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https://www.readbyqxmd.com/read/28499599/gas-chromatography-mass-spectrometry-data-processing-made-easy
#1
Lea G Johnsen, Peter B Skou, Bekzod Khakimov, Rasmus Bro
Evaluation of GC-MS data may be challenging due to the high complexity of data including overlapped, embedded, retention time shifted and low S/N ratio peaks. In this work, we demonstrate a new approach, PARAFAC2 based Deconvolution and Identification System (PARADISe), for processing raw GC-MS data. PARADISe is a computer platform independent freely available software incorporating a number of newly developed algorithms in a coherent framework. It offers a solution for analysts dealing with complex chromatographic data...
April 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28466057/whole-genome-sequence-and-comparative-genomic-sequence-analysis-of-helicoverpa-armigera-nucleopolyhedrovirus-hearnpv-l1-isolated-from-india
#2
Ashika T Raghavendra, Sushil K Jalali, Rakshit Ojha, Timalapur M Shivalingaswamy, Raj Bhatnagar
The whole genome of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) from India, HearNPV-L1, was sequenced and analyzed, with a view to look for genes and/or nucleotide sequences that might be involved in the differences and virulence among other HearNPVs sequenced from other countries like SP1A (Spain), NNg1 (Kenya) and G4 (China). The entire nucleotide sequence of the HearNPV-L1 genome was 136,740 bp in length having GC content of 39.19% and contained 113 ORFs that could encode polypeptides with more than 50 amino acids (GenBank accession number KT013224)...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28449840/collectively-operated-fellow-initiated-research-as-a-novel-teaching-model-to-bolster-interest-and-increase-proficiency-in-academic-research
#3
Guillaume Marquis-Gravel, Robert Avram, Maxime Tremblay-Gravel, Olivier Desplantie, Hung Q Ly, Anique Ducharme, E Marc Jolicoeur
Research is a core aspect of training in academic medicine, but fellows face many challenges thwarting their ability to perform clinically meaningful projects. The concept of a multicentre clinical trial collectively operated by fellows, and integrated longitudinally into training, has never been described. In this article, the authors expose the key principles of Collectively Operated Fellow-Initiated Research (COFIR) that they put in place. The aim of COFIR is to introduce a cohort of fellows to the career of clinician-scientists by conducting a longitudinal research project integrated into the curriculum of their clinical fellowship at a level they would not have access to as single individuals...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28392286/a-comparison-of-the-adaptations-of-strains-of-lymantria-dispar-multiple-nucleopolyhedrovirus-to-hosts-from-spatially-isolated-populations
#4
V V Martemyanov, J D Podgwaite, I A Belousova, S V Pavlushin, J M Slavicek, O A Baturina, M R Kabilov, A V Ilyinykh
The adaptation of pathogens to either their hosts or to environmental conditions is the focus of many current ecological studies. In this work we compared the ability of six spatially-distant Lymantria dispar (gypsy moth) multiple nucleopolyhedrovirus (LdMNPV) strains (three from eastern North America and three from central Asia) to induce acute infection in gypsy moth larvae. We also sequenced the complete genome of one Asian (LdMNPV-27/0) and one North American (LdMNPV-45/0) strain which were used for bioassay...
April 7, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28365116/differential-somatic-cell-count-a-novel-method-for-routine-mastitis-screening-in-the-frame-of-dairy-herd-improvement-testing-programs
#5
Malin Damm, Claus Holm, Mette Blaabjerg, Morten Novak Bro, Daniel Schwarz
Somatic cell count (SCC) is used as key indicator in mastitis screening programs typically applied in the frame of Dairy Herd Improvement (DHI) testing programs. However, mastitis is still causing tremendous economic losses to the dairy industry. Hence, new biomarkers are needed that can be used for enhanced management of mastitis on dairy farms. Besides the determination of SCC, differentiation of cells has been described to be beneficial for a more definite description of the actual udder health status of dairy cows...
March 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28364490/sleep-disturbances-in-individuals-with-phelan-mcdermid-syndrome-correlation-with-caregivers-sleep-quality-and-daytime-functioning
#6
Della Bro, Ruth O'Hara, Michelle Primeau, Andrea Hanson-Kahn, Joachim Hallmayer, Jonathan A Bernstein
Study Objectives: The aims of this study were to document sleep disturbances in individuals with Phelan-McDermid syndrome (PMS), to assess whether these individuals had been evaluated for sleep disorders, and to examine relationships between the sleep behavior of these individuals and the sleep behavior and daytime functioning of their caregivers. Methods: Participants were 193 caregivers of individuals with PMS recruited by the Phelan-McDermid Syndrome Foundation...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28327100/impact-of-a-continuing-medical-education-meeting-on-the-use-and-timing-of-urgent-cancer-referrals-among-general-practitioners-a-before-after-study
#7
Berit Skjødeberg Toftegaard, Flemming Bro, Alina Zalounina Falborg, Peter Vedsted
BACKGROUND: Detection of cancer in general practice is challenging because symptoms are diverse. Even so-called alarm symptoms have low positive predictive values of cancer. Nevertheless, appropriate referral is crucial. As 85% of cancer patients initiate their cancer diagnostic pathway in general practice, a Continuing Medical Education meeting (CME-M) in early cancer diagnosis was launched in Denmark in 2012. We aimed to investigate the effect of the CME-M on the primary care interval, patient contacts with general practice and use of urgent cancer referrals...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28288114/disruption-of-the-atxn1-cic-complex-causes-a-spectrum-of-neurobehavioral-phenotypes-in-mice-and-humans
#8
Hsiang-Chih Lu, Qiumin Tan, Maxime W C Rousseaux, Wei Wang, Ji-Yoen Kim, Ronald Richman, Ying-Wooi Wan, Szu-Ying Yeh, Jay M Patel, Xiuyun Liu, Tao Lin, Yoontae Lee, John D Fryer, Jing Han, Maria Chahrour, Richard H Finnell, Yunping Lei, Maria E Zurita-Jimenez, Priyanka Ahimaz, Kwame Anyane-Yeboa, Lionel Van Maldergem, Daphne Lehalle, Nolwenn Jean-Marcais, Anne-Laure Mosca-Boidron, Julien Thevenon, Margot A Cousin, Della E Bro, Brendan C Lanpher, Eric W Klee, Nora Alexander, Matthew N Bainbridge, Harry T Orr, Roy V Sillitoe, M Cecilia Ljungberg, Zhandong Liu, Christian P Schaaf, Huda Y Zoghbi
Gain-of-function mutations in some genes underlie neurodegenerative conditions, whereas loss-of-function mutations in the same genes have distinct phenotypes. This appears to be the case with the protein ataxin 1 (ATXN1), which forms a transcriptional repressor complex with capicua (CIC). Gain of function of the complex leads to neurodegeneration, but ATXN1-CIC is also essential for survival. We set out to understand the functions of the ATXN1-CIC complex in the developing forebrain and found that losing this complex results in hyperactivity, impaired learning and memory, and abnormal maturation and maintenance of upper-layer cortical neurons...
April 2017: Nature Genetics
https://www.readbyqxmd.com/read/28271588/preloss-grief-in-family-caregivers-during-end-of-life-cancer-care-a-nationwide-population-based-cohort-study
#9
Mette Kjaergaard Nielsen, Mette Asbjoern Neergaard, Anders Bonde Jensen, Peter Vedsted, Flemming Bro, Mai-Britt Guldin
OBJECTIVE: Severe grief symptoms in family caregivers during end-of-life cancer trajectories are associated with complicated grief and depression after the loss. Nevertheless, severe grief symptoms during end-of-life caregiving in caregivers to cancer patients have been scarcely studied. We aimed to explore associations between severe preloss grief symptoms in caregivers and modifiable factors such as depressive symptoms, caregiver burden, preparedness for death, and end-of-life communication...
March 7, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28193288/accreditation-in-general-practice-in-denmark-study-protocol-for-a-cluster-randomized-controlled-trial
#10
Merethe K Andersen, Line B Pedersen, Volkert Siersma, Flemming Bro, Susanne Reventlow, Jens Søndergaard, Marius Brostrøm Kousgaard, Frans B Waldorff
BACKGROUND: Accreditation is used increasingly in health systems worldwide. However, there is a lack of evidence on the effects of accreditation, particularly in general practice. In 2016 a mandatory accreditation scheme was initiated in Denmark, and during a 3-year period all practices, as default, should undergo accreditation according to the Danish Healthcare Quality Program. The aim of this study is primarily to evaluate the effects of a mandatory accreditation scheme. METHODS/DESIGN: The study is conducted as a cluster-randomized controlled trial among 1252 practices (clusters) with 2211 general practitioners in Denmark...
February 13, 2017: Trials
https://www.readbyqxmd.com/read/28157059/danish-mmr-vaccination-coverage-is-considerably-higher-than-reported
#11
Nanna Holt, Anna Mygind, Flemming Bro
INTRODUCTION: The Danish childhood vaccination programme offers protection against measles, mumps, and rubella (MMR). Nevertheless, many children appear to be unvaccinated according to the national registers. The aim of this study was to estimate the MMR1 vaccination coverage based on a medical record review of children whose vaccination status is negative according to the register-based data. METHODS: We conducted a cross-sectional study of 19 randomly selected general practices in the Central Denmark Region including 1,712 children aged 18-42 months...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28125965/microbiological-point-of-care-testing-before-antibiotic-prescribing-in-primary-care-considerable-variations-between-practices
#12
Steffen Haldrup, Reimar W Thomsen, Flemming Bro, Robert Skov, Lars Bjerrum, Mette Søgaard
BACKGROUND: Point-of-care testing (POCT) in primary care may improve rational antibiotic prescribing. We examined use of POCT in Denmark, including patient- and general practitioner (GP)-related predictors. METHODS: We linked nationwide health care databases to assess POCT use (C-reactive protein (CRP), group A streptococcal (GAS) antigen swabs, bacteriological cultures, and urine test strips) per 1,000 overall GP consultations, 2004-2013. We computed odds ratios (OR) of POCT in patients prescribed antibiotics according to patient and GP age and sex, GP practice type, location, and workload...
January 26, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28122273/competence-evaluation-processes-for-nursing-students-abroad-findings-from-an-international-case-study
#13
Cristina Tommasini, Beata Dobrowolska, Danuta Zarzycka, Claudia Bacatum, Anne Marie Gran Bruun, Dag Korsath, Siv Roel, Mette Bro Jansen, Tine Milling, Anne Deschamps, Stefanos Mantzoukas, Christine Mantzouka, Alvisa Palese
BACKGROUND: Assessing clinical competence in nursing students abroad is a challenge, and requires both methods and instruments capable of capturing the multidimensional nature of the clinical competences acquired. OBJECTIVES: The aim of the study was to compare the clinical competence assessment processes and instruments adopted for nursing students during their clinical placement abroad. DESIGN: A case study design was adopted in 2015. SETTING AND PARTICIPANTS: A purposeful sample of eight nursing programmes located in seven countries (Belgium, Denmark, Greece, Norway, Poland, Portugal and Italy) were approached...
January 10, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28099439/single-versus-serial-measurements-of-neuron-specific-enolase-and-prediction-of-poor-neurological-outcome-in-persistently-unconscious-patients-after-out-of-hospital-cardiac-arrest-a-ttm-trial-substudy
#14
Sebastian Wiberg, Christian Hassager, Pascal Stammet, Matilde Winther-Jensen, Jakob Hartvig Thomsen, David Erlinge, Michael Wanscher, Niklas Nielsen, Tommaso Pellis, Anders Åneman, Hans Friberg, Jan Hovdenes, Janneke Horn, Jørn Wetterslev, John Bro-Jeppesen, Matthew P Wise, Michael Kuiper, Tobias Cronberg, Yvan Gasche, Yvan Devaux, Jesper Kjaergaard
BACKGROUND: Prediction of neurological outcome is a crucial part of post cardiac arrest care and prediction in patients remaining unconscious and/or sedated after rewarming from targeted temperature management (TTM) remains difficult. Current guidelines suggest the use of serial measurements of the biomarker neuron-specific enolase (NSE) in combination with other predictors of outcome in patients admitted after out-of-hospital cardiac arrest (OHCA). This study sought to investigate the ability of NSE to predict poor outcome in patients remaining unconscious at day three after OHCA...
2017: PloS One
https://www.readbyqxmd.com/read/28095314/cloning-and-expression-characterization-of-peroxisome-proliferator-activated-receptors-ppars-with-their-agonists-dietary-lipids-and-ambient-salinity-in-rabbitfish-siganus-canaliculatus
#15
Cuihong You, Danli Jiang, Qinghao Zhang, Dizhi Xie, Shuqi Wang, Yewei Dong, Yuanyou Li
Rabbitfish Siganus canaliculatus is the first marine teleost reported to have the ability of biosynthesizing C20-22 long-chain polyunsaturated fatty acids (LC-PUFA) from C18 precursors, and thus provides a model for studying the regulatory mechanisms of LC-PUFA biosynthesis in teleosts. To investigate the possible roles of peroxisome proliferator-activated receptors (PPARs), critical transcription factors involved in the regulation of lipid metabolism, in the regulation of LC-PUFA biosynthesis in rabbitfish, the PPAR genes were cloned and their expression characterization with PPAR agonists, dietary lipid resource, and ambient salinity were examined...
April 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28095147/management-of-small-renal-masses-american-society-of-clinical-oncology-clinical-practice-guideline
#16
Antonio Finelli, Nofisat Ismaila, Bill Bro, Jeremy Durack, Scott Eggener, Andrew Evans, Inderbir Gill, David Graham, William Huang, Michael A S Jewett, Sheron Latcha, William Lowrance, Mitchell Rosner, Bobby Shayegan, R Houston Thompson, Robert Uzzo, Paul Russo
Purpose To provide recommendations for the management options for patients with small renal masses (SRMs). Methods By using a literature search and prospectively defined study selection, we sought systematic reviews, meta-analyses, randomized clinical trials, prospective comparative observational studies, and retrospective studies published from 2000 through 2015. Outcomes included recurrence-free survival, disease-specific survival, and overall survival. Results Eighty-three studies, including 20 systematic reviews and 63 primary studies, met the eligibility criteria and form the evidentiary basis for the guideline recommendations...
February 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28058732/bromocriptine-treatment-at-the-end-of-lactation-prevents-hyperphagia-higher-visceral-fat-and-liver-triglycerides-in-early-weaned-rats-at-adulthood
#17
Nayara Peixoto-Silva, Egberto G Moura, Janaine C Carvalho, Jéssica L Nobre, Fernanda T Quitete, Cintia R Pinheiro, Ana Paula Santos-Silva, Elaine de Oliveira, Patricia C Lisboa
Non-pharmacological early weaning (NPEW) leads offspring to obesity, higher liver oxidative stress and microsteatosis in adulthood. Pharmacological EW (PEW) by maternal treatment with bromocriptine (BRO) causes obesity in the adult progeny but precludes hepatic injury. To test the hypothesis that BRO prevents the deleterious changes of NPEW, we injected BRO into the pups from the NPEW model on late lactation. Lactating rats were divided into 2 groups: dams with an adhesive bandage around the body to prevent breastfeeding on the last 3 days of lactation and dams whose pups had free suckling (C)...
January 6, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28057435/antimicrobial-susceptibility-to-%C3%AE-lactam-antibiotics-and-production-of-bro-%C3%AE-lactamase-in-clinical-isolates-of-moraxella-catarrhalis-from-a-japanese-hospital
#18
Kageto Yamada, Katsumi Arai, Ryoichi Saito
We investigated BRO-β-lactamase production of Moraxella catarrhalis isolates and its antimicrobial susceptibility to β-lactams. Of the 233 isolates, 232 were BRO producers and 224 were BRO-1 producers. Four isolates exhibited elevated ceftriaxone minimum inhibitory concentration (2 μg/mL) and different pulsed-field gel electrophoresis patterns and we expect this number to increase in the near future.
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28049321/communication-interaction-of-bro-radical-with-the-surface-of-water
#19
Chongqin Zhu, Yurui Gao, Jie Zhong, Yingying Huang, Joseph S Francisco, Xiao Cheng Zeng
Solvation of a BrO radical in a slab of water is investigated using adaptive buffered force quantum mechanics/molecular mechanics (QM/MM) dynamics simulations. The simulation results show that the BrO radical exhibits preference towards the water surface with respect to the interior region of the water slab, despite BrO's high affinity to water. Another important finding is the weakening of (BrO)Br⋯O(water) interaction at the water surface due to competitive interactions between (BrO)Br⋯O(water) and (water)H⋯O(water)...
December 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28042073/predictors-of-complicated-grief-and-depression-in-bereaved-caregivers-a-nationwide-prospective-cohort-study
#20
Mette Kjaergaard Nielsen, Mette Asbjoern Neergaard, Anders Bonde Jensen, Peter Vedsted, Flemming Bro, Mai-Britt Guldin
CONTEXT: Complicated grief and depressive symptoms in bereaved caregivers have been associated with female gender, spousal relation, and preloss psychological distress, but population-based, prospective studies are scarce. OBJECTIVES: We aimed to investigate whether severe preloss grief and depressive symptoms, caregiver burden, preparedness for death, communication about dying, and socioeconomic factors predicted complicated grief and postloss depressive symptoms...
December 29, 2016: Journal of Pain and Symptom Management
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