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https://www.readbyqxmd.com/read/29314761/keratinous-matrices-for-the-assessment-of-drugs-of-abuse-consumption-a-correlation-study-between-hair-and-nails
#1
Delphine Cappelle, Steven De Keukeleire, Hugo Neels, Frederic Been, Mireille De Doncker, Geert Dom, Cleo L Crunelle, Adrian Covaci, Alexander L N van Nuijs
Keratinous matrices - hair and nails - accumulate substances over time and allow retrospective investigation of past consumption. Analysis of these matrices can provide information complementary to blood and urine analysis or can be used as standalone. So far, research has primarily focused on the detection of substances in hair, while studies in nails are scarce. In this study, we assessed concentrations of drugs of abuse and their metabolites in hair, finger- and toenails collected from the same individuals to evaluate differences and correlations between matrices...
January 5, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29314106/toenail-mercury-levels-are-associated-with-amyotrophic-lateral-sclerosis-als-risk
#2
Angeline S Andrew, Celia Y Chen, Tracie A Caller, Rup Tandan, Patricia L Henegan, Brian P Jackson, Brenda P Hall, Walter G Bradley, Elijah W Stommel
INTRODUCTION: Mercury is a neurotoxic metal that is potentially a risk factor for amyotrophic lateral sclerosis (ALS). Consumption of methylmercury contaminated fish is the primary source of U.S. population exposure to mercury. METHODS: We used inductively coupled plasma mass spectrometry to measure levels of mercury in toenail samples from ALS patients (n=46) and from controls (n=66), as a biomarker of mercury exposure. RESULTS: ALS patients had higher toenail mercury levels (OR 2...
January 4, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29305107/five-threads-how-u-shaped-thinking-weaves-together-dogs-men-selenium-and-prostate-cancer-risk
#3
REVIEW
David J Waters, Emily C Chiang
Prostate cancer is one of the leading causes of cancer-related mortality among men living in developed countries, making the development of safe, practical approaches to prostate cancer risk reduction a high research priority. The relationship between prostate cancer risk and selenium, an essential nutrient required for a number of metabolically important enzymes including glutathione peroxidases, has been investigated, but a satisfactory integration of results has proven elusive. Dogs, like men, naturally develop prostate cancer during aging, providing an appropriate context to study the effects of selenium supplementation on the dysregulation of homeostasis that drives cancer development within the aging prostate...
January 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29304040/serum-selenium-levels-and-the-risk-of-progression-of-laryngeal-cancer
#4
Jan Lubiński, Wojciech Marciniak, Magdalena Muszynska, Ewa Jaworowska, Mieczyslaw Sulikowski, Anna Jakubowska, Katarzyna Kaczmarek, Grzegorz Sukiennicki, Michal Falco, Piotr Baszuk, Magdalena Mojsiewicz, Joanne Kotsopoulos, Ping Sun, Steven A Narod, Jan A Lubiński
BACKGROUND: Observational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, the impact of low serum selenium level on survival has not been evaluated. METHODS: We conducted a prospective study of 296 patients diagnosed with laryngeal cancer in Szczecin, Poland. Serum selenium was measured at diagnosis and prior to treatment. Patients were followed from the date of diagnosis to death at five years...
2018: PloS One
https://www.readbyqxmd.com/read/29287923/manganese-and-lead-levels-in-settled-dust-in-elementary-schools-are-correlated-with-biomarkers-of-exposure-in-school-aged-children
#5
Juliana L G Rodrigues, Matheus J Bandeira, Cecília F S Araújo, Nathália R Dos Santos, Ana Laura S Anjos, Ng Lai Koin, Laiz C Pereira, Sérgio S P Oliveira, Donna Mergler, José A Menezes-Filho
Previously, we showed that manganese (Mn) levels in settled dust in elementary schools increased at a rate of 34.1% per km closer to a ferro-manganese alloy plant in the rainy season. In this study, we investigated how this environmental pollution indicator varied in the dry season and if there was an association with Mn biomarker levels in school-aged children. Dust samples were collected with passive samplers (disposable Petri dishes) placed in interior and exterior environments of 14 elementary schools. Occipital hair, toenails and blood samples were collected from 173 students aged 7-12 years from three of these schools, with varying distance from the industrial plant...
December 26, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29286021/toenail-onychomycosis-by-trichophyton-rubrum-and-concurrent-infestation-with-tyrophagus-putrescentiae
#6
Valentina Fabrizi, Ivana Zacconi, Mario Principato, Cristina Pesca, Deborah Cruciani, Silvia Crotti, Manuela Papini
A remarkable case of onychomycosis by Trichophyton (T.) rubrum combined with nail infestation by Tyrophagus (T.) putrescentiae in an elderly diabetic farmer is described and discussed. Large numbers of eggs and mites in all development stages were present in nail debris, reflecting active reproduction on site. Treatment with ivermectin 0.1% cream and environmental decontamination cleared the mite infestation, while onychomycosis responded well to oral terbinafine and ciclopirox 8% nail lacquer. Such a combination of onychomycosis and mite infestation of the same nail is an exceptional finding reported only twice in the literature...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29273187/distal-syme-hallux-amputation-for-tip-of-toe-wounds-and-gangrene-complicated-by-osteomyelitis-of-the-distal-phalanx-surgical-technique-and-outcome-in-consecutive-cases
#7
Troy J Boffeli, Mark S Goss
Distal hallux gangrene and neuropathic ulceration associated with digit deformity frequently result in osteomyelitis of the distal phalanx. Ideal treatment would involve limited resection to preserve function. We describe our surgical technique and retrospective results for distal Syme hallux amputation with plantar flap closure. An institutional review board-approved review was conducted on cases performed over 8 years. A total of 15 consecutive patients (16 digits) with hallux soft tissue loss who had undergone distal Syme hallux amputation were included...
December 19, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29245039/prenatal-arsenic-exposure-child-marriage-and-pregnancy-weight-gain-associations-with-preterm-birth-in-bangladesh
#8
Mohammad L Rahman, Molly L Kile, Ema G Rodrigues, Linda Valeri, Anita Raj, Maitreyi Mazumdar, Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Russ Hauser, Andrea Baccarelli, Liming Liang, David C Christiani
BACKGROUND: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. Individual studies have shown that exposure to arsenic contaminated drinking water, child marriage, and low maternal weight gain during pregnancy contribute to preterm birth. These factors are highly prevalent and often co-exist in Bangladesh, a country in South Asia with one of the world's highest prevalences of preterm birth. OBJECTIVE: To evaluate the individual and interactive effects of prenatal arsenic exposure, child marriage, and pregnancy weight gain on preterm birth in a prospective birth cohort in Bangladesh...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29240863/long-term-follow-up-of-onychomycosis-patients-treated-with-efinaconazole
#9
Richard A Pollak, Carla Ilie
Onychomycosis is a common disease that remains difficult to treat despite the introduction of new topical agents. Clinical trials on efinaconazole and tavaborole included 48 weeks' daily treatment regimens with a 4-week follow-up. It has been suggested that either a longer treatment regimen or longer follow-up would lead to even better results, primarily due to the time taken for the diseased nail to grow out, especially in those patients with more severe disease. <p>OBJECTIVE: To investigate the impact of a longer follow-up period on the efficacy of efinaconazole 10% topical solution in patients with moderate-to-severe onychomycosis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29204392/subungual-melanoma-is-not-so-rare-report-of-four-cases-from-india
#10
Archana Singal, Deepika Pandhi, Priyanka Gogoi, Chander Grover
Subungual melanoma (SUM) is an uncommon form of acral melanoma that arises within the nail matrix. The incidence for acral melanomas is similar worldwide, however, the proportion is higher in dark-skinned individuals. The subungual form represents approximately 2% of cutaneous non-sun-induced melanomas in the western world and up to 75% in Africans, 10% in Japanese, and 25% in the Chinese. No specific figures are available from the Indian subcontinent; however, the authors could trace three anecdotal case reports published over the last two decades...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29186301/toenail-manganese-a-sensitive-and-specific-biomarker-of-exposure-to-manganese-in-career-welders
#11
Eric J Ward, David A Edmondson, Mahmoud M Nour, Sandy Snyder, Frank S Rosenthal, Ulrike Dydak
Manganese (Mn) is an essential trace metal. It is also a component of welding fume. Chronic inhalation of manganese from welding fume has been associated with decreased neurological function. Currently, there is not a universally recognized biomarker for Mn exposure; however, hair and toenails have shown promise. In a cohort of 45 male welders and 35 age-matched factory control subjects, we assessed the sensitivity and specificity of toenail Mn to distinguish occupationally exposed subjects from unexposed controls...
November 25, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29182795/epidermolysis-bullosa-acquisita-in-an-adult-patient-with-previously-unrecognized-mild-dystrophic-eb-and-biallelic-col7a1-mutations
#12
Liliana Guerra, Angelo Giuseppe Condorelli, Paola Fortugno, Valentina Calabresi, Cristina Pedicelli, Giovanni Di Zenzo, Daniele Castiglia
Circulating anti-type VII collagen autoantibodies are frequently detected in patients with recessive dystrophic epidermolysis bullosa (RDEB). However, evidence supporting their pathogenic role in inducing epidermolysis bullosa acquisita (EBA) has been provided for only 1 individual with dominant dystrophic epidermolysis bullosa (DDEB). We describe here a patient who presented with dystrophic toenails since early childhood and developed trauma-induced skin blisters and oral erosions at age 26 years. Direct immunofluorescence showed IgG deposits with a u-serrated pattern along the cutaneous basement membrane zone, while no change in the expression of collagen VII could be detected by antigen mapping...
November 28, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29177144/habit-tic-deformity-of-bilateral-thumb-and-toenails-in-a-young-boy-an-unusual-occurrence
#13
Archana Singal
No abstract text is available yet for this article.
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29170880/fingernail-and-toenail-clippings-as-a-non-invasive-measure-of-chronic-cortisol-levels-in-adult-cancer-survivors
#14
Andrew D Frugé, Mallory G Cases, Carrie R Howell, Yuko Tsuruta, Kelley Smith-Johnston, Douglas R Moellering, Wendy Demark-Wahnefried
PURPOSE: Cancer survivors are at greater risk of comorbidities and functional decline due to physiological and psychological stress which can be measured by salivary cortisol. If saliva is used, multiple samples must be collected to accurately quantify long-term stress; however, fingernail (FN) and toenail (TN) clippings offer an opportunity to measure retrospective cortisol levels in a non-invasive manner. METHODS: Three sets of FN and TN clippings were collected at 12-month intervals in conjunction with saliva samples from cancer survivors (n = 109) participating in two clinical trials...
November 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29164433/distal-lateral-subungual-onychomycosis-owing-to-tritirachium-oryzae-a-bystander-or-invader
#15
Hari Pankaj Vanam, P Narsimha Rao, Kalyani Mohanram, Prakash Peralam Yegneswaran, Shiva Prakash Mandya Rudramurthy
The genus Tritirachium is a mitosporic fungus which inhabits in soil and decaying plant material and also a notable insect pathogen. Human infections with Tritirachium species though rare were previously reported to cause corneal ulcers, otomycosis, onychomycosis, and dermatomycosis of the scalp and hence may be considered as a potential pathogen. Here we report a case of distal lateral subungual onychomycosis involving right great toenail in a 22-year-old female, wherein direct potassium hydroxide preparations, fungal cultures, and molecular sequencing of the isolate established Tritirachium oryzae as the etiological agent...
November 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29152064/development-of-a-population-based-cancer-case-control-study-in-southern-china
#16
Weimin Ye, Ellen T Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L Vaughan, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami
With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29147866/a-review-of-onychomycosis-due-to-aspergillus-species
#17
REVIEW
Felix Bongomin, C R Batac, Malcolm D Richardson, David W Denning
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29144037/a-15-year-old-girl-with-a-funky-looking-great-toenail
#18
Katerina Yale, Julie Jefferson, A Yasmine Kirkorian
No abstract text is available yet for this article.
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29126627/-clinical-and-mycological-characteristics-of-onychomycosis-due-to-candida-at-institut-pasteur-of-c%C3%A3-te-d-ivoire
#19
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29125237/toenail-mineral-concentration-and-risk-of-esophageal-squamous-cell-carcinoma-results-from-the-golestan-cohort-study
#20
Maryam Hashemian, Gwen Murphy, Arash Etemadi, Hossein Poustchi, John D Brockman, Farin Kamangar, Akram Pourshams, Masoud Khoshnia, Abdolsamad Gharavi, Sanford M Dawsey, Paul J Brennan, Paolo Boffetta, Azita Hekmatdoost, Reza Malekzadeh, Christian C Abnet
Studies conducted in China linked selenium deficiency to higher risk of esophageal squamous cell carcinoma (ESCC), but this has not been widely tested outside that selenium-deficient region. The aim of this study was to investigate the association between selenium and other mineral concentrations in toenails and risk of ESCC in a region with high incidence rates. In this nested case-control study, we identified 222 cases of ESCC from the Golestan Cohort Study, Iran, which has followed up 50,045 participants since enrollment (2004-2008)...
November 10, 2017: Cancer Medicine
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