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https://www.readbyqxmd.com/read/28716995/impact-of-gp-reminders-on-follow-up-of-abnormal-cervical-cytology-a-before-after-study-in-danish-general-practice
#1
Bettina Kjær Kristiansen, Berit Andersen, Flemming Bro, Hans Svanholm, Peter Vedsted
BACKGROUND: Dysplasia may progress because of a loss to follow-up after an abnormal cervical cytology. Approximately 18% of Danish women postpone the recommended follow-up, which depends on the cytology results. AIM: To investigate if a reminder to the GP about missed follow-up could reduce the proportion of women who fail to act on a recommended follow-up, and to analyse the effect on sociodemographic and general practice variations. DESIGN AND SETTING: A national electronic GP reminder system was launched in Denmark in 2012 to target missed follow-up after screening, opportunistic testing, or surveillance indication...
July 17, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28697531/pain-reduction-in-the-recanalization-of-chronic-iliofemoral-venous-occlusion-with-a%C3%A2-new-scoring-balloon-a-retrospective-series-in-10-consecutive-patients
#2
Christian Hohl, Anders Bro, Ronald Bruce Friedberg
No abstract text is available yet for this article.
July 11, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28686096/the-community-dental-service-in-abertawe-bro-morgannwg-university-health-board
#3
David Howell James Davies
No abstract text is available yet for this article.
July 2, 2017: British Journal of Community Nursing
https://www.readbyqxmd.com/read/28678731/the-potential-of-gelam-honey-in-promoting-the-proliferative-phase-of-corneal-reepithelialization
#4
Muhammad Fairuz Azmi, Norzana Abd Ghafar, Jemaima Che Hamzah, Ng Sook Luan, Chua Kien Hui
OBJECTIVE: The aim of this study is to investigate the potential bene ts of Gelam honey (GH) in promoting proliferation of ex vivo cor- neal epithelial cells (CECs) and its effects on the phenotypical features. MATERIALS AND METHODS: Corneal epithelial cells were isolated from the corneas of rabbits (n = 6). The optimal dose of GH for CEC proliferation in both basal medium (BM) and cornea medium (CM) was determined via MTT (3-[4, 5-dimethyl thiazolyl-2]-2, 5-diphenyl tetrazolium bro- mide) assay...
June 28, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28629377/quantitative-phosphoproteome-on-the-silkworm-bombyx-mori-cells-infected-with-baculovirus
#5
Jauharotus Shobahah, Shengjie Xue, Dongbing Hu, Cui Zhao, Ming Wei, Yanping Quan, Wei Yu
BACKGROUND: Bombyx mori has become an important model organism for many fundamental studies. Bombyx mori nucleopolyhedrovirus (BmNPV) is a significant pathogen to Bombyx mori, yet also an efficient vector for recombinant protein production. A previous study indicated that acetylation plays many vital roles in several cellular processes of Bombyx mori while global phosphorylation pattern upon BmNPV infection remains elusive. METHOD: Employing tandem mass tag (TMT) labeling and phosphorylation affinity enrichment followed by high-resolution LC-MS/MS analysis and intensive bioinformatics analysis, the quantitative phosphoproteome in Bombyx mori cells infected by BmNPV at 24 hpi with an MOI of 10 was extensively examined...
June 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/28626867/kind-of-blue-a-systematic-review-and-meta-analysis-of-music-interventions-in-cancer-treatment
#6
REVIEW
Margrethe Langer Bro, Kira Vibe Jespersen, Julie Bolvig Hansen, Peter Vuust, Niels Abildgaard, Jeppe Gram, Christoffer Johansen
OBJECTIVES: Music may be a valuable and low-cost coping strategy for cancer patients. We conducted a systematic review and meta-analysis to identify the psychological and physical effects of music interventions in cancer treatment. METHODS: We included randomized, controlled trials with adult patients in active cancer treatment exposed to different music interventions versus control conditions. Qualitative studies and systematic reviews were excluded. We identified a total of 2624 records through two systematic searches (June 2015, September 2016) in PubMed, Scopus, EMBASE, Cinahl, Web of Science, Cochrane and PsycINFO and used Risk of Bias Assessment, GRADE and Checklist for Reporting Music-Based Interventions to evaluate the music applied and quality of the studies...
June 18, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28596261/kidney-cancer-version-2-2017-nccn-clinical-practice-guidelines-in-oncology
#7
Robert J Motzer, Eric Jonasch, Neeraj Agarwal, Sam Bhayani, William P Bro, Sam S Chang, Toni K Choueiri, Brian A Costello, Ithaar H Derweesh, Mayer Fishman, Thomas H Gallagher, John L Gore, Steven L Hancock, Michael R Harrison, Won Kim, Christos Kyriakopoulos, Chad LaGrange, Elaine T Lam, Clayton Lau, M Dror Michaelson, Thomas Olencki, Phillip M Pierorazio, Elizabeth R Plimack, Bruce G Redman, Brian Shuch, Brad Somer, Guru Sonpavde, Jeffrey Sosman, Mary Dwyer, Rashmi Kumar
The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the clinical management of patients with clear cell and non-clear cell renal carcinoma. These guidelines are developed by a multidisciplinary panel of leading experts from NCCN Member Institutions consisting of medical oncologists, hematologists and hematologic oncologists, radiation oncologists, urologists, and pathologists. The NCCN Guidelines are in continuous evolution and are updated annually or sometimes more often, if new high-quality clinical data become available in the interim...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28581558/effects-of-halogens-on-european-air-quality
#8
T Sherwen, M J Evans, R Sommariva, L D J Hollis, S M Ball, P S Monks, C Reed, L J Carpenter, J D Lee, G Forster, B Bandy, C E Reeves, W J Bloss
Halogens (Cl, Br) have a profound influence on stratospheric ozone (O3). They (Cl, Br and I) have recently also been shown to impact the troposphere, notably by reducing the mixing ratios of O3 and OH. Their potential for impacting regional air-quality is less well understood. We explore the impact of halogens on regional pollutants (focussing on O3) with the European grid of the GEOS-Chem model (0.25° × 0.3125°). It has recently been updated to include a representation of halogen chemistry. We focus on the summer of 2015 during the ICOZA campaign at the Weybourne Atmospheric Observatory on the North Sea coast of the UK...
June 5, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28570902/bromate-formation-from-the-oxidation-of-bromide-in-the-uv-chlorine-process-with-low-pressure-and-medium-pressure-uv-lamps
#9
Jingyun Fang, Quan Zhao, Chihhao Fan, Chii Shang, Yun Fu, Xiangru Zhang
When a bromide-containing water is treated by the ultraviolet (UV)/chlorine process, hydroxyl radicals (HO) and halogen radicals such as Cl or Br are formed due to the UV photolysis of free halogens. These reactive species may induce the formation of bromate, which is a probable human carcinogen. Bromate formation in the UV/chlorine process using low pressure (LP) and medium pressure (MP) lamps in the presence of bromide was investigated in the present study. The UV/chlorine process significantly enhanced bromate formation as compared to dark chlorination...
May 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28560871/forecasting-chronic-diseases-using-data-fusion
#10
Evrim Acar, Gözde Gürdeniz, Francesco Savorani, Louise Hansen, Anja Olsen, Anne Tjønneland, Lars Ove Dragsted, Rasmus Bro
Data fusion, that is, extracting information through the fusion of complementary data sets, is a topic of great interest in metabolomics because analytical platforms such as liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy commonly used for chemical profiling of biofluids provide complementary information. In this study, with a goal of forecasting acute coronary syndrome (ACS), breast cancer, and colon cancer, we jointly analyzed LC-MS, NMR measurements of plasma samples, and the metadata corresponding to the lifestyle of participants...
June 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28499599/gas-chromatography-mass-spectrometry-data-processing-made-easy
#11
Lea G Johnsen, Peter B Skou, Bekzod Khakimov, Rasmus Bro
Evaluation of GC-MS data may be challenging due to the high complexity of data including overlapped, embedded, retention time shifted and low S/N ratio peaks. In this work, we demonstrate a new approach, PARAFAC2 based Deconvolution and Identification System (PARADISe), for processing raw GC-MS data. PARADISe is a computer platform independent freely available software incorporating a number of newly developed algorithms in a coherent framework. It offers a solution for analysts dealing with complex chromatographic data...
June 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28466057/whole-genome-sequence-and-comparative-genomic-sequence-analysis-of-helicoverpa-armigera-nucleopolyhedrovirus-hearnpv-l1-isolated-from-india
#12
Ashika T Raghavendra, Sushil K Jalali, Rakshit Ojha, Timalapur M Shivalingaswamy, Raj Bhatnagar
The whole genome of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) from India, HearNPV-L1, was sequenced and analyzed, with a view to look for genes and/or nucleotide sequences that might be involved in the differences and virulence among other HearNPVs sequenced from other countries like SP1A (Spain), NNg1 (Kenya) and G4 (China). The entire nucleotide sequence of the HearNPV-L1 genome was 136,740 bp in length having GC content of 39.19% and contained 113 ORFs that could encode polypeptides with more than 50 amino acids (GenBank accession number KT013224)...
March 2017: Virusdisease
https://www.readbyqxmd.com/read/28449840/collectively-operated-fellow-initiated-research-as-a-novel-teaching-model-to-bolster-interest-and-increase-proficiency-in-academic-research
#13
Guillaume Marquis-Gravel, Robert Avram, Maxime Tremblay-Gravel, Olivier Desplantie, Hung Q Ly, Anique Ducharme, E Marc Jolicoeur
Research is a core aspect of training in academic medicine, but fellows face many challenges thwarting their ability to perform clinically meaningful projects. The concept of a multicentre clinical trial collectively operated by fellows, and integrated longitudinally into training, has never been described. In this article, the authors expose the key principles of Collectively Operated Fellow-Initiated Research (COFIR) that they put in place. The aim of COFIR is to introduce a cohort of fellows to the career of clinician-scientists by conducting a longitudinal research project integrated into the curriculum of their clinical fellowship at a level they would not have access to as single individuals...
May 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28392286/a-comparison-of-the-adaptations-of-strains-of-lymantria-dispar-multiple-nucleopolyhedrovirus-to-hosts-from-spatially-isolated-populations
#14
V V Martemyanov, J D Podgwaite, I A Belousova, S V Pavlushin, J M Slavicek, O A Baturina, M R Kabilov, A V Ilyinykh
The adaptation of pathogens to either their hosts or to environmental conditions is the focus of many current ecological studies. In this work we compared the ability of six spatially-distant Lymantria dispar (gypsy moth) multiple nucleopolyhedrovirus (LdMNPV) strains (three from eastern North America and three from central Asia) to induce acute infection in gypsy moth larvae. We also sequenced the complete genome of one Asian (LdMNPV-27/0) and one North American (LdMNPV-45/0) strain which were used for bioassay...
April 7, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28365116/differential-somatic-cell-count-a-novel-method-for-routine-mastitis-screening-in-the-frame-of-dairy-herd-improvement-testing-programs
#15
Malin Damm, Claus Holm, Mette Blaabjerg, Morten Novak Bro, Daniel Schwarz
Somatic cell count (SCC) is used as key indicator in mastitis screening programs typically applied in the frame of Dairy Herd Improvement (DHI) testing programs. However, mastitis is still causing tremendous economic losses to the dairy industry. Hence, new biomarkers are needed that can be used for enhanced management of mastitis on dairy farms. Besides the determination of SCC, differentiation of cells has been described to be beneficial for a more definite description of the actual udder health status of dairy cows...
March 29, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28364490/sleep-disturbances-in-individuals-with-phelan-mcdermid-syndrome-correlation-with-caregivers-sleep-quality-and-daytime-functioning
#16
Della Bro, Ruth O'Hara, Michelle Primeau, Andrea Hanson-Kahn, Joachim Hallmayer, Jonathan A Bernstein
Study Objectives: The aims of this study were to document sleep disturbances in individuals with Phelan-McDermid syndrome (PMS), to assess whether these individuals had been evaluated for sleep disorders, and to examine relationships between the sleep behavior of these individuals and the sleep behavior and daytime functioning of their caregivers. Methods: Participants were 193 caregivers of individuals with PMS recruited by the Phelan-McDermid Syndrome Foundation...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28327100/impact-of-a-continuing-medical-education-meeting-on-the-use-and-timing-of-urgent-cancer-referrals-among-general-practitioners-a-before-after-study
#17
Berit Skjødeberg Toftegaard, Flemming Bro, Alina Zalounina Falborg, Peter Vedsted
BACKGROUND: Detection of cancer in general practice is challenging because symptoms are diverse. Even so-called alarm symptoms have low positive predictive values of cancer. Nevertheless, appropriate referral is crucial. As 85% of cancer patients initiate their cancer diagnostic pathway in general practice, a Continuing Medical Education meeting (CME-M) in early cancer diagnosis was launched in Denmark in 2012. We aimed to investigate the effect of the CME-M on the primary care interval, patient contacts with general practice and use of urgent cancer referrals...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28288114/disruption-of-the-atxn1-cic-complex-causes-a-spectrum-of-neurobehavioral-phenotypes-in-mice-and-humans
#18
Hsiang-Chih Lu, Qiumin Tan, Maxime W C Rousseaux, Wei Wang, Ji-Yoen Kim, Ronald Richman, Ying-Wooi Wan, Szu-Ying Yeh, Jay M Patel, Xiuyun Liu, Tao Lin, Yoontae Lee, John D Fryer, Jing Han, Maria Chahrour, Richard H Finnell, Yunping Lei, Maria E Zurita-Jimenez, Priyanka Ahimaz, Kwame Anyane-Yeboa, Lionel Van Maldergem, Daphne Lehalle, Nolwenn Jean-Marcais, Anne-Laure Mosca-Boidron, Julien Thevenon, Margot A Cousin, Della E Bro, Brendan C Lanpher, Eric W Klee, Nora Alexander, Matthew N Bainbridge, Harry T Orr, Roy V Sillitoe, M Cecilia Ljungberg, Zhandong Liu, Christian P Schaaf, Huda Y Zoghbi
Gain-of-function mutations in some genes underlie neurodegenerative conditions, whereas loss-of-function mutations in the same genes have distinct phenotypes. This appears to be the case with the protein ataxin 1 (ATXN1), which forms a transcriptional repressor complex with capicua (CIC). Gain of function of the complex leads to neurodegeneration, but ATXN1-CIC is also essential for survival. We set out to understand the functions of the ATXN1-CIC complex in the developing forebrain and found that losing this complex results in hyperactivity, impaired learning and memory, and abnormal maturation and maintenance of upper-layer cortical neurons...
April 2017: Nature Genetics
https://www.readbyqxmd.com/read/28271588/preloss-grief-in-family-caregivers-during-end-of-life-cancer-care-a-nationwide-population-based-cohort-study
#19
Mette Kjaergaard Nielsen, Mette Asbjoern Neergaard, Anders Bonde Jensen, Peter Vedsted, Flemming Bro, Mai-Britt Guldin
OBJECTIVE: Severe grief symptoms in family caregivers during end-of-life cancer trajectories are associated with complicated grief and depression after the loss. Nevertheless, severe grief symptoms during end-of-life caregiving in caregivers to cancer patients have been scarcely studied. We aimed to explore associations between severe preloss grief symptoms in caregivers and modifiable factors such as depressive symptoms, caregiver burden, preparedness for death, and end-of-life communication...
March 7, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28193288/accreditation-in-general-practice-in-denmark-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Merethe K Andersen, Line B Pedersen, Volkert Siersma, Flemming Bro, Susanne Reventlow, Jens Søndergaard, Marius Brostrøm Kousgaard, Frans B Waldorff
BACKGROUND: Accreditation is used increasingly in health systems worldwide. However, there is a lack of evidence on the effects of accreditation, particularly in general practice. In 2016 a mandatory accreditation scheme was initiated in Denmark, and during a 3-year period all practices, as default, should undergo accreditation according to the Danish Healthcare Quality Program. The aim of this study is primarily to evaluate the effects of a mandatory accreditation scheme. METHODS/DESIGN: The study is conducted as a cluster-randomized controlled trial among 1252 practices (clusters) with 2211 general practitioners in Denmark...
February 13, 2017: Trials
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