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Methylation & vitamin D

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https://www.readbyqxmd.com/read/29914667/methylation-in-3-near-region-of-gc-gene-and-its-association-with-the-level-of-vitamin-d-binding-protein-and-type-2-diabetes-mellitus
#1
Songcheng Yu, Yan Wang, Xing Li, Zhenxing Mao, Fei Yu, Ling Wang, Yue Ba, Chongjian Wang, Wenjie Li
As the major vitamin D binding protein (DBP), the group-specific component (GC) plays an important role in the bioactivity of vitamin D. Abnormal expression of GC gene may be associated with vitamin D related disease, type 2 diabetes mellitus (T2DM). DNA methylation is an important regulator of gene expression. It has been reported that methylation in 3' untranslated region played a role in regulation of protein expression via interaction with miRNA. This study hypothesized that DNA methylation of 3' near region of GC gene (3'GC) might be associated with T2DM...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29883100/the-biochemical-basis-of-vitamin-a-production-from-asymmetric-carotenoid-%C3%AE-cryptoxanthin
#2
Mary E Kelly, Srinivasagan Ramkumar, Weizhong Sun, Crystal Colon Ortiz, Philip D Kiser, Marcin Golczak, Johannes von Lintig
Vitamin A serves essential functions in mammalian biology as a signaling molecule and chromophore. This lipid can be synthesized from more than 50 putative dietary provitamin A precursor molecules which contain at least one unsubstituted β-ionone ring. We here scrutinized the enzymatic properties and substrate specificities of the two structurally related carotenoid cleavage dioxygenases (CCDs) which catalyze this synthesis. Recombinant BCO1 split substrates across the C15,C15' double bond adjacent to a canonical β-ionone ring site to vitamin A aldehyde...
June 8, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29878267/l-5-methyltetrahydrofolate-supplementation-increases-blood-folate-concentrations-to-a-greater-extent-than-folic-acid-supplementation-in-malaysian-women
#3
Amanda M Henderson, Rika E Aleliunas, Su Peng Loh, Geok Lin Khor, Sarah Harvey-Leeson, Melissa B Glier, David D Kitts, Tim J Green, Angela M Devlin
Background: Folic acid fortification of grains is mandated in many countries to prevent neural tube defects. Concerns regarding excessive intakes of folic acid have been raised. A synthetic analog of the circulating form of folate, l-5-methyltetrahydrofolate (l-5-MTHF), may be a potential alternative. Objective: The objective of this study was to determine the effects of folic acid or l-5-MTHF supplementation on blood folate concentrations, methyl nutrient metabolites, and DNA methylation in women living in Malaysia, where there is no mandatory fortification policy...
June 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29808256/cdx-2-polymorphism-in-the-vitamin-d-receptor-gene-vdr-marks-vdr-expression-in-monocyte-macrophages-through-vdr-promoter-methylation
#4
Vanessa Meyer, Liza Bornman
Caudal-type homeobox protein 2 (CDX-2) is an intestine-specific transcription factor (TF), with a polymorphic binding site (Cdx-2, rs11568820, A/G) in the vitamin D receptor gene (VDR). The molecular mechanism underlying Cdx-2 association with conditions like osteoporosis, which depends on intestinal VDR expression and calcium absorption, is believed to be due to higher affinity of CDX-2 for the ancestral A allele compared to the G allele. However, it is unclear why the polymorphism is associated with diseases like tuberculosis, which is dependent on VDR expression in immune cells that do not express CDX-2...
May 28, 2018: Immunogenetics
https://www.readbyqxmd.com/read/29782187/effects-of-maternal-vitamin-d-supplementation-on-the-maternal-and-infant-epigenome
#5
Cindy M Anderson, Shannon L Gillespie, Doria K Thiele, Jody L Ralph, Joyce E Ohm
INTRODUCTION: Mothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly understood. OBJECTIVE: This study quantified the effects of vitamin D3 supplementation on DNA methylation in pregnant and lactating women and their breastfed infants. MATERIALS AND METHODS: In this randomized controlled pilot study, pregnant women received vitamin D3 400 international units (IU) (n = 6; control) or 3,800 IU (n = 7; intervention) daily from late second trimester through 4-6 weeks postpartum...
May 21, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29766504/indene-compounds-synthetically-derived-from-vitamin-d-have-selective-antibacterial-action-on-helicobacter-pylori
#6
Kiyofumi Wanibuchi, Kouichi Hosoda, Masato Ihara, Kentaro Tajiri, Yuki Sakai, Hisashi Masui, Takashi Takahashi, Yoshikazu Hirai, Hirofumi Shimomura
Helicobacter pylori infects the human stomach and is closely linked with the development of gastric cancer. When detected, this pathogen can be eradicated from the human stomach using wide-spectrum antibiotics. However, year by year, H. pylori strains resistant to the antibacterial action of antibiotics have been increasing. The development of new antibacterial substances effective against drug-resistant H. pylori is urgently required. Our group has recently identified extremely selective bactericidal effects against H...
May 16, 2018: Lipids
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#7
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29719581/adipose-tissue-inflammation-and-vdr-expression-and-methylation-in-colorectal-cancer
#8
Daniel Castellano-Castillo, Sonsoles Morcillo, Mercedes Clemente-Postigo, Ana Belén Crujeiras, Jose Carlos Fernandez-García, Esperanza Torres, Francisco José Tinahones, Manuel Macias-Gonzalez
Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. Adipose tissue dysfunction has been related to low-grade inflammation, which is related to diseases like cancer. The aim of this study was to explore the relationship between serum 25-hydroxyvitamin D (25(OH)D), adipose tissue gene expression of VD receptor (VDR), pro-inflammatory markers, and the epigenetic factor DNA methyltransferase 3a (DNMT3A) as well as VDR promoter methylation in CRC...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29706929/neuromodulatory-effect-of-thymoquinone-in-attenuating-glutamate-mediated-neurotoxicity-targeting-the-amyloidogenic-and-apoptotic-pathways
#9
Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed
Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca2+ , mitochondrial dysfunction, and apoptosis. Moreover, it was previously reported that prolonged activation of the NMDA receptor increased beta-amyloid (Aβ) levels in the brain. Thymoquinone (TQ), the active constituent of Nigella sativa seeds, has been shown to have potent antioxidant and antiapoptotic effects...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29698861/lc-ms-based-urinary-metabolomics-study-of-the-intervention-effect-of-aloe-emodin-on-hyperlipidemia-rats
#10
Hongyu Ji, Yu Liu, Fang He, Ran An, Zhimin Du
Hyperlipidemia has been highlighted to be one of the most prominent and global chronic condition nowadays. Daming capsule (DMC), a traditional Chinese medicine (TCM) preparation, has treated hyperlipidemia on clinic in China for decades. Our recent study showed that aloe-emodin (AE) is one of the main bioactive components in DMC. Therefore, the present study aims to further investigate the lipid-lowering effect by serum biochemistry and histopathological examination, and reveal the underlying mechanisms by urinary metabolomics approach...
July 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29652161/synthesis-of-side-chain-locked-analogs-of-1%C3%AE-25-dihydroxyvitamin-d-3-bearing-a-c17-methyl-group
#11
Rita Sigüeiro, Miguel A Maestro, Antonio Mouriño
A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described. The synthetic approach features an SN 2'- syn displacement of carbamates by cuprates to set the challenging quaternary stereogenic center at C17 and a Pd-catalyzed construction of the triene system in the presence of a diyne moiety.
May 4, 2018: Organic Letters
https://www.readbyqxmd.com/read/29577619/cellular-and-molecular-mechanisms-of-vitamin-d-in-food-allergy
#12
REVIEW
Ashlyn Poole, Yong Song, Helen Brown, Prue H Hart, Guicheng Brad Zhang
Food allergies are becoming increasingly prevalent, especially in young children. Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis. Links have been made between variations in sunlight exposure, latitude, birth season and vitamin D status with food allergy risk. Despite the heightened interest in vitamin D in food allergies, it remains unclear by which exact mechanism(s) it acts. An understanding of the roles vitamin D plays within the immune system at the cellular and genetic levels, as well as the interplay between the microbiome and vitamin D, will provide insight into the importance of the vitamin in food allergies...
March 25, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29560490/effects-of-2-substitution-on-14-epi-19-nortachysterol-mediated-biological-events-based-on-synthesis-and-x-ray-co-crystallographic-analysis-with-the-human-vitamin-d-receptor
#13
Daisuke Sawada, Shinji Kakuda, Akiko Takeuchi, Fumihiro Kawagoe, Midori Takimoto-Kamimura, Atsushi Kittaka
Both 2α- and 2β-hydroxypropyl substituted 14-epi-1α,25-dihydroxy-19-nortachysterols were synthesized to study the human vitamin D receptor (hVDR) binding affinity, binding configurations, and interactions with amino acid residues in the ligand binding domain of hVDR by X-ray co-crystallographic analysis. In conjunction with our previous results on 14-epi-19-nortachysterol, 2-methylidene-, 2α-methyl-, 2β-methyl, and 2α-hydroxypropoxy-14-epi-19-nortachysterol, we propose a variety of effects of substitution at the C2 position in the 14-epi-19-nortachysterol skeleton on biological activities...
April 4, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29492317/multigenerational-analysis-of-sex-specific-phenotypic-differences-at-midgestation-caused-by-abnormal-folate-metabolism
#14
Nisha Padmanabhan, Joanna Rakoczy, Monika Kondratowicz, Katerina Menelaou, Georgina E T Blake, Erica D Watson
The exposure to adverse environmental conditions (e.g. poor nutrition) may lead to increased disease risk in an individual and their descendants. In some cases, the results may be sexually dimorphic. A range of phenotypes has been associated with deficiency in or defective metabolism of the vitamin folate. However, the molecular mechanism linking folate metabolism to development is still not well defined nor is it clear whether phenotypes are sex-specific. The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle...
October 2017: Environmental Epigenetics
https://www.readbyqxmd.com/read/29490089/use-of-mathematical-optimization-models-to-derive-healthy-and-safe-fish-intake
#15
Maria Persson, Sisse Fagt, Sara M Pires, Morten Poulsen, Florent Vieux, Maarten J Nauta
Background: Recommended fish intake differs substantially from observed fish intake. In Denmark, ∼15% of the population consumes the state-recommended fish intake. How much fish individuals eat varies greatly, and this variation cannot be captured by considering the fish intake of the average population. Objective: We developed a method intended to provide realistic and achievable personalized dietary recommendations based on an individual's body weight and current fish intake...
February 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29477222/recent-developments-in-folate-nutrition
#16
REVIEW
Nassim Naderi, James D House
The term folate (vitamin B9) refers to a group of water-soluble compounds that are nutritionally essential for the support of optimal human health and development. Folates participate in numerous one-carbon transfer reactions, including the methylation of important biomolecules (lipids, amino acids, DNA). A deficiency of folate leads to pathological outcomes including anemia and impairments in reproductive health and fetal development. Due to the linkage of impaired folate status with an increased prevalence of neural tube defects (NTDs) in babies, several jurisdictions required the fortification of the food supply with folic acid, a synthetic and stable form of folate...
2018: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/29432833/structure-of-an-entangled-heteropolysaccharide-from-pholidota-chinensis-lindl-and-its-antioxidant-and-anti-cancer-properties
#17
Dianhui Luo, Zhaojing Wang, Zhiming Li, Xiao-Qiang Yu
A major polysaccharide PCP-I was isolated and purified from Pholidota chinensis Lindl. The physicochemical and structural properties of PCP-I were studied using high-performance size-exclusion chromatography (HPSEC), gas chromatography (GC), Fourier transform infrared spectroscopy (FTIR), periodate oxidation-smith degradation, methylation-GC-MS analysis, nuclear magnetic resonance (NMR) spectroscopy and transmission electron microscopy (TEM) analysis. PCP-I was homogeneous with molecular weight (Mw) of 249kDa and composed of xylose and fucose at a molar ratio of 2...
June 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29432829/vitamin-d-receptor-gene-methylation-in-hepatocellular-carcinoma
#18
Mai Abdalla, Eman Khairy, Manal L Louka, Randa Ali-Labib, Eman Abdel-Salam Ibrahim
Worldwide, hepatocellular carcinoma (HCC) is the major subtype of primary liver cancers. HCC is typically diagnosed late in its course. With respect to cancer, the genomic actions of vitamin D are mediated through binding to the Vitamin D Receptor (VDR), which allows it to modulate the expression of genes in a cell-and tissue-specific manner. Epigenetics is a rapidly evolving field of genetic study applicable to HCC. Changes in DNA methylation patterns are thought to be early events in hepatocarcinogenesis...
May 5, 2018: Gene
https://www.readbyqxmd.com/read/29395637/effect-of-adding-b-vitamins-to-vitamin-d-and-calcium-supplementation-on-cpg-methylation-of-epigenetic-aging-markers
#19
R Obeid, U Hübner, M Bodis, S Graeber, J Geisel
BACKGROUND AND AIM: B-vitamins may influence DNA methylation. We studied the effects of vitamin D + Ca + B versus D + Ca on epigenetic age markers and biological age. METHODS AND RESULTS: Participants (mean ± SD of age = 68.4 ± 10.1 years) were randomized to receive 1200 IE vitamin D3 plus 800 mg Ca-carbonate alone (n = 31) or with 0.5 mg B9, 50 mg B6, and 0.5 mg B12 (n = 32). The CpG methylation of 3 genes (ASPA, ITGA2B, and PDE4C) and the changes in methylation were compared between the groups after 1 year...
April 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29383703/epigenetic-changes-and-their-implications-in-autoimmune-hepatitis
#20
REVIEW
Albert J Czaja
BACKGROUND: The genetic risk of autoimmune hepatitis is insufficient to explain the observed risk, and epigenetic changes may explain disparities in disease occurrence in different populations within and between countries. The goal of this review was to examine how epigenetic changes induced by the environment or inherited as a phenotypic trait may affect autoimmune hepatitis and be amenable to therapeutic intervention. MATERIALS AND METHODS: Pertinent abstracts were identified in PubMed by multiple search terms...
April 2018: European Journal of Clinical Investigation
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