. Further, nasal obstruction can induce OSA in healthy individuals. We therefore aimed to compare nasal resistance before and after topical administration of a sympathomimetic between 10 individuals with tetraplegia (T) and 9 able-bodied (AB) controls matched for OSA severity, gender, and age...
November 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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