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JOURNAL ARTICLE
Ottavia De Simoni, Melania Scarpa, Ignazio Castagliuolo, Astghik Stepanyan, Imerio Angriman, Andromachi Kotsafti, Camilla Nacci, Federico Scognamiglio, Silvia Negro, Antonella D'Angelo, Valentina Chiminazzo, Gianluca Businello, Cesare Ruffolo, Roberta Salmaso, Boris Franzato, Mario Gruppo, Pierluigi Pilati, Antonio Scapinello, Anna Pozza, Tommaso Stecca, Marco Massani, Ivana Cataldo, Stefano Brignola, Angelo Paolo Dei Tos, Carlotta Ceccon, Vincenza Guzzardo, Chiara Vignotto, Luca Facci, Isacco Maretto, Marco Agostini, Francesco Marchegiani, Giulia Becherucci, Maurizio Zizzo, Giovanni Bordignon, Roberto Merenda, Giovanni Pirozzolo, Alfonso Recordare, Giulia Pozza, Mario Godina, Isabella Mondi, Daunia Verdi, Corrado Da Lio, Licia Laurino, Luca Saadeh, Giorgio Rivella, Silvio Guerriero, Chiara Romiti, Giuseppe Portale, Chiara Cipollari, Ylenia Camilla Spolverato, Giulia Noaro, Roberto Cola, Salvatore Candioli, Laura Gavagna, Fabio Ricagna, Monica Ortenzi, Mario Guerrieri, Giovanni Tagliente, Monica Tomassi, Umberto Tedeschi, Beatrice Salmaso, Gianluca Buzzi, Dario Parini, Daniela Prando, Matteo Zuin, Francesca Bergamo, Vittorina Zagonel, Andrea Porzionato, Francesco Cavallin, Barbara Di Camillo, Loretta Di Cristoforo, Quoc Riccardo Bao, Salvatore Pucciarelli, Romeo Bardini, Gaya Spolverato, Matteo Fassan, Marco Scarpa
BACKGROUND: Long-term daily use of aspirin reduces incidence and mortality due to colorectal cancer (CRC). This study aimed to analyze the effect of aspirin on the tumor microenvironment, systemic immunity, and on the healthy mucosa surrounding cancer. METHODS: Patients with a diagnosis of CRC operated on from 2015 to 2019 were retrospectively analyzed (METACCRE cohort). Expression of mRNA of immune surveillance-related genes (PD-L1, CD80, CD86, HLA I, and HLA II) in CRC primary cells treated with aspirin were extracted from Gene Expression Omnibus-deposited public database (GSE76583)...
April 22, 2024: Cancer
#22
JOURNAL ARTICLE
Holly B Lindsay, Michael E Scheurer, Anthony K Allam, Bryony J Lucas, Susan L McGovern, Murali Chintagumpala, Arnold C Paulino
BACKGROUND: Recent data found a correlation between lymphopenia occurring early during craniospinal radiation therapy (RT) and risk of disease recurrence in newly diagnosed childhood medulloblastoma. However, the population included patients who received chemotherapy prior to or during RT. Here, we investigate the effect of lymphopenia during RT in patients with newly diagnosed pediatric medulloblastoma who were chemotherapy-naïve. PROCEDURE: We analyzed 79 patients with newly diagnosed medulloblastoma (ages 2-21 years) treated between 1997 and 2013 with craniospinal RT...
April 21, 2024: Pediatric Blood & Cancer
#23
JOURNAL ARTICLE
Sara Coelho Rangel, Michelly Damasceno da Silva, Décio Gilberto Natrielli Filho, Samuel Nascimento Santos, Jonatas Bussador do Amaral, Jefferson Russo Victor, Kevin Cezar Nascimento Silva, Izabela Dorota Tuleta, Carolina Nunes França, Marina Tiemi Shio, Lucas Melo Neves, André Luis Lacerda Bachi, Luiz Henrique da Silva Nali
BACKGROUND: Bipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals' quality of life. The potential pro-inflammatory role in their pathogenesis is postulated and Human Endogenous Retrovirus W (HERV-W) is an emerging candidate to modulate this pathogenic finding. HERVs, ancient retroviruses in the human genome, may play roles in inflammation and disease pathogenesis. Despite HERVs' involvement in autoimmune diseases, their influence on mental disorders remains underexplored...
April 22, 2024: Retrovirology
#24
JOURNAL ARTICLE
Jessé Lopes da Silva, Lucas Zanetti de Albuquerque, Mariana Espírito Santo Rodrigues, Luiz Claudio Santos Thuler, Andréia Cristina de Melo
PURPOSE: To investigate breast cancer (BC) incidence and mortality rates among specific racial groups in Brazil. METHODS: BC incidence was evaluated from 2010 to 2015, using Brazilian Population-Based Cancer Registries, incorporating crude ratios and annual average percentage change (AAPC). Clinical and sociodemographic data from 2000 to 2019 were obtained from Hospital-Based Cancer Registries. Mortality data from 2000 to 2020 were sourced from the National Mortality Information System, comparing White women and Black women...
April 21, 2024: Breast Cancer Research and Treatment
#25
JOURNAL ARTICLE
Elena Niccolai, Matteo Pedone, Ilaria Martinelli, Giulia Nannini, Simone Baldi, Cecilia Simonini, Leandro Di Gloria, Elisabetta Zucchi, Matteo Ramazzotti, Pietro Giorgio Spezia, Fabrizio Maggi, Gianluca Quaranta, Luca Masucci, Gianluca Bartolucci, Francesco Claudio Stingo, Jessica Mandrioli, Amedeo Amedei
Amyotrophic lateral sclerosis (ALS) is an untreatable and clinically heterogeneous condition primarily affecting motor neurons. The ongoing quest for reliable biomarkers that mirror the disease status and progression has led to investigations that extend beyond motor neurons' pathology, encompassing broader systemic factors such as metabolism, immunity, and the microbiome. Our study contributes to this effort by examining the potential role of microbiome-related components, including viral elements, such as torque tenovirus (TTV), and various inflammatory factors, in ALS...
April 21, 2024: Journal of Neurology
#26
JOURNAL ARTICLE
Mariana Gil Barturen, Rosalía Laporta Hernández, Antonio Romero Berrocal, Marina Pérez Redondo, Natalia Gómez Lozano, Javier Martín López, Ana Royuela Vicente, Alejandra Romero Román, Lucas Hoyos Mejía, Silvana Crowley Carrasco, David Gómez de Antonio, Jose Manuel Naranjo Gómez, Mar Córdoba Peláez, Nuria María Novoa, Jose Luis Campo-Cañaveral de la Cruz
INTRODUCTION: Cold static donor lung preservation at 10°C appears to be a promising method to safely extend the cold ischemic time (CIT) and improve lung transplant (LTx) logistics. METHODS: LTx from November 2021 to February 2023 were included in this single institution, prospective, non-randomized study comparing prolonged preservation at 10°C versus standard preservation on ice. The inclusion criteria for 10°C preservation were suitable grafts for LTx without any donor retrieval concerns...
April 6, 2024: Archivos de Bronconeumología
#27
JOURNAL ARTICLE
Jingyao Deng, David Joshua Cohen, Enrique B Matias, Lucas O Olson, Michael J McClure, Barbara D Boyan, Zvi Schwartz
Immobilization-induced skeletal unloading results in muscle atrophy and rapid bone loss, thereby increasing the risk of falling and the need for implant therapy in patients with extended bed rest or neuromuscular injuries. Skeletal unloading causes bone loss by altering bone growth and resorption, suggesting that implant performance might be affected. To test this, we focused on early events in implant osseointegration. We used the rat sciatic neurectomy-induced disuse model under two different settings. In Study 1, 16 Sprague Dawley rats (SD) were separated into control, sham operated+cast immobilization, and sciatic neurectomy+casting groups; titanium implants with multiscale microtextured topography and hydrophilic chemistry (modSLA) were inserted in the distal femoral metaphysis...
April 21, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
#28
JOURNAL ARTICLE
André Vianna Martins, Laís Lisboa Corrêa, Mariana Santos Ribeiro, Aline de Lima Coelho, Lucas Fernandes Lobão, João Pedro Siqueira Palmer, Fabiana Batalha Knackfuss, Marcelo Beltrão Molento, Alynne da Silva Barbosa
The aims of the present study were to identify strongyles in the feces of Thoroughbred horses based on larval morphology; to detect Strongylus vulgaris using molecular diagnosis and compare results to those of feces culture; and to determine the association between the presence of S. vulgaris with corresponding animal information (age range, gender, and anthelmintic use). Feces of horses kept in six Training Centers in Rio de Janeiro State, that showed the presence of ≥500 eggs per gram of feces (EPG) were subjected to strongyle identification...
May 2024: Veterinary Parasitology (Amsterdam)
#29
JOURNAL ARTICLE
Lorena María Sebastián de Lucas, Polán Ordás Álvarez, Laura de Castro Marzo, Tamara Illescas Molina, Beatriz Herrero, José Luis Bartha, Eugenia Antolín
INTRODUCTION: Non-immune hydrops fetalis (NIHF) is the most frequent etiology of hydrops fetalis (HF), accounting for around 95% of cases. It associates high perinatal mortality and morbidity rates. The aim of the study was firstly, to investigate etiology, prenatal management, and perinatal outcome in a large single center series of HF; secondly, to identify prenatal prognostic factors with impact on perinatal outcome. MATERIAL AND METHODS: Observational retrospective study of 80 HF diagnosed or referred to a single tertiary center between 2012 and 2021...
April 20, 2024: Fetal Diagnosis and Therapy
#30
REVIEW
Marcio Y Ferreira, Lucas P Mitre, Anthony E Bishay, Sávio Batista, Lucca B Palavani, Leonardo B Oliveira, Gabriel Semione, Filipi F Andreão, Silvio Porto Junior, Marcelo P Sousa, Pedro G L B Borges, Raphael Camerotte, Raphael Bertani, Michael T Lawton, Eberval G Figueiredo
Brain Arteriovenous Malformations (bAVMs) are rare but high-risk developmental anomalies of the vascular system. Microsurgery through craniotomy is believed to be the mainstay standard treatment for many grades of bAVMs. However, a significant challenge emerges in the existing body of clinical studies on open surgery for bAVMs: the lack of reproducibility and comparability. This study aims to assess the quality of studies reporting clinical and surgical outcomes for bAVMs treated by open surgery and develop a reporting guideline checklist focusing on essential elements to ensure comparability and reproducibility...
April 21, 2024: Neurosurgical Review
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JOURNAL ARTICLE
Francesca Pagliari, Jeannette Jansen, Jan Knoll, Rachel Hanley, Joao Seco, Luca Tirinato
BACKGROUND: Cancer radiation treatments have seen substantial advancements, yet the biomolecular mechanisms underlying cancer cell radioresistance continue to elude full understanding. The effectiveness of radiation on cancer is hindered by various factors, such as oxygen concentrations within tumors, cells' ability to repair DNA damage and metabolic changes. Moreover, the initial and radiation-induced cell cycle profiles can significantly influence radiotherapy responses as radiation sensitivity fluctuates across different cell cycle stages...
April 20, 2024: Cell Division
#32
JOURNAL ARTICLE
Ricardo Machado, Guilherme Moreira, Daniel Comparin, Arthur Pimentel Barroso, Jaqueline Nascimento, Caio Cézar Randi Ferraz, Sérgio Aparecido Ignácio, Lucas da Fonseca Roberti Garcia, Rodrigo Rodrigues Amaral, David Shadid, Ulisses Xavier da Silva Neto
OBJECTIVES: This prospective randomized multicenter clinical trial (PRMCT) investigated postoperative pain after single-visit root canal treatments in teeth affected by pulp necrosis (PN), and asymptomatic apical periodontitis (AAP) (with apical radiolucent areas) or normal periradicular tissues (without apical radiolucent areas) comparing different instruments' kinematics and apical instrumentation limits. METHODS: Before chemomechanical preparation, 240 patients/teeth were randomly distributed into four groups (n = 60) according to the instruments' kinematics (rotary or reciprocating) and apical instrumentation limits (with or without intentional foraminal enlargement [IFE])...
April 20, 2024: BMC Oral Health
#33
JOURNAL ARTICLE
Kent F Sutton, Grant H Cabell, Lucas W Ashley, Trevor A Lentz, Brian D Lewis, Steven A Olson, Richard C Mather
BACKGROUND: Clinicians and public health professionals have allocated resources to curb opioid over-prescription and address psychological needs among patients with musculoskeletal pain. However, associations between psychological distress, risk of surgery, and opioid prescribing among those with hip pathologies remain unclear. METHODS: Using a retrospective cohort study design, we identified patients that were evaluated for hip pain from January 13, 2020 to October 27, 2021...
April 20, 2024: BMC Musculoskeletal Disorders
#34
JOURNAL ARTICLE
Sarah Abu Arqub, Renee Greene, Sara Greene, Kolbe Laing, Chia-Ling Kuo, Lucas Da Cunha Godoy, Flavio Uribe
BACKGROUND: An uncommon location for placing miniscrews, used to provide anchorage control in various tooth movements, is the alveolar ridge. This study aimed to provide an evaluation of the success rate of alveolar ridge miniscrews and examine variables that might impact their success. METHODS: Charts for 295 patients who had miniscrews were screened. Twenty patients (5 male and 15 female: average age = 38.15 ± 15.10 years) with a total of 50 alveolar ridge miniscrews were analyzed...
April 19, 2024: Journal of the World Federation of Orthodontists
#35
JOURNAL ARTICLE
Cristian Petolicchio, Sara Brasili, Stefano Gay, Francesco Cocchiara, Irene Campi, Luca Persani, Lara Vera, Diego Ferone, Federico Gatto
SUMMARY: The resistance to thyroid hormone syndrome (RTHβ) occurs uncommonly and requires a high level of clinical suspicion and specific investigations to reach a precise diagnosis and to avoid unnecessary and potentially harmful therapies. We report a case of a young male patient referred to our unit for SARS-CoV-2 infection and atrial fibrillation with elevated thyroid hormones and non-suppressed thyroid-stimulating hormone (TSH), for which antithyroid therapy was prescribed...
April 1, 2024: Endocrinology, Diabetes & Metabolism Case Reports
#36
JOURNAL ARTICLE
Pierluigi Marzuillo, Stefano Guarino, Salvatore Alfiero, Luigi Annicchiarico Petruzzelli, Mattia Arenella, Francesco Baccelli, Milena Brugnara, Ciro Corrado, Giulia Delcaro, Anna Di Sessa, Giulia Gallotta, Marcello Lanari, Maya Lorenzi, Gabriele Malgieri, Emanuele Miraglia Del Giudice, Carmine Pecoraro, Marco Pennesi, Sara Picassi, Luca Pierantoni, Giuseppe Puccio, Floriana Scozzola, Francesca Taroni, Chiara Tosolini, Laura Venditto, Andrea Pasini, Claudio La Scola, Giovanni Montini
AIM: To determine (i) prevalence and the risk factors for acute kidney injury (AKI) in children hospitalised for febrile urinary tract infection (fUTI) and (ii) role of AKI as indicator of an underlying VUR. AKI, in fact, is favoured by a reduced nephron mass, often associated to VUR. METHODS: This retrospective Italian multicentre study enrolled children aged 18 years or younger (median age = 0.5 years) discharged with a primary diagnosis of fUTI...
April 20, 2024: Acta Paediatrica
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JOURNAL ARTICLE
Lucas Amoudruz, Athena Economides, Petros Koumoutsakos
Red blood cells (RBCs) are vital for transporting oxygen from the lungs to the body's tissues through the intricate circulatory system. They achieve this by binding and releasing oxygen molecules to the abundant hemoglobin within their cytosol. The volume of RBCs affects the amount of oxygen they can carry, yet whether this volume is optimal for transporting oxygen through the circulatory system remains an open question. This study explores, through high-fidelity numerical simulations, the impact of RBC volume on advectve oxygen transport efficiency through arterioles which form the area of greatest flow resistance in the circulatory system...
April 18, 2024: Biophysical Journal
#38
JOURNAL ARTICLE
Alice Di Paolo, Valentina Membrino, Sonila Alia, Laura Nanetti, Lucia Emanuela Svarca, Massimo Leone Perrone, Luca Aquilanti, Laura Mazzanti, Arianna Vignini, Eleonora Salvolini, Michele Severini
Anorexia nervosa (AN) is a complex disorder affecting mainly, but not only, teenagers. Researchers agree that AN is deeply associated with a pro-inflammatory state following an impaired immune system, resulting from altered levels of cytokines such as IL-1β and TNF-α, also impacted by the frequent depressive states. Thus, the aim of the present case-control study was to evaluate the relationship between patients suffering from AN undergoing specialized eating disorder (ED) treatment for AN and pro-inflammatory cytokines...
April 19, 2024: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
#39
JOURNAL ARTICLE
Gabriela Manco Machado, Ana Clara Falabello Luca, Renata Paz Leal Pereira, Ana Yne Fernandez, Lucas Gabriel Santini Rodrigues, Isabella Petroline Leite, Maximiliano Sergio Cenci, Tatiana Pereira Cenci, Ana Paula Pires Santos, Branca Heloisa Oliveira, Paulo Nadanovsky, Marina Deus Moura Lima, Marcoeli Silva Moura, Edson Hilan Gomes Lucena, Tathiane Larissa Lenzi, Ana Carla Crispim, Fernanda Campos Almeida Carrer, Mariana Gabriel, Claudia Cazal Lira, Carla Vecchione Gurgel, Helder Henrique Costa Pinheiro, Gilberto Alfredo Pucca, Fábio Carneiro Martins, Paola Gondim Calvasina, Maria Fernanda Montezuma Tricoli, Camila Menezes Costa Castelo Branco, Raiza Dias Freitas, José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Tamara Kerber Tedesco, Fausto Medeiros Mendes, Mariana Minatel Braga
BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that...
April 19, 2024: BMC Oral Health
#40
JOURNAL ARTICLE
Noemi Zampatti, Irene Bonato, Andrea Calandrino, Carolina Saffioti, Alessandro Parodi, Giorgia Brigati, Diego Minghetti, Luca Antonio Ramenghi
BACKGROUND: Preterms are at risk of systemic infections as the barrier function of their immature skin is insufficient. The long period of hospitalization and the huge number of invasive procedures represent a risk factor for complications. Among the nosocomial infections of the skin, methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality. We report a clinical case of cellulitis and abscess in two preterm twins caused by MRSA in a tertiary level Neonatal Intensive Care Unit (NICU)...
April 19, 2024: Italian Journal of Pediatrics
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