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https://www.readbyqxmd.com/read/28738392/multiple-lymph-node-basin-drainage-in-trunk-melanoma-is-not-associated-with-survival-of-sentinel-lymph-node-positive-patients
#1
Simone Ribero, Simona Osella Abate, Sadro Pasquali, Carlo Riccardo Rossi, Lorenzo Borgognoni, Dario Piazzalunga, Nicola Solari, Mauro Schiavon, Paola Brandani, Luca Ansaloni, Erica Ponte, Francesco Silan, Antonio Sommariva, Francesco Bellucci, Giuseppe Macripò, Pietro Quaglino
OBJECTIVES: This study was aimed at investigating the prognostic role of multiple lymph node basin drainage (MLBD) in patients with positive sentinel lymph node (SLN) biopsy. BACKGROUND: MLBD is frequently observed in patients with trunk melanoma undergoing SLN. The prognostic value of MLBD in SLN-positive patients is still debated. METHODS: Retrospective data from 312 trunk melanoma patients with positive SLN biopsy (1991-2012) at 6 Italian referral centres were gathered in a multicentre database...
July 25, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28738376/evaluation-of-the-impact-of-cognitive-training-on-quality-of-life-in-patients-with-multiple-sclerosis
#2
Maria Grazia Grasso, Marco Broccoli, Paolo Casillo, Sheila Catani, Luca Pace, Alessandra Pompa, Francesco Rizzi, Elio Troisi
OBJECTIVE: The aim of this study was to evaluate the effectiveness of cognitive rehabilitation in a group of multiple sclerosis (MS) patients. METHODS: Thirty-four patients were included in this study and randomly allocated either to treatment with multidisciplinary rehabilitation plus cognitive training or to treatment with multidisciplinary rehabilitation alone. RESULTS: After 3 months of cognitive treatment, the patients assigned to the rehabilitation plus cognitive training group displayed an improvement in the cognitive test of executive function and a marked improvement in quality of life (QoL)...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28737998/examination-of-the-patient-focused-impact-of-cancer-telegenetics-among-a-rural-population-comparison-with-traditional-in-person-services
#3
Nan M Solomons, Amanda E Lamb, Frances L Lucas, Eileen F McDonald, Susan Miesfeldt
BACKGROUND: Telecommunication models promise to improve access to cancer genetic counseling. Little is known about their impact among the geographically underserved. This work examined knowledge and emotional outcomes and attitudes/beliefs regarding cancer telegenetic services (via live-interactive videoconferencing) in Maine. MATERIALS AND METHODS: Cancer telegenetic patients seen at two remote sites and control (in-person) patients responded to pre-/postsurveys assessing care impact on hereditary breast and ovarian cancer (HBOC) knowledge and emotional health, ease of access to services, and telegenetics satisfaction/acceptability...
July 21, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28737866/algorithms-imaging-tests-comparison-following-the-first-febrile-urinary-tract-infection-in-children
#4
María M Tombesi, Laura F Alconcher, Lucas Lucarelli, Agustina Ciccioli
OBJETIVES: To compare the diagnostic sensitivity, costs and radiation doses of imaging tests algorithms developed by the Argentine Society of Pediatrics in 2003 and 2015, against British and American guidelines after the first febrile urinary tract infection (UTI). POPULATION AND METHODS: Inclusion criteria: children ≤ 2 years old with their first febrile UTI and normal ultrasound, voiding cystourethrography and dimercaptosuccinic acid scintigraphy, according to the algorithm established by the Argentine Society of Pediatrics in 2003, treated between 2003 and 2010...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737670/motor-control-training-for-the-shoulder-with-smart-garments
#5
Qi Wang, Liesbet De Baets, Annick Timmermans, Wei Chen, Luca Giacolini, Thomas Matheve, Panos Markopoulos
Wearable technologies for posture monitoring and posture correction are emerging as a way to support and enhance physical therapy treatment, e.g., for motor control training in neurological disorders or for treating musculoskeletal disorders, such as shoulder, neck, or lower back pain. Among the various technological options for posture monitoring, wearable systems offer potential advantages regarding mobility, use in different contexts and sustained tracking in daily life. We describe the design of a smart garment named Zishi to monitor compensatory movements and evaluate its applicability for shoulder motor control training in a clinical setting...
July 22, 2017: Sensors
https://www.readbyqxmd.com/read/28737588/longer-concentric-action-increases-muscle-activation-and-neuromuscular-fatigue-responses-in-protocols-equalized-by-repetition-duration
#6
Lucas T Lacerda, Cinara G Costa, Fernando V Lima, Hugo C Martins-Costa, Rodrigo C R Diniz, André G P Andrade, Gustavo H C Peixoto, Michael G Bemben, Mauro H Chagas
The aim of this study was to investigate the impact of protocols equalized by the repetition duration but composed of different concentric and eccentric durations on muscle activation and neuromuscular fatigue. Seventeen males with previous experience in resistance training performed 3 training protocols (A - 2s con : 4s ecc; B - 3s con : 3s ecc; and C - 4s con : 2s ecc) with the Smith machine bench press exercise, all with 3 sets, 6 repetitions, 3 minutes' rest, and 60% of 1RM. The normalized root mean square of the electromyographic signal (EMGRMS) and mean frequency electromyography (EMGMF) for pectoralis major and triceps brachii muscles were calculated for 2nd and 5th repetitions in each set...
July 19, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28737569/elevated-hemoglobin-level-is-associated-with-advanced-fibrosis-in-pediatric-nonalcoholic-fatty-liver-disease
#7
Valentina Giorgio, Antonella Mosca, Arianna Alterio, Anna Alisi, Antonio Grieco, Valerio Nobili, Luca Miele
OBJECTIVES: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the association between hematological parameters, and the severity of disease in children with biopsy-proven NAFLD. METHODS: A total of 117 children (85 boys, mean age 12 years) with ultrasound evidence of NAFLD undergoing liver biopsy for diagnosis of nonalcoholic steatohepatitis (NASH), were prospectively enrolled between January 2011 and May 2013 in the setting of a tertiary care center...
August 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28737529/observation-about-open-surgical-release-of-posttraumatic-elbow-contracture-in-children-and-adolescents
#8
Daniele Coraci, Valter Santilli, Silvia Giovannini, Luca Padua
No abstract text is available yet for this article.
July 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28737443/fertirrigation-with-sugarcane-vinasse-foreseeing-potential-impacts-on-soil-and-water-resources-through-vinasse-characterization
#9
Lucas T Fuess, Isabella J Rodrigues, Marcelo L Garcia
This paper reports the characterization of the polluting potential of sugarcane vinasse, the main wastewater from ethanol production. Compositional data from vinasse samples collected from sugarcane biorefineries were used to predict negative effects on the soil, water resources and crops potentially associated with fertirrigation, the primary final destination of vinasse in Brazil. High risks of soil salinization were associated with the land disposal of vinasse, as evidenced by the high levels of total dissolved solids (TDS; >4,000 mg L(-1)) and electrical conductivity (>6...
July 24, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28737394/l-proline-and-rna-duplex-m-value-temperature-dependence
#10
Jeffrey J Schwinefus, Nadia L Baka, Kalpit Modi, Kaylyn N Billmeyer, Shutian Lu, Lucas R Haase, Ryan J Menssen
The temperature dependence of l-proline interactions with the RNA dodecamer duplex surface exposed after unfolding was quantified using thermal and isothermal titration denaturation monitored by uv-absorbance. The m-value quantifying proline interactions with the RNA duplex surface area exposed after unfolding was measured using RNA duplexes with GC content ranging between 17 and 83%. The m-values from thermal denaturation decreased with increasing GC content signifying increasingly favorable proline interactions with the exposed RNA surface area...
July 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28736931/genetic-variants-in-hsd17b3-smad3-and-ipo11-impact-circulating-lipids-in-response-to-fenofibrate-in-individuals-with-type-2-diabetes
#11
Daniel M Rotroff, Sonja S Pijut, Skylar W Marvel, John R Jack, Tammy M Havener, Aurora Pujol, Agatha Schluter, Greg A Graf, Henry N Ginsberg, Hetal S Shah, He Gao, Mario-Luca Morieri, Alessandro Doria, Josyf C Mychaleckyi, Howard L McLeod, John B Buse, Michael J Wagner, Alison A Motsinger-Reif
Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofibrate in statin-treated T2D patients, we examined lipid changes in response to fenofibrate therapy using genome-wide association(GWA). Associations were followed-up using gene expression studies in mice. Common variants in SMAD3 and IPO11 were marginally associated with lipid changes in black subjects(p<5x10(-6) )...
July 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28736644/overall-and-disease-free-survival-in-patients-treated-with-crs-hipec-with-cisplatin-and-paclitaxel-for-gastric-cancer-with-peritoneal-carcinomatosis
#12
Paola Fugazzola, Federico Coccolini, Giulia Montori, Marco Ceresoli, Paolo Baggi, Antonio Costanzo, Matteo Tomasoni, Francesco Gregis, Silvia Nozza, Luca Ansaloni
BACKGROUND: Our experience regarding cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was reviewed in terms of overall survival (OS) and disease-free survival (DFS) in patients with synchronous peritoneal carcinomatosis (SPC) and metachronous peritoneal carcinomatosis (MPC) from gastric cancer (GC). METHODS: An analysis of prospectively collected data about patients who underwent CRS and HIPEC from July 2011 to July 2016 was carried out...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736604/comparison-between-three-glass-fiber-post-cementation-techniques
#13
Guido Migliau, Luca Piccoli, Stefano Di Carlo, Giorgio Pompa, Laith Konstantinos Besharat, Marco Dolci
OBJECTIVE: The aim of this experimental study was to compare the traditional cement systems with those of the latest generation, to assess if indeed these could represent of viable substitutes in the cementation of indirect restorations, and in the specific case of endodontic posts. METHODS: The assessment of the validity of the cementing methods was performed according to the test of the push-out, conducted on sections obtained from the roots of treated teeth. The samples were divided into three groups...
January 2017: Annali di Stomatologia
https://www.readbyqxmd.com/read/28736214/genetic-variants-in-gastric-cancer-risks-and-clinical-implications
#14
REVIEW
Carolina Oliveira Gigek, Danielle Queiroz Calcagno, Lucas Trevizani Rasmussen, Leonardo Caires Santos, Mariana Ferreira Leal, Fernanda Wisnieski, Rommel Rodriguez Burbano, Laercio Gomes Lourenço, Gaspar de Jesus Lopes-Filho, Marilia Arruda Cardoso Smith
Cancer is a multifactorial disease that involves many molecular alterations. Gastric cancer (GC) is the third leading cause of cancer death worldwide. GC is a highly heterogeneous disease with different molecular and genetics features. Therefore, this review focuses on an overview of the genetic aspects of gastric cancer by highlighting the important impact and role of deletions and/or duplications of chromosomal segments, genomic variants, H. pylori infection and interleukin variants, as found in gene expression and newly proposed molecular classification studies...
July 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28736182/immune-checkpoint-therapy-of-mesothelioma-pre-clinical-bases-and-clinical-evidences
#15
Luana Calabrò, Giovanni Luca Ceresoli, Armida D'Incecco, Arnaud Scherpereel, Joachim Aerts, Michele Maio
Treatment with immune-checkpoint blocking monoclonal antibody (mAb) is demonstrating a significant efficacy in different tumor types. Here, we discuss the impact of this promising approach in malignant mesothelioma (MM), a still dreadful disease in which medical treatment has been set on platinum based chemotherapy for decades with unsatisfactory results.
July 12, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28735821/medical-practitioners-attitudes-towards-animal-assisted-interventions-an-italian-survey
#16
Anna Pinto, Marta De Santis, Carlo Moretti, Luca Farina, Licia Ravarotto
OBJECTIVES: The present study had a dual purpose: to obtain a comprehensive picture of the Italian medical practitioners' opinions, professional experiences, training needs and knowledge of Animal Assisted Interventions (AAI); and to provide a detailed description of the medical practitioners who are characterized by a strongly positive attitude towards AAI. METHODS: An online survey addressed to Italian medical practitioners was carried out using a 35-items structured questionnaire...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28735802/correction-of-patellofemoral-malalignment-with-patellofemoral-arthroplasty
#17
Marco Valoroso, Mo Saffarini, Giuseppe La Barbera, Cécile Toanen, Gerjon Hannink, Luca Nover, David H Dejour
BACKGROUND: The goal of patellofemoral arthroplasty (PFA) is to replace damaged cartilage and correct underlying deformities to reduce pain and prevent maltracking. We aimed to determine how PFA modifies patellar height, tilt, and tibial tuberosity-trochlear groove (TT-TG) distance. The hypothesis was that PFA would correct trochlear dysplasia or extensor mechanism malalignment. METHODS: The authors prospectively studied a series of 16 patients (13 women and 3 men) aged 64...
July 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28735643/disrupted-relationship-between-resting-state-connectivity-and-task-evoked-activity-during-social-perception-in-schizophrenia
#18
Sjoerd J H Ebisch, Vittorio Gallese, Anatolia Salone, Giovanni Martinotti, Giuseppe di Iorio, Dante Mantini, Mauro Gianni Perrucci, Gian Luca Romani, Massimo Di Giannantonio, Georg Northoff
Schizophrenia has been described as a self-disorder, whereas social deficits are key features of the illness. Changes in "resting state" activity of brain networks involved in self-related processing have been consistently reported in schizophrenia, but their meaning for social perception deficits remains poorly understood. Here, we applied a novel approach investigating the relationship between task-evoked neural activity during social perception and functional organization of self-related brain networks during a "resting state"...
July 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28735558/nicotinic-receptor-abnormalities-in-the-cerebellar-cortex-of-sudden-unexplained-fetal-and-infant-death-victims-possible-correlation-with-maternal-smoking
#19
Anna M Lavezzi, Stefano Ferrero, Luca Roncati, Francesco Piscioli, Luigi Matturri, Teresa Pusiol
Nicotinic acetylcholine receptors (nAChRs) are cationic channels of the neuronal cell membrane, differentially expressed in the central nervous system which, when activated by endogenous acetylcholine or exogenous nicotine, are able to enhance cholinergic transmission. The aim of this study was to investigate in human perinatal age the immunohistochemical expression of the α7-nAChR subtype, given its involvement in neuronal differentiation and its significant vulnerability to the toxic effects of nicotine...
July 2017: ASN Neuro
https://www.readbyqxmd.com/read/28735518/the-possible-prognostic-role-of-histone-deacetylase-and-transforming-growth-factor-%C3%AE-smad-signaling-in-high-grade-gliomas-treated-by-radio-chemotherapy-a-preliminary-immunohistochemical-study
#20
Roberta Sferra, Simona Pompili, Claudio Festuccia, Francesco Marampon, Giovanni L Gravina, Luca Ventura, Ernesto Di Cesare, Sara Cicchinelli, Eugenio Gaudio, Antonella Vetuschi
Glioblastoma (GBM) is the most common and aggressive tumor of the central nervous system. Unfortunately, patients affected by this disease have a very poor prognosis, due to high level of invasiveness and resistance to standard therapies. Although the molecular profile of GBM has been extensively investigated, the events responsible for its pathogenesis and progression remain largely unknown. Histone Deacetylases (HDAC) dependent epigenetic modifications and transforming growth factor (TGF)-β/Smad pathway seem to play an important role in GBM tumorigenesis, resistance to common therapies and poor clinical outcome...
May 16, 2017: European Journal of Histochemistry: EJH
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