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https://www.readbyqxmd.com/read/28616595/a-rare-case-of-anal-carcinosarcoma-with-human-papilloma-virus-infection-in-both-biphasic-tumor-elements-an-immunohistochemical-molecular-and-ultrastructural-study
#1
Richard A Hickman, Azore-Dee Bradshaw, Nicholas Cassai, Antonio Galvao Neto, David Zhou, Tinghao Fu, Peng Lee, Zhiheng Pei, Rosemary Wieczorek
Carcinosarcoma of the anus is rare and has yet to be reportedly associated with the keratinocyte-specific Human Papilloma Virus (HPV). We describe a case of anal carcinosarcoma with HPV infection in both the epithelial and mesenchymal components of the tumor by immunohistochemistry, chromogenic in-situ hybridization (CISH) and further supported by electron microscopy (EM). Microscopic examination of the tumor showed nests of poorly-differentiated invasive squamous cell carcinoma with basaloid features intermixed with a hypercellular, atypical spindle cell proliferation...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/28615224/risk-of-second-malignancies-in-solid-organ-transplant-recipients-who-develop-keratinocyte%C3%A2-cancers
#2
Rachel Zamoiski, Elizabeth L Yanik, Todd M Gibson, Elizabeth K Cahoon, Margaret M Madeleine, Charles F Lynch, Sally Gustafson, Marc T Goodman, Melissa Skeans, Ajay Israni, Eric A Engels, Lindsay M Morton
Solid organ transplant recipients have increased risk for developing keratinocyte cancers (KC), including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), in part as a result of immunosuppressive medications administered to prevent graft rejection. In the general population, KC are associated with increased risks of subsequent malignancy, however, the risk in organ transplant populations has not been evaluated. We addressed this question by linking the U.S. Scientific Registry of Transplant Recipients, which includes data on KC occurrence, with 15 state cancer registries...
June 14, 2017: Cancer Research
https://www.readbyqxmd.com/read/28610905/anal-cancer-french-intergroup-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#3
REVIEW
Laurence Moureau-Zabotto, Veronique Vendrely, Laurent Abramowitz, Christophe Borg, Eric Francois, Diane Goere, Florence Huguet, Didier Peiffert, Laurent Siproudhis, Michel Ducreux, Olivier Bouché
INTRODUCTION: This document is a summary of the French Intergroup guidelines regarding the management of anal carcinomas, published in November 2016. METHODS: It is a collaborative work produced under the auspices of the majority of the French medical societies involved in the management of anal cancer. It is based on the previous guidelines published in 2010. Recommendations are graded in three categories, according to the amount of evidence found in the literature...
May 23, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28608917/elevated-risk-of-human-papillomavirus-related-second-cancers-in-survivors-of-anal-canal-cancer
#4
Rebecca A Nelson, Lily L Lai
BACKGROUND: Over the last decade, the causal link between human papillomavirus (HPV) infection and squamous cell carcinoma of the anus (SCCA) has been well described. Because HPV infection in one site is often associated with other sites of infection, it then follows that patients with SCCA may have an increased risk of additional HPV-related cancers. Identifying and targeting at-risk sites through cancer screening and surveillance may help to guide best practices. The current study sought to ascertain sites and risk of HPV-related second primary malignancies (SPMs) in survivors of SCCA...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28603602/a-rare-case-of-perianal-granular-cell-tumor-case-report-and-literature-review
#5
Emily F Kelly, Alan A Stein, Xiaoling Charlene Ma, Jose Yeguez
Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28601342/organ-preservation-for-rectal-cancer-greccar-2-a-prospective-randomised-open-label-multicentre-phase-3-trial
#6
Eric Rullier, Philippe Rouanet, Jean-Jacques Tuech, Alain Valverde, Bernard Lelong, Michel Rivoire, Jean-Luc Faucheron, Mehrdad Jafari, Guillaume Portier, Bernard Meunier, Igor Sileznieff, Michel Prudhomme, Frédéric Marchal, Marc Pocard, Denis Pezet, Anne Rullier, Véronique Vendrely, Quentin Denost, Julien Asselineau, Adélaïde Doussau
BACKGROUND: Organ preservation is a concept proposed for patients with rectal cancer after a good clinical response to neoadjuvant chemotherapy, to potentially avoid morbidity and side-effects of rectal excision. The objective of this study was to compare local excision and total mesorectal excision in patients with a good response after chemoradiotherapy for lower rectal cancer. METHODS: We did a prospective, randomised, open-label, multicentre, phase 3 trial at 15 tertiary centres in France that were experts in the treatment of rectal cancer...
June 7, 2017: Lancet
https://www.readbyqxmd.com/read/28578653/chemotherapy-induced-takotsubo-cardiomyopathy-a-case-report-and-review-of-the-literature
#7
Matteo Coen, Fabio Rigamonti, Arnaud Roth, Thibaud Koessler
BACKGROUND: Several chemotherapy molecules, monoclonal antibodies and tyrosine kinase inhibitors, have been linked to Takotsubo cardiomyopathy (TC). CASE PRESENTATION: In this article, we describe the case of a 45-year-old woman who developed TC after receiving an intra-arterial and intra-venous polychemotherapy for locally advanced epidermoid carcinoma of the anal canal. This is the first described case of TC associated with intra-arterial chemotherapy. CONCLUSIONS: A review of the literature points to 5-fluorouracil as the most common molecule associated with TC and highlights the potential risk associated with rechallenging patient with the same drug...
June 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28577728/socioeconomic-and-gender-disparities-in-anal-cancer-diagnosis-and-treatment
#8
Karel-Bart Celie, Christopher Jackson, Surbhi Agrawal, Chetan Dodhia, Carlos Guzman, Theodor Kaufman, Nicholas Hellenthal, Daphne Monie, Jose Monzon, Luis Oceguera
BACKGROUND AND OBJECTIVES: We investigated whether receipt of radiation in patients with anal carcinoma is related to income level and other demographic factors. METHODS: The SEER database (1988-2011) was queried and linked to the Area Health Resources File (AHRF). We used logistic regression and Kaplan-Meier analyses to correlate receipt of radiation and overall and cancer-specific survival with tumor stage, age, gender, and income. RESULTS: Of 28,028 patients with anal cancer, 14,783 (53%) received radiation...
June 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28566881/inflammatory-bowel-disease-in-liver-transplanted-patients
#9
REVIEW
Tajana Filipec Kanizaj, Maja Mijic
Most common hepatobiliary manifestation of inflammatory bowel disease (IBD) are primary sclerosing cholangitis (PSC) and autoimmune hepatitis, ranking them as the main cause of liver transplantation (LT) in IBD setting. Course of pre-existing IBD after LT differs depending on many transplant related factors. Potential risk factors related to IBD deterioration after LT are tacrolimus-based immunosuppressive regimens, active IBD and cessation of 5-aminosalicylates at the time of LT. About 30% patients experience improvement of IBD after LT, while approximately the same percentage of patients worsens...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28557585/pet-ct-guided-sib-imrt-combined-with-concurrent-5-fu-mmc-for-the-treatment-of-anal-cancer
#10
Michel Zimmermann, Jürgen Beer, Stefan Bodis, Roger von Moos, Vasiliki Vlachopoulou, Daniel R Zwahlen, Christoph Oehler
BACKGROUND: To evaluate local control (LC), survival and toxicity in anal cancer patients treated with intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy at a single institution. MATERIAL AND METHODS: From August 2010 to May 2015, 26 patients were treated at our institution with IMRT and concurrent 5-fluorouracil/mitomycin-C (5-FU/MMC) for localized squamous cell carcinoma of the anal canal (SCCAC). Radiotherapy (RT) with 50.4-60 Gy was delivered with a sequential boost in 31%, and a simultaneous-integrated boost (SIB-IMRT) in 69% of cases...
May 30, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28556593/comparative-molecular-profiling-of-hpv-induced-squamous-cell-carcinomas
#11
Robert F Koncar, Rebecca Feldman, El Mustapha Bahassi, Nooshin Hashemi Sadraei
Approximately 5% of all cancer incidences result from human papillomavirus (HPV) infection. HPV infection most commonly leads to cancers of the anogenital region or oropharynx. It is unknown whether different HPV-mediated cancers collectively share a molecular signature and it is important to determine if there are targetable alterations common to different types of HPV-positive tumors. We analyzed 743 p53 wild-type samples of anal, cervical, oropharyngeal, and vulvar squamous cell carcinomas which underwent multiplatform testing at a commercial molecular profiling service...
May 29, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28541790/long-lasting-increased-risk-of-human-papillomavirus-related-carcinomas-and-premalignancies-after-cervical-intraepithelial-neoplasia-grade-3-a-population-based-cohort-study
#12
Renée M F Ebisch, Dominiek W E Rutten, Joanna IntHout, Willem J G Melchers, Leon F A G Massuger, Johan Bulten, Ruud L M Bekkers, Albert G Siebers
Purpose The aim of this study was to determine the risk of human papillomavirus (HPV)-related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. Methods Women diagnosed with a CIN3 between 1990 and 2010 were identified from the Dutch nationwide registry of histopathology and cytopathology (PALGA) and matched with a control group of women without CIN3...
May 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28534319/case-report-human-papilloma-virus-type-120-related-papillomatosis-mimicking-laryngeal-carcinoma
#13
Valeria Belvisi, Salvatore Martellucci, Anna Rosa Garbuglia, Cosmo Del Borgo, Stanislao Martellucci, Andrea Baiocchini, Anna Maria Manicone, Oreste Bagni, Claudio Maria Mastroianni, Andrea Gallo
INTRODUCTION: The relationship between human papilloma virus (HPV) and upper respiratory tract pathology was better understood in recent years and represents now an issue of particular interest in carcinogenesis and in immunocompromised host. We describe a case in which a rare genotype HPV-related papillomatosis mimics laryngeal carcinoma in an immunocompromised host. METHODS: A 54-year-old woman with a history of HIV-HCV coinfection and anal and laryngeal cancer successfully treated some years before was hospitalized for severe dyspnea, cough and dysphagia...
May 22, 2017: Infection
https://www.readbyqxmd.com/read/28533658/checkpoint-inhibitors-in-gastrointestinal-cancers-expectations-and-reality
#14
EDITORIAL
Hampig Raphael Kourie, Samer Tabchi, Marwan Ghosn
Immune checkpoint inhibitors represent revolutionary anti-cancer agents, being rapidly approved in different malignancies and settings. Gastrointestinal (GI) cancers represent a wide variety of tumors with specific characteristics and different responses to various therapeutic alternatives; while some are chemo-sensitive others are chemo-resistant and only respond to more aggressive cytotoxic regimens, targeted therapies or a combination of both. Preliminary results of immune checkpoint inhibitors in some GI cancers are promising, namely in hepatocellular carcinoma, anal cancers and microsatellite instability high colorectal cancers...
May 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28530494/review-anal-intraepithelial-neoplasia-in-hiv-infected-men-who-have-sex-with-men-is-screening-and-treatment-justified
#15
Peter Wasserman, David S Rubin, Glenn Turett
Anal squamous cell carcinoma (SCC) is the fourth most prevalent cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Human papillomavirus (HPV) has been detected in over 90% of anal carcinoma biopsy specimens from MSM, and is considered a necessary, but alone, insufficient factor for carcinogenesis. Anal intraepithelial neoplasia (AIN) may be precursive for SCC, and screening cytology with referral of persons with abnormality for high-resolution anoscopy-guided biopsy, and AIN treatment, has been recommended for prevention...
June 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28528797/a-case-control-study-of-non-aids-defining-cancers-in-a-prospective-cohort-of-hiv-infected-patients
#16
Francisco Rodríguez Arrondo, Miguel Ángel von Wichmann, Xabier Camino, Miguel Ángel Goenaga, Maialen Ibarguren, Harkaitz Azcune, María Jesús Bustinduy, Oscar Ferrero, Josefa Muñoz, Sofía Ibarra, Koldo Aguirrebengoa, Josune Goicoetxea, Elena Bereciartua, Miguel Montejo, M Asunción García, Eduardo Martínez, Joseba Portu, Luis Metola, Rafael Silvariño, Cristina Sarasqueta, Julio Arrizabalaga, Jose Antonio Iribarren
INTRODUCTION: We present a case-control study of non-AIDS-defining cancers (NADCs) in a cohort of HIV-infected patients where we value the incidence, survival and prognostic factors of mortality. METHODS: All NADCs diagnosis conducted from 2007 to 2011 in 7 hospitals were collected prospectively, with a subsequent follow up until December 2013. A control group of 221 HIV patients without a diagnosis of cancer was randomly selected. RESULTS: Two hundred and twenty-one NADCs were diagnosed in an initial cohort of 7,067 HIV-infected patients...
May 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28501560/the-immune-microenvironment-and-hpv-in-anal-cancer-rationale-to-complement-chemoradiation-with-immunotherapy
#17
REVIEW
Daniel Martin, Franz Rödel, Panagiotis Balermpas, Claus Rödel, Emmanouil Fokas
Anal squamous cell carcinomas (ASCC) are increasing in frequency across the developed world, and 70-90% of all cases originate from infection with human papilloma viruses (HPV). Primary chemoradiotherapy (CRT) is the standard treatment for ASCC, but local and/or distant failure still occurs in up to 30% of patients. HPV-associated ASCC and tumors with a higher density of tumor infiltrating lymphocytes (TIL) carry a better prognosis. Furthermore, HPV can render tumors more immunogenic, whereas it correlates with elevated TIL densities...
May 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28480075/concurrent-chemoradiation-with-volumetric-modulated-arc-therapy-of-patients-treated-for-anal-cancer-acute-toxicity-and-treatment-outcome
#18
Kaloyan Yordanov, Simona Cima, Antonella Richetti, Gianfranco Pesce, Francesco Martucci, Ngwa Che Azinwi, Maria Carla Valli
BACKGROUND: to report the acute toxicity and clinical results in patients with anal cancer treated with volumetric modulated arc therapy (VMAT) concomitant with chemotherapy. METHODS: A cohort of 21 patients with histologically confirmed squamous cell carcinoma of the anal canal was treated with VMAT and chemotherapy. Dose prescription was 39.6 Gy, 1.8 Gy/ fraction for the elective nodal PTV, the macroscopic (tumor and involved lymph nodes) PTV doses were 14.4 Gy up to a total dose of 54 Gy in 4 patients and 19...
April 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28470395/irreversible-electroporation-to-treat-malignant-tumor-recurrences-within-the-pelvic-cavity-a-case-series
#19
L G P H Vroomen, H J Scheffer, M C A M Melenhorst, N van Grieken, M P van den Tol, M R Meijerink
OBJECTIVE: To describe the initial experience with irreversible electroporation (IRE) to treat pelvic tumor recurrences. METHODS: A retrospective single-center analysis was performed. Adverse events were recorded using Common Terminology Criteria of Adverse Events (CTCAE) 4.0. Clinical outcome was determined using pain- and general- symptom assessment, including Seddon's peripheral nerve injury (PNI) types. Radiological outcome was evaluated by comparing baseline with three-month 18F-FDG PET-CT follow-up...
May 3, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28469370/narrow-band-imaging-for-diagnosis-of-squamous-cell-carcinoma-in-the-anal-canal
#20
Yoji Takeuchi, Artur Nemeth, Otto Ljungberg, Ervin Toth, Henrik Thorlacius
No abstract text is available yet for this article.
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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