Matastasized cancer

INTRODUCTION: The surgical treatment of non-small cell lung cancer (NSCLC) with synchronous brain matastases is more effective than other therapeutic options, but this management is still controversial. THE AIM OF THE STUDY: The aim of the study was to evaluate the survival of patients after pulmonary resection NSCLC preceded by resection of brain metastases. MATERIAL AND METHODS: From 2007 to 2012, 645 patients underwent pulmonary resection for NSCLC at our department...

Lymph node matastases (LNM) are the most important prognostic factor of the cervical cancer regardless the stage and other prognostic factors. Lymph node status is the basis for tailoring the management strategies. In negative for metastases lymph nodes adjuvant radiotherapy can be omitted, as well as the risk for complications. LNM can be detected by histopathologic examination after meticulous lymphadenectomy. Other methods for detection of LNM such as PET/CT, CT, MRI, frozen section, sentinel lymph node biopsy have low sensitivity...

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OBJECTIVE: To evaluate the efficacy, survival and toxicity in patients with brain metastases from non-small cell lung cancer (NSCLC), treated with concurrent systemic chemotherapy and whole brain radiation therapy (WBRT) or sequential systemic chemotherapy/WBRT. METHODS: A total of 60 NSCLC patients with brain metastases were divided into two groups in this prospective clinical study: concurrent systemic chemotherapy and WBRT group (concurrent group) and sequential systemic chemotherapy/WBRT group (sequential group)...

UNLABELLED: Breast cancer in women is the most common source of parenchymal brain metastases and takes the second place in brain matastasing neoplasms. The goal of this publication is to analyse the patients with parenchymal brain metastases who have been operated in the Department of Neurosurgery in last 10 years and match the results with literature datum. MATERIAL: Analysis was made for 28 patients with parenchymal brain metastases from breast cancer who underwent neurosurgical operations in a 10-years period (1995-2004)...

Background. The objective of this paper is an efficacy analysis of surgical treatment of femoral bone cancer metasases depending on surgical technique and tumor localisation.<br /> Material and methods. 144 patients who underwent surgery in 1996-2002 were assesed. In 32 patients with proximal femur matastases tumor resection and angled plate stabilisation was made, 68 patients underwent THR.<br /> In 20 patients with tumor situated in femoral shaft an intramedullary nailing was performed and the rest 14 patients were treated with plate (AO/ASIF) technique...

Two cases of recurrent breast cancer, for which combined therapy using toremifene and oral chemotherapeutic agents were effective, are reported. In case 1, high-dose toremifene (120 mg/day) and 5'-DFUR were administered to a forty-seven-year-old woman with lung metastasis of estrogen-receptor positive breast cancer, who had been previously treated with polychemotherapy and tamoxifen. A complete response was obtained after six months of treatment and this condition has remained for longer than one year. In case 2, a fifty-year-old woman developed liver and lung matastasis of breast cancer with increased tumor marker levels...

The consideration is based on a finite urn model (drawn balls are not returned). One important conclusion is that increasing effects of selection on the surviving population are to be assumed only by selection of death. Inaccuracy of official death rates results from insufficiency in registration of the confidential part of death certificates. 57% (in females) and 58% (in males) of all malignant tumors (based on examinations in the presented autopsy material) are found beyond the age of 60. More rare than expected are multiple tumors: formal arguments for this are discussed, the phenomenon being explained by a considerably increased death rate...

A microspectrophotometric study of DNA content in nuclei of cells of the normal larynx mucosa, papiloma, epithelial layer of fibromas, areas of atypical hyperplasia of the epithelium of papillomas, intraepithelial cancer, squamous-cell carcinoma of the larynx, matastases in the regional lymph nodes, was carried out on the basis of bioptic and operation materials. A total of 82 histological sections and 50 cytological preparations (impressions) obtained from the same specimens of the tissue were investigated...

A pretherapeutic evaluation of skeletal metastases should be carried out in all patients with proven mammary cancer including early stages. The scintigraphy is more reliable for detecting bone metastases than the conventional roentgenological survey. We recommend to employ complementally skeletall scintigraphy and conventional X-ray survey in the search for bone tumors. Negative scintigraphical results do not require any supplementary research. In case of a pathological scan or skeletal pain, a target roentgneological examination should be carried out to differentiate between benign diseases and neoplatic lesions...

Forty-three patients with inoperable or recurring malignant gliomas, and 30 patients with multiple recurring brain metastases were treated with a combination of Adriamycin (45 mg/m2) and 4-dimethyl-epipodophyllotoxin D-thenylidene (VM 26) (60 mg/m2 for 2 days) with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (60 mg/m2 for 2 days). These cycles of treatment were repeated as soon as the hematologic restoration was complete. The treatment was well tolerated and the clinical condition of 31 of 43 glioblastoma patients improved during the 2 months after the beginning of the treatment...

Squamous cell carcinoma (SCC) of the skin, a fairly slow-growing locally invasive tumor that occasionally matastasizes, was studied in 12 patients in vivo with the use of intralesional tritiated thymidine as a marker for cell proliferation kinetics. Analysis of the cell cycle of the germinative population revealed that the duration of S-phase was 12.5 hours; G1-phase, 28.8 hours; mitotic period (M-phase), 2 hours; G-pahse, 6.9 hours; and the total germinative cell cycle, 50.2 hours. The application of cell kinetics to programming chemotherapy for skin cancer with phase-specific cytotoxins was discussed...

The case of an 83-year-old woman, who was operated on for an adenocarcinoma of the sigmoid colon and died with retroperitoneal matastases, is described. The post mortem examination showed widespread heterotopic bone formation in these metastases. Gastrointestinal cancers and their metastases are liable to calcify and ossify, and they do so more frequently than other malignant epithelial tumors. A search through the literature led to the discovery of 35 other cases of this type. The highest frequency of heterotopic bone formation occurs in cancers of the distal portion of the large intestine and in pulmonary and lymph node metastases...