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https://www.readbyqxmd.com/read/27926948/intrinsic-subtype-switching-and-acquired-erbb2-her2-amplifications-and-mutations-in-breast-cancer-brain-metastases
#1
Nolan Priedigkeit, Ryan J Hartmaier, Yijing Chen, Damir Vareslija, Ahmed Basudan, Rebecca J Watters, Roby Thomas, Jose P Leone, Peter C Lucas, Rohit Bhargava, Ronald L Hamilton, Juliann Chmielecki, Shannon L Puhalla, Nancy E Davidson, Steffi Oesterreich, Adam M Brufsky, Leonie Young, Adrian V Lee
Importance: Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies. Objective: To determine whether there are intrinsic subtype differences between primary tumors and matched BrM and to uncover BrM-acquired alterations that are clinically actionable. Design, Setting, and Participants: In total, 20 cases of primary breast cancer tissue and resected BrM (10 estrogen receptor [ER]-negative and 10 ER-positive) from 2 academic institutions were included...
December 7, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27926559/preoperative-immunonutrition-and-elective-colorectal-resection-outcomes
#2
Lucas W Thornblade, Thomas K Varghese, Xu Shi, Eric K Johnson, Amir Bastawrous, Richard P Billingham, Richard Thirlby, Alessandro Fichera, David R Flum
BACKGROUND: Randomized controlled trials demonstrate the efficacy of arginine-enriched nutritional supplements (immunonutrition) in reducing complications after surgery. The effectiveness of preoperative immunonutrition has not been evaluated in a community setting. OBJECTIVE: This study aims to determine whether immunonutrition before elective colorectal surgery improves outcomes in the community at large. DESIGN: This is a prospective cohort study with a propensity score-matched comparative effectiveness evaluation...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926551/the-role-of-surgeons-and-oncologists-combined-to-properly-apply-colon-cancer-guidelines
#3
Luca Stocchi
No abstract text is available yet for this article.
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27925848/hospitalizations-for-pneumococcal-diseases-in-tuscany-from-2002-to-2014-impact-of-universal-pediatric-vaccination-on-the-population
#4
Sara Boccalini, Ornella Varone, Martina Chellini, Luca Pieri, Antonino Sala, Cesare Berardi, Paolo Bonanni, Angela Bechini
Streptococcus pneumoniae is the main causative organism of acute media otitis in children and meningitis and bacterial pneumonia in the community. Since 2008 in Tuscany, central Italy, the pneumococcal conjugate vaccine (7-valent vaccine, switched in 13-valent vaccine in 2010) was actively offered free of charge to all newborns. Aim of the study is to evaluate the impact of pneumococcal paediatric vaccination on the Tuscan population on hospitalizations potentially caused by S. pneumoniae, during pre-vaccination (PVP, 2002-2007) and vaccination period (VP, 2009-2014)...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925747/eigenvalue-outliers-of-non-hermitian-random-matrices-with-a-local-tree-structure
#5
Izaak Neri, Fernando Lucas Metz
Spectra of sparse non-Hermitian random matrices determine the dynamics of complex processes on graphs. Eigenvalue outliers in the spectrum are of particular interest, since they determine the stationary state and the stability of dynamical processes. We present a general and exact theory for the eigenvalue outliers of random matrices with a local tree structure. For adjacency and Laplacian matrices of oriented random graphs, we derive analytical expressions for the eigenvalue outliers, the first moments of the distribution of eigenvector elements associated with an outlier, the support of the spectral density, and the spectral gap...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925490/the-vicious-cycle-of-stigma-and-disclosure-in-self-management-a-study-among-the-dutch-hiv-population
#6
Daniel H de Vries, Luca Koppen, Adolfo Mejia Lopez, Reina Foppen
Though HIV has become a chronic disease, HIV-related stigma has remained. This article reports on a study that asked how Dutch people living with HIV-AIDS (PLWHA) experienced stigmatization and devised self-management strategies. We used qualitative findings from a survey questionnaire conducted among 468 Dutch HIV-positive people (3% of the population), using a stratified research sample. Findings show how respondents experience relatively high public (30%), self- (26%) and structural (15%) stigma. At the same time, results show the importance of selective disclosure as a self-management strategy...
December 2016: AIDS Education and Prevention: Official Publication of the International Society for AIDS Education
https://www.readbyqxmd.com/read/27925323/synthesis-binding-properties-and-differences-on-cell-uptake-of-g-quadruplex-ligands-based-on-carbohydrate-naphthalene-diimide-conjugates
#7
Matilde Arevalo, Filippo Doria, Efres Belmonte-Reche, Aurore De Rache, Jenny Campos-Salinas, Ricardo Lucas, Eva Falomir, Miguel Carda, Jose María Pérez-Victoria, Jean-Louis Mergny, Mauro Freccero, Juan Carlos Morales
G-quadruplex (G4) are currently being explored as therapeutic targets in cancer and other pathologies. We have synthesized six carbohydrate naphthalene diimide conjugates (carb-NDIs) as G4 ligands to investigate their potential selectivity on G4 binding and on cell penetration. Carb-NDIs have shown certain selectivity for G4 structures against DNA duplexes but the different sugar moieties did not induce a preference for a specific G4 topology. Interestingly, when monosaccharides were attached through a short ethylene linker to the NDI scaffold their cellular uptake was 2-3 fold more efficient than when the sugar was directly attached through its anomeric position...
December 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27925192/pathogenic-role-of-associated-adherent-invasive-escherichia-coli-in-crohn-s-disease
#8
Giuseppe Mazzarella, Angelica Perna, Angela Marano, Angela Lucariello, Vera Rotondi Aufiero, Raffaele Melina, Germano Guerra, Fabio Silvio Taccone, Gaetano Iaquinto, Antonio De Luca
Several lines of evidence suggest that adherent-invasive E. coli (AIEC) strains play an important role in Crohn's disease (CD). The objective of this study was to investigate the pathogenic role of two AIEC strains, LF82 and O83:H1, in CD patients. Organ cultures of colonic biopsies from patients were set up to assess the effects of LF82 and O83:H1 on the expression of CEACAM6, LAMP1, HLA-DR, ICAM1 by immunohistochemistry and of IL-8, IFNΓ and TNF-α genes by RT-PCR. Moreover, on Caco2 cells we analyzed the cell cycle, the expression of MGMT and DNMT1 genes and DNA damage induced by LF82 and O83:H1, by FACS, RT-PCR and DAPI staining, respectively...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27925118/alcohol-abuse-and-involvement-in-traffic-accidents-in-the-brazilian-population-2013
#9
Giseli Nogueira Damacena, Deborah Carvalho Malta, Cristiano Siqueira Boccolini, Paulo Roberto Borges de Souza, Wanessa da Silva de Almeida, Lucas Sisinno Ribeiro, Célia Landmann Szwarcwald
Abstract This article aims to analyze alcohol abuse and frequent consumption according to sociodemographic characteristics and investigate the risk of greater involvement in traffic accidents, using data from the National Health Survey (PNS), 2013, Brazil. Events investigated were alcohol abuse and frequent consumption and if the individual was involved in a traffic accident and sustained an injury in the last 12 months. We investigated both events according to sociodemographic characteristics and assessed the association among them through multivariate logistic regression...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27925060/hepatozoon-canis-and-leishmania-spp-coinfection-in-dogs-diagnosed-with-visceral-leishmaniasis
#10
Fernanda Nazaré Morgado, Amanda Dos Santos Cavalcanti, Luisa Helena de Miranda, Lúcia Helena O'Dwyer, Maria Regina Lucas da Silva, Rodrigo Caldas Menezes, Aurea Virgínia Andrade da Silva, Mariana Côrtes Boité, Elisa Cupolillo, Renato Porrozzi
This study describes the occurrence of dogs naturally co-infected with Hepatozoon canis and two Leishmania species: L. infantum or L. braziliensis. Four dogs serologically diagnosed with Visceral Leishmaniasis were euthanized. Liver and spleen samples were collected for histopathological analysis and DNA isolation. H. canis meronts were observed in tissues from all four dogs. H. canis infection was confirmed by PCR followed by sequencing of a fragment of 18S rRNA gene. Leishmania detection and typing was confirmed by ITS1' PCR-RFLP and parasite burden was calculated using ssrRNA quantitative qPCR...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27924814/mature-igm-expressing-plasma-cells-sense-antigen-and-develop-competence-for-cytokine-production-upon-antigenic-challenge
#11
Pascal Blanc, Ludovic Moro-Sibilot, Lucas Barthly, Ferdinand Jagot, Sébastien This, Simon de Bernard, Laurent Buffat, Sébastien Dussurgey, Renaud Colisson, Elias Hobeika, Thierry Fest, Morgan Taillardet, Olivier Thaunat, Antoine Sicard, Paul Mondière, Laurent Genestier, Stephen L Nutt, Thierry Defrance
Dogma holds that plasma cells, as opposed to B cells, cannot bind antigen because they have switched from expression of membrane-bound immunoglobulins (Ig) that constitute the B-cell receptor (BCR) to production of the secreted form of immunoglobulins. Here we compare the phenotypical and functional attributes of plasma cells generated by the T-cell-dependent and T-cell-independent forms of the hapten NP. We show that the nature of the secreted Ig isotype, rather than the chemical structure of the immunizing antigen, defines two functionally distinct populations of plasma cells...
December 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/27924728/synthesis-and-immunosuppressive-activity-of-new-mycophenolic-acid-derivatives
#12
Karina Pereira Barbieri, Lucas Dos Reis Ercolin, Thierry Louat, Marisa Campos Polesi, Chung Man Chin, Iracilda Carlos Zeppone, Jean Leandro Dos Santos
BACKGROUND: Immunosuppressive drugs are widely used to prevent and treat allograft rejection and autoimmune diseases. Mycophenolic acid (MPA) and its derivatives are currently one of the most prescribed immunosuppressive drugs; however, metabolic drawbacks and variable inter- and intrapatient responses limit its use. OBJECTIVE: In order to find out new safe and effective immunosuppressive compounds we report here the synthesis and pharmacological evaluation of hybrid MPA derivatives containing the thalidomide/phthalimide subunits...
December 7, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27924492/progression-of-gait-ataxia-in-patients-with-degenerative-cerebellar-disorders-a-4-year-follow-up-study
#13
Mariano Serrao, Giorgia Chini, Carlo Casali, Carmela Conte, Martina Rinaldi, Alberto Ranavolo, Christian Marcotulli, Luca Leonardi, Gaia Fragiotta, Fabiano Bini, Gianluca Coppola, Francesco Pierelli
In the present study, the progression of gait impairment in a group of patients with primary degenerative cerebellar ataxias was observed over a period of 4 years. A total of 30 patients underwent an initial gait analysis study, and thereafter only 12 were evaluated because they completed the 2- and 4-year follow-up evaluations. Time-distance parameters, trunk and joint range of motion (RoM), and variability parameters (e.g., coefficients of variation) were measured at the baseline and at each follow-up evaluation...
December 6, 2016: Cerebellum
https://www.readbyqxmd.com/read/27924386/cost-analysis-of-laparoendoscopic-rendezvous-versus-preoperative-ercp-and-laparoscopic-cholecystectomy-in-the-management-of-cholecystocholedocholithiasis
#14
Aldo Garbarini, Dario Reggio, Simone Arolfo, Marco Bruno, Roberto Passera, Giorgia Catalano, Claudio Barletti, Mauro Salizzoni, Mario Morino, Luca Petruzzelli, Alberto Arezzo
BACKGROUND: Evidence from controlled trials and meta-analyses suggests that laparoendoscopic rendezvous (LERV) is preferable to sequential treatment in the management of common bile duct stones. MATERIALS AND METHODS: With this retrospective analysis of a prospective database that included consecutive patients treated for cholecystocholedocholithiasis at our institution between January 2007 and July 2015, we compared LERV with sequential treatment. The primary endpoint was global cost, defined as the cost/patient/hospital stay, and the secondary end points were efficacy and morbidity...
December 6, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27923944/membrane-oxygenator-use-with-biventricular-assist-device-facilitation-of-support-and-lung-recovery
#15
Kristen Nelson-McMillan, William J Ravekes, William R Thompson, Kristen M Brown, Larry Wolff, Rajeev S Wadia, LeAnn M McNamara, Donald H Shaffner, Ivor D Berkowitz, Marshall L Jacobs, Luca A Vricella
We present the use of a low-resistance membrane oxygenator (Quadrox D, Maquet) in series with a pulsatile right ventricular assist device (Berlin Heart EXCOR, Berlin Heart) in a patient with biventricular support who required high-frequency oscillatory ventilation (HFOV), due to refractory acute respiratory distress syndrome associated with Cytomegalovirus pneumonia. The high mean airway pressure associated with the use of HFOV resulted in a significant negative impact on left ventricular assist device (LVAD) filling that led to a combined respiratory and metabolic acidosis and the need for vasopressor support...
December 6, 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27923704/il-17-receptor-signaling-in-oral-epithelial-cells-is-critical-for-protection-against-oropharyngeal-candidiasis
#16
Heather R Conti, Vincent M Bruno, Erin E Childs, Sean Daugherty, Joseph P Hunter, Bemnet G Mengesha, Danielle L Saevig, Matthew R Hendricks, Bianca M Coleman, Lucas Brane, Norma Solis, J Agustin Cruz, Akash H Verma, Abhishek V Garg, Amy G Hise, Jonathan P Richardson, Julian R Naglik, Scott G Filler, Jay K Kolls, Satrajit Sinha, Sarah L Gaffen
Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras, we were able to rule out a requirement for IL-17RA in the hematopoietic compartment. We saw remarkable concordance of IL-17-controlled gene expression in C. albicans-infected human oral epithelial cells (OECs) and in tongue tissue from mice with OPC. To interrogate the role of the IL-17R in OECs, we generated mice with conditional deletion of IL-17RA in superficial oral and esophageal epithelial cells (Il17ra(ΔK13))...
November 9, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27923648/drug-reaction-with-eosinophilia-and-systemic-symptoms-from-ceftriaxone-confirmed-by-positive-patch-test-an-immunohistochemical-study
#17
Katharina Hansel, Veronica Bellini, Leonardo Bianchi, Jacopo Brozzi, Luca Stingeni
No abstract text is available yet for this article.
December 3, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27923499/validation-of-34betae12-immunoexpression-in-clear-cell-papillary-renal-cell-carcinoma-as-a-sensitive-biomarker
#18
Guido Martignoni, Matteo Brunelli, Diego Segala, Enrico Munari, Stefano Gobbo, Luca Cima, Ioana Borze, Tina Wirtanen, Virinder Kaur Sarhadi, Lilit Atanesyan, Suvi Savola, Luisa Barzon, Giulia Masi, Matteo Fassan, John N Eble, Tom Bohling, Liang Cheng, Brett Delahunt, Sakari Knuutila
Clear cell papillary renal cell carcinoma (CCPRCC) is a recently recognised neoplasm with a broad spectrum of morphological characteristics, thus representing a challenging differential diagnosis, especially with the low malignant potential multicystic renal cell neoplasms and clear cell renal cell carcinoma. We selected 14 cases of CCPRCC with a wide spectrum of morphological features diagnosed on morphology and CK7 immunoreactivity and analysed them using a panel of immunohistochemical markers, focusing on 34βE12 and related CKs 1,5,10 and 14 and several molecular analyses such as fluorescence in situ hybridisation (FISH), array comparative genomic hybridisation (aCGH), VHL methylation, VHL and TCEB1 sequencing and multiplex ligation-dependent probe amplification (MLPA)...
December 3, 2016: Pathology
https://www.readbyqxmd.com/read/27923038/comment-on-statin-use-and-all-cancer-survival-prospective-results-from-the-women-s-health-initiative
#19
Luca Mascitelli, Mark R Goldstein
No abstract text is available yet for this article.
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27922242/neck-epidermoid-cyst-mimicking-tuberculosis-at-ultrasound-case-report-and-review-of-literature
#20
Jacopo Cambi, Giovanni Monciatti, Luca Pelliccia, Maria Carla Spinosi, Leopoldo Brindisi
Neck masses in children can be inflammatory, congenital or neoplastic. When a congenital cyst becomes infected repeatedly, it may mimic inflammatory disease and the diagnosis may be challenging with ultrasound. An increasing incidence of infection with non-tuberculous mycobacterial organisms has been observed in recent decades in children with cervical lymphadenopathy. An ultrasound scan performed during the infectious phase of a mass can be misleading and can lead to an incorrect diagnostic hypothesis with the risk of erroneous medical and surgical therapies...
2016: Turkish Journal of Pediatrics
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