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Kyle D Custard, Kerri A Pratt, Siyuan Wang, Paul B Shepson
During springtime, unique halogen chemistry involving chlorine and bromine atoms controls the prevalence of volatile organic compounds, ozone, and mercury in the Arctic lower troposphere. In situ measurements of the chlorine monoxide radical (ClO) and its precursor Cl2, along with BrO and Br2, were conducted using chemical ionization mass spectrometry (CIMS) during the BRomine, Ozone, and Mercury EXperiment (BROMEX) near Barrow, Alaska in March 2012. To our knowledge, these data represent the first ClO measurements made using CIMS...
October 21, 2016: Environmental Science & Technology
David M Warsinger, Emily W Tow, Kishor G Nayar, Laith A Maswadeh, John H Lienhard V
As reverse osmosis (RO) desalination capacity increases worldwide, the need to reduce its specific energy consumption becomes more urgent. In addition to the incremental changes attainable with improved components such as membranes and pumps, more significant reduction of energy consumption can be achieved through time-varying RO processes including semi-batch processes such as closed-circuit reverse osmosis (CCRO) and fully-batch processes that have not yet been commercialized or modelled in detail. In this study, numerical models of the energy consumption of batch RO (BRO), CCRO, and the standard continuous RO process are detailed...
September 25, 2016: Water Research
Jingwen Zhang, John B Jemmott, Ann O'Leary, Robin Stevens, Loretta Sweet Jemmott, Larry D Icard, Janet Hsu, Scott E Rutledge
BACKGROUND: Few trials have tested physical-activity interventions among sexual minorities, including African American men who have sex with men (MSM). PURPOSE: We examined the efficacy and mediation of the Being Responsible for Ourselves (BRO) physical-activity intervention among African American MSM. METHOD: African American MSM were randomized to the physical-activity intervention consisting of three 90-min one-on-one sessions or an attention-matched control intervention and completed pre-intervention, immediately post-intervention, and 6- and 12-month post-intervention audio computer-based surveys...
September 22, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Ayman Alsebaey, Eman Aly Ahmedy
BACKGROUND: Hepatocellular carcinoma (HCC) is a dreadful complication of end stage liver disease with high morbidity and mortality. AIM: The aim was to assess the role of serum talin-1 and non-invasive brosis in patients with HCC. MATERIALS AND METHODS: A total of eighty seven subjects were enrolled, with 22 two healthy individuals as a control group (n=22), 22 patients in the cirrhosis group and finally 43 in the group with HCC diagnosed with positive triphasic CT abdomen criteria...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Martin Frydland, Jesper Kjaergaard, David Erlinge, Pascal Stammet, Niklas Nielsen, Michael Wanscher, Tommaso Pellis, Hans Friberg, Jan Hovdenes, Janneke Horn, Jørn Wetterslev, Jakob H Thomsen, John Bro-Jeppesen, Matilde Winther-Jensen, Matthew P Wise, Michael Kuiper, Tobias Cronberg, Yvan Gasche, Yvan Devaux, Anders Åneman, Christian Hassager
N-terminal pro-B-type natriuretic (NT-proBNP) is expressed in the heart and brain, and serum levels are elevated in acute heart and brain diseases. We aimed to assess the possible association between serum levels and neurological outcome and death in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA). Of the 939 comatose OHCA patients enrolled and randomized in the Targeted Temperature Management (TTM) trial to TTM at 33°C or 36°C for 24 hours, 700 were included in the biomarker substudy...
October 1, 2016: American Journal of Cardiology
Frans Boch Waldorff, Dagný Rós Nicolaisdóttir, Marius Brostrøm Kousgaard, Susanne Reventlow, Jens Søndergaard, Thorkil Thorsen, Merethe Kirstine Andersen, Line Bjørnskov Pedersen, Louise Bisgaard, Cecilie Lybeck Hutters, Flemming Bro
INTRODUCTION: The objective of this study was to analyse Danish general practitioners' (GPs) a priori attitudes and expectations towards a nationwide mandatory accreditation programme. METHODS: This study is based on a nationwide electronic survey comprising all Danish GPs (n = 3,403). RESULTS: A total of 1,906 (56%) GPs completed the questionnaire. In all, 861 (45%) had a negative attitude towards accreditation, whereas 429 (21%) were very positive or posi-tive...
September 2016: Danish Medical Journal
Sophie Blakemore
What is your job? As nurse director I lead nursing strategy, and the approaches to care and nursing standards, in the mental health and learning disabilities service delivery unit for Abertawe Bro Morgannwg University Health Board.
September 2016: Nursing Management (Harrow)
Rine Bakkestrøm, Mads J Andersen, Mads Ersbøll, John Bro-Jeppesen, Finn Gustafsson, Lars Køber, Christian Hassager, Jacob E Møller
BACKGROUND: Dilatation of left atrium (LA) reflects chronic LA pressure or volume overload that possesses considerable prognostic information. Little is known regarding the interaction between LA remodeling after acute myocardial infarction (MI) and left atrial pressure at rest and during exercise. The objective was to assess changes in LA volume early after MI in patients with diastolic dysfunction and the relation to invasive hemodynamics and natriuretic peptides. METHODS: 62 patients with left ventricle ejection fraction (LVEF)≥45%, diastolic E/e'>8 and LA volume index >34ml/m(2) within 48h of MI were enrolled...
November 15, 2016: International Journal of Cardiology
Johannes Grand, Jakob Hartvig Thomsen, Jesper Kjaergaard, Niklas Nielsen, David Erlinge, Sebastian Wiberg, Michael Wanscher, John Bro-Jeppesen, Christian Hassager
This study reports the prevalence and prognostic impact of right bundle branch block (RBBB) and left bundle branch block (LBBB) in the admission electrocardiogram (ECG) of comatose survivors of out-of-hospital cardiac arrest (OHCA). The present study is part of the predefined electrocardiographic substudy of the prospective randomized target temperature management trial, which found no benefit of targeting 33°C over 36°C in terms of outcome. Six-hundred eighty-two patients were included in the substudy. An admission ECG, which defined the present study population, was available in 602 patients (88%)...
October 15, 2016: American Journal of Cardiology
Allan Riis, Cathrine E Jensen, Helle T Maindal, Flemming Bro, Martin B Jensen
INTRODUCTION: Health service research often involves the active participation of healthcare professionals. However, their ability and commitment to research varies. This can cause recruitment difficulties and thereby prolong the study period and inflate budgets. Solberg has identified seven R-factors as determinants for successfully recruiting healthcare professionals: relationships, reputation, requirements, rewards, reciprocity, resolution, and respect. METHOD: This is a process evaluation of the seven R-factors...
2016: SAGE Open Medicine
John Bro-Jeppesen, Pär I Johansson, Christian Hassager, Michael Wanscher, Sisse R Ostrowski, Mette Bjerre, Jesper Kjaergaard
BACKGROUND: Post-cardiac arrest syndrome (PCAS) is characterized by whole-body ischemia triggering systemic inflammation and damage of the endothelium. This study investigated the relationship between systemic inflammation, endothelial damage and severity of PCAS and the association between endothelial damage and outcome after out-of-hospital cardiac arrest (OHCA). METHODS: In this post hoc study, we analyzed 163 comatose patients included at a single center in the target temperature management (TTM) trial, randomly assigned to TTM at 33°C or 36°C for 24h...
October 2016: Resuscitation
Francisca F Gouveia, Jesper P Rahbek, Asmus R Mortensen, Mette T Pedersen, Pedro M Felizardo, Rasmus Bro, Michael J Mealy
Significant improvements can be realized by converting conventional batch processes into continuous ones. The main drivers include reduction of cost and waste, increased safety, and simpler scale-up and tech transfer activities. Re-designing the process layout offers the opportunity to incorporate a set of process analytical technologies (PAT) embraced in the Quality-by-Design (QbD) framework. These tools are used for process state estimation, providing enhanced understanding of the underlying variability in the process impacting quality and yield...
August 11, 2016: Analytical and Bioanalytical Chemistry
Jakob Hartvig Thomsen, Christian Hassager, David Erlinge, Niklas Nielsen, Janneke Horn, Jan Hovdenes, John Bro-Jeppesen, Michael Wanscher, Steen Pehrson, Lars Køber, Jesper Kjaergaard
OBJECTIVES: Atrial fibrillation has been associated with increased mortality in the general population and mixed populations of critical ill. Atrial fibrillation can also affect patients during post-cardiac arrest care. We sought to assess the prognostic implications of atrial fibrillation following out-of-hospital cardiac arrest, including relation to the level of targeted temperature management. DESIGN: A post hoc analysis of a prospective randomized trial. SETTING: Thirty-six ICUs...
August 4, 2016: Critical Care Medicine
Berit Skjødeberg Toftegaard, Flemming Bro, Alina Zalounina Falborg, Peter Vedsted
BACKGROUND: Continuing medical education (CME) in earlier cancer diagnosis was launched in Denmark in 2012 as part of the Danish National Cancer Plan. The CME programme was introduced to improve the recognition among general practitioners (GPs) of symptoms suggestive of cancer and improve the selection of patients requiring urgent investigation. This study aims to explore the effect of CME on GP knowledge about cancer diagnosis, attitude towards own role in cancer detection, self-assessed readiness to investigate and cancer risk assessment of urgently referred patients...
2016: BMC Family Practice
Jakob Bro-Jørgensen
BACKGROUND: Dewlaps are iconic features of several ungulate species and, although a role in signalling has been postulated, their function remains largely unexplored. We recently failed to find any age-independent link between dewlap size and social status in the common eland (Tragelaphus oryx), pointing to the possibility that sexual selection may not be the primary cause of dewlap evolution in ungulates. Here I use a two-pronged approach to test hypotheses on the function of ungulate dewlaps: an interspecific comparative analysis of bovids and deer, and an intraspecific study of eland antelopes in the wild...
2016: Frontiers in Zoology
Pasquale Raia, Federico Passaro, Francesco Carotenuto, Shai Meiri, Paolo Piras
Conventional wisdom holds that the complex shapes of deer antlers are produced under the sole influence of sexual selection. We questioned this view by demonstrating that trends for increased body size evolution passively yield more-complex ornaments, even in organisms where no effect of sexual selection is possible, with similar allometric slopes. Recent investigations suggest that sexual selection on antlers of larger deer species is stronger than that in smaller species; hence, the use of conspicuous antlers for display in large male deer is a secondary function driven by especially intense sexual selection on these large-bodied species...
August 2016: American Naturalist
Luke Holman, Jakob Bro-Jørgensen
Raia et al. propose that the evolution of the shape and complexity of animal ornaments (e.g., deer antlers) can be explained by interspecific variation in body size and is not influenced by sexual selection. They claim to show that ornament complexity is related to body size by an 0.25-power law and argue that this finding precludes a role for sexual selection in the evolution of ornament complexity. However, their study does not test alternative hypotheses and mismeasures antler shape allometry by omitting much of the published data...
August 2016: American Naturalist
Anette Svarre Lund, Lars Lund, Morten Jønler, Peder Graversen, Flemming Bro, Michael Borre
OBJECTIVE: The aim of this study was to investigate 3 year follow-up in patients with stable prostate cancer (PCa) managed in a shared care program by general practitioners (GPs) in collaboration with urological departments. PCa patients who have undergone curative treatment or endocrine therapy require long-term follow-up. Until recently, follow-up has primarily been managed by urologists at hospital-based outpatient clinics. However, new organizational strategies are needed to meet the needs of the growing number of elderly, comorbid cancer patients...
October 2016: Scandinavian Journal of Urology
Jakob Søgaard Juul, Flemming Bro, Nete Hornung, Berit Sanne Andersen, Søren Laurberg, Frede Olesen, Peter Vedsted
BACKGROUND: Colorectal cancer is a common malignancy and a leading cause of cancer-related death. Half of patients with colorectal cancer initially present with non-specific or vague symptoms. In the need for a safe low-cost test, the immunochemical faecal occult blood test (iFOBT) may be part of the evaluation of such patients in primary care. Currently, Danish general practitioners have limited access to this test. The aim of this article is to describe a study that will assess the uptake and clinical use of iFOBT in general practice...
2016: BMC Cancer
Zbyšek Pavelek, Oldřich Vyšata, Vojtěch Tambor, Kristýna Pimková, Dai Long Vu, Kamil Kuča, Pavel Šťourač, Martin Vališ
Early diagnosis and treatment of multiple sclerosis (MS) in the initial stages of the disease can significantly retard its progression. The aim of the present study was to identify changes in the cerebrospinal fluid proteome in patients with relapsing-remitting MS and clinically isolated MS syndrome who are at high risk of developing MS (case group) compared to healthy population (control) in order to identify potential new markers, which could ultimately aid in early diagnosis of MS. The protein concentrations of each of the 11 case and 15 control samples were determined using a bicinchoninic acid assay...
July 2016: Biomedical Reports
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