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https://www.readbyqxmd.com/read/28109990/ictal-eeg-fmri-study-of-vertiginous-seizures
#1
Alessandra Morano, Marco Carnì, Sara Casciato, Anna Elisabetta Vaudano, Jinane Fattouch, Martina Fanella, Mariarita Albini, Luca Manfredi Basili, Giulia Lucignani, Marco Scapeccia, Regina Tomassi, Elisabetta Di Castro, Claudio Colonnese, Anna Teresa Giallonardo, Carlo Di Bonaventura
Vertigo and dizziness are extremely common complaints, related to either peripheral or central nervous system disorders. Among the latter, epilepsy has to be taken into consideration: indeed, vertigo may be part of the initial aura of a focal epileptic seizure in association with other signs/symptoms, or represent the only ictal manifestation, a rare phenomenon known as "vertiginous" or "vestibular" seizure. These ictal symptoms are usually related to a discharge arising from/involving temporal or parietal areas, which are supposed to be a crucial component of the so-called "vestibular cortex"...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109904/immune-function-trade-offs-in-response-to-parasite-threats
#2
Lucas J Kirschman, Adam H Quade, Anthony J Zera, Robin W Warne
Immune function is often involved in physiological trade-offs because of the energetic costs of maintaining constitutive immunity and mounting responses to infection. However, immune function is a collection of discrete immunity factors and animals should allocate towards factors that combat the parasite threat with the highest fitness cost. For example, animals on dispersal fronts of expanding population may be released from density-dependent diseases. The costs of immunity, however, and life history trade-offs in general, are often context dependent...
January 18, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28109767/thromboelastometry-hypercoagulable-profiles-and-portal-vein-thrombosis-in-cirrhotic-patients-with-hepatocellular-carcinoma
#3
Alberto Zanetto, Marco Senzolo, Alessandro Vitale, Umberto Cillo, Claudia Radu, Francesca Sartorello, Luca Spiezia, Elena Campello, Kryssia Rodriguez-Castro, Alberto Ferrarese, Fabio Farinati, Patrizia Burra, Paolo Simioni
BACKGROUND: Cirrhotic patients with hepatocellular carcinoma (HCC) exhibit hypercoagulability. AIM: We investigated whether thromboelastometry can detect hypercoagulability in these patients and the association with portal vein thrombosis (PVT). METHODS: At baseline, cirrhotic patients with and without HCC underwent thromboelastometry. PVT onset was recorded over a 12-month follow-up period. RESULTS: Seventy-six patients (41 with and 35 without HCC) were included...
December 26, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28109621/-the-latest-in-paediatric-resuscitation-recommendations
#4
Jesús López-Herce, Antonio Rodríguez, Angel Carrillo, Nieves de Lucas, Custodio Calvo, Eva Civantos, Eva Suárez, Sara Pons, Ignacio Manrique
Cardiac arrest has a high mortality in children. To improve the performance of cardiopulmonary resuscitation, it is essential to disseminate the international recommendations and the training of health professionals and the general population in resuscitation. This article summarises the 2015 European Paediatric Cardiopulmonary Resuscitation recommendations, which are based on a review of the advances in cardiopulmonary resuscitation and consensus in the science and treatment by the International Council on Resuscitation...
January 18, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28109406/salivary-biomarkers-in-the-diagnosis-of-breast-cancer-a-review
#5
REVIEW
Elisa Cançado Porto-Mascarenhas, Daniele Xavier Assad, Hélène Chardin, David Gozal, Graziela De Luca Canto, Ana Carolina Acevedo, Eliete Neves Silva Guerra
Salivary biomarkers could be helpful to characterize breast cancer. Therefore, this review was performed to evaluate the capability of salivary biological markers in the diagnosis and monitoring of breast cancer. Studies were eligible for inclusion if they assessed the potential diagnostic value or other discriminatory properties of biological markers in saliva of patients with breast cancer. The search was performed in six electronic databases (Cochrane, LILACS, PubMed, Science Direct, Scopus, Web of Science)...
February 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28109383/portico-sheathless-transcatheter-aortic-valve-implantation-via-distal-axillary-artery
#6
Giuseppe Bruschi, Paola Colombo, Luca Botta, Stefano Nava, Bruno Merlanti, Oriana Belli, Francesco Musca, Francesco Soriano, Claudio F Russo, Fabrizio Oliva
Transcatheter aortic valve implantation has been designed to treat older patients affected by severe aortic stenosis who are considered high-risk surgical candidates because of multiple comorbidities. The least invasive approach for transcatheter aortic valves implantation should be considered the transfemoral retrograde route, because it is minimally invasive and is feasible with local anesthesia and mild sedation. Despite significant technical improvements in recent years, the transfemoral approach is contraindicated in cases of severe peripheral artery disease...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109371/-second-primary-cardiac-sarcoma-in-a-patient-with-ewing-sarcoma-always-expect%C3%A2-the-unexpected
#7
Antonino Di Franco, Mario Gaudino, Jonathan W Weinsaft, Shawn C Pun, Navneet Narula, Saadat A Khan, Zahra M Malik, Lucas B Ohmes, Nickolaos J Skubas, Leonard N Girardi
A high suspicion for relapsed metastatic disease must arise when an intracardiac mass is detected in a patient with a recent history of Ewing sarcoma. Nevertheless, the scenario may eventually turn out to be much more complex than expected, and the possibility that the intracardiac tumor may instead be a "second" primary sarcoma, although extremely rare, should also be considered. We describe the first case of concomitant diagnosis of Ewing sarcoma and low-grade myxoid spindle cell sarcoma in the same young patient...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28109194/family-health-strategy-and-equity-in-prenatal-care-a-population-based-cross-sectional-study-in-minas-gerais-brazil
#8
Mônica Viegas Andrade, Kenya Valéria Micaela de Souza Noronha, Allan Claudius Queiroz Barbosa, Michelle Nepomuceno Souza, Júlia Almeida Calazans, Lucas Resende de Carvalho, Thiago Augusto Hernandes Rocha, Núbia Cristina Silva
BACKGROUND: Prenatal care coverage is still not universal or adequately provided in many low and middle income countries. One of the main barriers regards the presence of socioeconomic inequalities in prenatal care utilization. In Brazil, prenatal care is supplied for the entire population at the community level as part of the Family Health Strategy (FHS), which is the main source of primary care provided by the public health system. Brazil has some of the greatest income inequalities in the world, and little research has been conducted to investigate prenatal care utilization of FHS across socioeconomic groups...
January 21, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28109033/a-quality-improvement-initiative-to-decrease-the-rate-of-solitary-blood-cultures-in-the-emergency-department
#9
Joseph Choi, Sahand Ensafi, Lucas Brien Chartier, Oliver Van Praet
OBJECTIVES: Best practice guidelines recommend that at least two sets of blood cultures (BCs) be sent when blood cultures are required. However, high rates of solitary BCs are still common in the emergency department (ED). The aim of this study was to evaluate the efficacy of different quality improvement initiatives aimed at reducing the rate of solitary blood cultures being sent to the lab on patients ultimately discharged from our ED. METHODS: This was a multi-centre, multi-phase, prospective study evaluating a comprehensive education-based intervention and a second intervention that combined a computerized forcing function along with a brief education-based intervention...
January 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28108936/a-group-mediated-physical-activity-intervention-in-older-knee-osteoarthritis-patients-effects-on-social-cognitive-outcomes
#10
Brian C Focht, Matthew J Garver, Alexander R Lucas, Steven T Devor, Charles F Emery, Kevin V Hackshaw, Ciaran M Fairman, Jessica Bowman, W Jack Rejeski
The objective of the present study was to compare a group-mediated cognitive behavioral (GMCB) physical activity intervention with traditional exercise therapy (TRAD) upon select social cognitive outcomes in sedentary knee osteoarthritis (knee OA) patients. A total of 80 patients (mean age = 63.5 years; 84% women) were recruited using clinic and community-based strategies to a 12-month, single-blind, two-arm, randomized controlled trial. Mobility-related self-efficacy, self-regulatory self-efficacy (SRSE), and satisfaction with physical function (SPF) were assessed at baseline, 3, and 12 months...
January 20, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28108849/toll-like-receptor-4-affects-the-cerebral-biochemical-changes-induced-by-mptp-treatment
#11
Carmela Conte, Luca Roscini, Roccaldo Sardella, Giuseppina Mariucci, Stefania Scorzoni, Tommaso Beccari, Laura Corte
The etiology and pathogenesis of Parkinson's disease (PD) are still unclear. However, multiple lines of evidence suggest a critical role of the toll like receptor 4 (TLR4) in inflammatory response and neuronal death. Neuroinflammation may be associated with the misfolding and aggregation of proteins accompanied by a change in their secondary structure. Recent findings also suggest that biochemical perturbations in cerebral lipid content could contribute to the pathogenesis of central nervous system (CNS) disorders, including PD...
January 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28108575/uniportal-thoracoscopic-decortication-for-pleural-empyema-and-the-role-of-ultrasonographic-preoperative-staging%C3%A2
#12
Stefano Bongiolatti, Luca Voltolini, Sara Borgianni, Roberto Borrelli, Giorgia Tancredi, Domenico Viggiano, Alessandro Gonfiotti
OBJECTIVES: The surgical approach to chronic pleural empyema is still controversial. Video-assisted thoracic surgery (VATS) debridement and decortication has shown favourable outcomes, while the uniportal VATS (U-VATS) approach is still anecdotal. We report our experience with ultrasonographic (US) preoperative staging followed by U-VATS decortication for pleural empyema. METHODS: We performed a retrospective analysis of patients who underwent surgical treatment of stage II and stage III pleural empyema from 2012 to 2015...
January 19, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28108565/frozen-versus-conventional-elephant-trunk-technique-application-in-clinical-practice
#13
REVIEW
Roberto Di Bartolomeo, Giacomo Murana, Luca Di Marco, Antonio Pantaleo, Jacopo Alfonsi, Alessandro Leone, Davide Pacini
SummaryTreating complex aortic arch disease with proximal and distal aortic segment involvement is challenging. In recent years, different surgical and endovascular techniques have been applied in a single or multiple-stage approach with the aim to cure and simplify these conditions. The first procedure available for this purpose was the conventional elephant trunk technique. Its recent evolution is the frozen elephant trunk, which treats the descending thoracic aorta using the antegrade release of a self-expandable stent graft...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28107762/thulium-laser-in-interventional-endoscopy-animal-and-human-studies
#14
Gian E Tontini, Helmut Neumann, Luca Pastorelli, Luisa Spina, Flaminia Cavallaro, Paola Soriani, Alessandro Rimondi, Barbara Bruni, Claudio Clemente, Filippo Fagnani, Pavlos Lagoussis, Luca Carmignani, Maurizio Vecchi
Background and study aims The thulium laser system (TLS) is an emerging surgical tool. The 2-μm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For the first time ever, we assessed TLS feasibility for endoscopic hemostasis ex vivo in pigs. In addition, we performed the first in vivo hemostatic treatments in humans. Patients and methods Tissue damage induced by TLS using different settings and optical fibers was compared to that from argon plasma coagulation (APC) in established ex vivo animal models...
January 20, 2017: Endoscopy
https://www.readbyqxmd.com/read/28107530/broad-scale-genetic-diversity-of-cannabis-for-forensic-applications
#15
Christophe Dufresnes, Catherine Jan, Friederike Bienert, Jérôme Goudet, Luca Fumagalli
Cannabis (hemp and marijuana) is an iconic yet controversial crop. On the one hand, it represents a growing market for pharmaceutical and agricultural sectors. On the other hand, plants synthesizing the psychoactive THC produce the most widespread illicit drug in the world. Yet, the difficulty to reliably distinguish between Cannabis varieties based on morphological or biochemical criteria impedes the development of promising industrial programs and hinders the fight against narcotrafficking. Genetics offers an appropriate alternative to characterize drug vs...
2017: PloS One
https://www.readbyqxmd.com/read/28107513/the-zebrafish-anillin-egfp-reporter-marks-late-dividing-retinal-precursors-and-stem-cells-entering-neuronal-lineages
#16
Meret Cepero Malo, Anne-Laure Duchemin, Luca Guglielmi, Eva Patzel, Saadettin Sel, Gerd U Auffarth, Matthias Carl, Lucia Poggi
Monitoring cycling behaviours of stem and somatic cells in the living animal is a powerful tool to better understand tissue development and homeostasis. The tg(anillin:anillin-eGFP) transgenic line carries the full-length zebrafish F-actin binding protein Anillin fused to eGFP from a bacterial artificial chromosome (BAC) containing Anillin cis-regulatory sequences. Here we report the suitability of the Anillin-eGFP reporter as a direct indicator of cycling cells in the late embryonic and post-embryonic retina...
2017: PloS One
https://www.readbyqxmd.com/read/28107368/multi-channel-optical-coherence-elastography-using-relative-and-absolute-shear-wave-time-of-flight
#17
Eli Elyas, Alex Grimwood, Janine T Erler, Simon P Robinson, Thomas R Cox, Daniel Woods, Peter Clowes, Ramona De Luca, Franco Marinozzi, Jérémie Fromageau, Jeffrey C Bamber
Elastography, the imaging of elastic properties of soft tissues, is well developed for macroscopic clinical imaging of soft tissues and can provide useful information about various pathological processes which is complementary to that provided by the original modality. Scaling down of this technique should ply the field of cellular biology with valuable information with regard to elastic properties of cells and their environment. This paper evaluates the potential to develop such a tool by modifying a commercial optical coherence tomography (OCT) device to measure the speed of shear waves propagating in a three-dimensional (3D) medium...
2017: PloS One
https://www.readbyqxmd.com/read/28107279/prevalence-and-risk-factors-for-symptoms-of-methotrexate-intolerance-in-pediatric-inflammatory-bowel-disease
#18
Claire Dupont-Lucas, Charlotte Grandjean-Blanchet, Bertrand Leduc, Martina Tripcovici, Christine Larocque, France Gervais, Prévost Jantchou, Devendra Amre, Colette Deslandres
BACKGROUND: Methotrexate (MTX) intolerance is defined as gastrointestinal and behavioral symptoms occurring before or after MTX administration that may lead to treatment discontinuation. The aim of this study was to determine prevalence of MTX intolerance in pediatric inflammatory bowel disease (IBD) using the Methotrexate Intolerance Severity Score developed in rheumatology and to identify risk factors for MTX intolerance. METHODS: Patients with pediatric IBD followed in the IBD clinic of Sainte Justine Hospital who had received MTX for IBD between 2004 and 2016 and were still actively on MTX were invited to fill out the Methotrexate Intolerance Severity Score questionnaire...
February 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28107182/the-nitrobenzoxadiazole-derivative-mc3181-blocks-melanoma-invasion-and-metastasis
#19
Anastasia De Luca, Debora Carpanese, Maria Cristina Rapanotti, Tara Mayte Suarez Viguria, Maria Antonietta Forgione, Dante Rotili, Chiara Fulci, Egidio Iorio, Luigi Quintieri, Sergio Chimenti, Luca Bianchi, Antonio Rosato, Anna Maria Caccuri
The novel nitrobenzoxadiazole (NBD) derivative MC3181 is endowed with remarkable therapeutic activity in mice bearing both sensitive and vemurafenib-resistant human melanoma xenografts. Here, we report that subtoxic concentrations of this compound significantly reduced invasiveness of BRAF-V600D mutated WM115 and WM266.4 melanoma cell lines derived from the primary lesion and related skin metastasis of the same patient, respectively. The strong antimetastatic activity of MC3181 was observed in both 2D monolayer cultures and 3D multicellular tumor spheroids, and confirmed in vivo by the significant decrease in the number of B16-F10 melanoma lung metastases in drug-treated mice...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28107084/can-diffusion-weighted-imaging-and-related-apparent-diffusion-coefficient-be-a-prognostic-value-in-women-with-breast-cancer
#20
Paola Rabasco, Rocchina Caivano, Vittorio Simeon, Giuseppina Dinardo, Antonella Lotumolo, Matilde Gioioso, Antonio Villonio, Giancarlo Iannelli, Felice D'Antuono, Alexis Zandolino, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To analyze diffusion-weighted imaging (DWI) and the related apparent diffusion coefficient (ADC) in women with breast cancer, correlating these values with the presence at 3 years of distant metastases, and to demonstrate that DWI-Magnetic Resonance Imaging (MRI) and related ADC values may represent a prognostic value in the study of women with breast cancer. MATERIALS AND METHODS: Sixty women (aged 45-73 years) affected with breast cancer with a follow-up in 3 years were enrolled...
January 20, 2017: Cancer Investigation
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