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https://www.readbyqxmd.com/read/28527386/gait-patterns-of-children-and-adolescents-with-charcot-marie-tooth-disease
#1
Elizabeth Wojciechowski, Amy Sman, Kayla Cornett, Jacqueline Raymond, Kathryn Refshauge, Manoj P Menezes, Joshua Burns
Gait abnormalities reported in childhood Charcot-Marie-Tooth disease (CMT) include foot-drop, reduced ankle power at push-off and increased knee and hip flexion for swing clearance ('steppage-gait'). The purpose of this study was to describe the gait patterns of 60 children aged 6-17 years with CMT (CMTall) and distinguish differences based on functional weakness using the CMT Pediatric Scale (CMTPedS). Data were captured using Vicon Nexus system and compared to 50 healthy norms. Data were subdivided into three groups denoting increasing severity of dorsiflexion and plantarflexion weakness from the CMTPedS: no difficulty heel or toe walking (CMTND), difficulty heel walking (CMTDH), difficulty toe and heel walking (CMTDTH)...
May 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28527376/the-effectiveness-of-cutoff-walls-to-control-saltwater-intrusion-in-multi-layered-coastal-aquifers-experimental-and-numerical-study
#2
Antoifi Abdoulhalik, Ashraf A Ahmed
The objective of this study was to examine the performance of cutoff walls in controlling saltwater intrusion in stratified heterogeneous coastal aquifers. Numerical and laboratory experiments were completed in laboratory-scale aquifer where the effectiveness of cutoff walls was assessed in three different configurations, including a homogeneous scenario, a stratified aquifer with high K-low K-high K pattern (case HLH) and another stratified aquifer with low K-high K-low K pattern (case LHL). The results show that the cutoff wall was effective in reducing the saltwater wedge in all the investigated cases of layered-aquifers with toe length reduction of up to 43%...
May 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28527190/tight-medial-knot-tying-may-increase-retearing-risk-after-transosseous-equivalent-repair-of-rotator-cuff-tendon
#3
Hirotaka Sano, Masako Tokunaga, Moriyuki Noguchi, Takashi Inawashiro, Taichi Irie, Hiroo Abe, A Toshimitsu Yokobori
BACKGROUND: Retearing mechanism after transosseous equivalent (TOE) rotator cuff repair has not been fully clarified yet. OBJECTIVE: The purposes of this study were to compare the stress distribution pattern in the tendon stump between knotted and knotless TOE repair and to investigate the role of suture tension applied during medial knot tying using a 3-dimensional finite element (3D-FE) method. METHODS: Both knotted and knotless TOE repairs were simulated on the 3D-FE human rotator cuff tear model...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28527188/optimum-pure-intrusion-of-a-mandibular-canine-with-the-segmented-arch-in-lingual-orthodontics
#4
Abhishek M Thote, Krishna Sharma, Rashmi V Uddanwadiker, Sunita Shrivastava
BACKGROUND: Approximately 50% patients with a deep bite possess anatomically extruded mandibular canines. OBJECTIVE: The objective of this study was to specify an optimum toe (Θ) of the vertical segment of a cantilever from the distal aspect to achieve pure intrusion of a mandibular canine with the segmented arch in lingual orthodontics (LiO). METHODS: The geometrical model of a mandibular canine was developed to compute the required values of Θ (positive values - toe-in, negative values - toe-out)...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28526335/the-spider-toxin-ph%C3%AE-1%C3%AE-recombinant-possesses-strong-analgesic-activity
#5
Flavia Karine Rigo, Gabriela Trevisan, Samira Dal-Toé De Prá, Marta Nascimento Cordeiro, Marcia Helena Borges, Juliana Figueiredo Silva, Flavia Viana Santa Cecilia, Alessandra Hubner de Souza, Gabriela de Oliveira Adamante, Alessandra Marcon Milioli, Célio José de Castro Junior, Juliano Ferreira, Marcus Vinicius Gomez
The native Phα1β - a Voltage-Gated Calcium Channel (VGCC) blocker - and its Recombinant Version - were both tested in rodent pain models with an intraplantar injections of capsaicin or formalin, a chronic constriction injury, and melanoma cancer related pain. The formalin nociceptive behaviour in the neurogenic phase was not affected by the toxin pre-treatments, while in the inflammatory phase, Phα1β and the Recombinant form caused a significant reduction. The nociception that was triggered by capsaicin, an agonist of the TRPV1 vanilloid receptor, was totally blocked by 100 pmol/site, i...
May 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28523890/handy-hints-about-raynaud-s-phenomenon-in-children-a-critical-review
#6
REVIEW
Donato Rigante, Michele Fastiggi, Francesco Ricci, Francesca D'Errico, Benedetta Bracci, Cristina Guerriero
Raynaud's phenomenon (RP) is a vasospastic disorder characterized by recurrent self-limited episodes of skin pallor, cyanosis, and hyperemia caused by paroxysmal spasms in the small arteries of the fingers and toes and can occur in any age group. Hands, feet, nose, ears, and nipples can be affected. The diagnosis is made clinically, assessing varying degrees of ischemia in the involved areas of skin, but this transient ischemia may also herald the onset of connective tissue disease. Investigation is recommended when RP starts in childhood to exclude an underlying autoimmune condition and close follow-up for its development...
May 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28523332/apert-syndrome-clinical-case
#7
Mirela Anişoara Siminel, Cristian Ovidiu NeamŢu, Damian DiŢescu, Mircea Cătălin ForŢofoiu, Alexandru Cristian Comănescu, Marius Bogdan Novac, Simona Daniela NeamŢu, Adrian Gluhovschi
Apert syndrome - acrocephalosyndactyly - is a rare autosomal dominant disorder representing 1:65 000 cases of living newborns. Characteristic malformations of the Apert syndrome are early craniostenosis, microviscerocranium and II-V finger syndactyly of hand and toes with proximal phalanx of the bilateral thumb "in delta". It is difficult to determine prenatal diagnosis in the second quarter, when examining the morphology of fetal signs; the dysmorphism signs appeared in the third pregnancy quarter. We present here the case of a newborn with Apert syndrome that was born prematurely in our Clinic after a monitored pregnancy, where there was issued a suspicion of cranio-facial dysmorphism, malposition and malformation of the feet and hands in the third quarter of prenatal pregnancy...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28520458/anchored-transosseous-equivalent-versus-anchorless-transosseous-rotator-cuff-repair-a-biomechanical-analysis-in-a-cadaveric-model
#8
Kelly G Kilcoyne, Stanley G Guillaume, Catherine V Hannan, Evan R Langdale, Stephen M Belkoff, Uma Srikumaran
BACKGROUND: The original approach for the repair of torn rotator cuffs involved an open technique with sutures passing through the greater tuberosity and tendon. The development of suture anchors allowed for an all-arthroscopic approach with anchor configurations attempting to re-create a transosseous fixation pattern. Presently, an arthroscopic approach can be combined with a transosseous suture configuration without using anchors. PURPOSE: To evaluate cyclic loading, ultimate load to failure, and the failure mechanisms of transosseous-equivalent (TOE) repair with anchors and anchorless transosseous (AT) repair of rotator cuff tears...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28516802/the-influence-of-heating-on-toe-pressure-in-patients-with-peripheral-arterial-disease
#9
N Settembre, T Kagayama, P Kauhanen, P Vikatmaa, Y Inoue, M Venermo
BACKGROUND AND AIM: The toe skin temperature in vascular patients can be low, making reliable toe pressure measurements difficult to obtain. The aim of this study was to evaluate the effect of heating on the toe pressure measurements. MATERIALS AND METHODS: A total of 86 legs were examined. Brachial pressure and toe pressure were measured at rest in a supine position using a laser Doppler device that also measured skin temperature. After heating the toes for 5 min with a heating pad, we re-measured the toe pressure...
May 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28516052/whole-body-mri-of-the-non-human-primate-using-a-clinical-3t-scanner-initial-experiences
#10
Chun-Xia Li, Xiaodong Zhang
With the advent of parallel imaging MRI techniques, whole-body MRI is being increasingly used in clinical diagnosis. However, its application in preclinical research using large animals remains very limited. In the present study, the whole-body MRI techniques for adult macaque monkeys were explored using a conventional clinic 3T scanner. The T1, T2 anatomical images, and MR angiography of adult macaque whole bodies were illustrated. The preliminary results suggest whole-body MRI can be a robust tool to examine multiple organs of non-human primate (NHP) models from head to toe non-invasively and simultaneously using a conventional clinical setting...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28515978/variation-in-medial-and-lateral-gastrocnemius-muscle-activity-with-foot-position
#11
Michael Cibulka, April Wenthe, Zach Boyle, Dylan Callier, Adam Schwerdt, Deidra Jarman, Michael J Strube
BACKGROUND: The gastrocnemius has two heads, medial gastrocnemius (MG) and lateral gastrocnemius (LG); little is known how they contract with different foot positions. The MG is more frequently strained than the LG; and gastrocnemius activation pattern altered by foot position may play a role in injury. Leg exercises often use a toe-in versus toe-out foot position to isolate one gastrocnemius head over another. PURPOSE: The purpose of this study was to determine the electromyographic gastrocnemius muscle activity in the toe-out and toe-in foot positions during weight bearing and non-weight bearing activities...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#12
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28514726/retrospective-analysis-of-risk-factors-associated-with-kawasaki-disease-in-china
#13
Lihua Bai, Tienan Feng, Lifang Yang, Yi Zhang, Xuejuan Jiang, Jiayao Liao, Lihua Chen, Xiaoyan Feng, Yanming Rong, Yuehua Li, Zhiqiang Qin, Jing Qiao
In order to provide early intervention for coronary artery lesion (CAL) caused by Kawasaki Disease (KD), we analyzed clinical characteristics of typical and incomplete KD cases from 1998 to 2008 in Northwest and Central China. A total of 383 patients included 298 cases of typical KD and 85 cases of incomplete KD. The morbidity of incomplete KD was 28.5%, a percentage significantly lower than that of typical KD. The occurrence of bulbar conjunctiva congestion, erythra, crissum red, film-like decrustation, lip red, rhagades, raspberry tongue, bilateral toe-end decrustation, limb sclerosis, cervical lymph nodes enlargement, agitation and irritability in incomplete KD group was lower than that in the group of typical KD (p < 0...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28513212/an-optical-fiber-based-smart-textile-smart-socks-to-manage-biomechanical-risk-factors-associated-with-diabetic-foot-amputation
#14
Bijan Najafi, Hooman Mohseni, Gurtej S Grewal, Talal K Talal, Robert A Menzies, David G Armstrong
OBJECTIVE: This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN). METHODS: After in-vitro validation in the laboratory, 33 eligible subjects with DPN were recruited (age: 58 ± 8 years, BMI: 31.5 ± 8 kg/m(2)) for assessing plantar pressure and temperature during habitual gait-speed in a clinical-setting. All participants were asked to walk at their habitual speed while wearing a pair of sensorized socks made from highly flexible fiber optics (SmartSox)...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28511170/mosaic-trisomy-9p-in-a-patient-with-mild-dysmorphic-features-and-normal-intelligence
#15
Randeep Brar, Donald G Basel, David P Bick, LuAnn Weik, Peter vanTuinen, Jess F Peterson
To the Editor: Partial and whole duplications of the short arm of chromosome 9 have been commonly reported in the literature with characteristic phenotypic features and intellectual disabilities. The clinical features of 9p duplications are broad and can include growth retardation, developmental delay, intellectual disability, microbrachycephaly, deep set eyes, hypertelorism, downslanting palpebral fissures, prominent nasal root, bulbous nasal tip, low-set ears, short fingers and toes with hypoplastic nails, and delayed bone age (Bonaglia et al...
2017: Journal of the Association of Genetic Technologists
https://www.readbyqxmd.com/read/28510739/comparison-of-preoperative-and-intraoperative-assessment-of-aortic-stenosis-severity-by-echocardiography
#16
Y Uda, B Cowie, R Kluger
Background: General anaesthesia and surgically induced changes in cardiac loading conditions may alter flow across the aortic valve. This study examined how echocardiographic assessment of the severity of aortic stenosis (AS) changes during surgery. Methods: Patients who underwent aortic valve replacement for any severity of AS between July 2007 and June 2015 were identified. Peak velocities, mean gradients, and dimensionless indices (DI) measured with preoperative transthoracic echocardiography (TTE) were compared with those measured with intraoperative transoesophageal echocardiography (TOE)...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28509696/on-top-index-pollicization-after-a-partial-amputation-of-a-syndactylized-hypoplastic-thumb-in-a-patient-with-townes-brocks-syndrome
#17
Mia Lorencin, Kresimir Bulic
Townes-Brocks syndrome is a rare autosomal dominant syndrome characterized by multiple malformations, including thumb anomalies. Thumb hypoplasia poses a specific problem, where a deficient thumb creates a significant handicap in hand function. The treatment goal is enabling pinch and grip activity, and the preferred procedure for a severely hypoplastic thumb is index finger pollicization. We present a case of on-top index pollicization in a 10-year-old, after a partial amputation of a previously syndactylized hypoplastic thumb, with a well-formed first carpometacarpal joint...
May 15, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28508973/phlegmasia-cerulean-dolens-complication-of-femoral-vein-catheterization
#18
M Hari Krishna Reddy, B Sangeetha, M Aruna, V Sarat Chandra, Anil C Venkata Kumar, R Ram, V Sivakumar
There are three less frequent manifestations of acute massive venous thrombosis and obstruction of the venous drainage of an extremity. They are phlegmasia alba dolens, phlegmasia cerulean dolens (PCD), and venous gangrene. The term PCD differentiates ischemia-associated massive venous thrombosis from phlegmasia alba dolens, which describes fulminant venous thrombosis without ischemia. We present a 55-year-old hypertensive, who presented with paedal oedema and breathlessness at rest. About a month prior to this admission, she suffered dislocation of left patella...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28507859/the-double-volar-flap-technique-for-aesthetic-repair-of-syndactyly-and-polysyndactyly-of-toe-without-skin-grafting
#19
Toru Miyanaga, Kenichi Shimada, Miyuki Kishibe, Masanobu Yamashita, Akiko Yamashita
BACKGROUND: Aesthetic repair of syndactyly of the toes is desirable because patients may have psychological concerns about its appearance. There are 2 important factors for the aesthetic repair of syndactyly of the toe. One is to hide the operative scar from the visual site (dorsal site), whereas the other is to create an interdigital space close to the normal anatomical skin characteristics (2 general types of skin: glabrous and hairy). METHODS: In total, 12 patients (4 males and 8 females) with 15 syndactylous webs were operated on by using the double volar flap technique...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28507300/minimum-toe-clearance-probing-the-neural-control-of-locomotion
#20
Tim Killeen, Christopher S Easthope, László Demkó, Linard Filli, Lilla Lőrincz, Michael Linnebank, Armin Curt, Björn Zörner, Marc Bolliger
Minimum toe clearance (MTC) occurs during a highly dynamic phase of the gait cycle and is associated with the highest risk of unintentional contact with obstacles or the ground. Age, cognitive function, attention and visual feedback affect foot clearance but how these factors interact to influence MTC control is not fully understood. We measured MTC in 121 healthy individuals aged 20-80 under four treadmill walking conditions; normal walking, lower visual field restriction and two Stroop colour/word naming tasks of two difficulty levels...
May 15, 2017: Scientific Reports
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