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https://www.readbyqxmd.com/read/29147866/a-review-of-onychomycosis-due-to-aspergillus-species
#1
REVIEW
Felix Bongomin, C R Batac, Malcolm D Richardson, David W Denning
Aspergillus spp. are emerging causative agents of non-dermatophyte mould onychomycosis (NDMO). New Aspergillus spp. have recently been described to cause nail infections. The following criteria are required to diagnose onychomycosis due to Aspergillus spp.: (1) positive direct microscopy and (2) repeated culture or molecular detection of Aspergillus spp., provided no dermatophyte was isolated. A review of 42 epidemiological studies showed that onychomycosis due to Aspergillus spp. varies between < 1 and 35% of all cases of onychomycosis in the general population and higher among diabetic populations accounting for up to 71% and the elderly; it is very uncommon among children and adolescence...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29144037/a-15-year-old-girl-with-a-funky-looking-great-toenail
#2
Katerina Yale, Julie Jefferson, A Yasmine Kirkorian
No abstract text is available yet for this article.
November 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29126627/-clinical-and-mycological-characteristics-of-onychomycosis-due-to-candida-at-institut-pasteur-of-c%C3%A3-te-d-ivoire
#3
K E Angora, A Ira-Bonouman, A H Vanga-Bosson, A Konaté, F K Kassi, K Tuo, K Sylla-Thanon, P C Kiki-Barro, S Miezan, A V Bedia-Tanoh, V Djohan, W Yavo, E H Menan, A T Offianan
OBJECTIVE: This study aims to study the clinical and mycological characteristics of onychomycosis due to Candida in mycology unit of Institut Pasteur of Côte d'Ivoire. PATIENTS AND METHODS: This is a retrospective study which was carried out on patients from 1990 to 2016 for mycological diagnosis of onychomycosis and which socio-demographic characteristics, direct examination and culture results were recorded. RESULTS: In this study, 1898 patient files were selected...
November 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29125237/toenail-mineral-concentration-and-risk-of-esophageal-squamous-cell-carcinoma-results-from-the-golestan-cohort-study
#4
Maryam Hashemian, Gwen Murphy, Arash Etemadi, Hossein Poustchi, John D Brockman, Farin Kamangar, Akram Pourshams, Masoud Khoshnia, Abdolsamad Gharavi, Sanford M Dawsey, Paul J Brennan, Paolo Boffetta, Azita Hekmatdoost, Reza Malekzadeh, Christian C Abnet
Studies conducted in China linked selenium deficiency to higher risk of esophageal squamous cell carcinoma (ESCC), but this has not been widely tested outside that selenium-deficient region. The aim of this study was to investigate the association between selenium and other mineral concentrations in toenails and risk of ESCC in a region with high incidence rates. In this nested case-control study, we identified 222 cases of ESCC from the Golestan Cohort Study, Iran, which has followed up 50,045 participants since enrollment (2004-2008)...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29116824/paronychia-with-sporangium-formation-causing-an-ingrown-toenail-a-rare-case-report
#5
Chi-Yu Wang, Chung-Chih Hong, Ting-Fu Su, Shun-Cheng Chang
Ingrown toenail, or onychocryptosis, is a common inflammatory disease of the hallux. It results from the alteration of fit of the nail plate in the lateral nail fold. They are usually seen in adolescents and young adults and can affect daily activities and social life. Generally, ingrown toenails are classified into three stages, including inflammatory stage, abscess stage and granulation stage. Here we have presented the rare case of a male with a diagnosis of paronychia with sporangium formation causing an ingrown toenail...
November 8, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29090033/first-report-of-pachyonychia-congenita-type-pc-k6a-in-the-romanian-population
#6
Anca Chiriac, Cristina Rusu, Alina Murgu, Anca E Chiriac, Neil J Wilson, Frances J D Smith
Pachyonychia congenita (PC) is a rare autosomal dominant skin disorder, with unknown prevalence, although it is estimated there are between 2,000 and 10,000 cases of PC worldwide. The International PC Research Registry (IPCRR) has currently identified (as of November 2016) 746 individuals (in 403 families) with genetically confirmed PC. Heterozygous mutations, predominantly missense mutations, in any one of five keratin genes, KRT6A, KRT6B, KRT6C, KRT16, or KRT17 cause PC. The predominant clinical findings include plantar keratoderma, plantar pain and variable dystrophy of some or all toenails and/ or fingernails...
June 2017: Mædica
https://www.readbyqxmd.com/read/29077504/point-of-care-diagnosis-of-onychomycosis-by-dermoscopy
#7
Myron A Bodman
BACKGROUND: Onychomycosis is one of the most common diseases of the toenails. The costs of diagnosis and treatment are substantial, and as the population ages, the overall cost burden will continue to escalate. The purpose of this study was to correlate dermoscopic features with pathologic diagnosis to support the accuracy of point-of-care diagnosis by dermoscopic examination. METHODS: Nail unit pathology reports of 52 patients with abnormal great toenails were compared with the dermoscopic features detected by nail unit dermoscopy...
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29077500/behcet-s-diseasea-case-report
#8
James M Mahoney, Kelsey Millonig
Behcet's disease is a rare autoimmune systemic vasculitis. It usually presents with a symptom complex involving primarily mucocutaneous lesions, genital lesions, and uveitis. When it involves the lower extremity, venous and arterial disease predominates, and joint involvement occurs in approximately 50% of patients. We present a patient with Behcet's disease who was initially referred to us for chronic toenail pathology.
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29071506/opacity-of-big-toenail-predicts-poor-prognosis-in-patients-with-end-stage-renal-disease-on-hemodialysis
#9
Osamu Soma, Shingo Hatakeyama, Teppei Matsumoto, Toshikazu Tanaka, Yoshimi Tanaka, Shogo Hosogoe, Hirotake Kodama, Hirotaka Horiguchi, Yuka Kubota, Koichi Kido, Masaki Momota, Go Anan, Ikuyo Narita, Ryuji Kitahara, Hisao Saitoh, Tadashi Suzuki, Chikara Ohyama
BACKGROUND: The impact of nail abnormalities on prognosis in hemodialysis patients is unknown. This study investigated whether toenail opacity as a readout of nail abnormalities predicted prognosis in hemodialysis patients. METHODS: In this observational study, 494 eligible hemodialysis patients who received hemodialysis at Oyokyo Kidney Research Institute between September 2010 and December 2015 were included. The presence of nail abnormalities was objectively evaluated by big toenail opacity ratio measurement...
October 25, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29068262/correction-to-zhang-et-al-quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#10
(no author information available yet)
No abstract text is available yet for this article.
October 25, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29052949/the-risks-and-external-effects-of-diabetic-foot-ulcer-on-diabetic-patients-a-hospital-based-survey-in-wuhan-area-china
#11
Aimei Zhong, Gongchi Li, Dan Wang, Yi Sun, Xinghua Zou, Binghui Li
Diabetic foot ulcer (DFU) is a common complication observed in diabetic patients and affects diabetic patients in multiple ways. Severe DFU even leads to amputation in many cases. Early detection and intervention of DFU in diabetic patients can significantly relieve the pain caused by the ulcer and also keep patients from losing limbs in severe cases. In this study, the risks of diabetic patients getting DFU were estimated through a hospital-based survey. This survey collected information from hospitalized diabetic patients in Wuhan City, Hubei Province, China, using a questionnaire...
October 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29036255/tavaborole-in-difficult-to-treat-onychomycosis-cases-a-post-hoc-assessment-of-phase-iii-subjects
#12
Raza Aly, Aditya K Gupta, Tate Winter, Lee T Zane, Tracey Vlahovic
Toenail onychomycosis is a chronic fungal infection that often requires prolonged treatment in order to effectively manage pathogenic organisms and obtain a clear nail. Traditionally, certain clinical features of onychomycosis, including the presence of substantial lateral disease, focal fungal masses, yellow/brown streaks, and extensive nail involvement (ie, >50%), indicate a poor treatment prognosis and have proven difficult-to-treat with oral or traditional topical therapies. Owing to the novel features of topical tavaborole, we sought to understand the potential utility of tavaborole in difficult-to-treat onychomycosis...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28985222/trace-element-contents-in-toenails-are-related-to-regular-physical-activity-in-older-adults
#13
MULTICENTER STUDY
Antoni Sureda, Maria Del Mar Bibiloni, Alicia Julibert, Raquel Aparicio-Ugarriza, Gonzalo Palacios-Le Blé, Antoni Pons, Marcela Gonzalez-Gross, Josep A Tur
The aim was to assess the trace element contents in toenails of older adults and its association with regular physical activity. Cross-sectional multicentre study in Spain, collecting data from a random sample of 380 participants (54% female) aged 55-80 years (men) and 60-80 years (women) with no previously documented cardiovascular disease. Physical activity performed was measured using the Minnesota Leisure-time Physical Activity Questionnaire. The 25 most inactive and 25 most active individuals for each sex were selected for this study (final sample n = 100)...
2017: PloS One
https://www.readbyqxmd.com/read/28980892/toenail-selenium-levels-and-prevalence-of-dyslipidaemia-among-korean-adults
#14
Jiyoung Jang, J Steven Morris, Kyong Park
Multiple studies have elucidated the antioxidant properties of Se, which are now well known among the nutrition and biomedical science communities. Recently, considerable interest has been focused on the possible association between Se exposure and risk of metabolic disease, such as lipid dysregulation; however, there is limited epidemiological data on this topic. The present study aimed to investigate associations between toenail Se levels and dyslipidaemia or individual lipid levels, and to examine the effect of dietary supplement use on these associations...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28979665/1340nm-laser-therapy-for-onychomycosis-negative-results-of-prospective-treatment-of-72-toenails-and-a-literature-review
#15
Graciela Araújo Do Espírito-Santo, Diniz Pereira Leite, Hugo Dias Hoffmann-Santos, Luciana Basili Dias, Rosane Christine Hahn
Onychomycosis is an infection of the nail plate by fungal microorganisms. This infection has an important social impact on women and men and poses a major challenge for its treatment. The traditional treatment of onychomycosis involves the use of topical and oral antifungal agents. However, the presence of adverse effects frequently associated with oral antifungals, their high cost, and their potential interactions with other drugs reflect some of the problems associated with conventional therapy. The current report details the evaluation of a 1340nm laser as monotherapy for toenails affected by onychomycosis...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28978624/oral-antifungals-for-toenail-onychomycosis
#16
(no author information available yet)
No abstract text is available yet for this article.
October 4, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28954534/confirmatory-testing-prior-to-initiating-onychomycosis-therapy-is-cost-effective
#17
Aditya K Gupta, Sarah G Versteeg, Neil H Shear
BACKGROUND: Onychomycosis can be investigated by sampling. Information gleaned includes nail bed involvement, nail plate penetration, fungal viability, and species identification. Testing samples can confirm a diagnosis. While diagnostic testing is considered useful in directing therapy, a substantial number of clinicians do not confirm diagnosis prior to treatment. OBJECTIVES: The aim of this study is to quantify the benefit of confirmatory testing prior to treating toenail onychomycosis...
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#18
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28904300/hair-mercury-levels-in-relation-to-fish-consumption-among-vietnamese-in-hanoi
#19
Van Anh Thi Hoang, Hien Thu Thi Do, Tetsuro Agusa, Chihaya Koriyama, Suminori Akiba, Yasuhiro Ishibashi, Mineshi Sakamoto, Megumi Yamamoto
People are exposed to methylmercury (MeHg) mainly through fish consumption, which is increasing in Vietnam. However, little information is available on estimating the health risk of MeHg exposure through fish consumption in Vietnam. The present study examined the association between mercury (Hg) levels in hair and selenium (Se) levels in toenails of 196 Vietnamese people and their fish consumption, using a dietary questionnaire to obtain information pertinent for assessing health risk owing to MeHg exposure...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28901783/quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#20
Xinxin Zhang, Aaron J Specht, Marc G Weisskopf, Jennifer Weuve, Linda H Nie
BACKGROUND AND OBJECTIVE: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as inductively coupled plasma mass spectrometry and atomic absorption spectrophotometry. In this project, a practical and convenient technology-portable X-ray florescence (XRF)-is studied for the noninvasive in vivo quantification of manganese and mercury in toenail. MATERIAL AND METHODS: The portable XRF method has advantages in that it does not require toenail clipping and it can be done in 3 min, which will greatly benefit human studies involving the assessment of manganese and mercury exposures...
October 10, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
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