keyword
MENU ▼
Read by QxMD icon Read
search

Anal carcinoma

keyword
https://www.readbyqxmd.com/read/28802802/nodal-stage-migration-and-prognosis-in-anal-cancer-a-systematic-review-meta-regression-and-simulation-study
#1
Hema Sekhar, Marcel Zwahlen, Sven Trelle, Lee Malcomson, Rohit Kochhar, Mark P Saunders, Matthew Sperrin, Marcel van Herk, David Sebag-Montefiore, Matthias Egger, Andrew G Renehan
BACKGROUND: In patients with squamous cell carcinoma of the anus (SCCA), lymph node positivity (LNP) indicates poor prognosis for survival and is central to radiotherapy planning. Over the past three decades, LNP proportion has increased, mainly reflecting enhanced detection with newer imaging modalities; a process known as nodal stage migration. If accompanied by constant T stage distributions, prognosis for both lymph node-positive and lymph node-negative groups may improve without any increase in overall survival for individual patients; a paradox termed the Will Rogers phenomenon...
August 9, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28799187/safety-evaluation-of-combination-carboplatin-and-toceranib-phosphate-palladia-in-tumour-bearing-dogs-a-phase-i-dose-finding-study
#2
R M Wouda, S E Hocker, M L Higginbotham
Combining conventional cytotoxic maximum tolerated dose (MTD) chemotherapy with low-dose metronomic and/or anti-angiogenic agents is a exciting area of oncologic research. The objective of this study was to establish the MTD, safety and adverse event (AE) profile of 1 such drug combination. This prospective phase I dose-finding clinical trial assumed an open-label 3 + 3 cohort design. Client-owned dogs with 1 or more cytologically and/or histologically confirmed and macroscopically measurable, naive or recurrent, malignant tumours, were enrolled...
August 10, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28796733/outcomes-of-immediate-internal-pudendal-artery-perforator-flap-reconstruction-for-irradiated-abdominoperineal-resection-defects
#3
Pedro S Coltro, Fábio F Busnardo, Franklin C Mônaco Filho, Marcelo V Olivan, Lincoln S Millan, Victor A Grillo, Carlos F Marques, Caio S Nahas, Sérgio C Nahas, Ulysses Ribeiro, Rolf Gemperli
BACKGROUND: There are many previous reports for using the internal pudendal artery perforator flap in vulvovaginal reconstruction; however, reports of this flap for perineal reconstruction after abdominoperineal excision of the rectum are scarce. OBJECTIVE: The purpose of this study was to evaluate the outcomes of immediate internal pudendal artery perforator flap reconstruction for irradiated abdominoperineal resection defects. DESIGN: This was a prospective case series...
September 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28770514/pharmacotherapy-of-anal-cancer
#4
Jane E Rogers, Cathy Eng
Anal squamous cell carcinoma (SCCA), among other malignancies, is associated with the human papillomavirus (HPV) and its incidence continues to rise. Anal SCCA will likely remain an existing healthcare concern given compliance issues with the HPV vaccination seen in the US. Localized disease is predominantly treated with standard of care (SOC) definitive chemoradiation that has remained unchanged for decades. Clinical and molecular prognostic factors have emerged to characterize patients unresponsive to SOC, revealing the need for an alternate approach...
August 2, 2017: Drugs
https://www.readbyqxmd.com/read/28766008/concurrent-paclitaxel-capecitabine-mitomycin-c-and-pelvic-radiation-therapy-for-patients-with-squamous-cell-anal-carcinoma
#5
Sergey S Gordeyev, Arsen O Rasulov, Vera A Gorbounova, Sergey I Tkachev, Valeriya V Glebovskaya, Mikhail Yu Fedyanin, Nataliya S Besova, Yulia E Surayeva
PURPOSE: The goals of this study were to assess safety and efficacy of triplet chemoradiotherapy (CRT) with paclitaxel for squamous cell anal carcinoma (SCAC). METHODS: Patients with stage I-IIIB SCAC were enrolled and received 52-58 Gy intensity-modulated radiotherapy (IMRT) (with dose based on the T stage) in consecutive daily 1.8-2.2 Gy fractions. The concurrent chemotherapy consisted of paclitaxel 45 mg/m(2) days 3, 10, 17, 24, 31, capecitabine 625 mg/m(2) bid on treatment days and mitomycin C 10 g/m(2) on day 1...
August 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28762852/primary-management-of-squamous-cell-carcinoma-of-the-anal-canal-a-30-year-community-hospital-experience
#6
Mohit S Agarwal, Daniel A Jones, Charles M Mendenhall, Christopher G Morris, Andrew Johns, William J McAfee, William M Mendenhall
We reviewed outcomes of 41 patients treated with curative-intent radiotherapy for anal canal carcinoma at a community hospital between 1985 and 2015. Twenty-six (63%) presented with stage I or II disease while 15 (37%) had stage III. Thirty-seven received definitive chemoradiation and 4 radiotherapy alone. Thirteen (31.7%) received ≤59.4Gy. Thirty-two (78%) were treated with 3-dimensional conformal radiotherapy while 9 (22%) received intensity-modulated radiotherapy. At 5 years, local control, regional control, freedom from distant metastasis, cause-specific survival, and overall survival were 80%, 98%, 88%, 77%, and 51%...
August 1, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28747781/targeting-phosphorylation-of-stat3-delays-tumor-growth-in-hpv-negative-anal-squamous-cell-carcinoma-mouse-model
#7
Lin-Lin Bu, Yi-Cun Li, Guang-Tao Yu, Jian-Feng Liu, Wei-Wei Deng, Wen-Feng Zhang, Lu Zhang, Zhi-Jun Sun
Although conventional chemoradiotherapy is effective for most anal squamous cell carcinoma (ASCC) patients, HPV-negative ASCC patients respond poorly to this treatment and new therapeutic approach is required. Our group has previously established an HPV-negative ASCC mouse model and demonstrated that signal transducer and activation of transcription 3 (STAT3) is hyper-activated in the model. Here, we show that in vivo inhibition of STAT3 by S3I-201 effectively delays tumor growth in ASCC mouse model indicated by significantly smaller tumor size and burden in the treatment group compared with control group at the same point...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740921/long-term-outcomes-and-toxicities-of-a-large-cohort-of-anal-cancer-patients-treated-with-dose-painted-imrt-per-rtog-0529
#8
Devarati Mitra, Theodore S Hong, Nora Horick, Brent Rose, Lorraine N Drapek, Lawrence S Blaszkowsky, Jill N Allen, Eunice L Kwak, Janet E Murphy, Jeffrey W Clark, David P Ryan, James C Cusack, Liliana G Bordeianou, David L Berger, Jennifer Y Wo
PURPOSE: To describe the outcomes and toxicities of the largest cohort to date of patients with anal squamous cell carcinoma uniformly treated with concurrent chemoradiation using dose-painted intensity modulated radiation therapy (DP-IMRT) according to RTOG 0529. METHODS AND MATERIALS: We identified 99 eligible patients with anal cancer who were treated at our institution with definitive chemoradiation using DP-IMRT between 2005 and 2015 per RTOG 0529 dosing guidelines...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28729224/robotic-placement-of-fenix-continence-restoration-system-in-a-patient-with-previous-radiation-to-the-pelvis-a-case-report
#9
Mariana Espinal, Christopher C DeStephano, Paulami Guha, Shilpa P Gajarawala, Anita H Chen, Paul D Pettit
Fecal incontinence (FI) is a disabling problem affecting women. Conservative treatment includes dietary modification, antimotility agents, and pelvic floor physical therapy. If conservative medical management is unsuccessful, surgical intervention may be required. Surgical options include rectal sphincteroplasty, bulking agent injection, radiofrequency anal sphincter remodeling procedure and sacral nerve stimulation (SNS) therapy. Recently, a new therapy for FI, the FENIX Continence Restoration System has become available...
July 17, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28721892/capecitabine-with-mitomycin-reduces-acute-hematologic-toxicity-and-treatment-delays-in-patients-undergoing-definitive-chemoradiation-using-intensity-modulated-radiation-therapy-for-anal-cancer
#10
Karyn A Goodman, Diana Julie, Andrea Cercek, Lajhem Cambridge, Kaitlin M Woo, Zhigang Zhang, Abraham J Wu, Diane L Reidy, Neil H Segal, Zsofia K Stadler, Leonard B Saltz
PURPOSE: To assess the impact on acute toxicity of replacing 5-fluorouracil (5-FU) with capecitabine in definitive chemoradiation for patients with anal squamous cell carcinoma (ASCC). METHODS AND MATERIALS: We retrospectively reviewed the records of 107 consecutive patients with nonmetastatic ASCC treated with definitive chemoradiation from January 2009 to May 2014. In 2011, based on the noninferiority of capecitabine versus 5-FU, our institutional practice shifted to use capecitabine instead of 5-FU for ASCC...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28708948/hospitalizations-associated-with-malignant-neoplasia-and-in-situ-carcinoma-in-the-anus-and-penis-in-men-and-women-during-a-5-year-period-2009-2013-in-spain-an-epidemiological-study
#11
Noelia López, Ángel Gil-de-Miguel, Raquel Pascual-García, Ruth Gil-Prieto
BACKGROUND: Approximately 40,000 new cases of anal cancer and 26,000 new cases of penile cancer occurred in 2012 worldwide. Human Papillomavirus (HPV) infection is responsible for 88.3% and 33.0% of these cancers, respectively. The aim of this study was to describe the hospital burden associated with malignant neoplasm (MN) and in situ carcinoma (ISC) in the anus and penis in Spain from 2009 to 2013. METHODS: This observational, retrospective study used discharge information obtained from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos, provided by the Ministry of Health...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28698447/-a-case-of-perianal-squamous-cell-carcinoma-with-left-inguinal-lymph-node-metastasis-that-showed-a-complete-response-more-than-five-years-after-chemotherapy-and-concomitant-proton-beam-therapy
#12
Nobuyasu Suzuki, Ayaka Azami, Yukitoshi Todate, Takeshi Tada, Mitsuru Waragai, Michitaka Honda, Atai Sato, Yoshinao Takano, Tsuyoshi Abe, Tatsuya Nakamura, Yasushi Teranishi
We report a case of perianal squamous cell carcinoma and left inguinal lymph node metastasis that showed a complete response more than 5 years after chemotherapy and concomitant proton beam therapy. A 34-year-old woman was referred to our hospital for an anal tumor and a left inguinal tumor. A digital rectal examination revealed a tumor in the anterior wall of the anal canal. In addition, the left inguinal lymph nodes were swollen, leading us to suspect metastases. Biopsy specimens confirmed poorly differentiated squamous cell carcinoma...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28697656/impact-of-liver-transplantation-on-the-risk-of-second-malignant-tumors-among-hepatocellular-carcinoma-patients
#13
Hani Oweira, Jan Schmidt, Daniel Helbling, Ulf Petrausch, Othmar Schöb, Arianeb Mehrabi, Anwar Giryes, Hazem Elhadedy, Omar Abdel-Rahman
BACKGROUND: Population-based data on the development of second malignant neoplasms (SMNs) following the diagnosis of hepatocellular carcinoma (HCC) are uncommon. We evaluated this clinical vignette in HCC patients within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1973-2012) was queried using the SEER*Stat program to determine the clinico-pathological features of HCC patients with more than one year survival who developed SMNs...
July 18, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28685744/endorectal-fusion-imaging-a-description-of-a-new-technique
#14
Andre Ignee, Yi Dong, Gudrun Schuessler, Ulrich Baum, Christoph F Dietrich
BACKGROUND: Fusion imaging is an accepted method in abdominal imaging allowing a simultaneous display of reference imaging with a live ultrasound (US) investigation. For prostate cancer, promising results have been published for endorectal US (ERUS)-guided biopsy of suspicious lesions in magnetic resonance imaging (MRI). To our knowledge, no other indication for the fusion of ERUS with MRI has been reported so far. METHODS: We report on three patients scheduled for ERUS due to anorectal fistulae after treatment (n = 2) or rectal carcinoma (n = 1), which were scheduled for real-time virtual onography (RVS), a method for the fusion of MRI imaging with US...
July 6, 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28680779/first-case-of-the-cervical-lymph-node-as-the-only-site-of-metastasis-from-anal-cancer
#15
Bo Wang, Sunny Jaiswal, Muhammad W Saif
Anal squamous cell carcinoma was a previously uncommon malignancy that has steadily increased in incidence with the increased prevalence of human papillomavirus (HPV) and human immunodeficiency virus (HIV). Anal squamous cell carcinoma is typically characterized by local and regional involvement and distant metastases are far less common. Here, we report a case of a 36-year-old female initially diagnosed with anal squamous cell carcinoma manifesting as an anal mass along with an enlarged inguinal lymph node...
May 30, 2017: Curēus
https://www.readbyqxmd.com/read/28670746/hpv-circulating-tumor-dna-to-monitor-the-efficacy-of-anti-pd-1-therapy-in-metastatic-squamous-cell-carcinoma-of-the-anal-canal-a-case-report
#16
Luc Cabel, François-Clément Bidard, Vincent Servois, Wulfran Cacheux, Pascale Mariani, Emanuela Romano, Mathieu Minsat, Ivan Bieche, Fereshteh Farkhondeh, Emmanuelle Jeannot, Bruno Buecher
Squamous cell carcinoma of the anal canal (SCCA) is a rare HPV-associated cancer with limited sensitivity to standard chemotherapy. In a phase 2 study, nivolumab, an anti PD-1 immune checkpoint inhibitor, demonstrated significant efficacy as single-agent therapy in metastatic SCCA patients. Nevertheless, imaging assessment by standard RECIST criteria of the efficacy of immune therapy can be difficult in some patients due to tumor immune cell infiltration, and biomarkers of treatment efficacy are needed. We have previously developed a quantitative droplet digital PCR (ddPCR) technique to detect HPV circulating tumor DNA (HPV ctDNA), with excellent sensitivity and specificity...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28662871/external-validation-of-leukocytosis-and-neutrophilia-as-a-prognostic-marker-in-anal-carcinoma-treated-with-definitive-chemoradiation
#17
Antoine Schernberg, Florence Huguet, Laurence Moureau-Zabotto, Cyrus Chargari, Eleonor Rivin Del Campo, Michel Schlienger, Alexandre Escande, Emmanuel Touboul, Eric Deutsch
PURPOSE: To validate the prognostic value of leukocyte disorders in anal squamous cell carcinoma (SCC) patients receiving definitive concurrent chemoradiation. MATERIALS AND METHODS: Bi-institutional clinical records from consecutive patients treated between 2001 and 2015 with definitive chemoradiation for anal SCC were retrospectively reviewed. Prognostic value of pretreatment leukocyte disorders was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as leukocyte or neutrophil count exceeding 10G/L and 7G/L, respectively...
June 26, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28657837/mckittrick-wheelock-syndrome-treated-by-transanal-minimally-invasive-surgery-a-single-center-experience-and-review-of-the-literature
#18
Anne Elisabeth Maria van der Pool, Eelco Jan Rade de Graaf, Maarten Vermaas, Renée Martine Barendse, Pascal Gabriël Doornebosch
INTRODUCTION: McKittrick Wheelock Syndrome (MKWS) is a rare syndrome characterized by secretory diarrhea, dehydration, prerenal acute kidney injury, and severe electrolyte abnormalities caused by a large hypersecretory villous adenoma located in the rectum or rectosigmoid junction. Transabdominal (laparoscopic) procedures are the most described procedures in the treatment of MKWS. We report an alternative surgical approach, transanal minimally invasive surgery (TAMIS), to solve this syndrome...
June 28, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28653119/surveillance-of-anal-carcinoma-after-radiochemotherapy-a-retrospective-analysis-of-80%C3%A2-patients
#19
Matthias Sauter, Stephan R Vavricka, Georg Keilholz, Henriette Heinrich, Thomas Winder, Helmut Kranzbühler, Norbert Lombriser, Benjamin Misselwitz
BACKGROUND: Surveillance after radiochemotherapy of anal carcinoma (ACa) with curative intent is recommended in guidelines, but data regarding the effectiveness of follow-up are lacking. We aimed to assess the performance of an ACa surveillance program in a real-life setting. METHODS: We retrospectively summarized clinical history, physical findings, and follow-up investigations (endoanal ultrasound, endoscopy, CT scan) obtained during 42 months (±27 months) from 80 patients after radiochemotherapy of ACa...
August 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28641314/no-additional-prognostic-value-for-mre11-in-squamous-cell-carcinomas-of-the-anus-treated-with-chemo-radiotherapy
#20
Alexandra K Walker, Christiana Kartsonaki, Elena Collantes, Judith Nicholson, Duncan C Gilbert, Anne E Kiltie
BACKGROUND: The majority of anal cancers (84-95%) are driven by infection with human papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-radiotherapy when compared with HPV-negative tumours. HPV infection is linked to alterations in DNA damage response proteins, including MRE11. MRE11 is a potential predictive biomarker for response to radiotherapy in muscle-invasive bladder cancer and may hold predictive power in other cancers. METHODS: Using a previously reported cohort, we evaluated the levels of MRE11 in anal cancer and assessed its predictive value in this disease...
July 25, 2017: British Journal of Cancer
keyword
keyword
67688
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"