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https://www.readbyqxmd.com/read/29166305/botulinum-toxin-therapy-is-syringe-type-related-to-cost-effectiveness
#1
Mark Anthony Foglietti, Lauren Wright, Alanna Foglietti-Fostyk
INTRODUCTION: Clostridium botulinum toxin is effective through cleaving presynaptic proteins at the neuromuscular junction, which prevents the release of acetylcholine and inhibits muscle contraction. Several serotypes of botulinum toxin (BT) exist; however, only 2 types have been approved by the US Food and Drug Administration for commercial and medical use, A and B. Both types of BT must be administered intramuscularly with a syringe, but the type of syringe is the injector's preference...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29165135/potential-predictors-of-susceptibility-to-occupational-stress-in-japanese-novice-nurses-a-pilot-study
#2
Shinobu Okita, Satoshi Daitoku, Masaharu Abe, Emi Arimura, Hitoshi Setoyama, Chihaya Koriyama, Miharu Ushikai, Hiroaki Kawaguchi, Masahisa Horiuchi
BACKGROUND: Occupational stress is a known factor behind employee resignations; thus, early identification of individuals prone to such stress is important. Accordingly, in this pilot study we evaluated potential predictors of susceptibility to occupational stress in Japanese novice nurses. METHODS: Forty-two female novice nurses at Kagoshima University Hospital were recruited for the study population. Each underwent physical health and urinary examinations, and completed a lifestyle questionnaire at the time of job entry...
April 4, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164850/exploring-highly-reversible-1-5-electron-reactions-v3-v4-v5-in-na3vcr-po4-3-cathode-for-sodium-ion-batteries
#3
Rui Liu, Guiliang Xu, Qi Li, Shiyao Zheng, Guorui Zheng, Zhengliang Gong, Yixiao Li, Elizaveta Kruskop, Riqiang Fu, Zonghai Chen, Khalil Amine, Yong Yang
Development of highly reversible multi-electron reaction per redox center in NASICON-structured cathode materials is desired to improve the energy density of Sodium-ion batteries. Here, we investigated more than one electron storage of Na in Na3VCr(PO4)3. Combining a series of advanced characterization techniques such as ex situ 51V solid-state nuclear magnetic resonance, X-ray absorption near edge structure and in situ X-ray diffraction, we reveal that, V3+/V4+ and V4+/V5+ redox couples in the materials can be accessed, leading to 1...
November 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29163901/violations-of-l%C3%A3-wenstein-s-rule-in-zeolites
#4
Rachel E Fletcher, Sanliang Ling, Ben Slater
Zeolites, microporous aluminosilicates, are amongst the most widely used catalysts in the petrochemical industry. Zeolite catalytic functionality is influenced by the location of tetrahedral alumina and associated counter-cations in the aluminosilicate framework, yet little is definitively known about the factors that govern the framework aluminium arrangement. It is generally accepted that all zeolites obey Löwenstein's rule of "aluminium avoidance", and that -Al-O-Al- bond formation is forbidden. Here, we describe an unprecedented screening of aluminium distribution in catalytically active zeolite SSZ-13 (CHA) in both its protonated and sodium-containing forms, H-SSZ-13 and Na-SSZ-13, using density functional theory (DFT)...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163194/on-the-metabolism-of-exogenous-ketones-in-humans
#5
Brianna J Stubbs, Pete J Cox, Rhys D Evans, Peter Santer, Jack J Miller, Olivia K Faull, Snapper Magor-Elliott, Satoshi Hiyama, Matthew Stirling, Kieran Clarke
Background and aims: Currently there is considerable interest in ketone metabolism owing to recently reported benefits of ketosis for human health. Traditionally, ketosis has been achieved by following a high-fat, low-carbohydrate "ketogenic" diet, but adherence to such diets can be difficult. An alternative way to increase blood D-β-hydroxybutyrate (D-βHB) concentrations is ketone drinks, but the metabolic effects of exogenous ketones are relatively unknown. Here, healthy human volunteers took part in three randomized metabolic studies of drinks containing a ketone ester (KE); (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, or ketone salts (KS); sodium plus potassium βHB...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162423/manipulating-aggregation-behaviour-of-the-uncharged-peptide-carbetocin
#6
Ulrich B Høgstedt, Jesper Østergaard, Torsten Weiss, Helen Sjögren, Marco van de Weert
Peptides are usually administered through subcutaneous injection. For low potency drugs, this may require high concentration formulations increasing the risk of peptide aggregation, especially for compounds without any intrinsic chargeable groups. Carbetocin was used as a model to study the behaviour of uncharged peptides at high concentrations. Manipulation of the aggregation behaviour of 70 mg/ml carbetocin was attempted by selecting excipients which interact with hydrophobic groups in carbetocin, and/or cover hydrophobic surfaces and interfaces...
November 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29161423/partial-bisulfite-conversion-for-unique-template-sequencing
#7
Vijay Kumar, Julie Rosenbaum, Zihua Wang, Talitha Forcier, Michael Ronemus, Michael Wigler, Dan Levy
We introduce a new protocol, mutational sequencing or muSeq, which uses sodium bisulfite to randomly deaminate unmethylated cytosines at a fixed and tunable rate. The muSeq protocol marks each initial template molecule with a unique mutation signature that is present in every copy of the template, and in every fragmented copy of a copy. In the sequenced read data, this signature is observed as a unique pattern of C-to-T or G-to-A nucleotide conversions. Clustering reads with the same conversion pattern enables accurate count and long-range assembly of initial template molecules from short-read sequence data...
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29161081/diet-obesity-and-asthma
#8
Lisa G Wood
Obesity has reached epidemic proportions in many developed countries as Western dietary patterns have been widely adopted. These diets are characterized by excess energy intake as well as regular consumption of processed or "fast" foods and limited consumption of fruit, vegetables, and whole grains. The result is a high intake of saturated fat, refined carbohydrates, and sodium; and a low intake of fiber, vitamins, and other phytochemicals. This type of poor-quality diet has been associated with increased risk of chronic inflammatory diseases, including asthma...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29161009/a-sensitive-microbead-based-organic-media-assisted-method-for-proteomics-sample-preparation-from-dilute-and-denaturing-solutions
#9
Masato Taoka, Michihiko Fujii, Masahiro Tsuchiya, Takamasa Uekita, Tohru Ichimura
We developed a robust and sensitive sample preparation method for proteomics termed microbead-based and organic-media-assisted proteolysis strategy (BOPs). BOPs combine two advantages of current techniques, (1) unbiased binding of reversed-phase polymeric microbeads to any type of protein and (2) enhanced trypsin digestion efficiency in CH3CN-aqueous solvent systems, into a single-tube workflow. Compared with conventional techniques, this method effectively concentrates proteins and improves proteolytic digestion, and can be used with submicromolar protein samples in dilute and/or denaturing solutions such as 70 % formic acid, 8 M urea, or 7 M guanidine hydrochloride without any sample pretreatment...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29159314/vasoconstriction-triggered-by-hydrogen-sulfide-evidence-for-na-k-2cl-cotransport-and-l-type-ca-2-channel-mediated-pathway
#10
Sergei N Orlov, Svetlana V Gusakova, Liudmila V Smaglii, Svetlana V Koltsova, Svetalana V Sidorenko
Objectives: This study examined the dose-dependent actions of hydrogen sulfide donor sodium hydrosulphide (NaHS) on isometric contractions and ion transport in rat aorta smooth muscle cells (SMC). Methods: Isometric contraction was measured in ring aortas segments from male Wistar rats. Activity of Na(+)/K(+)-pump and Na(+),K(+),2Cl(-)cotransport was measured in cultured endothelial and smooth muscle cells from the rat aorta as ouabain-sensitive and ouabain-resistant, bumetanide-sensitive components of the (86)Rb influx, respectively...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29158713/formulation-and-characterization-of-novel-soft-nanovesicles-for-enhanced-transdermal-delivery-of-eprosartan-mesylate
#11
Abdul Ahad, Abdulmohsen A Al-Saleh, Abdullah M Al-Mohizea, Fahad I Al-Jenoobi, Mohammad Raish, Alaa Eldeen B Yassin, Mohd Aftab Alam
The objective of the present work was to formulate, optimize and evaluate the potential of novel soft nanovesicles i.e. nano-transfersomes, containing eprosartan mesylate (EM) for transdermal delivery. Nano-transfersomes of EM were developed using Phospholipon 90G, Span 80 (SP) and sodium deoxycholate (SDC) and characterized for vesicle size, shape, entrapment efficiency, in vitro skin permeation study and confocal laser scanning microscopy. The optimized nano-transfersomes formulation showed vesicles size of 108...
November 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29157908/recent-trends-on-gellan-gum-blends-with-natural-and-synthetic-polymers-a-review
#12
REVIEW
Khalid Mahmood Zia, Shazia Tabasum, Muhammad Faris Khan, Nadia Akram, Naheed Akhter, Aqdas Noreen, Mohammad Zuber
Gellan gum (GG), a linear negatively charged exopolysaccharide,is biodegradable and non-toxic in nature. It produces hard and translucent gel in the presence of metallic ions which is stable at low pH. However, GG has poor mechanical strength, poor stability in physiological conditions, high gelling temperature and small temperature window.Therefore,it is blended with different polymers such as agar, chitosan, cellulose, sodium alginate, starch, pectin, polyanaline, pullulan, polyvinyl chloride, and xanthan gum...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#13
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29156926/-oral-feeding-and-nutritional-improvement-in-hospitals-and-residential-care-homes-industry-innovations
#14
Rosa M Ortega, Ana Isabel Jiménez Ortega, José Miguel Perea Sánchez, Esther Cuadrado Soto, Rosa M Martínez García, Ana M López Sobaler
OBJECTIVES: Inpatient and institutionalized elderly patients are population groups vulnerable from the nutritional point of view because oftheir greater risk of deficiencies and because in them the effects of imbalances are more serious than in other groups. Analyzing the possible usefulness of industry innovations offering solutions in the oral feeding of these population groups constitutes the objective of the present work. METHODS: Bibliographic search related to the topic...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29156289/the-extracellular-metaproteome-of-soils-under-semiarid-climate-a-methodological-comparison-of-extraction-buffers
#15
F Bastida, N Jehmlich, I F Torres, C García
We compare the protein extraction efficiencies, as well as the phylogenetic and functional information provided, of two extraction protocols in soils that differ mainly in their organic matter and clay contents, the main factors limiting protein extraction in semiarid soils. These protocols utilise extractants commonly used for the assay of extracellular enzyme activities. The first method was based on the utilisation of the modified universal buffer (MUB). The second was based on the extraction of humic substances with sodium pyrophosphate...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155968/novel-spiroplasma-spp-cultured-from-brains-and-lymph-nodes-from-ruminants-affected-with-transmissible-spongiform-encephalopathy
#16
Frank O Bastian, James Lynch, Sue Hagius, Xiaochu Wu, Greg McCormick, Donald G Luther, Philip H Elzer
Spiroplasma spp., tiny filterable wall-less bacteria, are consistently associated with the transmissible spongiform encephalopathies (TSE). Spiral forms have been transiently isolated from TSE-affected brain tissues in SP4 growth media designed for isolation of Spiroplasma spp., but the isolate could not be propagated in SP4 media. A bacterium must grow in vitro in cell-free cultures to allow full characterization of a suspect pathogen. Here, a novel Spiroplasma sp. was isolated from scrapie- and chronic wasting disease (CWD)-affected brains and lymph nodes...
November 15, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29155895/correction-enhancing-antibacterial-effect-of-sodium-hypochlorite-by-low-electric-current-assisted-sonic-agitation
#17
Murat Maden, İhsan Furkan Ertuğrul, Ekim Onur Orhan, Cevat Emre Erik, Ceylan Çağıl Yetiş, Yasin Tuncer, Mesud Kahriman
[This corrects the article DOI: 10.1371/journal.pone.0183895.].
2017: PloS One
https://www.readbyqxmd.com/read/29155717/synthesis-of-high-purity-nonsymmetric-dialkylphosphinic-acid-extractants
#18
Junlian Wang, Meiying Xie, Xinyu Liu, Shengming Xu
We present the synthesis of (2,3-dimethylbutyl)(2,4,4'-trimethylpentyl)phosphinic acid as an example to demonstrate a method for the synthesis of high purity nonsymmetric dialkylphosphinic acid extractants. Low toxic sodium hypophosphite was chosen as the phosphorus source to react with olefin A (2,3-dimethyl-1-butene) to generate a monoalkylphosphinic acid intermediate. Amantadine was adopted to remove the dialkylphosphinic acid byproduct, as only the monoalkylphosphinic acid can react with amantadine to form an amantadine∙mono-alkylphosphinic acid salt, while the dialkylphosphinic acid cannot react with amantadine due to its large steric hindrance...
October 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155085/ir-spectroscopy-analysis-of-pancreatic-lipase-related-protein-2-interaction-with-phospholipids-2-discriminative-recognition-of-various-micellar-systems-and-characterization-of-plrp2-dppc-bile-salt-complexes
#19
Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Deborah Byrne, Hélène Gaussier, Frédéric Carrière
The interaction of pancreatic lipase-related protein 2 (PLRP2) with various micelles containing phospholipids was investigated using pHstat enzyme activity measurements, differential light scattering, size exclusion chromatography (SEC) and transmission IR spectroscopy. Various micelles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and lysophosphatidylcholine were prepared with either bile salts (sodium taurodeoxycholate or glycodeoxycholate) or Triton X-100, which are substrate-dispersing agents commonly used for measuring phospholipase activities...
November 16, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/29153984/influence-of-mixed-additives-on-the-physicochemical-properties-of-a-5-25-sodium-hypochlorite-solution-an-unsupervised-multivariate-statistical-approach
#20
Oana Dragan, Ioan Tomuta, Dorina Casoni, Costel Sarbu, Radu Campian, Tiberiu Frentiu
INTRODUCTION: This article reports for the first time the effects of multiple additives (polyethylene glycol 400, Triton X-100, benzalkonium chloride, and ethyl formate) on the surface tension, pH, and viscosity of 5.25% sodium hypochlorite (NaOCl) irrigant solution. Advanced statistical approaches based on unsupervised multivariate analysis (cluster analysis and principal component analysis) were used to quantify the variability of the physicochemical properties of the modified NaOCl solution for the first time in dentistry...
November 16, 2017: Journal of Endodontics
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