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Muscle tissue lymphoma

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https://www.readbyqxmd.com/read/27741519/h2s-releasing-nanoemulsions-a-new-formulation-to-inhibit-tumor-cells-proliferation-and-improve-tissue-repair
#1
Matteo Ciocci, Egidio Iorio, Felicia Carotenuto, Haneen A Khashoggi, Francesca Nanni, Sonia Melino
The improvement of solubility and/or dissolution rate of poorly soluble natural compounds is an ideal strategy to make them optimal candidates as new potential drugs. Accordingly, the allyl sulfur compounds and omega-3 fatty acids are natural hydrophobic compounds that exhibit two important combined properties: cardiovascular protection and antitumor activity. Here, we have synthesized and characterized a novel formulation of diallyl disulfide (DADS) and α-linolenic acid (ALA) as protein-nanoemulsions (BAD-NEs), using ultrasounds...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27646518/mri-guided-wire-localization-surgical-biopsy-in-an-adolescent-patient-with-a-difficult-to-diagnose-case-of-lymphoma
#2
Scott M Thompson, Krzysztof R Gorny, Danielle E Jondal, Karen L Rech, Samir Mardini, David A Woodrum
A 17-year-old previously healthy female presented with a progressive soft tissue infiltrative process involving the neck and thorax. Extensive diagnostic evaluation including multiple imaging, laboratory, and biopsy studies was nondiagnostic. Due to an urgent need to establish a diagnosis and several previous nondiagnostic biopsies, she was referred to interventional radiology for MRI-guided wire localization immediately prior to open surgical biopsy. Under general anesthesia, wires were placed in the areas of increased T2 signal within the bilateral splenius capitis muscles using intermittent MRI-guidance followed by immediate surgical biopsy down to the wires...
September 19, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27630925/spectrum-of-radiological-manifestations-in-lymphoproliferative-malignancies-with-unusual-extra-nodal-soft-tissue-involvement
#3
Shantiranjan Sanyal, Kahila Prasad, Lalendra Upreti, Umesh Chandra Garga
Lymphoproliferative malignancies constitute a wide spectrum of haematological malignancies and their prevalence is widely increasing. Non-Hodgkin lymphomas and Hodgkin disease, frequently involve extranodal soft tissue structures in the head and neck, thorax and abdomen. These malignancies may involve virtually any type of soft tissues to any extent; hence many different imaging manifestations are possible which may mimic other disorders. The imaging characteristics of extranodal lymphomatous soft tissue involvement are described and classified here according to the site of involvement in 6 cases (primary diseases with orbital, muscle, extra testicular, scalp, sinonasal and pachymeningeal/dural involvement)...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27529214/apoptotic-pathways-linked-to-endocrine-system-as-potential-therapeutic-targets-for-benign-prostatic-hyperplasia
#4
REVIEW
Letteria Minutoli, Mariagrazia Rinaldi, Herbert Marini, Natasha Irrera, Giovanni Crea, Cesare Lorenzini, Domenico Puzzolo, Andrea Valenti, Antonina Pisani, Elena B Adamo, Domenica Altavilla, Francesco Squadrito, Antonio Micali
Benign prostatic hyperplasia (BPH) is a chronic condition common in older men that can result in bothersome lower urinary tract symptoms. The molecular mechanisms and networks underlying the development and the progression of the disease are still far from being fully understood. BPH results from smooth muscle cell and epithelial cell proliferation, primarily within the transition zone of the prostate. Apoptosis and inflammation play important roles in the control of cell growth and in the maintenance of tissue homeostasis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27526298/pax7-expression-in-rhabdomyosarcoma-related-soft-tissue-tumors-and-small-round-blue-cell-neoplasms
#5
Gregory W Charville, Sushama Varma, Erna Forgó, Sarah N Dumont, Eduardo Zambrano, Jonathan C Trent, Alexander J Lazar, Matt van de Rijn
Rhabdomyosarcoma, the most common soft tissue malignancy of childhood, is a morphologically variable tumor defined by its phenotype of skeletal muscle differentiation. The diagnosis of rhabdomyosarcoma often relies in part on the identification of myogenic gene expression using immunohistochemical or molecular techniques. However, these techniques show imperfect sensitivity and specificity, particularly in scant tissue biopsies. Here, we expand the toolkit for rhabdomyosarcoma diagnosis by studying the expression of PAX7, a transcriptional regulator of mammalian muscle progenitor cells implicated in the pathogenesis of rhabdomyosarcoma...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27524195/-clinical-and-myopathological-features-of-jo-1-syndrome
#6
L C Meng, Y Li, W Zhang, H J Hao, F Gao, Y Yuan
OBJECTIVE: To report the clinical and myopathological features of 16 patients with Jo-1 syndrome. METHODS: Sixteen patients were recruited in this study, who were diagnosed as Jo-1 syndrome in Department of Neurology of Peking University First Hospital from January, 2011 to July, 2015. The clinical data and myopathological data were analyzed. RESULTS: The mean onset age was 41±14 (21-68) years old. 87.5% was female. The median duration was 9...
August 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27516932/malt-lymphoma-of-the-left-biceps-muscle-a-rare-case-with-an-interesting-presentation
#7
Ipek Yonal-Hindilerden, Fehmi Hindilerden, Ibrahim Oner Dogan, Meliha Nalcaci
BACKGROUND: Extranodal marginal zone lymphoma (MZL), also called mucosa-associated lymphoid tissue (MALT) lymphoma accounts for 7-8 % of non-Hodgkin lymphomas (NHLs) and most commonly involves the stomach. However, muscle involvement is very rare. CASE DESCRIPTION: A 57-year-old woman was referred to our orthopaedics and traumatology clinic with a painful lump in the left arm. Physical examination revealed a red-colored mass on the left arm and an enlarged lymph node measuring almost 5 cm in the left axillary region and 3 cm in the right axillary region...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27500890/intranodal-palisaded-myofibroblastoma-a-rare-case-report-and-literature-review
#8
Yasemin Yuyucu Karabulut, Tuba Kara, Mustafa Berkeşoğlu
Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal neoplasm originating from smooth muscle cells and myofibroblasts. The inguinal region is the most common site of this rare tumor. As there are only about 89 such cases reported in the literature, the precise etiology and pathogenesis have yet to be explained adequately. It is characterized by spindle cells, amianthoid fibers, and by the proliferation of hemosiderin-containing histiocytes in the lymph node. A nodular lesion was excised from the inguinal region of a 47-year-old female patient with the clinical diagnosis of lymphoma and/or metastase...
October 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27398038/aggressive-lymphoma-sarcoma-mimicker-originating-in-the-gluteus-and-adductor-muscles-a-case-report-and-literature-review
#9
Sarah A Elkourashy, Abdulqadir J Nashwan, Syed I Alam, Adham A Ammar, Ahmed M El Sayed, Halima El Omri, Mohamed A Yassin
Extranodal lymphoma (ENL) occurs in approximately 30%-40% of all patients with non-Hodgkin lymphoma and has been described in almost all organs and tissues. However, diffuse large B-cell lymphoma is the most common histological subtype of non-Hodgkin lymphoma, primarily arising in the retroperitoneal region. In this article, we report a rare case of an adult male diagnosed with primary diffuse large B-cell lymphoma of the gluteal and adductor muscles with aggressive bone involvement. All appropriate radiological and histopathological studies were done for diagnosis and staging...
2016: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/27391986/-radiation-induced-radiculopathy-with-paresis-of-the-neck-and-autochthonous-back-muscles-with-additional-myopathy
#10
G Ellrichmann, C Lukas, I A Adamietz, C Grunwald, C Schneider-Gold, R Gold
Radiation-induced tissue damage is caused by ionizing radiation mainly affecting the skin, vascular, neuronal or muscle tissue. Early damages occur within weeks and months while late damages may occur months or even decades after radiation.Radiation-induced paresis of the spine or the trunk muscles with camptocormia or dropped-head syndrome are rare but have already been described as long-term sequelae after treatment of Hodgkin's lymphoma. The differential diagnosis includes limb-girdle muscular dystrophy, fascioscapulohumeral muscular dystrophy (FSHD) or lysosomal storage diseases (e...
June 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27385213/anaplastic-lymphoma-kinase-aberrations-correlate-with-metastatic-features-in-pediatric-rhabdomyosarcoma
#11
Patrizia Gasparini, Michela Casanova, Raffaella Villa, Paola Collini, Rita Alaggio, Angelica Zin, Paolo Bonvini, Cristina R Antonescu, Renata Boldrini, Roberto Caserini, Massimo Moro, Giovanni Centonze, Cristina Meazza, Maura Massimino, Luca Bergamaschi, Roberto Luksch, Stefano Chiaravalli, Gianni Bisogno, Nadia Zaffaroni, MariaGrazia Daidone, Gabriella Sozzi, Andrea Ferrari
Rhabdomyosarcoma (RMS) is the most frequent soft tissue tumor in childhood and arises from immature mesenchymal cells committed to skeletal muscle differentiation. Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in several cancers. Moreover, ALK full-length receptor protein has been observed in RMS, although its clinical and functional significance is yet controversial. The role of ALK and its clinical relevance were investigated in a selected cohort of 74 FFPE pediatric RMS and a panel of RMS cell lines, evaluating its gene and protein status, utilizing Fluorescent In Situ Hybridization (FISH), immunohistochemistry (IHC) and Western blot approaches...
July 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27330951/extranodal-pulmonary-marginal-zone-b-cell-lymphoma
#12
Şehnaz Olgun Yildizeli, Emel Eryüksel, Yasin Abul, Pegah Golabi, Işık Kaygusuz, Nihat Kodallı, Rengin Ahıskalı, Berrin Ceyhan
AIM: Extranodal mucosa-associated lymphoid tissue (MALT) arises a number of epithelial tissues, including the stomach, salivary gland, lung, small bowel, and elsewhere. Here we present a male patient with an uncommon site of extranodal MALT such as a pelvic mass diagnosed after a long period of evaluation, which initially presented with an incidental pulmonary nodule. METHOD: We report a 60 years old man presenting with pulmonary nodules and consolidation. He refused invasive procedures and 3 years later was administered to our clinic with disseminated pulmonary nodules on chest X-ray...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27304679/nodular-fasciitis-of-external-auditory-canal
#13
Jihyun Ahn, Sunyoung Kim, Youngsil Park
Nodular fasciitis is a pseudosarcomatous reactive process composed of fibroblasts and myofibroblasts, and it is most common in the upper extremities. Nodular fasciitis of the external auditory canal is rare. To the best of our knowledge, less than 20 cases have been reported to date. We present a case of nodular fasciitis arising in the cartilaginous part of the external auditory canal. A 19-year-old man complained of an auricular mass with pruritus. Computed tomography showed a 1.7 cm sized soft tissue mass in the right external auditory canal, and total excision was performed...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27247818/an-unusual-case-of-extranodal-diffuse-large-b-cell-lymphoma-infiltrating-skeletal-muscle-a-case-report-and-review-of-the-literature
#14
Joseph Hatem, Agata M Bogusz
Diffuse large B-cell lymphoma is extranodal in approximately 40% of cases, arising in nearly any organ system. DLBCL involvement of soft tissue and in particular skeletal muscle is extremely rare, comprising less than 1% of all extranodal non-Hodgkin lymphomas (NHL). We report a case of a 79-year-old man that presented with a DLBCL of the left triceps. In particular, we describe an unusual histologic appearance of pseudoglandular structures, resembling adenocarcinoma. We performed a review of lymphoma cases involving skeletal muscle diagnosed at our institution over the past 15 years as well as thorough PubMed review of the literature...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27224222/radiologic-and-clinicopathologic-findings-of-inflammatory-myofibroblastic-tumor
#15
Hongna Tan, Bo Wang, Huijuan Xiao, Yanbang Lian, Jianbo Gao
PURPOSE: The aim of the study was to describe the clinical, radiographic, and pathologic features of inflammatory myofibroblastic tumor (IMT) to enhance the recognition of this rare disease. MATERIALS AND METHODS: The clinical, imaging, and pathologic findings were retrospectively reviewed in 54 patients with IMT lesions, which were conformed by biopsy or surgical pathology. Of 54 patients, 51 had preoperative computed tomography (CT) examination and 13 had preoperative magnetic resonance imaging records...
May 25, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27194875/a-rare-spindle-cell-variant-of-non-hodgkin-s-lymphoma-of-the-mandible
#16
N Srikant, Shanmukha Raviteja Yinti, Mohan Baliga, Hema Kini
A 64-year-old male farmer presented with a rapidly progressive swelling of the left mandible since 6 months. The swelling was firm to hard, diffuse, nontender, obliterating the vestibule with paresthesia of lower lip. The cone beam computed tomography imaging revealed an ill-defined, moth-eaten radiolucency with destruction of the buccal and lingual cortical plates. The rapid growth and aggressive behavior of the lesion coupled with guidance from the patient's previous reports from the incisional biopsy and fine needle aspiration cytology warranted a mandibular resection...
January 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27191897/the-effects-of-the-5-ht2a-receptor-antagonist-sarpogrelate-hydrochloride-on-chronic-hypoxic-pulmonary-hypertension-in-rats
#17
Jie Geng, Fen-Ling Fan, Sai He, Ya Liu, Yan Meng, Hua Tian, Dan Zhang, Qiang Ma, Jun-Bo Zhang, Hong-Yan Tian
PURPOSE OF THE STUDY: This study investigated whether sarpogrelate hydrochloride (SPG), a 5-HT2A receptor antagonist, alleviates chronic hypoxic pulmonary hypertension (CH-PH) in rats by stimulating apoptosis and inhibiting proliferation in pulmonary artery smooth muscle cells (PASMCs). MATERIALS AND METHODS: Forty male Sprague-Dawley rats were pretreated with SPG (50 mg/kg/day by oral gavage) or saline vehicle and then subjected to chronic hypoxia (CH) (hypobaric chamber set to 380 mmHg, 10% oxygen) or normoxia for 14 days...
May 2016: Experimental Lung Research
https://www.readbyqxmd.com/read/27158055/structural-and-functional-abnormalities-of-hepatic-tissues-in-male-wistar-rats-fed-hyperwhey-and-super-amino-anabolic-protein
#18
Doaa A Ali, Hassan I H El-Sayyad, Osama A Moftah, Phil D Chilibeck
OBJECTIVE: Athletes and bodybuilders consume high-protein supplements to obtain energy and enhance the development and strength of their muscles. Over time, different investigations have revealed dysfunctions of their body organs. There are contradictions among scientists concerning the benefits and the alarm of developing body dysfunction. The aim of this study was to illustrate the effects on consumption of two anabolic protein supplements on body weight and structure and function of hepatocytes in male albino Wistar rats...
July 2016: Nutrition
https://www.readbyqxmd.com/read/27123276/back-to-the-start-evaluation-of-prognostic-markers-in-gastrointestinal-stromal-tumors
#19
Eckhard Klieser, Maximilian Pichelstorfer, Denis Weyland, Ralf Kemmerling, Stefan Swierczynski, Adam Dinnewitzer, Tarkan Jäger, Tobias Kiesslich, Daniel Neureiter, Romana Illig
The aim of this study was to provide a standardized risk stratification model for gastrointestinal stromal tumors (GISTs) based on tumor localization, tumor size, involved lymph nodes and metastases, as well as mitotic activity and other morphological and molecular markers, in order to improve the risk evaluation scheme for recurrence, metastatic spread and survival for patients with GIST. A total of 201 cases of patients with GIST were investigated according to standardized morphological markers, including nuclear pleomorphism, tumor cell necrosis, mucosal infiltration, ulceration, skeinoid fibers and growth pattern...
May 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27122220/-effects-of-1-25-oh-2d3-on-airway-remodeling-and-airway-epithelial-cell-apoptosis-in-a-murine-model-of-asthma
#20
Lu Zhang, Jiangtao Lin, Jing Guo, Weiliang Sun, Lin Pan
OBJECTIVE: To investigate the effects of calcitriol on airway remodeling and airway epithelial cell apoptosis in a murine model of bronchial asthma. METHODS: Twenty-four SPF female Balb/c mice were randomly allocated into three groups according to a random digits table with 8 mice in each group: the control group, the chronic asthma group and the calcitriol intervention group.(1) The chronic asthma group: the mice were sensitized by intraperitoneal injection of Ovalbumin (OVA, 20 μg) and aluminium hydroxide (50 μl) on days 1 and 14...
December 19, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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